HPLC of Formula: 954238-81-4On May 11, 2017 ,《2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Mo, Cheng; Zhang, Zhang; Guise, Christopher P.; Li, Xueqiang; Luo, Jinfeng; Tu, Zhengchao; Xu, Yong; Patterson, Adam V.; Smaill, Jeff B.; Ren, Xiaomei; Lu, Xiaoyun; Ding, Ke. The article conveys some information:
A series of 2-aminopyrimidine derivatives were designed and synthesized as highly selective FGFR4 inhibitors. One of the most promising compounds I tightly bound FGFR4 with a Kd value of 3.3 nM and potently inhibited its enzymic activity with an IC50 value of 2.6 nM, but completely spared FGFR1/2/3. The compound selectively suppressed proliferation of breast cancer cells harboring dysregulated FGFR4 signaling with an IC50 value of 0.38 μM. Furthermore, I exhibited extraordinary target specificity in a Kinome-wide screen against 468 kinases, with S(35) and S(10) selectivity scores of 0.01 and 0.007 at 1.0 μM, resp. In addition to this study using tert-Butyl (2-amino-3-chlorophenyl)carbamate, there are many other studies that have used tert-Butyl (2-amino-3-chlorophenyl)carbamate(cas: 954238-81-4HPLC of Formula: 954238-81-4) was used in this study.
tert-Butyl (2-amino-3-chlorophenyl)carbamate(cas: 954238-81-4) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 954238-81-4
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