Category: 95-88-5

Preparation of the CNTs/AG/ITO electrode with high electro-catalytic activity for 2-chlorophenol degradation and the potential risks from intermediates was written by Liu, Haiyang;Zhang, Zhaocheng;Ren, Miao;Guan, Jiunian;Lu, Nan;Qu, Jiao;Yuan, Xing;Zhang, Ya-nan. And the article was included in Journal of Hazardous Materials in 2018.HPLC of Formula: 95-88-5 The following contents are mentioned in the article:

A novel carbon nanotubes (CNTs)/agarose (AG)/ITO electrode with high electro-catalytic activity was prepared using a simple sol-gel method. Characterization results showed that the prepared CNTs/AG membrane, coated on the ITO conductive glass, was consisted of C and O. The electro-catalytic degradation for 2-chlorophenol (2-CP) and the influence factors were investigated. The results meant that electro-catalytic degradation for 2-CP was highly dependent on pH, bias voltage, and catalyst dosage. At pH 2, 4V bias voltage, and 5wt% CNTs dosage, the electro-catalytic efficiency of CNTs/AG/ITO electrode for 2-CP (20 mg/L) achieved 98% within 180 min. Afterwards, the electro-catalytic properties of recycling electrode, roles of the generated reactive oxygen species, and the reaction pathways were also investigated and proposed. In addition, the toxicities of the generated intermediates from the electro-catalytic degradation were calculated by easy methods. The results indicated that the toxicities of some intermediates were higher than the parent pollutant, especially the formation of 2-CP dimer which was seldom reported in the advanced oxidation process. The findings of using AG as the carrier and conductive adhesive for catalytic material and the assessment methods for the possible increasing risks from the intermediates were reported firstly in this paper. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5HPLC of Formula: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of reliable quantitative structure-toxicity relationship models for toxicity prediction of benzene derivatives using semiempirical descriptors was written by Singh, Ayushi;Kumar, Sunil;Kapoor, Archana;Kumar, Parvin;Kumar, Ashwani. And the article was included in Toxicology Mechanisms and Methods.Name: 4-Chlororesorcinol The following contents are mentioned in the article:

The Health and environmental hazards of benzene and nitrobenzene (NB) derivatives have remained a topic of interest of researchers. In silico methods for prediction of toxicity of chems. have proved their worth in accurate forecast of environmental as well as health toxicity and are strongly recommended by regulatory authorities. Two quant. structure-toxicity relationship (QSTR) models explaining Scenedesmus obliquus toxicity trends among 39 benzene derivatives and Tetrahymena pyriformis toxicity of 103 NB and 392 benzene derivatives are developed using semiempirical quantum chem. parameters. The best constructed QSTR models have good fitting ability (R² = 0.8053, 0.7591, and 0.8283) and robustness (Q²LOO = 0.7507, 0.7227, and 0.8194; Q²LMO = 0.7338, 0.7153, and 0.8172). The external predictivity of all the models are quite good (R2EXT = 0.8256, 0.9349, and 0.8698). Electronegativity, Cosmo volume, total energy, and mol. weight are responsible for the increase and decrease of toxicity of benzene derivatives against S. obliquus while electronegativity, electrophilicity index, the heat of formation, total energy, hydrophobicity, and cosmo volume are responsible for modulation of toxicity of NB and benzene derivatives toward T. pyriformis. These models fulfill the requirements of all the five OECD principles. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Name: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Contact sensitizers in commercial hair dye products sold in Thailand was written by Boonchai, Waranya;Bunyavaree, Monthathip;Winayanuwattikun, Waranaree;Kasemsarn, Pranee. And the article was included in Contact Dermatitis in 2016.Recommanded Product: 95-88-5 The following contents are mentioned in the article:

Summary : Background : Hair dyes are known to contain potent contact allergens for which sensitization rates have increased over the last decade. Objective : To examine the type and frequency of potent contact sensitizers labeled on hair dyes sold in metropolitan Bangkok, Thailand. Methods : During the 2013-2014 study period, labeled ingredient information from home use and professional hair dye products was collected. Results : Two hundred and fifty-two hair dye products were evaluated. One hundred and forty-nine products from 48 brands were domestically produced in Thailand, and 103 products were from 23 multinational brands produced in countries other than Thailand. Two hundred and fourteen of 252 (84.9%) hair dye products were found to contain strong skin sensitizers, with 118 (46.8%) being found in domestically produced products, and 96 (38.1%) being found in multinational brand products. Thirty-eight hair dye products (15.1%) were free of potent skin sensitizers. The number of domestically produced products (31, 20.8%) that were free of potent skin sensitizers was significantly higher (p = 0.002) than the number of multinational brand products (7, 6.8%). Conclusions : p-Phenylenediamine was the most prevalent potent sensitizer found among domestically produced hair dyes available on the market. Our findings indicate regional differences in hair dye allergen exposure. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Engineering of a near-infrared fluorescent probe for real-time simultaneous visualization of intracellular hypoxia and induced mitophagy was written by Liu, Yongchao;Teng, Lili;Chen, Lanlan;Ma, Hongchang;Liu, Hong-Wen;Zhang, Xiao-Bing. And the article was included in Chemical Science in 2018.COA of Formula: C6H5ClO2 The following contents are mentioned in the article:

Mitophagy induced by hypoxia plays an important role in regulating cellular homeostasis via the removal of dysfunctional mitochondria in the lysosomal degradation pathway, which results in physiol. changes in the mitochondria, such as the pH, polarity and viscosity. However, the lack of an effective method for imaging of both the hypoxic microenvironment and the resulting variable mitochondria limits the visualization of hypoxia-induced mitophagy. Based on the specific mitochondrial pH changes during the hypoxia-induced mitophagy process, we have reported a near-IR fluorescent probe (NIR-HMA) for real-time simultaneous visualization of the hypoxic microenvironment and the subsequent mitophagy process in live cells. NIR-HMA selectively accumulated in the hypoxic mitochondria in the NIR-MAO form, emitting at 710 nm, and then transformed into NIR-MAOH, emitting at 675 nm, in the acidified mitochondria-containing autolysosomes. Importantly, by smartly tethering the hypoxia-responsive group to the hydroxyl group of the NIR-fluorochrome, which shows ratiometric pH changes, NIR-HMA can differentiate between different levels of the hypoxic microenvironment and mitophagy. Furthermore, using NIR-HMA, we could track the complete mitophagy process from the mitochondria to the autolysosomes and visualize mitophagy caused only by hypoxia both in cancer cells and normal cells. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5COA of Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparative time-based intermediates study of ozone oxidation of 4-chloro- and 4-nitrophenols followed by LCMS-TOF was written by Akharame, Michael Ovbare;Fatoki, Olalekan Siyanbola;Opeolu, Beatrice Olutoyin;Olorunfemi, Daniel Ikudayisi;Oputu, Ogheneochuko Utieyin. And the article was included in Journal of Environmental Science and Health in 2020.Formula: C6H5ClO2 The following contents are mentioned in the article:

Greater insights on the degradation pathways and intermediates formed during the oxidation of organics can be achieved by more suitable and compatible instrumentation. In our research, we sought to explore the relative advantages of the liquid chromatog. coupled to a time of flight mass spectrometer (LCMS-TOF) technique for the comparative time-based degradation intermediates and pathways of 4-chlorophenol (4CP) and 4-nitrophenol (4NP). The ozonation of the analytes solution (100 mL of 2 x 10^-3 M) was done in a sintered glass reactor, with an ozone dose of 0.14 mg min^-1 (O₂/O₃ 10 mL/min). The comparative oxidation results revealed that the 4-chloro- and 4-nitrocatechol pathways via hydroxylation were the major degradation route for 4CP and 4NP. Catechol intermediate was present as a primary breakdown product for the two analytes. Hydroquinone was observed as transient degradation intermediate for 4CP, but was absent for 4NP. Rather, a novel ozonation intermediate 2, 4-dinitrophenol was identified which was further oxidized to 3,6-dinitrocatechol. Several dimer products were identified in the oxidation processes, favored by alk. conditions with more versatility shown by 4CP. The study provided a great insight into the ozone degradation intermediates and pathways, with some intermediates scarce in literature identified. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

High-throughput macromolecular polymorph screening via an NMR and X-ray powder diffraction synergistic approach: the case of human insulin co-crystallized with resorcinol derivatives was written by Spiliopoulou, Maria;Valmas, Alexandros;Triandafillidis, Dimitris-Panagiotis;Fili, Stavroula;Christopoulou, Magdalini;Filopoulou, Aikaterini J.;Piskopou, Anastasia;Papadea, Polyxeni;Fitch, Andrew N.;Beckers, Detlef;Degen, Thomas;Gozzo, Fabia;Morin, Mickael;Reinle-Schmitt, Mathilde L.;Karavassili, Fotini;Rosmaraki, Eleftheria;Chasapis, Christos T.;Margiolaki, Irene. And the article was included in Journal of Applied Crystallography in 2021.Formula: C6H5ClO2 The following contents are mentioned in the article:

Regular injections of insulin provide life-saving benefits to millions of diabetics. Apart from native insulin and insulin analog formulations, microcrystalline insulin suspensions are also com. available. The onset of action of the currently available basal insulins relies on the slow dissociation of insulin hexamers in the s.c. space due to the strong binding of small organic ligands. With the aim of identifying insulin-ligand complexes with enhanced pharmacokinetic and pharmacodynamic profiles, the binding affinity of two resorcinol-based mols. (4-chlororesorcinol and 4-bromoresorcinol) and the structural characteristics of insulin upon co-crystallization with them were investigated in the present study. ‘In solution’ measurements were performed via saturation transfer difference (STD) NMR. Co-crystallization upon pH variation resulted in the production of polycrystalline precipitates, whose structural characteristics (i.e. unit-cell symmetry and dimension) were assessed. In both cases, different polymorphs (four and three, resp.) of monoclinic symmetry (P2₁ and C2 space groups) were identified via X-ray powder diffraction. The results demonstrate the efficiency of a new approach that combines spectroscopy and diffraction techniques and provides an innovative alternative for high-throughput examination of insulin and other therapeutic proteins. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A room temperature acetone sensor based on synthesized tetranitro-oxacalix[4]arenes: Thin film fabrication and sensing properties was written by Sen, S.;Comert Onder, F.;Capan, R.;Ay, M.. And the article was included in Sensors and Actuators, A: Physical in 2020.Name: 4-Chlororesorcinol The following contents are mentioned in the article:

Tetranitro-oxacalix[4]arenes were prepared to determine their thin film fabrication and gas sensing applications. Firstly, tetranitro-oxacalix[4]arenes (1-3) were synthesized via nucleophilic aromatic substitution reaction (SNAr) using substituted resorcinol derivatives and 1,5-difluoro-2,4-dinitrobenzene with moderate to high yields. Later, successfully synthesized materials were utilized to construct thin films using the spin coating method and the characterization of the deposited films was performed with UV-vis and surface plasmon resonance (SPR). Characterization results indicated that high-quality spin-coated thin films were prepared using these materials. The sensing abilities of the spin-coated thin films of tetranitro-oxacalix[4]arenes (1-3) were tested using the SPR method for volatile organic vapors of acetone, chloroform, toluene, ethanol and benzene. High concentration sensitivity values of 0.0700 x 10-3, 0.1001 x 10-3 and 0.8653 x 10-3 with normalized response/ppm unit for acetone vapor were obtained for thin films (1-3), resp. The sensors obtained using especially thin films 1 and 3 showed high responses toward acetone even at low concentration ranges between 3.8-15.2 ppm. These sensors have the advantages of high sensitivity, reusability and reproducibility of results which make them compatible for practical acetone-detection applications. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Name: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Name: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The effect of the sp³/sp² carbon ratio on the electrochemical oxidation of 2,4-D with p-Si BDD anodes was written by Souza, F. L.;Saez, C.;Lanza, M. R. V.;Canizares, P.;Rodrigo, M. A.. And the article was included in Electrochimica Acta in 2016.Synthetic Route of C6H5ClO2 The following contents are mentioned in the article:

B-doped diamond films on Si substrates (p-Si BDD) with different sp³/sp² C ratios are systematically varied in electrodes used to oxidize 2,4-dichlorophenoxyacetic acid (2,4-D) in synthetic wastewater containing chlorides. 2,4-D is completely mineralized during the electrolysis. A higher sp³/sp² ratio in the anode results in a more rapid and efficient oxidative removal of 2,4-D. Chlorinated compounds such as 4-chlororesorcinol, 2-chlorophenol, and 2,4-dichlorophenol form as intermediates during the oxidative treatment. Although these compounds are completely depleted during the electrolysis, their maximum observed concentrations decrease as the sp³ content increases in the anode. On the contrary, higher maximum concentrations are observed for nonchlorinated intermediates, especially hydroquinone, and there is a greater formation of chlorates and perchlorates in chloride-containing solutions as the sp³ content increases in the anode. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Synthetic Route of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Simultaneous determination of 33 hair dyes in oxidative hair dye products by high performance liquid chromatography was written by Zuo, Xue;Di, Zheng;Zhang, Rong;Wu, Guoqing. And the article was included in Sepu in 2019.Recommanded Product: 95-88-5 The following contents are mentioned in the article:

A method was developed for the simultaneous determination of 33 hair dyes in oxidative hair dye products by high-performance liquid chromatog. (HPLC). The analytes were separated on a Waters Atlantis T3 MV Kit column (250 mm × 4.6 mm, 5μm) by gradient elution using phosphate buffer-acetonitrile as mobile phases. The components were detected at two different wavelengths of 235 and 280 nm using a diode array detector. The results showed that the method had good linearity with correlation coefficients exceeding 0.999. Precision was good for the 33 analytes, with the relative standard deviations (RSDs) less than 2%. Stabilities of tetraaminopyrimidine sulfate and 2,4-diaminophenoxyethanol HCl in 12 h, as well as other analytes in 24 h, were good, with RSDs less than 5%. Recoveries of the method ranged from 77.6% to 116.3% at three different concentration levels. The method proved to be simple, rapid, and accurate, suitable for the determination of various hair dyes in oxidative hair dye products. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Characterization of human S-adenosyl-homocysteine hydrolase in vitro and identification of its potential inhibitors was written by Hao, Weiwei;Li, Yanhua;Shan, Qiuli;Han, Tian;Li, Wencheng;He, Sheng;Zhu, Kongkai;Li, Yumei;Tan, Xiaojun;Gu, Jinsong. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2017.SDS of cas: 95-88-5 The following contents are mentioned in the article:

Human S-adenosyl-homocysteine hydrolase (SAHH, E.C.3.3.1.1) has been considered to be an attractive target for the design of medicines to treat human disease, because of its important role in regulating biol. methylation reactions to catalyze the reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine (Ado) and L-homocysteine (Hcy). In this study, SAHH protein was successfully cloned and purified with optimized, Pichia pastoris (P. pastoris) expression system. The biol. activity results revealed that, among the tested compounds screened by ChemMapper and SciFinder Scholar, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenol (coniferyl alc., CAS: 458-35-5, ZINC: 12359045) exhibited the highest inhibition against rSAHH (IC₅₀= 34 nM). Mol. docking studies showed that coniferyl alc. was well docked into the active cavity of SAHH. And several H-bonds formed between them, which stabilized coniferyl alc. in the active site of rSAHH with a proper conformation. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5SDS of cas: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics