Category: 95-88-5

The fabrication of carboxylic acid-functionalized porous layer open tube column and its application in hydrophilic interaction chromatography for small polar molecules was written by Tang, Shiyun;Duan, Yuanxing;Chang, Feng;Jiang, Wei;Zhang, Fengmei;Liu, Zhihua;Yang, Yuting;Liu, Chunbo;Chen, Yingzhuang. And the article was included in Journal of Liquid Chromatography & Related Technologies in 2020.Application In Synthesis of 4-Chlororesorcinol The following contents are mentioned in the article:

The porous layer open-tube (PLOT) columns, characterized by their considerable sp. surface area and high permeability, have attracted a growing attention from researchers in liquid chromatog. In this work, a hydrophilic PLOT column rich in carboxylic acid functional groups was successfully synthesized in capillary with an inner diameter of 200μm by thermally initiated aqueous two-phase polymerization Methacrylic acid (MAA) areas monomers that responsible for the introduction of polar functional groups, and poly(ethylene glycol) diacrylate (PEGDA) are as cross-linker. The optimized PLOT column has a uniform, moderately thick porous layer, which is tightly bonded to the inner wall without any detachment. The hollow structure gives the PLOT column good permeability, which facilitates fast mass transfer. The systematical evaluations of the resulting PLOT columns were performed by using polar analytes including nucleosides, bases, amides, phenols and carboxylic acids. Those results demonstrated excellent separation performance for the small polar mols. Compared to the poly(PEGDA) PLOT column, the hydrophilic retention of analytes on poly(PEGDA-co-MAA) porous layer open-tube column is significantly improved by the introduction of carboxylic acids. Furthermore, with modified nucleosides and chlorophenols being disease markers and the persistent pollutant of wide concern, resp., the separation was optimized and the linear range of the quant. anal. was examined for both targets. which indicates the potential application of such PLOT column for anal. of real samples. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application In Synthesis of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Substitution and addition reactions of ^•OH with p-substituted-phenols was written by Albarran, Guadalupe;Galicia-Jimenez, Eduardo;Mendoza, Edith;Schuler, Robert H.. And the article was included in Radiation Physics and Chemistry in 2017.Product Details of 95-88-5 The following contents are mentioned in the article:

The directing effect of a hydroxyl group on the substitution and addition reactions of ^•OH to the substituted and free positions in aromatic rings of p-substituted-phenols were studied in aqueous solutions containing either K₃Fe(CN)₆ as an oxidant of the substituted hydroxycyclohexadienyl radical initially formed or using ascorbic acid. The results showed that the attack of the ^•OH to the substituted position (ipso position) was followed by elimination of the substituent producing hydroquinone. The addition reaction of the ^•OH to the free position on the ring produced 4-substituent-catechol and 4-substituent-resorcinol derivatives Identification and quantification of the radiolytic products were carried out using high performance liquid chromatog. The results of the yields are given for the p-halogen-phenols (p-X-Ph) p-F-Ph, p-Cl-Ph, p-Br-Ph and p-I-Ph. Other compounds, p-nitro-Ph, p-OH-benzoic acid, p-OH-benzonitrile, p-OH-benzaldehyde, p-OH-anisole and p-OH-benzyl alc. (represented as p-Z-Ph), were only studied using K₃Fe(CN)₆ as the oxidant. The results show that the p-X-Ph are attacked by the ^•OH at the ipso position to the halogen in the proportion 1:0.53:0.46:0.11 for F>Cl>Br>I. The ^•OH attacked at the ipso position to the p-Z-Phs through a substitution reaction, which depended on the substituent group. Thus, the strongly deactivating groups produced less hydroquinone, indicating less substitution reaction than the strongly activating groups. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Product Details of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rational Identification of Hsp90 Inhibitors as Anticancer Lead Molecules by Structure Based Drug Designing Approach was written by Gupta, Sayan D.;Swapanthi, Pappu S.;Bhagya, Deshetti;Federicci, Fernando;Mazaira, Gisela I.;Galigniana, Mario D.;Subrahmanyam, Chavali V. S.;Gowrishankar, Naryanasamy L.;Raghavendra, Nulgumnalli M.. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2020.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

Heat shock protein 90 (Hsp90) is an encouraging anticancer target for the development of clin. significant mols. Schiff bases play a crucial role in anticancer research because of their ease of synthesis and excellent antiproliferative effect against multiple cancer cell lines. Therefore, we started our research work with the discovery of resorcinol/4-chloro resorcinol derived Schiff bases as Hsp90 inhibitors, which resulted in the discovery of a viable anticancer lead mol. The objective of the study is to discover more promising lead mols. using our previously established drug discovery program, wherein the rational drug design is achieved by mol. docking studies. The docking studies were carried out by using Surflex Geom X program of Sybyl X-1.2 version software. The mols. with good docking scores were synthesized and their structures were confirmed by IR, ¹H NMR and mass spectral anal. Subsequently, the mols. were evaluated for their potential to attenuate Hsp90 ATPase activity by Malachite green assay. The anticancer effect of the mols. was examined on PC3 prostate cancer cell lines by utilizing 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay methodol. Schiff bases 11, 12, 20, 23 and 27 exhibiting IC₅₀ value below 1μM and 15μM, in malachite green assay and MTT assay, resp., emerged as viable lead mols. for future optimization. The research work will pave the way for the rational development of cost-effective Schiff bases as Hsp90 inhibitors as the method employed for the synthesis of the mols. is simple, economic and facile. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electrochemical Oxidation of Phenolic Compounds at Boron-Doped Diamond Anodes: Structure-Reactivity Relationships was written by Jiang, Yi;Zhu, Xiuping;Xing, Xuan. And the article was included in Journal of Physical Chemistry A in 2017.Formula: C6H5ClO2 The following contents are mentioned in the article:

Electrochem. oxidation of phenolic compounds using B-doped diamond (BDD) anodes was shown as an effective approach to remove these contaminants from H₂O. However, the understanding of the reaction mechanisms of substituted phenolic compounds at the BDD anode remains incomplete. The authors studied the electrochem. oxidation of 12 representative phenolic compounds (with varied substitution groups (e.g., -CH₃, -OCH₃, -NH₂, -Cl, -OH, -COOH, -NO₂, -CHO) and positions (-ortho, -meta, and -para)) at the BDD anode. The authors’ anal. shows that unlike previous studies the two parameters, the Hammett constants of the substituents and the highest at. charge on the aromatic ring, fail to adequately describe the reaction rate change when the chem. structures become complicated (i.e., with increased steric effects). Instead, a quant. structure-property relation (QSPR) was established with 26 mol descriptors and using a partial least-squares regression approach. The QSPR anal. shows that the energy gap between the LUMO and the HOMO, E_LUMO – E_HOMO, which reflects the chem. stability of a mol., is the predominant mol. descriptor determining the reaction rate constant Also, the predicated rate constants agree well with the observed ones. The findings are consistent with previous studies of SnO₂ anodes, suggesting that chem. structural parameters such as the MO energies are critical to consider when elucidating and predicating the electrochem. reactivity of phenolic compounds at these nonactive anodes. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Imaging Ca²⁺ with a Fluorescent Rhodol was written by Contractor, Alisha A.;Miller, Evan W.. And the article was included in Biochemistry in 2018.Related Products of 95-88-5 The following contents are mentioned in the article:

Ca²⁺ mediates a host of biochem. and biophys. signaling processes in cells. The development of synthetic, Ca²⁺-sensitive fluorophores has played an instrumental role in the authors’ understanding of the temporal and spatial dynamics of Ca²⁺. Coupling Ca²⁺-selective ligands to fluorescent reporters provided a wealth of excellent indicators that span the visible excitation and emission spectrum and possess Ca²⁺ affinities suited to a variety of cellular contexts. One underdeveloped area is the use of hybrid rhodamine/fluorescein fluorophores, or rhodols, in the context of Ca²⁺ sensing. Rhodols are bright and photostable and have good two-photon absorption cross sections (σ_TPA), making them excellent candidates for incorporation into Ca²⁺-sensing scaffolds. Here, the authors present the design, synthesis, and application of rhodol Ca²⁺ sensor 1 (RCS-1) (I), a chlorinated pyrrolidine-based rhodol. RCS-1 possesses a Ca²⁺ binding constant of 240 nM and a 10-fold turn response to Ca²⁺. RCS-1 effectively absorbs IR light and has a σ_TPA of 76 GM at 840 nm, 3-fold greater than that of its fluorescein-based counterpart. The acetoxy-Me ester of I stains the cytosol of live cells, enabling observation of Ca²⁺ fluctuations and cultured neurons using both one- and two-photon illumination. Together, these results demonstrate the utility of rhodol-based scaffolds for Ca²⁺ sensing using two-photon illumination in neurons. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Related Products of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of a fluidized three-dimensional electrochemical reactor with Ti/SnO₂-Sb/β-PbO₂ anode and granular activated carbon particles for degradation and mineralization of 2,4-dichlorophenol: Process optimization and degradation pathway was written by Samarghandi, Mohammad Reza;Dargahi, Abdollah;Rahmani, Alireza;Shabanloo, Amir;Ansari, Amin;Nematollahi, Davood. And the article was included in Chemosphere in 2021.Related Products of 95-88-5 The following contents are mentioned in the article:

A three-dimensional electrochem. reactor with Ti/SnO2-Sb/β-PbO2 anode and granular activated carbon (3DER-GAC) particle electrodes were used for degradation of 2,4-dichlorophenol (2,4-DCP). Process modeling and optimization were performed using an orthogonal central composite design (OCCD) and genetic algorithm (GA), resp. Ti/SnO2-Sb/β-PbO2 anode was prepared by electrochem. deposition method and then its properties were studied by FESEM, EDX, XRD, Linear sweep voltammetry and accelerated lifetime test techniques. The results showed that lead oxide was precipitated as highly compact pyramidal clusters in the form of β-PbO2 on the electrode surface. In addition, the prepared anode had high stability (170 h) and oxygen evolution potential (2.32 V). A robust quadratic model (p-value < 0.0001 and R2 > 0.99) was developed to predict the 2,4-DCP removal efficiency in the 3DER-GAC system. Under optimal conditions (pH = 4.98, Na2SO4 concentration = 0.07 M, c.d. = 35 mA cm^-2, GAC amount = 25 g and reaction time = 50 min), the removal efficiency of 2,4-DCP in the 3DER-GAC system and the sep. electrochem. degradation process (without GAC particle electrode) were 99.8 and 71%, resp. At a reaction time of 80 min, the TOC removal efficiencies in the 3DER-GAC and the sep. electrochem. degradation system were 100 and 57.5%, resp. Accordingly, the energy consumed in these two systems was calculated to be 0.81 and 1.57 kWh g-1 TOC, resp. Based on the results of LC-MS anal., possible degradation pathways of 2,4-DCP were proposed. Trimerization and ring opening reactions were the two dominant mechanisms in 2,4-DCP degradation This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Related Products of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

QSAR modeling of algal low level toxicity values of different phenol and aniline derivatives using 2D descriptors was written by Seth, Arnab;Roy, Kunal. And the article was included in Aquatic Toxicology in 2020.Quality Control of 4-Chlororesorcinol The following contents are mentioned in the article:

The deposition of different types of phenol and aniline derivatives in the aquatic environment leads to toxicity to living organisms. Under such condition, evaluation of these toxicants is very much important. Due to non-availability of sufficient exptl. data as well as sufficient number of Quant. Structure-Activity Relationship (QSAR) models for the low level toxicity values for such pollutants, we have employed here the partial least squares (PLS) regression for the development of robust and predictive QSAR models using low level toxicity values against algal species. Here, we have used both Extended Topochem. Atom (ETA) and non-ETA indexes as 2D descriptors for model development. The statistical validation parameters ensure the robustness and the predictivity of the developed models. From the insights of the final PLS models, it can be concluded that presence of nitro groups (in the ortho position to phenolic hydroxyl group increasing intramol. hydrogen bonding capacity), presence of chlorine substituents (influencing lipophilicity) especially at the para position, oxygen and nitrogen at the topol. distance three, aliphatic side chain (contributing to hydrophobicity), mols. with large size atoms and higher mol. bulk will increase the toxicity towards the algal species. On the other hand, the phenol ring without any substituent or with a polar substituent (like amino group), presence of chlorine at ortho-ortho or ortho-para position, absence of nitro group, presence of chlorine and oxygen at the topol. distance three, presence of lower number of aliphatic groups will decrease the toxic effect towards the algal species. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Quality Control of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection was written by Guo, Yuying;Chen, Jiabao;Ren, Dan;Du, Bo;Wu, Lei;Zhang, Yuanyuan;Wang, Zhouyu;Qian, Shan. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Electric Literature of C6H5ClO2 The following contents are mentioned in the article:

Plant pathogenic fungi decrease the quality and productivity of plant production The botanical fungicides have better biocompatibility and rapid biodegradation, little or no cross resistance, and the structural diversity, and thus are beneficial to deal with plant fungal diseases. Osthole has been widely used as the com. botanical fungicide against powdery mildew in China. In this article, a series of osthole derivatives were synthesized, which resp. contain different substituents on the benzene ring, at the C8-position and pyrone ring. All the target compounds were evaluated in vitro for their antifungal activity against resistant phytopathogenic fungi. Colletotrichum fragariae, Strawberry Botrytis cinerea, Kiwifruit Botrytis cinerea, Kiwifruit brown Rots, which are common in fruit fungal diseases. The compound 7-hydroxy-8-methyl-4-(trifuoromethyl)-2H-chromen-2-one (I) was identified as the most promising candidate with the EC₅₀ values at 38.7μg/mL against Colletotrichum Fragariae, 14.5μg/mL against Strawberry Botrytis Cinerea and 24.3μg/mL against Kiwifruit Botrytis Cinerea, resp., whereas the antifungal activity against resistant phytopathogenic fungi. of osthole is too low to be used (EC₅₀ > 400 ppm). The results of mycelial relative conductivity determination, PI uptake and fluorescence spectroscopy indicated that the cell membrane of fungi is the key action site of I. Besides, I has the potent inhibitory activity against both of plant and human pathogenic bacteria. Our studies showed that C₄ was worthy for further attention as a promising botanical fungicide candidate in crop protection. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Electric Literature of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient Fenton-like treatment of high-concentration chlorophenol wastewater catalysed by Cu-Doped SBA-15 mesoporous silica was written by Hu, Huanting;Miao, Kangkang;Luo, Xiaolin;Guo, Sifan;Yuan, Xueqin;Pei, Fei;Qian, Huaming;Feng, Guodong. And the article was included in Journal of Cleaner Production in 2021.Recommanded Product: 95-88-5 The following contents are mentioned in the article:

Effective treatment for industrial wastewater that contains high concentration of chlorophenols is urgent and indispensable for environmental governance and human health due to their nonbiodegradable, carcinogenic and cytotoxic properties. Four kinds of Cu-containing mesoporous silica materials were utilized to catalyze Fenton-like treatment of high-concentration chlorophenols wastewater (1.0 g L-1). All of chlorophenols in various water matrixes could be oxidatively decomposed in 35 min with the catalysis of Cu-doped SBA-15. Cu-doped SBA-15 with a Cu/Si molar ratio of 0.133 had the best catalytic activity in the oxidative degradation of 4-chlorophenol with an apparent reaction rate constant of 0.170 min-1 which was 1.3-3.6 times higher than those with other Cu-containing catalysts. After 300 min reaction, total organic carbon content of 4-chlorophenol solution declined continuously to 23.8% with an advisable utilization efficiency of H₂O₂ of 26.5%-68.4%. ESR tests and quenching experiments demonstrated that Cu-doped SBA-15 had a selective catalytic activity in the decomposition of H2O2 into hydroxyl radicals which dominated the degradation of chlorophenols in wastewater. The redox of Cu(II)/Cu(I) in Cu-doped SBA-15 occurred efficiently, which could be attributed to chem. adsorption and electron transformation of organic mol. fragments onto Lewis acidic sites formed by the incorporation of Cu²⁺ ions in SBA-15. The biol. toxicity of the treated 4-CP wastewater declined significantly in comparison with that of the original wastewater. Our work provided an effective way of the heterogeneous treatment of high-concentration chlorophenol wastewater. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Photosensitizing and antioxidant activities of humic substances: A case study of β2-adrenoceptor agonist terbutaline was written by Zhou, Lei;Sleiman, Mohamad;Halladja, Sabrina;Ferronato, Corinne;Chovelon, Jean-Marc;Richard, Claire. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2020.Formula: C6H5ClO2 The following contents are mentioned in the article:

Humic substances (HS) play an important role in the phototransformation of micro-pollutants in surface waters and a significant part of this reactivity is often attributed to oxidant triplet excited states (³HS*). The present study aims to understand why ³HS* were found to be negligibly involved in the HS-mediated phototransformation of β2-adrenoceptor agonist terbutaline (TBL) while this chem. shows a high reactivity towards triplet 3-carboxybenzophenone (³CBP*), a typical HS model sensitizer. To clarify this apparent discrepancy, several experiments were conducted. We first confirmed that TBL can be easily oxidized by triplet riboflavin (³RF*), another sensitizer (k = (1.7 ± 0.4)x10⁹ M^-1 s^-1). Afterwards, we studied the effect of TBL on the HS-mediated phototransformation of 2,4,6-trimethylphenol (TMP), chosen for its high reactivity with ³HS*. TBL was found to enhance the rate of TMP loss. This result is rationalized by postulating that (i) TMP and TBL are both oxidized by ³HS* to yield the phenoxyl radicals TMP^•_-H and TBL^•_-H, resp., and (ii) TBL^•_-H is further reduced by TMP which generates addnl. TMP^•_-H. Fitting the exptl. data gives k = (1.8 ± 0.5)x10⁹ M^-1 s^-1 for the reaction between ³HS* and TBL and DFT calculations further support the conclusion that TBL^•_-H can be reduced by a lot of phenols. Hence, in the case of TBL, the oxidant effect of ³HS* is counterbalanced by the antioxidant properties of HS. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics