Category: 93118-03-7

Safak, Cihat published the artcileSynthesis and Myorelaxant Activity of Fused 1,4-Dihydropyridines on Isolated Rabbit Gastric Fundus, Quality Control of 93118-03-7, the main research area is dihydropyridine derivative myorelaxant gastric fundus smooth muscle calcium channel.

Strategy, Management and Health PolicyEnabling Technol., Genomics, ProteomicsPreclin. ResearchPreclin. Development Toxicol., Formulation Drug Delivery, PharmacokineticsClin. Development Phases I-III Regulatory, Quality, ManufacturingPostmarketing Phase IV In the present study, 25 novel condensed 1,4-dihydropyridine (DHP) derivatives bearing cyclopentane, cyclohexane, or tetrahydrothiopene ring with a bulky and lipophilic moiety (3-pyridylmethyl) in the ester group were synthesized via a modified Hantzsch reaction, and their calcium channel modulator activities were assayed on isolated rabbit gastric fundus smooth muscle strips. To evaluate the myorelaxant effects of the compounds, the maximum relaxant response (Emax) and pD2 values were calculated The results indicated that all compounds produced concentration-dependent relaxation and the introduction of five- or six-membered rings to the DHP nucleus and 3-pyridiylmethyl moiety to the ester group led to potent calcium antagonists.

Drug Development Research published new progress about Calcium channels Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Quality Control of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marino, Joseph P. published the artcileThe discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages, COA of Formula: C8H4ClF3O, the main research area is tertiary amine preparation reductive amination nucleophilic substitution; liver X receptor LXR agonist cholesterol efflux macrophage pharmacokinetics; structure activity coronary heart disease cholesterol homeostasis lipid metabolism.

The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism SAR studies around tertiary-amine lead mol. I, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.

Bioorganic & Medicinal Chemistry Letters published new progress about Liver X receptor β Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (agonists). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Saha, Debasmita published the artcileFacile Construction of Imidazo-benzothia-/oxazepines by a Quick and Efficient van Leusen Protocol, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is dihydrodibenzoimidazothiazepine preparation; isocyanide dibenzothiazepine preparation Van Leusen; dihydrodibenzoimidazooxazepine preparation; dibenzoxazepine preparation isocyanide Van Leusen protocol.

A facile, elegant, and operationally simple Van Leusen protocol for the synthesis of bicyclic dihydrodibenzo[b,f]imidazo[1,2-d][1,4]thiazepines I [X = S; R1 = R2 = R4 = H, Cl; R3 = H, NO2; R5 = C(O)OEt, Ts] and dihydrodibenzo[b,f]imidazo[1,2-d][1,4]oxazepines I [X = O] was developed. The reaction proceeded without any catalyst and in high yields to provide bicyclic imidazo-dibenzothia-/oxazepines at room temperature by using dibenzothiazepines or dibenzoxazepines as imine counterparts.

Asian Journal of Organic Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Senkardes, Sevil published the artcileSynthesis, antimicrobial properties and in silico studies of aryloxyacetic acid derivatives with hydrazone or thiazolidine-4-one scaffold, Application In Synthesis of 93118-03-7, the main research area is arylideneamino phenoxyacetamide preparation antibacterial antifungal SAR docking; arylthiazolidinyl phenoxyacetamide preparation antibacterial antifungal SAR docking; 4-thiazolidinone; Cresol; antimicrobial activity; hydrazone; molecular docking.

In this work, twenty hydrazide-hydrazones I [Ar = 3,5-dimethylphenyl, 2-chloro-3-methoxyphenyl, 4-phenylthiophen-2-yl, etc.] and 4-thiazolidinone derivatives II were synthesized starting from m-cresol. Antimicrobial evaluation was carried out by microdilution method against Enterococcus faecalis and Staphylococcus aureus as Gram-pos. bacteria and Escherichia coli and Pseudomonas aeruginosa as Gram-neg. bacteria, and three pathogenic fungi Candida albicans, Candida parapsilosis and Candida krusei. Some compounds possessed considerable antimicrobial properties against the tested microorganisms, particularly against E. coli. Compounds II [Ar = 3-methoxyphenyl, 3,5-dichlorophenyl] were found to be the most active derivatives with MICs of 2 μg/mL against E. coli and compounds I [Ar = 3,5-dichlorophenyl] also displayed antifungal activity against Candida krusei that was comparable to fluconazole. Calculated drug-likeness and ADMET parameters of the most active compounds confirmed their potential as antimicrobial drug candidates. Mol. docking investigations were carried out in the thiamine diphosphate-binding site of pyruvate dehydrogenase multienzyme complex E1 component (PDHc-E1) to clarify the potential antibacterial mechanism against E. coli. The results showed the potential and importance of developing new hydrazones and 4-thiazolidinones that would be effective against microbial strains.

Journal of Biomolecular Structure and Dynamics published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application In Synthesis of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Zong-ying published the artcileSynthesis and evaluation of 1-(benzo[b]thiophen-2-yl)ethanone analogues as novel anti-osteoporosis agents acting on BMP-2 promotor, Quality Control of 93118-03-7, the main research area is benzothiophenyl ethanone derivative preparation BMP2 promotor antiosteoporosis agent.

A novel series of 1-(benzo[b]thiophen-2-yl)ethanone analogs were prepared and evaluated for enhancing BMP-2 expression. Some compounds exhibited potent effect for enhancing BMP-2 expression. Compounds I and II produced a dose-dependent increase on bone histol. and histomorphometry, and effectively reduced bone defects induced by ovariectomy in an ovariectomized rat model (OVX).

Bioorganic & Medicinal Chemistry Letters published new progress about Antiosteoporotic agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Quality Control of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics