Design, Synthesis, and Biological Activity of Novel Polycyclic Aza-Amide FKBP12 Ligands was written by Hudack, Raymond A. Jr.;Barta, Nancy S.;Guo, Chuangxing;Deal, Judith;Dong, Liming;Fay, Lorraine K.;Caprathe, Bradley;Chatterjee, Arindam;Vanderpool, Darin;Bigge, Christopher;Showalter, Richard;Bender, Steve;Augelli-Szafran, Corinne E.;Lunney, Elizabeth;Hou, Xinjun. And the article was included in Journal of Medicinal Chemistry in 2006.Name: 2-(2,3-Dichlorophenyl)-2-oxoacetic acid The following contents are mentioned in the article:
Since the discovery that FK-506 promotes neurite outgrowth, considerable attention has been focused on the development of potent non-immunosuppressive ligands for FK-506 binding proteins (FKBPs). Such neuroimmunophilin agents have been reported to show neuroregenerative activity in a variety of cell and animal models including neurite outgrowth, age-related cognitive decline, Parkinson’s disease, peripheral nerve injury, optic nerve degeneration, and diabetic neuropathy. A unique series of tetracyclic aza-amides that have been shown to be potent FKBP-12 rotamase inhibitors were designed and synthesized. The structure-activity relationships established in this study have demonstrated diverse structural modifications that result in potent rotamase inhibitory activity. This study involved multiple reactions and reactants, such as 2-(2,3-Dichlorophenyl)-2-oxoacetic acid (cas: 93942-57-5Name: 2-(2,3-Dichlorophenyl)-2-oxoacetic acid).
2-(2,3-Dichlorophenyl)-2-oxoacetic acid (cas: 93942-57-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 2-(2,3-Dichlorophenyl)-2-oxoacetic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics