Category: 95-88-5

Catalytic oxidation of 4-chlorophenol on in-situ sulfur-doped activated carbon with sulfate radicals was written by Guo, Yaoping;Zeng, Zequan;Li, Yulin;Huang, Zhanggen;Yang, Jieyang. And the article was included in Separation and Purification Technology in 2017.Formula: C6H5ClO2 The following contents are mentioned in the article:

In-situ S-doped activated C (ACS) was prepared and used as a heterogeneous catalyst to activate persulfate (PS) for 4-chlorophenol (4CP) oxidation The effects of several operation parameters, including PS concentration, initial pH, ACS dosage, and reaction temperature, on 4CP degradation were investigated in detail via batch experiments Results show that ACS exhibited excellent catalytic activity for PS activation and a complete 4CP degradation as well as 65.3% COD removal can be achieved in 170 min at 25° with ACS dosage of 0.1 g/L, PS/4CP molar ratio of 24/1 and initial pH of 4.4. The biodegradability was greatly improved after a 170 min reaction. Quenching tests reveal that SO₄^-· was the dominant active species taking part in the degradation of 4CP. Based on the stability tests and the corresponding characterizations of ACS before and after use, it was speculated that the loss of the sp. surface area and the change of the surface chem. led to the significant deactivation of ACS. Meanwhile, a possible mechanism of PS activation on ACS was proposed. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases was written by Vo, Chau D.;Shebert, Hanna L.;Zikovich, Shannon;Dryer, Rebecca A.;Huang, Tony P.;Moran, Lindsey J.;Cho, Juno;Wassarman, Douglas R.;Falahee, Bryn E.;Young, Peter D.;Gu, Garrick H.;Heinl, James F.;Hammond, John W.;Jackvony, Taylor N.;Frederick, Thomas E.;Blair, Jimmy A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of 4-Chlororesorcinol The following contents are mentioned in the article:

To address the growing need for new antimicrobial agents, we explored whether inhibition of bacterial signaling machinery could inhibit bacterial growth. Because bacteria rely on two-component signaling systems to respond to environmental changes, and because these systems are both highly conserved and mediated by histidine kinases, inhibiting histidine kinases may provide broad spectrum antimicrobial activity. The histidine kinase ATP binding domain is conserved with the ATPase domain of eukaryotic Hsp90 mol. chaperones. To find a chem. scaffold for compounds that target histidine kinases, we leveraged this conservation. We screened ATP competitive Hsp90 inhibitors against CckA, an essential histidine kinase in Caulobacter crescentus that controls cell growth, and showed that the diaryl pyrazole is a promising scaffold for histidine kinase inhibition. We synthesized a panel of derivatives and found that they inhibit the histidine kinases C. crescentus CckA and Salmonella PhoQ but not C. crescentus DivJ; and they inhibit bacterial growth in both Gram-neg. and Gram-pos. bacterial strains. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Quality Control of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dimers of coumarin-1,2,3-triazole hybrids bearing alkyl spacer: Design, microwave-assisted synthesis, molecular docking and evaluation as antimycobacterial and antimicrobial agents was written by Ashok, Dongamanti;Gundu, Srinivas;Aamate, Vikas Kumar;Devulapally, Mohan Gandhi;Bathini, Raju;Manga, Vijjulatha. And the article was included in Journal of Molecular Structure in 2018.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The present study demonstrated the synthesis of new series of coumarin-1,2,3-triazole hybrids under microwave irradiation method. Several dimers of coumarin based 1,2,3-triazole derivatives were synthesized and their antimycobacterial and antimicrobial activities were investigated. The antimycobacterial activity screening results revealed that compounds I (R = Cl; n = 6, 8) were the most active against Mycobacterium tuberculosis H37Rv strain. The active compounds were further evaluated for cytotoxicity with HEK cell lines and exhibited less % of inhibition. The same synthetic hybrids were evaluated for their antimicrobial activity against various bacterial strains and fungal strains and compounds I (R = H, n = 8; R = Cl, n = 5, 6, 8) were found to be the most promising antimicrobial potent mols. Furthermore, the active compounds against Mycobacterium tuberculosis were evaluated for their mol. docking studies against pantothenate synthetase (PS) enzyme of MTB and the docking results are in well agreement with the antitubercular evaluation results. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Category: chlorides-buliding-blocks).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Convenient synthesis of regioisomerically pure 5- and 6-functionalized xanthene dyes via S_NAr reaction and comparison of their reactivity towards click reaction was written by Mori, Masaya;Fujikawa, Yuuta;Inoue, Hideshi. And the article was included in Tetrahedron in 2020.Synthetic Route of C6H5ClO2 The following contents are mentioned in the article:

In this study, we present an efficient and general strategy for the individual preparation of both isomers of 5(6)-functionalized xanthene-based fluorophores. Spectroscopic anal. of the acid-base equilibrium of 5(6)-nitro xanthene dyes has shown that they exist predominantly in the colorless spirolactone form in certain aprotic dipolar solvents. In such solvents, regioisomerically selective ipso-substitution of the nitro group by sodium azide occurs at the 6- position but not at the 5- position due to the electron-withdrawing spirolactone moiety at the para-position, relative to the nitro group. This reaction allows the separation of the isomer with the 6-azide group and the intact 5-nitro isomer. The 5-nitro group of the latter was then reduced to an amino group and subsequently converted to an azide group. This strategy enables the preparation of both the 5- and 6-functionalized isomers individually from a mixture of precursors, which is otherwise unachievable. The azide isomers were then compared in reactivity by strain-promoted azide-alkyne cycloaddition (SPAAC) with bicycle[6.1.0]non-4-yene (BCN). This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Synthetic Route of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Influence of linking units on the photo responsive studies of azobenzene liquid Crystals: Application in optical storage devices was written by Shruthi, S.;Smahel, Michal;Kohout, Michal;Shanker, G.;Hegde, Gurumurthy. And the article was included in Journal of Molecular Liquids in 2021.Recommanded Product: 95-88-5 The following contents are mentioned in the article:

In this paper, we report on the photoisomerization process of three series of photosensitive bent-core liquid crystals with a lateral chlorine atom in the central resorcinol core and various linkers. The effect of linkers, such as benzoate ester, biphenyl, cinnamate, Schiff base and stilbene on the photoisomerization and thermal back relaxation have been studied using UV-Vis spectroscopy. Resorcinol with benzoate ester showed the longest thermal back relaxation of 7 h, whereas, the bent-cores with the stilbene linker rendered the shortest relaxation time of 4 h. The compiled results suggest the influence of linkers, central resorcinol core and position of the azobenzene moiety on the photoisomerization. Addnl., optical storage device fabricated using cinnamate containing bent-core LC (A3), showed the visibility of bright and dark regions in a crossed polarizers upon illumination at λ = 365 nm, indicating the changes from the ordered to disordered state. The observed properties of constructed device demonstrate the potential application of reported azobenzene derivatives in optical storage devices. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rational design of a near-infrared fluorescence probe for highly selective sensing butyrylcholinesterase (BChE) and its bioimaging applications in living cell was written by Ma, Jianlong;Lu, Xiaofeng;Zhai, Honglin;Li, Qiang;Qiao, Li;Guo, Yong. And the article was included in Talanta in 2020.COA of Formula: C6H5ClO2 The following contents are mentioned in the article:

In the current work, a near-IR (NIR) fluorescent probe (CyClCP) was developed for fast (35 min), highly sensitive (LOD of 3.75 U/L) and selective response to BChE in vitro and in vivo. Upon the addition of BChE, CyClCP could be efficiently activated with remarkable NIR (λ_em = 708 nm) fluorescence enhancement and obvious absorbance red shift (581 nm-687 nm). Specifically, according to the subtle differences structural features and substrate preference between BChE and its sister enzyme AChE, CyClCP was constructed by introducing chlorine atom at the ortho-position of the phenolic hydroxyl in the previous reported probe (CyCP). Fortunately, CyClCP exhibited better selectivity towards BChE over AChE compared with CyCP. This mol. design strategy was further rationalized by docking mol. of fluorescence probes (CyClCP and CyCP) and enzymes (BChE and AChE). Finally, CyClCP was membrane permeable and successfully applied to image endogenous BChE level in HepG2 and LO2 cells. Therefore, CyClCP could serve as a promising tool for BChE-related physiol. function studies in complex biol. systems. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5COA of Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A near infrared fluorescent probe for the detection and imaging of prolyl aminopeptidase activity in living cells was written by Liu, Xianjun;Zhang, Quan-Yu;Wang, Fenglin;Jiang, Jian-Hui. And the article was included in Analyst (Cambridge, United Kingdom) in 2019.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

Prolyl aminopeptidase (PAP) is an important exopeptidase which might be a biomarker for pathogen infection and a potential therapeutic target. However, very few fluorescent probes have been developed for detecting PAP activity. Here we report the development of the first near IR (NIR) turn-on fluorescent probe (NIR-PAP) for detecting and imaging PAP in living cells. The probe is prepared by reacting a cysteine-proline dipeptide with an acryloylated NIR fluorophore via a facile thiol-Michael addition reaction. NIR-PAP exhibits a dynamic response toward PAP in the range of 0.02-2.5 U mL^-1 with an estimated limit of detection of 0.013 U mL^-1. In vitro studies also reveal that the probe displays high specificity and robust responses toward PAP under physiol. pH and temperature conditions. Moreover, NIR-PAP is successfully introduced to detect and differentiate PAP activity in four different cell lines via both confocal fluorescence imaging and flow cytometry. Therefore, our probe may hold great promise in diagnosing infectious diseases caused by pathogens and screening therapeutic drugs in vivo. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A near-infrared “turn-on” fluorescent probe with a self-immolative linker for the in vivo quantitative detection and imaging of hydrogen sulfide was written by Park, Chul Soon;Ha, Tai Hwan;Choi, Seon-Ae;Nguyen, Duong Nguyen;Noh, Seonmyeong;Kwon, Oh Seok;Lee, Chang-Soo;Yoon, Hyeonseok. And the article was included in Biosensors & Bioelectronics in 2017.Electric Literature of C6H5ClO2 The following contents are mentioned in the article:

Hydrogen sulfide is a critical biol. messenger, but few biol. compatible methods are available for its detection in vivo. Here, we describe the design and synthesis of a novel azide-functionalized near-IR probe, NIR-Az, for a hydrogen sulfide assay in which a self-immolative linker is incorporated between the azide moiety and phenolic dihydroxanthene fluorophore from a cyanine dye. A large “turn-on” near-IR fluorescence signal results from the reduction of the azide group of the fluorogenic moiety to an amine, in which the self-immolative linker also enhances the accessibility of NIR-Az to hydrogen sulfide. NIR-Az can select hydrogen sulfide from among 16 analytes, including cysteine, glutathione, and homocysteine. By exploiting the superior properties of NIR-Az, such as its good biocompatibility and rapid cell internalization, we successfully demonstrated its usefulness in monitoring both the concentration- and time-dependent variations of hydrogen sulfide in living cells and animals (detection limit less than 0.26μM), thereby providing a powerful approach for probing hydrogen sulfide chem. in biol. systems. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Electric Literature of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dichlororesorufin-Based Colorimetric and Fluorescent Probe for Ultrasensitive Detection of Mercury Ions in Living Cells and Zebrafish was written by Duan, Qingxia;Lv, Xiaoyu;Liu, Caiyun;Geng, Zhuofan;Zhang, Fenfen;Sheng, Wenlong;Wang, Zuokai;Jia, Pan;Li, Zilu;Zhu, Hanchuang;Zhu, Baocun. And the article was included in Industrial & Engineering Chemistry Research in 2019.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

In this work, a simple dichlororesorufin-based colorimetric and fluorescent probe R-Hg with the recognition receptor of carbonothioate was designed, synthesized, and exploited to determine mercury ions in aqueous solution and living cells as well as in zebrafish. After a series of anal. tests, probe R-Hg showed some excellent characteristics, such as ultrasensitivity, high selectivity, and good water solubility The probe solution exhibited a very large fluorescence enhancement (about 150-fold) upon addition of Hg²⁺. Addnl., probe R-Hg exhibited excellent sensitivity, which could quantificationally detect Hg²⁺ at the nanomolar level, and the detection limit was 0.49 nM. Moreover, probe R-Hg could be used as a “naked-eye” probe for monitoring Hg²⁺, because the color of its solution transformed remarkably from yellow into pink with the participation of Hg²⁺. Importantly, probe R-Hg has potential application value and has been successfully applied to the determination of Hg²⁺ in practical water samples and in living RAW 264.7 cells as well as in zebrafish as a bioimaging reagent. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Category: chlorides-buliding-blocks).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids was written by Dai, Hong;Huang, Meiling;Qian, Jianqiang;Liu, Ji;Meng, Chi;Li, Yangyang;Ming, Guxu;Zhang, Ting;Wang, Senling;Shi, Yujun;Yao, Yong;Ge, Shushan;Zhang, Yanan;Ling, Yong. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

A series of hybridsbased on coumarin/pyrazole oxime I (n = 1, 2; R = 3-F, 4-I, 2-CH₃, etc.) have been synthesized, and exhibited good to excellent antitumor activities. Compound I (n = 2; R = 4-Cl) has shown remarkable anticancer effect on SMMC-7721 cells (IC₅₀ = 2.08 μM), which is considerably lower than 5-FU (IC₅₀ = 37.8 μM) and similar to ADM (IC₅₀ = 2.67 μM), with little effect on normal hepatic cells LO2. Notably, the suppression experiments of metastatic activities reveal that I (n = 2; R = 4-Cl) also displays significant anti-metastasis effects through inhibiting cell migration and invasion in highly metastatic SMMC-7721 cell line, and dose-dependently reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) procedure better than ADM. Finally, I (n = 2; R = 4-Cl) also possesses low acute toxicity and potent tumor growth inhibitory property against SMMC-7721 cell lines in vivo. These findings suggest that novel coumarin/pyrazole oxime hybrids are promising therapeutic agent candidates for further research. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics