Category: 95-88-5

Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin was written by Dubois, Lilian;Pietrancosta, Nicolas;Cabaye, Alexandre;Fanget, Isabelle;Debacker, Cecile;Gilormini, Pierre-Andre;Dansette, Patrick M.;Dairou, Julien;Biot, Christophe;Froissart, Roseline;Goupil-Lamy, Anne;Bertrand, Hugues-Olivier;Acher, Francine C.;McCort-Tranchepain, Isabelle;Gasnier, Bruno;Anne, Christine. And the article was included in Journal of Medicinal Chemistry in 2020.Synthetic Route of C6H5ClO2 The following contents are mentioned in the article:

Sialin, encoded by the SLC17A5 gene, is a lysosomal sialic acid transporter defective in Salla disease, a rare inherited leukodystrophy. It also enables metabolic incorporation of exogenous sialic acids, leading to autoantibodies against N-glycolylneuraminic acid in humans. Here, we identified a novel class of human sialin ligands by virtual screening and structure-activity relationship studies. The ligand scaffold is characterized by an amino acid backbone with a free carboxylate, an N-linked aromatic or heteroaromatic substituent, and a hydrophobic side chain. The most potent compound, 45 (LSP12-3129), inhibited N-acetylneuraminic acid 1 (Neu5Ac) transport in a non-competitive manner with IC₅₀ â‰?2.5μM, a value 400-fold lower than the K_M for Neu5Ac. In vitro and mol. docking studies attributed the non-competitive character to selective inhibitor binding to the Neu5Ac site in a cytosol-facing conformation. Moreover, compound 45 rescued the trafficking defect of the pathogenic mutant (R39C) causing Salla disease. This new class of cell-permeant inhibitors provides tools to investigate the physiol. roles of sialin and help develop pharmacol. chaperones for Salla disease. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Synthetic Route of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Total Syntheses Supramolecular Style: Solid-State Construction of [2.2]Cyclophanes with Modular Control of Stereochemistry was written by Friscic, Tomislav;Elacqua, Elizabeth;Dutta, Saikat;Oburn, Shalisa M.;MacGillivray, Leonard R.. And the article was included in Crystal Growth & Design in 2020.Synthetic Route of C6H5ClO2 The following contents are mentioned in the article:

A series of templated solid-state reactions are used to construct the ‘bent’ isomer of the [2.2]cyclophane family of mols. Small-mol. hydrogen-bond-donor templates based on resorcinol complete the supramol. construction of ortho-, meta-, and para-[2.2]cyclophanes in the solid state. The family of exo,exo-dicyclobutyl[2.2]cyclophanes forms regiospecifically in up to quant. yields. The confines of the organic solid state and the modular nature of the template approach allow for the generation of a less stable exo,endo-[2.2]metacyclophane by simply changing the template to enforce a concomitant change in self-assembly. Our results demonstrate the first completed solid-state construction of each member of the family of [2.2]cyclophanes. Small-mol. hydrogen-bond-donor templates based on resorcinol complete the supramol. construction of ortho-, meta-, and para-[2.2]cyclophanes in the solid state. The exo,exo-dicyclobutyl[2.2]cyclophanes and less stable exo,endo-[2.2]metacyclophane form regiospecifically in up to quant. yields. Solid-state fluorescence data of the orthocyclophane exhibits a markedly broader fluorescence envelope and red-shifted λ_max in comparison to the metacyclophanes. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Synthetic Route of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evolving a Unique Red-Emitting Fluorophore with an Optically Tunable Hydroxy Group for Imaging Nitroreductase in Cells, in Tissues, and in Vivo was written by Peng, Rong;Yuan, Jie;Cheng, Dan;Ren, Tianbing;Jin, Fangping;Yang, Ronghua;Yuan, Lin;Zhang, Xiaobing. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2019.Recommanded Product: 95-88-5 The following contents are mentioned in the article:

Fluorescence mol. imaging has attracted more and more attention due to its various advantages. Lots of fluorophores have been developed to meet various mol. imaging needs. However, it is still inconvenient due to lack excellent fluorophores with an optically tunable group for biol. mol. imaging. Here, a new platform of the versatile long wavelength fluorophore with an optically tunable hydroxyl group was successfully developed by regulating mol. planarity and twisted intramol. charge transfer effect with protected and deprotected-hydroxyl group approach via “step by step” modifying strategy. As an excellent representative of this new type fluorophore, LDOH-4 performs good chem. and optical properties, and shows a potential application prospect. As a proof-of-concept, a nitroreductase-activated TP fluorescent probe LDO-NTR was designed, which not only sensitively recognize NTR with more than 310-fold response signal enhancement in vitro, but also tracking NTR in hypoxia tumor mouse in vivo by using two-photon imaging. It is hopeful that the long wavelength fluorophore with the optically tunable hydroxyl group can serve as a useful platform to extend capable detection tools in biol. chem. and biomedical applications. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Near infrared fluorogenic probe as a prodrug model for evaluating cargo release by nanoemulsions was written by Bou, Sophie;Wang, Xinyue;Anton, Nicolas;Klymchenko, Andrey S.;Collot, Mayeul. And the article was included in Journal of Materials Chemistry B in 2020.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:

Nanoemulsions (NEs) are biocompatible and stealth nanodroplets that can efficiently encapsulate hydrophobic cytoactive drugs in their oily core. NEs were shown to accumulate in tumors by enhanced permeability and retention (EPR) effect and thus display appealing features as nanocarriers to selectively deliver drugs to the tumors. However, to ensure efficient encapsulation with minimal early release, drugs must possess a high degree of lipophilicity. To circumvent this limitation, the latter could be transformed into prodrugs with enhanced hydrophobicity. In return, once delivered in the cell, the prodrug must be efficiently transformed into its active drug form. Herein we chem. and reversibly modified a near IR Huda dye (HD) into pro-fluorophore (Pro-HD), a non-fluorescent and lipophilic prodrug model that was efficiently loaded in NEs. Thanks to the fluorogenecity of the system (fluorescence enhancement of 35-fold at 723 nm), we demonstrated that Pro-HD did not leak out of NEs, was efficiently delivered into cancer cells and was transformed in cellulo into HD. This proof of concept demonstrates the high potential of lipophilic “pro-fluorophore” approach for visualizing delivery of cargos using NEs as nanocarriers. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Controlling quantum-beating signals in 2D electronic spectra by packing synthetic heterodimers on single-walled carbon nanotubes was written by Wang, Lili;Griffin, Graham B.;Zhang, Alice;Zhai, Feng;Williams, Nicholas E.;Jordan, Richard F.;Engel, Gregory S.. And the article was included in Nature Chemistry in 2017.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

In multidimensional spectroscopy, dynamics of coherences between excited states report on the interactions between electronic states and their environment. The prolonged coherence lifetimes revealed through beating signals in the spectra of some systems may result from vibronic coupling between nearly degenerate excited states, and recent observations confirm the existence of such coupling in both model systems and photosynthetic complexes. Understanding the origin of beating signals in the spectra of photosynthetic complexes has been given considerable attention; however, strategies to generate them in artificial systems that would allow us to test the hypotheses in detail are still lacking. Here we demonstrate control over the presence of quantum-beating signals by packing structurally flexible synthetic heterodimers on single-walled carbon nanotubes, and thereby restrict the motions of chromophores. Using two-dimensional electronic spectroscopy, we find that both limiting the relative rotation of chromophores and tuning the energy difference between the two electronic transitions in the dimer to match a vibrational mode of the lower-energy monomer are necessary to enhance the observed quantum-beating signals. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alternative method for qualitative analysis of specific non-volatile organic compounds present in South African water systems was written by Brutti, R.;Magu, M. M.;Agorku, E. S.;Govender, P. P.. And the article was included in South African Journal of Chemistry in 2016.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:

Currently, water quality assessment has become a necessity in order to maintain healthy living. Point and non-point sources of water pollutants are either organic or inorganic in nature. Non-volatile organic compounds (nVOCs) mostly exist as solids at room temperature and are used on a large scale in most chem. industries. Since these nVOCs are toxic to both animals and humans and some of these non-volatile organic compounds are carcinogenic, it is important to analyze the water in order to ascertain its quality by identifying which types of compounds arepresent in these systems and quantifying them. This work reports on the use of a new and alternative method for qual. anal. of nVOCs in water systems. Anal. was done for 13 sampling sites (seven from wastewater and six from surface water found in Gauteng and KwaZulu-Natal provinces, resp.).Vacuum evaporation followed by methanol extraction of the residues was performed. Fourier Transform IR (FTIR) was conducted using NaCl disk and KBr pellets and their results compared. High Performance Liquid Chromatog. (HPLC) was chosen as a technique for comparison and to prove that the simple IR (IR) can be used instead. In addition, HPLC is an ideal anal. technique for non-volatile substances. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers was written by An, Jing;Tang, Shanliang;Hong, Gaobo;Chen, Wenlong;Chen, Miaomiao;Song, Jitao;Li, Zhiliang;Peng, Xiaojun;Song, Fengling;Zheng, Wen-Heng. And the article was included in Nature Communications in 2022.Quality Control of 4-Chlororesorcinol The following contents are mentioned in the article:

The most common working mechanism of photodynamic therapy is based on high-toxicity singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on oxygen consumption. Recently, Type I photodynamic therapy has been found to have better hypoxia tolerance to ease this restriction. However, few strategies are available on the design of Type I photosensitizers. We herein report an unexpected strategy to alleviate the limitation of traditional photodynamic therapy by biotinylation of three photosensitizers (two fluorescein-based photosensitizers and the com. available Protoporphyrin). The three biotiylated photosensitizers named as compound 1, 2 and 3, exhibit impressive ability in generating both superoxide anion radicals and singlet oxygen. Moreover, compound 1 can be activated upon low-power white light irradiation with stronger ability of anion radicals generation than the other two. The excellent combinational Type I / Type II photodynamic therapy performance has been demonstrated with the photosensitizers 1. This work presents a universal protocol to provide tumor-targeting ability and enhance or trigger the generation of anion radicals by biotinylation of Type II photosensitizers against tumor hypoxia. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Quality Control of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bent-core liquid crystal-functionalised flexible polymer substrates for liquid crystal alignment was written by Sivaranjini, B.;Ganesh, V.;Umadevi, S.. And the article was included in Liquid Crystals in 2020.HPLC of Formula: 95-88-5 The following contents are mentioned in the article:

A transparent flexible polymer film is chem. functionalised with a bent-core liquid crystal (BCLC) compound for effective alignment of the bulk BCLC sample at the substrate-LC interface. The surface attachment was achieved via a simple procedure which involved pre-treatment of the polymer film (com. name: over head projector film) using piranha solution followed by chem. attaching the BCLC compound through silane condensation reaction. Surface characterization of the unmodified and BC-modified flexible films was carried out through XPS, attenuated total reflectance fourier transform IR (ATR-FTIR) spectroscopy, contact angle (CA) and at. force microscopy (AFM) techniques. The BC-modified flexible substrates are analyzed for their efficiency to orient the bulk LC sample. Remarkably, the chem. modified polymer substrates are highly efficient in vertically aligning both the BC and rod-like LC samples at the substrate-LC interface, in comparison to their unmodified counterparts. The described method is simple, reproducible, surface modified substrates are highly stable and more importantly reusable. The demonstrated method for the alignment of BCLCs advances a step forward towards the realization of applications proposed for these fascinating compounds This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5HPLC of Formula: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The fabrication of poly (polyethylene glycol diacrylate) monolithic porous layer open tubular (mono-PLOT) columns and applications in hydrophilic interaction chromatography and capillary gas chromatography for small molecules was written by Chang, Feng;Yue, Yunfang;Yang, Zihui;Huang, Si;Liu, Zhihua;Wang, Kunmiao;Peng, Yan;Chen, Yingzhuang;Ma, Ming;Chen, Bo. And the article was included in Electrophoresis in 2019.SDS of cas: 95-88-5 The following contents are mentioned in the article:

The easy shrinkage and swelling of polymer monolithic column when exposed to mobile phase with different polarity is a problem that cannot be ignored. To overcome this drawback, a convenient aqueous two-phase polymerization approach was used to prepare poly (polyethylene glycol diacrylate, PEGDA) monolithic porous layer open tubular (mono-PLOT) columns (150 μm). The poly(PEGDA) mono-PLOT column with homogeneous polymer porous layer was synthesized successfully. A maximum plate number of 41,500 plates per m for allyl thiourea was obtained under a velocity of 1.8 mm/s. Several kinds of polar mol. were separated on the proposed mono-PLOT column and a typical hydrophilic interaction retention mechanism was observed High speed separation of benzoic acids was also carried out, baseline separation of five benzoic acids was successfully achieved within 5 min with a 70 cm mono-PLOT column at 50°C. Furthermore, the resulting PLOT column was also successfully applied to sep. standard analytes of three DNA oxidative damage products and RNA-modified nucleosides and four chlorophenols. At last, the column could sep. alcs., alkanes, and aromatic isomers via GC. It had more than 20,000 plates per m for butanol – higher than com. coatings open tubular columns. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5SDS of cas: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Colorimetric analysis of palladium using thiocarbamate hydrolysis and its application for detecting residual palladium in drugs was written by Choi, Myung Gil;Seo, Ju-Yeon;Cho, Eun Jin;Chang, Suk-Kyu. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Quality Control of 4-Chlororesorcinol The following contents are mentioned in the article:

In this research, we report a practical colorimetric method for the convenient anal. of residual palladium ions in drugs and drug intermediates. In a phosphate-buffered (pH 7.0) 50% aqueous DMSO solution, chlororhodol-based probe PP-1 demonstrated a prominent colorimetric (A_PP-1+Pd(II)/A_PP-1 at 531 nm is over 780) and turn-on type fluorescence signaling behavior (I_PP-1+Pd(II)/I_PP-1 at 561 nm is over 2000) toward palladium. The signaling was realized through the palladium-assisted hydrolysis of the thiocarbamate protecting moiety of the probe. Palladium-selective signaling was feasible in the presence of possibly interfering chem. species, and it was concluded within 7 min. The selective signaling was observed for palladium species with different oxidation states (Pd²⁺, Pd⁴⁺, and Pd⁰). The detection limit of the probe for palladium anal. was sufficiently sensitive to analyze the residual palladium in drugs and related products (LOD_PP-1 = 1.0 x 10^-8 M, LOD_PP-2 = 4.3 x 10^-8 M). In particular, palladium anal. could be performed in the presence of ibuprofen and 2-cyano-4â€?methylbiphenyl, as the drug and drug intermediate, resp. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Quality Control of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics