Category: 942069-73-0

He, Zhi-Tao published the artcileTrimethylphosphate as a Methylating Agent for Cross Coupling: A Slow-Release Mechanism for the Methylation of Arylboronic Esters, COA of Formula: C13H17BCl2O2, the publication is Journal of the American Chemical Society (2018), 140(49), 17197-17202, database is CAplus and MEDLINE.

Tri-Me phosphate acted as an effective source of Me groups; in the presence of CuI, and LiI, (MeO)₃P(:O) underwent chemoselective coupling with arylpinacolboronates mediated by LiOt-Bu in 1,3-dimethylimidazolidin-2-one (DMI) to yield methylarenes in higher yields than related coupling reactions using either Me iodide or Me tosylate. The methylation reaction was used in tandem with iridium-catalyzed regioselective borylation with bis(pinacolato)diboron to provide a one-pot methylation reaction for arenes, and for trideuteromethylation of arylpinacoboronates using tris(trideuteromethyl) phosphate. The chemoselectivity of the reaction was tested using additives possessing various functional groups (robustness screen); unprotected amines, alcs., and amides and terminal alkynes were not tolerated. The methylation of 1-naphthylpinacolboronate was demonstrated on a 200 mmol scale. The kinetics of the methylation and its dependence on Li⁺ and I^– ions was determined and a mechanism suggested. Me iodide is released slowly upon reaction of tri-Me phosphate with iodide; the low concentration of MeI enables selective reaction with arylcopper intermediates generated from the arylboronate rather than with other nucleophiles, while binding of tert-butoxide to the pinacolboronate reactants inhibits reaction of MeI with tert-butoxide.

Journal of the American Chemical Society published new progress about 942069-73-0. 942069-73-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(3,5-Dichloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H17BCl2O2, COA of Formula: C13H17BCl2O2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haydl, Alexander M. published the artcilePalladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters, HPLC of Formula: 942069-73-0, the publication is Organic Letters (2019), 21(5), 1337-1341, database is CAplus and MEDLINE.

A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu₂Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biol. active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.

Organic Letters published new progress about 942069-73-0. 942069-73-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(3,5-Dichloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H17BCl2O2, HPLC of Formula: 942069-73-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics