Category: 93765-83-4

Related Products of 93765-83-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 93765-83-4, name is 1-Bromo-5-chloro-2-fluoro-4-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation 12To a solution of 1-bromo-5-chloro-2-fluoro-4-methylbenzene (Comm, 10 g, 44.7 mmol) in methanol (200 ml_) was added 1 ,1′-binaphthalene-2,2′-diylbis(diphenylphosphine) – dichloropalladium (1:1) (358 mg, 0.447 mmol) and N,N-diethylethanamine (8.11 ml_, 58.2 mmol). The resulting mixture was placed in a bomb and pressurized with carbon monoxide to 80 psi and heated at 80C for 18 hours. The reaction mixture was then concentrated in vacuo to yield a semi-solid, which was dissolved in EtOAc (300 ml_) and washed with water (200 mL). The organic layer was separated, dried over magnesium sulphate, filtered and concentrated in vacuo to yield an orange oil, which solidified on standing (9.87 g). The solid was purified by silica gel chromatography eluting with 0 to 20% EtOAc in heptane to afford the title compound as a crystalline white solid (8.47 g, 93%).1H NMR (400 MHz, CDCI3): delta 2.40 (s, 3H), 3.92 (s, 3H), 7.03 (d, 1 H), 7.91 (d, 1 H) LCMS Rt = 1 .64 minutes Molecular ion not observed

The synthetic route of 1-Bromo-5-chloro-2-fluoro-4-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; BROWN, Alan, Daniel; RAWSON, David, James; STORER, Robert, Ian; SWAIN, Nigel, Alan; WO2012/7868; (2012); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93765-83-4, name is 1-Bromo-5-chloro-2-fluoro-4-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H5BrClF

A mixture of 1-bromo-5-chloro-2-fluoro-4-methylbenzene (500 mg, 2.3 mmol), N-bromosuccinimide (481 mg, 2.7 mmol) and azobisisobutyronitrile (38 mg, 0.23 mmol) in CCl4 (10 mL) was stirred at 90 C for 16 h. The mixture was diluted with DCM (20 ml) and water (20 ml). The organic layer was separated, dried over Na2S04, filtered and evaporated to get crude product. The residue was purified by silica column chromatography (eluting with petroleum ether/ethyl acetate = 50/1) to give 1-bromo-4-(bromomethyl)-5-chloro-2-fluorobenzene as a solid (324 mg, 47%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 93765-83-4.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; CHEN, Chien-An; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; SUN, Shaoyi; WO2014/144545; (2014); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 93765-83-4, The chemical industry reduces the impact on the environment during synthesis 93765-83-4, name is 1-Bromo-5-chloro-2-fluoro-4-methylbenzene, I believe this compound will play a more active role in future production and life.

A mixture of 1-bromo-5-chloro-2-fluoro-4-methylbenzene (5.0 g, 23 mmol), copper(I) cyanide (4.0 g, 45 mmol) and copper(I) iodide (8.6 g, 45 mmol) in NMP (50 mL) was heated at 140C over night. After cooling to room temperature, the mixture was filterted and the filtrate was diluted with water (100 mL) and extracted with ethyl acetate (100 mL chi 3). The combined organic layers were washed with water (100 mL) and dried over Na2SO4. The solvent was removed and the residue was purified by SGC (eluting with petroleum ether/EtOAc = 10/1) to afford 5-chloro-2-fluoro-4-methylbenzonitrile (1.7 g, 45% yield) as a white solid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-5-chloro-2-fluoro-4-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; CHEN, Chien-An; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; SUN, Shaoyi; WO2014/144545; (2014); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 93765-83-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 93765-83-4, name is 1-Bromo-5-chloro-2-fluoro-4-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation 12To a solution of 1-bromo-5-chloro-2-fluoro-4-methylbenzene (Comm, 10 g, 44.7 mmol) in methanol (200 ml_) was added 1 ,1′-binaphthalene-2,2′-diylbis(diphenylphosphine) – dichloropalladium (1:1) (358 mg, 0.447 mmol) and N,N-diethylethanamine (8.11 ml_, 58.2 mmol). The resulting mixture was placed in a bomb and pressurized with carbon monoxide to 80 psi and heated at 80C for 18 hours. The reaction mixture was then concentrated in vacuo to yield a semi-solid, which was dissolved in EtOAc (300 ml_) and washed with water (200 mL). The organic layer was separated, dried over magnesium sulphate, filtered and concentrated in vacuo to yield an orange oil, which solidified on standing (9.87 g). The solid was purified by silica gel chromatography eluting with 0 to 20% EtOAc in heptane to afford the title compound as a crystalline white solid (8.47 g, 93%).1H NMR (400 MHz, CDCI3): delta 2.40 (s, 3H), 3.92 (s, 3H), 7.03 (d, 1 H), 7.91 (d, 1 H) LCMS Rt = 1 .64 minutes Molecular ion not observed

The synthetic route of 1-Bromo-5-chloro-2-fluoro-4-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; BROWN, Alan, Daniel; RAWSON, David, James; STORER, Robert, Ian; SWAIN, Nigel, Alan; WO2012/7868; (2012); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

93765-83-4, name is 1-Bromo-5-chloro-2-fluoro-4-methylbenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1-Bromo-5-chloro-2-fluoro-4-methylbenzene

To a solution of 1-bromo-5-chloro-2-fluoro-4-methylbenzene (11.3 g, 50 mmol) in dry THF (100 mL) was added isopropylmagnesium chloride (30 mL, 2 M) dropwise. After stirring at room temperature for 30 min, dry CO2 was added and the mixture was stirred at room temperature for additional 30 min. The reaction was quenched by sat. NH4Cl and extracted with EtOAc (100 mL*3). The combined organic layers were washed with water (50 mL*3), dried over anhydrous Na2SO4, filtered and concentrated to give the desired product (4.7 g, 49%). LCMS (ESI) m/z: 187.0 [M-H]-.

The synthetic route of 93765-83-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XENON PHARMACEUTICALS INC.; GENENTECH, INC; Chowdhury, Sultan; Dehnhardt, Christoph Martin; Focken, Thilo; Grimwood, Michael Edward; Hemeon, Ivan William; Jia, Qi; Ortwine, Daniel; Safina, Brian; Sun, Shaoyi; Sutherlin, Daniel P.; Zenova, Alla Yurevna; US2013/317000; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics