Category: 98019-65-9

Mori, Miwako; Kagechika, Katsuji; Sasai, Hiroaki; Shibasaki, Masakatsu published an article on January 28 ,1991. The article was titled 《New synthesis of 4-acetoxy-2-azetidinones by use of electrochemical oxidation》, and you may find the article in Tetrahedron.HPLC of Formula: 98019-65-9 The information in the text is summarized as follows:

4-Acetoxy-2-azetidinone was synthesized from 4-carboxy-2-azetidinone by Kolbe-type electrolysis. Optically pure 4-acetoxy-3-[1-(t-butyldimethylsiloxy)ethyl]-2-azetidinone, which is an important intermediate for the synthesis of thienamycin, and (+)-PS-5 were synthesized by use of this method. In the experiment, the researchers used many compounds, for example, 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9HPLC of Formula: 98019-65-9)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 98019-65-9 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cha, J. K. published their research in Science of Synthesis on August 10 ,2005. The article was titled 《Product class 3: N-[α-(Heteroatom)alkyl]-substituted alkanamides》.HPLC of Formula: 98019-65-9 The article contains the following contents:

A review of the preparation of N-[α-(heteroatom)alkyl]-substituted alkanamides and applications to organic synthesis. The experimental part of the paper was very detailed, including the reaction process of 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9HPLC of Formula: 98019-65-9)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 98019-65-9 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《New synthesis of 4-acetoxy-2-azetidinones by use of electrochemical oxidation》 were Mori, Miwako; Kagechika, Katsuji; Tojima, Ko; Shibasaki, Masakatsu. And the article was published in Tetrahedron Letters in 1988. Application of 98019-65-9 The author mentioned the following in the article:

Optically pure 4-acetoxy-3-[1(t-butyldimethylsilyloxy)ethyl]-2-azetidinone, which is a highly versatile intermediate for the synthesis of thienamycin and other biol. active β-lactam analogs, was synthesized from 4-carboxy-3-[1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone by Kolbe type electrolysis. The results came from multiple reactions, including the reaction of 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9Application of 98019-65-9)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 98019-65-9 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Discovery of a Covalent Triazine Framework Photocatalyst for Visible-Light-Driven Chemical Synthesis using High-Throughput Screening》 was written by Vijayakrishnan, Sriram; Ward, John W.; Cooper, Andrew I.. Related Products of 98019-65-9 And the article was included in ACS Catalysis on August 19 ,2022. The article conveys some information:

Reported the discovery of a covalent triazine framework photocatalyst (CTF-2) for decarboxylative conjugate addition of a range of carboxylic acids under visible-light irradiation The decarboxylation reaction was coupled with a variety of other reactions, including metallaphotoredox arylation, alkylation, fluorination and dehydrogenative aniline synthesis. CTF-2 was prepared on a large scale and recycled without loss of catalytic efficiency for at least four cycles. To demonstrate application in pharmaceutical drug synthesis, synthesized (±)-rolipram in five steps from isovanillin using a CTF-2-catalyzed decarboxylative conjugate addition as the key step. In the experiment, the researchers used 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9Related Products of 98019-65-9)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 98019-65-9 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Chemical Fragments that Hydrogen Bond to Asp, Glu, Arg, and His Side Chains in Protein Binding Sites》 was written by Chan, A. W. Edith; Laskowski, Roman A.; Selwood, David L.. Formula: C4H5NO3 And the article was included in Journal of Medicinal Chemistry on April 22 ,2010. The article conveys some information:

We present an anal. of the chem. fragments from lead-like ligands in the Protein Data Bank (PDB) that form hydrogen bonds to the side chains of Asp, Glu, Arg, and His, which are the most common residues found in ligand binding sites. A fragment is defined as the largest ring assembly containing the atoms involved in hydrogen bonding. In total, 462 fragments were found in 2038 ligands from over 8000 protein-ligand structures in the PDB. The results show which fragments have a higher propensity for interaction with specific side chains. Some fragments interact with Asp but not with Glu, and vice versa, despite these side chains sharing the same chem. moiety. Arg side chains form hydrogen bonds almost exclusively with O-mediated ligands, and the fragments are the most diverse. Hydrogen bond distances from the imidazole of His showed a wider range than the other three amino acids. In the experimental materials used by the author, we found 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9Formula: C4H5NO3)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Formula: C4H5NO3 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Formation of fumaramic acid from asparagine in phosphate buffer》 was written by Talley, Eugene A.; Fitzpatrick, Thomas J.; Porter, William L.. Electric Literature of C4H5NO3 And the article was included in Journal of the American Chemical Society in 1959. The article conveys some information:

The product obtained by heating asparagine in pH 6.7 buffer (Na2HPO4, KH2PO4) 24 hrs. at 100° and previously regarded to be 4-carboxy-2-azetidinone (C.A. 51, 2715h), has been shown by chem. means, infrared absorption, X-ray powder diagram, and comparison with an authentic sample to be fumaramic acid (I). Absolute MeOH (10.7 g.) in 145 cc. dry C6H6 added dropwise to 51.0 g. fumaryl dichloride with stirring below 30°, kept overnight, and fractionally distilled gave the following fractions: (1) b18 62-71°, (2) b18 71-82°, (3) b18 82-4°, (4) b18 84-5° (di-Me fumarate); the combined fractions 2 and 3 stirred with cold H2O until emulsified, cooled, and filtered, and the residue washed with iced H2O gave 8.2 g. mono-Me ester (II) of fumaric acid, m. 144.0-4.5°. II (8.2 g.) shaken several min. at room temperature with 25 cc. concentrated NH4OH, kept 2 hrs., and evaporated in vacuo, the residue dissolved in H2O, redried, redissolved in H2O, and passed through Dowex 50 (H), the effluent and the washing from the column combined, concentrated at 40°, and allowed to stand, and the crystalline deposit recrystallized (H2O) and dried at 50° in vacuo yielded 6.3 g. I, which was identical with the product from asparagine. In the experiment, the researchers used 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9Electric Literature of C4H5NO3)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Electric Literature of C4H5NO3 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C4H5NO3On October 15, 2014 ,《Ternary Nylon-3 Copolymers as Host-Defense Peptide Mimics: Beyond Hydrophobic and Cationic Subunits》 was published in Journal of the American Chemical Society. The article was written by Chakraborty, Saswata; Liu, Runhui; Hayouka, Zvi; Chen, Xinyu; Ehrhardt, Jeffrey; Lu, Qin; Burke, Eileen; Yang, Yiqing; Weisblum, Bernard; Wong, Gerard C. L.; Masters, Kristyn S.; Gellman, Samuel H.. The article contains the following contents:

Host-defense peptides (HDPs) are produced by eukaryotes to defend against bacterial infection, and diverse synthetic polymers have recently been explored as mimics of these natural peptides. HDPs are rich in both hydrophobic and cationic amino acid residues, and most HDP-mimetic polymers have therefore contained binary combinations of hydrophobic and cationic subunits. However, HDP-mimetic polymers rarely duplicate the hydrophobic surface and cationic charge d. found among HDPs (Hu, K.; et al. Macromols. 2013, 46, 1908); the charge and hydrophobicity are generally higher among the polymers. Statistical anal. of HDP sequences (Wang, G.; et al. Nucleic Acids Res. 2009, 37, D933) has revealed that serine (polar but uncharged) is a very common HDP constituent and that glycine is more prevalent among HDPs than among proteins in general. These observations prompted us to prepare and evaluate ternary nylon-3 copolymers that contain a modestly polar but uncharged subunit, either serine-like or glycine-like, along with a hydrophobic subunit and a cationic subunit. Starting from binary hydrophobic-cationic copolymers that were previously shown to be highly active against bacteria but also highly hemolytic, we found that replacing a small proportion of the hydrophobic subunit with either of the polar, uncharged subunits can diminish the hemolytic activity with minimal impact on the antibacterial activity. These results indicate that the incorporation of polar, uncharged subunits may be generally useful for optimizing the biol. activity profiles of antimicrobial polymers. In the context of HDP evolution, our findings suggest that there is a selective advantage to retaining polar, uncharged residues in natural antimicrobial peptides. In the experiment, the researchers used many compounds, for example, 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9Electric Literature of C4H5NO3)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Electric Literature of C4H5NO3 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics