Category: 95-88-5

Prediction of aquatic toxicity of benzene derivatives using molecular descriptor from atomic weighted vectors was written by Martinez-Lopez, Yoan;Barigye, Stephen J.;Martinez-Santiago, Oscar;Marrero-Ponce, Yovani;Green, James;Castillo-Garit, Juan A.. And the article was included in Environmental Toxicology and Pharmacology in 2017.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

Several descriptors from atom weighted vectors are used in the prediction of aquatic toxicity of set of organic compounds of 392 benzene derivatives to the protozoo ciliate Tetrahymena pyriformis (log(IGC50)^-1). These descriptors are calculated using the MD-LOVIs software and various Aggregation Operators are examined with the aim comparing their performances in predicting aquatic toxicity. Variability anal. is used to quantify the information content of these mol. descriptors by an information theory-based algorithm. Multiple Linear Regression with Genetic Algorithms is used to obtain models of the structure-toxicity relationships; the best model shows values of Q² = 0.830 and R² = 0.837 using six variables. The authors’ models compare favorably with other previously published models that use the same data set. The obtained results suggest that these descriptors provide an effective alternative for determining aquatic toxicity of benzene derivatives This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence was written by Hossain, Mohammad Anwar;Sattenapally, Narsimha;Parikh, Hardik I.;Li, Wei;Rumbaugh, Kendra P.;German, Nadezhda A.. And the article was included in European Journal of Medicinal Chemistry in 2020.Name: 4-Chlororesorcinol The following contents are mentioned in the article:

Anti-virulence approaches in the treatment of Pseudomonas aeruginosa (PA)-induced infections have shown clin. potential in multiple in vitro and in vivo studies. However, development of these compounds is limited by several factors, including the lack of mols. capable of penetrating the membrane of gram-neg. organisms. Here, we report the identification of novel structurally diverse compounds that inhibit PqsR and LasR-based signaling and diminish virulence factor production and biofilm growth in two clin. relevant strains of P. aeruginosa. It is the first report where potential anti-virulent agents were evaluated for inhibition of several virulence factors of PA. Finally, co-treatment with these inhibitors significantly reduced the production of virulence factors induced by the presence of sub-inhibitory levels of ciprofloxacin. Further, we have analyzed the drug-likeness profile of designed compounds using quant. estimates of drug-likeness (QED) and confirmed their potential as hit mols. for further development. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Name: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electronic and Steric Optimization of Fluorogenic Probes for Biomolecular Imaging was written by Chyan, Wen;Kilgore, Henry R.;Gold, Brian;Raines, Ronald T.. And the article was included in Journal of Organic Chemistry in 2017.Application of 95-88-5 The following contents are mentioned in the article:

Fluorogenic probes are invaluable tools for spatiotemporal studies within live cells. In common fluorogenic probes, the intrinsic fluorescence of a small-mol. fluorophore is masked by esterification until entry into a cell, where endogenous esterases catalyze the hydrolysis of the masking groups, generating fluorescence. The susceptibility of masking groups to spontaneous hydrolysis is a major limitation of these probes. Previous attempts to address this problem have incorporated auto-immolative linkers at the cost of atom economy and synthetic adversity. Here, the authors report on a linker-free strategy that employs adventitious electronic and steric interactions in easy-to-synthesize probes. X···C:O n→π* interactions and acyl group size are optimized in 2′,7′-dichlorofluorescein diisobutyrate. This probe is relatively stable to spontaneous hydrolysis but is a highly reactive substrate for esterases both in vitro and in cellulo, yielding a bright, photostable fluorophore with utility in biomol. imaging. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of substituted tetrahydropyrimidin-2-ones through nucleophilic cyclization/electrophilic substitution of 1-(3,3-diethoxypropyl)urea with C-nucleophiles was written by Smolobochkin, Andrey V.;Gazizov, Almir S.;Yakhshilikova, Lola J.;Sidlyaruk, Nikita A.;Khamatgalimov, Airat R.;Burilov, Alexander R.;Pudovik, Michail A.. And the article was included in Tetrahedron in 2022.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

In this article, a regioselective method for the synthesis of new water-soluble 1,3,4-trisubstituted tetrahydropyrimidin-2(1H)-one derivatives I [R = Ph, 3-MeC₆H₄, 4-MeOC₆H₄, etc.; R¹ = 2,4-di-OH-5-ClC₆H₂, 6-hydroxy-1,3-benzodioxol-5-yl, 3-carboxy-2,6-dihydroxy-Ph, 4-hydroxy-6-methyl-2-oxo-pyran-3-yl] containing sodium methanesulfonate fragment in the first position of the heterocycle was reported. The method was based on the reaction of (1-(3,3-diethoxypropyl)ureido)methanesulfonates (EtO)₂CH(CH₂)₂N(CH₂SO₃Na)CONHR [R = Ph, 3-MeC₆H₄, 4-MeOC₆H₄, etc.] with aromatic and heterocyclic nucleophiles. The proposed method was distinguished by the possibility of obtaining a wide range of water-soluble substituted tetrahydropyrimidinones I, the absence of the need to use expensive metal complex catalysts, high product yield, and ease of purification This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aqueous-phase hydrodechlorination of model chlorinated organic compounds over Ru/C catalyst was written by Payal, Dipak D.;Vaidya, Prakash D.. And the article was included in Chemical Engineering Communications in 2018.Recommanded Product: 95-88-5 The following contents are mentioned in the article:

Effluents from the pharmaceutical and dye industries contain chlorinated organic pollutants. The effective treatment of such effluents constitutes a challenging task. 4-Chlororesorcinol (PCRE) and 4-chloro-2-aminophenol (PCAP) were selected as model chloro-organic compounds Catalytic hydrodechlorination (HDC) of PCRE and PCAP in the aqueous phase was investigated in a slurry reactor using com. carbon supported ruthenium catalyst. HDC reactions of PCRE and PCAP were studied over the ranges in temperature, 313-353 K, H₂ partial pressure, 0.69-2.76 MPa, and catalyst loading, 0.2-1.2 kg/M³. The performance of Ru/C catalyst for hydrodechlorination and ring saturation was promising. The kinetic data were modeled using Langmuir-Hinshelwood-Hougen-Watson kinetics. The HDC reaction of PCRE and PCAP using Ru/C catalyst proceeds via a dual-site mechanism, wherein at. H₂ reacts with the adsorbed organic substrate. The activation energy for the hydrodechlorination reactions of PCRE and PCAP was 41.6 and 49.4 kJ/mol, resp. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

3-Piperidylethoxypterocarpan: A potential bone anabolic agent that improves bone quality and restores trabecular micro-architecture in ovariectomized osteopenic rats was written by Raghuvanshi, Ashutosh;Kumar, Amit;Tyagi, Abdul M.;Kureel, Jyoti;Awasthi, Pallavi;Purohit, Deepak;Mansoori, Mohd. Nizam;Shukla, Priyanka;Srivastava, Kamini;Gautam, Abnish K.;Saxena, Ruchi;Dwivedi, Anila;Singh, Divya;Goel, Atul. And the article was included in Molecular and Cellular Endocrinology in 2017.HPLC of Formula: 95-88-5 The following contents are mentioned in the article:

A series of new 6H-benzofuro[3, 2-c]chromenes (BFC, pterocarpans) with structure-activity relationships were investigated for their potential use in osteoporosis treatment. One of the BFCs 3-piperidylethoxypterocarpan 20 promotes osteoblast differentiation and mineralization at a dose as low as 1 pM via activation of ER/P38MAPK/BMP-2 pathway. When evaluated for in-vivo osteogenic activity in female Sprague-Dawley rats, BFC 20 increased bone mineral d. and new bone formation, compared with control at 1.0 and 10.0 mg/kg/body weight by oral gavage for 30 days. The compound was devoid of any uterotrophic effect and led to the new bone formation in adult ovariectomized osteopenic rats. BFC 20 compound also inhibited bone resorption by reducing Ovx induced increase in urinary CTx, thus exhibiting both bone anabolic and anti-catabolic action. Finally, BFC 20 treatment to Ovx rats led to improved trabecular microarchitectural restoration and exhibited therapeutic potential as a dual acting anti-osteoporotic agent for the management of osteoporosis. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5HPLC of Formula: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reductive dehalogenation and dehalogenative sulfonation of phenols and heteroaromatics with sodium sulfite in an aqueous medium was written by Tomanova, Monika;Jedinak, Lukas;Cankar, Petr. And the article was included in Green Chemistry in 2019.Formula: C6H5ClO2 The following contents are mentioned in the article:

Prototropic tautomerism was used as a tool for the reductive dehalogenation of (hetero)aryl bromides and iodides, or dehalogenative sulfonation of (hetero)aryl chlorides and fluorides, using sodium sulfite as the sole reagent in an aqueous medium. This protocol does not require a metal or phase transfer catalyst and avoids using organic solvent as the reaction medium. This method is especially suitable for substrates that readily tautomerize (such as 2- or 4-halogenated aminophenols and 4-halogenated resorcinols), for which dehalogenation or sulfonation proceeds under mild reaction conditions (</= 60°). As sodium sulfite is an inexpensive, safe, and environmentally less hazardous reagent, this method has at least three potential applications: (i) in the deprotection of halogens as protecting groups, using sodium sulfite as a reducing agent; (ii) in the sulfonation of aromatic halides under mild reaction conditions avoiding hazardous and corrosive reagents/solvents; and (iii) in the transformation of toxic halogenated aromatics into less harmful compounds This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A benzo[b]xanthene-derived fluorescent probe capable of two-photon ratiometric imaging of lysosomal cysteine with high specificity was written by Tamima, Umme;Song, Chang Wook;Santra, Mithun;Reo, Ye Jin;Banna, Hasanul;Islam, Reyazul Md;Ahn, Kyo Han. And the article was included in Sensors and Actuators, B: Chemical in 2020.Quality Control of 4-Chlororesorcinol The following contents are mentioned in the article:

Cysteine, an important biothiol, is associated with diverse biol. processes, demanding efficient in vivo detection probes. Accordingly, various types of fluorescent probes have been reported so far, but still those with practical applicability are in demand. One of the challenges is how to minimize interference from other biomols. We disclose the benzoxanthene-based fluorescent probe that shows excellent substrate selectivity, and, furthermore, good ratiometric and two-photon imaging properties. The probe, which is also photostable and biocompatible, senses cysteine through very fast 1,6-conjugate addition to the benzoxanthene core, a new dipolar dye system that emits in the deep-red wavelength region. The probe enables reliable two-photon ratiometric imaging of the endogenous lysosomal cysteine. The cysteine adduct can be reverted to the probe by hydrogen peroxide most effectively among several reactive oxygen species both in solution as well as in cell. An application of the probe to quantify the cysteine level in human blood plasma is also demonstrated. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Quality Control of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Coumarin-Caged Compounds of 1-Naphthaleneacetic Acid as Light-Responsive Controlled-Release Plant Root Stimulators was written by Kaewchangwat, Narongpol;Thanayupong, Eknarin;Jarussophon, Suwatchai;Niamnont, Nakorn;Yata, Teerapong;Prateepchinda, Sagaw;Unger, Onuma;Han, Bao-hang;Suttisintong, Khomson. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

Six coumarin-caged compounds of 1-naphthaleneacetic acid (NAA) comprising different substituents on the coumarin moiety were synthesized and evaluated for their photophys. and chem. properties as light-responsive controlled-release plant root stimulators. The ¹H NMR and HPLC techniques were used to verify the release of NAA from the caged compounds After irradiation at 365 nm, the caged compounds exhibited the fastest release rate at t_1/2 of 6.7 days and the slowest release rate at t_1/2 of 73.7 days. Caged compounds at high concentrations (10^-5 and 10^-6 M) significantly stimulate secondary root germination while free NAA at the same level is toxic and leads to inhibition of secondary root germination. The cytotoxicity of the caged compounds against fibroblasts and vero cells were evaluated, and the results suggested that, at 10^-5-10^-6 M, caged compounds exhibited no significant cytotoxicity to the cells. Thus, the caged compounds of NAA in this study could be of great benefit as efficient agrochems. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structural transformation of lignin from eucalyptus during chlorine dioxide bleaching was written by Qin, Chengrong;Huang, Lingzhi;Lv, Quanfeng;Nie, Shuangxi;Yao, Shuangquan. And the article was included in BioResources in 2019.Product Details of 95-88-5 The following contents are mentioned in the article:

Enzymic/mild acidolysis lignin was extracted from both unbleached and bleached eucalyptus pulp, and the difference in lignin structures was analyzed by NMR spectroscopy. The unbleached pulp lignin was chlorinated with chlorine dioxide, and the mechanism of adsorbable organic halide (AOX) formation was investigated. Chlorinated reaction products were detected by gas chromatog.-mass spectrometry. There is a possibility of producing three different chlorobenzene or chlorophenol products from S/S lignin dimers that are connected with β-O-4 bonds. Based on quantum chem. theory, three reaction pathways were investigated using mol. simulation techniques. The results showed that pathway 1 possessed the lowest reaction activation energy, which made it the most favored thermodynamically. The β-O-4 bond of the lignin dimer was cleaved. Following that scission, 2-chloro-3,5-dimethoxy-Me benzene was the most likely product to be generated from the chlorination reaction of the syringyl unit. These results provide theor. guidance for further reduction of AOX in chlorine dioxide bleaching. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Product Details of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics