Category: 95-88-5

Biocatalytic Friedel-Crafts Acylation and Fries Reaction was written by Schmidt, Nina G.;Pavkov-Keller, Tea;Richter, Nina;Wiltschi, Birgit;Gruber, Karl;Kroutil, Wolfgang. And the article was included in Angewandte Chemie, International Edition in 2017.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to >99 %, and various C- or O-acyl donors, such as DAPG or isopropenyl acetate, are accepted by this enzyme. Furthermore the enzyme enables a Fries-like rearrangement reaction of resorcinol derivatives These findings open an avenue for the development of alternative and selective C-C bond formation methods. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Highly Z-Selective Coumarin Annulated Dioxocine, Dioxacindione and Macrocycles Using Grubbs’ Second-Generation Catalyst was written by Goud, E. Yadaiah;Rao, B. Kanakadurga;Thirupahi, G.;Hemasri, Y.;Rao, Ch. Prasad;Kumar, P. Vijay;Rao, Y. Jayaprakash. And the article was included in ChemistrySelect in 2017.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

The diversity-oriented organic synthesis of novel coumarin annulated dioxocine I [R = Me, Ph], dioxacindione II scaffolds with Z-selectivity and the sym. pentacyclic coumarin macrocyclic derivatives III [R = H, Me; R¹ = H, Cl; n = 1,2,4] is demonstrated from substituted hydroxyl coumarins via ring-closing metathesis in presence of Grubbs’ second-generation catalyst as the facile and efficient route with excellent yields. This synthetic strategy provides a route for the intramol. ring-closing metathesis to access a library of novel tricyclic coumarin heterocycles and pentacyclic coumarin macrocycles having different ring systems. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A multipronged QSAR approach to predict algal low-toxic-effect concentrations of substituted phenols and anilines was written by Tugcu, Gulcin;Sacan, Melek Turker. And the article was included in Journal of Hazardous Materials in 2018.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:

Environmental risk assessment procedures require acute and chronic toxicity values of hazardous chems. In this respect, the 96-h toxicity bioassays of nitro-, methyl-, methoxy-, chloro-, and nitrile- substituted phenols and anilines to Chlorella vulgaris were performed. Median inhibitory and low-toxic-effect concentrations were reported. Significant correlations between acute and chronic toxicities were found for the chems. in the data set regardless of mode of action. Consequently, linear models employing theor. and empirical descriptors were developed for the prediction of NOEC and IC₂₀. The outcome of the study will be beneficial in the risk assessments of organic chems. and setting water quality standards by the regulators. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

1-Nicotinoylbenzotriazole: A Convenient Tool for Site-Selective Protection of 5,7-Dihydroxycoumarins was written by Fatykhov, Ramil F.;Khalymbadzha, Igor A.;Chupakhin, Oleg N.;Charushin, Valery N.;Inyutina, Anna K.;Slepukhin, Pavel A.;Kartsev, Victor G.. And the article was included in Synthesis in 2019.Application In Synthesis of 4-Chlororesorcinol The following contents are mentioned in the article:

1-Nicotinoylbenzotriazole (NicBt) was uncovered as an efficient protecting agent for the site-selective acylation of resorcinol-type phenolic groups with almost equal reactivity. The use of NicBt allows selective protection of the 7-OH group in 5,7-dihydroxycoumarins in one simple scalable step, while combination of the nicotinoylation with tosylation-denicotinoylation or silylation-denicotinoylation yields 5-OH-protected 5,7-dihydroxycoumarins. Furthermore, nicotinoylated 5,7-dihydroxycoumarins proved useful in a gram-scale three-step preparation of a 2,2-dimethylpyrano[2,3-f]coumarin, a key intermediate for the synthesis of calanolide A, an HIV reverse transcriptase and Mycobacterium tuberculosis inhibitor, and its active analogs. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application In Synthesis of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chasing ChEs-MAO B multi-targeting 4-aminomethyl-7-benzyloxy-2H-chromen-2-ones was written by Rullo, Mariagrazia;Catto, Marco;Carrieri, Antonio;de Candia, Modesto;Altomare, Cosimo Damiano;Pisani, Leonardo. And the article was included in Molecules in 2019.Product Details of 95-88-5 The following contents are mentioned in the article:

A series of 4-aminomethyl-7-benzyloxy-2H-chromen-2-ones was investigated with the aim of identifying multiple inhibitors of cholinesterases (acetyl- and butyryl-, AChE and BChE) and monoamine oxidase B (MAO B) as potential anti-Alzheimer mols. Starting from a previously reported potent MAO B inhibitor (3), we studied single-point modifications at the benzyloxy or at the basic moiety. The in vitro screening highlighted triple-acting compounds (6, 8, 9, 16, 20) showing nanomolar and selective MAO B inhibition along with IC50 against ChEs at the low micromolar level. Enzyme kinetics anal. toward AChE and docking simulations on the target enzymes were run in order to get insight into the mechanism of action and plausible binding modes. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Product Details of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of coumarin derivatives as anti-inflammatory agents was written by Kayal, Gaurav;Kayal, Snehlata;Gokhale, Niharika;Jain, Sanjay. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2016.Related Products of 95-88-5 The following contents are mentioned in the article:

All the newly synthesized Coumarin derivatives have shown considerable anti-inflammatory activity. In the present research work, we synthesized a series of novel Coumarin derivatives The Coumarin derivatives such as substituted 7-hydroxy-4-methyl-2H-chromen-2-one and substituted 6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one were synthesized from substituted benzoyl chloride. The chem. structures of the synthesized compounds were confirmed by means of IR and 1H-NMR. These compounds were screened for anti-inflammatory activity by carrageenan induced paw edema method in rats at a dose of 30 mg/kg body weight All the tested compounds of Coumarin derivatives were found to be more potent when compared to standard drug Diclofenac. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Related Products of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Novel Inhibitor of the Obesity-Related Protein FTO was written by Qiao, Yan;Zhou, Bin;Zhang, Meizi;Liu, Weijia;Han, Zhifu;Song, Chuanjun;Yu, Wenquan;Yang, Qinghua;Wang, Ruiyong;Wang, Shaomin;Shi, Shuai;Zhao, Renbin;Chai, Jijie;Chang, Junbiao. And the article was included in Biochemistry in 2016.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

Fe^II and α-ketoglutarate-dependent fat mass and obesity associated protein (FTO)-dependent demethylation of m⁶A is important for regulation of mRNA splicing and adipogenesis. Developing FTO-specific inhibitors can help probe the biol. of FTO and unravel novel therapeutic targets for treatment of obesity or obesity-associated diseases. In the present paper, we have identified that 4-chloro-6-(6′-chloro-7′-hydroxy-2′,4′,4′-trimethyl-chroman-2′-yl)benzene-1,3-diol (CHTB) is an inhibitor of FTO. The crystal structure of CHTB complexed with human FTO reveals that the novel small mol. binds to FTO in a specific manner. The identification of the novel small mol. offers opportunities for further development of more selective and potent FTO inhibitors. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The Highly Regioselective Synthesis of Novel Imidazolidin-2-ones via the Intramolecular Cyclization/Electrophilic Substitution of Urea Derivatives and the Evaluation of Their Anticancer Activity was written by Gazizov, Almir S.;Smolobochkin, Andrey V.;Kuznetsova, Elizaveta A.;Abdullaeva, Dinara S.;Burilov, Alexander R.;Pudovik, Michail A.;Voloshina, Alexandra D.;Syakaev, Victor V.;Lyubina, Anna P.;Amerhanova, Syumbelya K.;Voronina, Julia K.. And the article was included in Molecules in 2021.Reference of 95-88-5 The following contents are mentioned in the article:

A series of novel 4-(het)arylimidazolidin-2-ones I [R = 5-Cl-2,4-di-HO-C₆H₂, 6-hydroxy-1,3-benzodioxol-5-yl, 4-hydroxy-6-methyl-2-oxo-pyran-3-yl; R¹ = H, Me; R² = Ph, 4-MeC₆H₄, 3-ClC₆H₄, etc.] was obtained by the acid-catalyzed reaction of (2,2-dimethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones I benefited from excellent regioselectivity, readily available starting materials and a simple procedure. The regioselectivity of the reaction was rationalized by quantum chem. calculations and control experiments The anti-cancer activity of the obtained compounds was tested in vitro. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Reference of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Fluorescent Probe for Neural Stem/Progenitor Cells with High Differentiation Capability into Neurons was written by Kim, Beomsue;Feng, Suihan;Yun, Seong-Wook;Leong, Cheryl;Satapathy, Rudrakanta;Wan, Si Yan Diana;Chang, Young-Tae. And the article was included in ChemBioChem in 2016.Name: 4-Chlororesorcinol The following contents are mentioned in the article:

Selection of a specific neural stem/progenitor cells (NSPCs) has attracted broad attention in regenerative medicine for neurol. disorders. Here, we report a fluorescent probe, CDg13, and its application for isolating strong neurogenic NSPCs. In comparison to the NSPCs isolated by other biomarkers, CDg13-stained NSPCs showed higher capability to differentiate into neurons. Target identification revealed that the fluorescence intensity of the probe within cells is inversely proportional to the expression levels of mouse and human Abcg2 transporters. These findings suggest that low Abcg2 expression is a biomarker for neurogenic NSPCs in mouse brain. Furthermore, CDg13 can be used to isolate Abcg2^low cells from heterogeneous cell populations. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Name: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyclization of 1-(4,4-diethoxybutyl)-3-arylureas: a case study was written by Smolobochkin, Andrey V.;Gazizov, Almir S.;Voronina, Julia K.;Burilov, Alexander R.;Pudovik, Michail A.. And the article was included in Monatshefte fuer Chemie in 2018.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:

The study on the reaction of (4,4-diethoxybutyl)ureas with nucleophilic aromatics was reported herein. It was found that the structure of the products mainly depends on the strength of the acid used as catalyst as well as aromatic nucleophile nature and its concentration Either 2-arylpyrrolidines e.g., (R,S)-2,2′-(4,6-Dihydroxy-5-methyl-1,3-phenylene)bis[N-(naphthalen-1-yl)pyrrolidine-1-carboxamide], diarylbutanes, 1-[4,4-Bis(5-chloro-2,4-dihydroxyphenyl)butyl]-3-(naphthalen-1-yl)urea, bispyrrole derivatives, N-(Naphthalen-1-yl)-4-[1-(naphthalen-1-ylcarbamoyl)pyrrolidin-2-yl]-2,3-dihydro-1H-pyrrole-1-carboxamide, or pyrrolidinequinazolinones can be synthesized via variation of these factors. The proposed mechanism of the reaction is discussed. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics