Category: 98946-18-0

Xiong, Yaoyao; Jentzsch, Andreas Vargas; Osterrieth, Johannes W. M.; Sezgin, Erdinc; Sazanovich, Igor V.; Reglinski, Katharina; Galiani, Silvia; Parker, Anthony W.; Eggeling, Christian; Anderson, Harry L. published an article in 2018, the title of the article was Correction: Spironaphthoxazine switchable dyes for biological imaging [Erratum to document cited in CA173:791332].HPLC of Formula: 98946-18-0 And the article contains the following content:

Andreas Vargas Jentzsch should have been included in the footnote reference, as the first two authors contributed equally. The correct affiliations and symbols for those affiliations are provided. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).HPLC of Formula: 98946-18-0

The Article related to spironaphthoxazine switchable dye biol imaging erratum, Placeholder for records without volume info and other aspects.HPLC of Formula: 98946-18-0

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 19, 2021, Fandrick, Keith R.; Patel, Nitinchandra D.; Radomkit, Suttipol; Chatterjee, Arindom; Braith, Stefan; Fandrick, Daniel R.; Busacca, Carl A.; Senanayake, Chris H. published an article.Safety of tert-Butyl trichloroacetimidate The title of the article was A Noncoordinating Acid-Base Catalyst for the Mild and Nonreversible tert-Butylation of Alcohols and Phenols. And the article contained the following:

A mild and nonreversible tert-butylation of alcs. and phenols can be achieved in high yields using the noncoordinating acid-base catalyst [bis(trifluoromethane)sulfonimide and 2,6-lutidine] with a tert-butylation reagent, tert-Bu 2,2,2-trichloroacetimidate. This method allows the use of substrates containing acid sensitive groups such as ketal, Boc, and boronate esters. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate

The Article related to alc tertbutyl trichloroacetimidate acid base tertbutylation catalyst, ether tertbutyl preparation, General Organic Chemistry: Synthetic Methods and other aspects.Safety of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 28, 2021, Drozdowska, Marta; Tromans, Jay; Zhang, Bian; Jarling, Rene; Wilkes, Heinz; Golding, Bernard T. published an article.Synthetic Route of 98946-18-0 The title of the article was Defining Pathways of Anaerobic Alkane Oxidation: Synthesis of Enantiomers of 4-Methylalkanoic Acids and (2-Methylalkyl)malonic Acids. And the article contained the following:

A generic method for synthesis of either (R)- or (S)-acid in high enantiomeric purity from enantiomers of Me 3-hydroxy-2-methylpropionate was described for (R)- and (S)-4-methyloctanoic acid and (R)-4-methyldodecanoic acid. In a typical procedure silyl-protection of Me (S)-3-hydroxy-2-methylpropionate was followed by reduction of the ester to a primary alc., which was tosylated. Cu(I)-catalyzed cross-coupling of the tosylate with propylmagnesium chloride followed by deprotection, tosylation and base-induced reaction with di-t-Bu malonate, gave di-t-Bu (R)-(2-methylhexyl)malonate. Microwave heating of the diester in 2,2,2-trifluoroethanol gave a 42% overall yield of (R)-4-methyloctanoic acid, which was shown to be the enantiomer derived by metabolism of hexane by proteobacterium Aromatoleum sp. HxN1. Deprotection of the diester with trifluoroacetic acid gave (R)-2-(2-methylhexyl)malonic acid, which was the biol. precursor of (R)-4-methyloctanoic acid (via CoA esters). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Synthetic Route of 98946-18-0

The Article related to methyl hydroxy methylpropionate enantioselective oxidation, methylalkanoic acid preparation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 3, 2015, Duffy, Brian C.; Howard, Kyle T.; Chisholm, John D. published an article.Name: tert-Butyl trichloroacetimidate The title of the article was Alkylation of thiols with trichloroacetimidates under neutral conditions. And the article contained the following:

Trichloroacetimidates are displaced with thiols to form the corresponding sulfides without the need for an added acid or base by simply heating the reactants in refluxing THF. This operationally simple procedure provides the corresponding sulfides in excellent yields with only the formation of the neutral trichloroacetamide as the side product. The imidate may also be formed in situ, allowing for a direct method for the formation of sulfides from alcs. This reaction provides a general method for the synthesis of a variety of sulfides from inexpensive and readily available alc. starting materials. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Name: tert-Butyl trichloroacetimidate

The Article related to thiol trichloroacetimidate substitution alkylation, sulfide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Name: tert-Butyl trichloroacetimidate

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 21, 2019, Mahajani, Nivedita S.; Meador, Rowan I. L.; Smith, Tomas J.; Canarelli, Sarah E.; Adhikari, Arijit A.; Shah, Jigisha P.; Russo, Christopher M.; Wallach, Daniel R.; Howard, Kyle T.; Millimaci, Alexandra M.; Chisholm, John D. published an article.Safety of tert-Butyl trichloroacetimidate The title of the article was Ester Formation via Symbiotic Activation Utilizing Trichloroacetimidate Electrophiles. And the article contained the following:

Trichloroacetimidates are useful reagents for the synthesis of esters under mild conditions that do not require an exogenous promoter. These conditions avoid the undesired decomposition of substrates with sensitive functional groups that are often observed with the use of strong Lewis or Bronsted acids. With heating, these reactions have been extended to benzyl esters without electron-donating groups. These inexpensive and convenient methods should find application in the formation of esters in complex substrates. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate

The Article related to ester formation symbiotic activation chloroacetimidate electrophile, General Organic Chemistry: Synthetic Methods and other aspects.Safety of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mou, Xue-Qing; Chen, Xiang-Yu; Chen, Gong; He, Gang published an article in 2018, the title of the article was Radical-mediated intramolecular β-C(sp3)-H amidation of alkylimidates: facile synthesis of 1,2-amino alcohols.Recommanded Product: tert-Butyl trichloroacetimidate And the article contains the following content:

A new radical-mediated intramol. β-C(sp3)-H amidation reaction of O-alkyl trichloro- or arylimidates is reported. Various oxazolines were efficiently prepared from easily accessible alc. starting materials. The trichloro-oxazoline products can be hydrolyzed under mild conditions to give valuable 1,2-amino alcs. This amidation reaction exhibits a broad substrate scope and good functional group tolerance, and offers a powerful means for the C(sp3)-H functionalization of alcs. Mechanistic studies suggest that a sequence of 1,5-HAT of an imidate radical, iodination and cyclization might be operative. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate

The Article related to amino alc preparation alkylimidate radical intramol amidation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 20, 2020, Baalmann, Mathis; Neises, Laura; Bitsch, Sebastian; Schneider, Hendrik; Deweid, Lukas; Werther, Philipp; Ilkenhans, Nadja; Wolfring, Martin; Ziegler, Michael J.; Wilhelm, Jonas; Kolmar, Harald; Wombacher, Richard published an article.Category: chlorides-buliding-blocks The title of the article was A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates. And the article contained the following:

Bioorthogonal chem. holds great potential to generate difficult-to-access protein-protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation chem., use of undesirable catalysts, or often do not result in quant. product formation. Here the authors present a highly efficient technol. for protein functionalization with commonly used bioorthogonal motifs for Diels-Alder cycloaddition with inverse electron demand (DAinv). With the aim of precisely generating branched protein chimeras, the authors systematically assessed the reactivity, stability and side product formation of various bioorthogonal chemistries directly at the protein level. The authors demonstrate the efficiency and versatility of the authors′ conjugation platform using different functional proteins and the therapeutic antibody trastuzumab. This technol. enables fast and routine access to tailored and hitherto inaccessible protein chimeras useful for a variety of scientific disciplines. The authors expect the authors′ work to substantially enhance antibody applications such as immunodetection and protein toxin-based targeted cancer therapies. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Category: chlorides-buliding-blocks

The Article related to bioorthogonal click chem branched protein conjugate, antibody-drug conjugates, bioorthogonal chemistry, click chemistry, protein ligation, protein-protein conjugates, Placeholder for records without volume info and other aspects.Category: chlorides-buliding-blocks

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Chlorides – an overview | ScienceDirect Topics

Stanley, Mathew; Virdee, Satpal published an article in 2016, the title of the article was Genetically Directed Production of Recombinant, Isosteric and Nonhydrolysable Ubiquitin Conjugates.Recommanded Product: tert-Butyl trichloroacetimidate And the article contains the following content:

We describe the genetically directed incorporation of aminooxy functionality into recombinant proteins by using a mutant Methanosarcina barkeri pyrrolysyl-tRNA synthetase/tRNACUA pair. This allows the general production of nonhydrolysable ubiquitin conjugates of recombinant origin by bioorthogonal oxime ligation. This was exemplified by the preparation of nonhydrolysable versions of diubiquitin, polymeric ubiquitin chains and ubiquitylated SUMO. The conjugates exhibited unrivalled isostery with the native isopeptide bond, as inferred from structural and biophys. characterization. Furthermore, the conjugates functioned as nanomolar inhibitors of deubiquitylating enzymes and were recognized by linkage-specific antibodies. This technol. should provide a versatile platform for the development of powerful tools for studying deubiquitylating enzymes and for elucidating the cellular roles of diverse polyubiquitin linkages. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate

The Article related to genetically recombinant isosteric nonhydrolysable ubiquitin conjugate, genetic code expansion, isopeptide, oxime, polymerization, synthetic methods, ubiquitylation, Placeholder for records without volume info and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 1, 2019, Liu, Zhenxing; Xu, Chaofan; del Pozo, Juan; Torker, Sebastian; Hoveyda, Amir H. published an article.Computed Properties of 98946-18-0 The title of the article was Ru-Based Catechothiolate Complexes Bearing an Unsaturated NHC Ligand: Effective Cross-Metathesis Catalysts for Synthesis of (Z)-α,β-Unsaturated Esters, Carboxylic Acids, and Primary, Secondary, and Weinreb Amides. And the article contained the following:

Despite notable progress, olefin metathesis methods for preparation of (Z)-α,β-unsaturated carbonyl compounds, applicable to the synthesis of a large variety of bioactive mols., remain scarce. Especially desirable are transformations that can be promoted by ruthenium-based catalysts, as such entities would allow direct access to carboxylic esters and amides, or acids (in contrast to molybdenum- or tungsten-based alkylidenes). Here, we detail how, based on the mechanistic insight obtained through computational and exptl. studies, a readily accessible ruthenium catechothiolate complex was found that may be used to generate many α,β-unsaturated carbonyl compounds in up to 81% yield and ≥98:2 Z/E ratio. We show that through the use of a complex bearing an unsaturated N-heterocyclic carbene (NHC) ligand, for the first time, products derived from the more electron-deficient esters, acids, and Weinreb amides (vs primary or secondary amides) can be synthesized efficiently and with high stereochem. control. The importance of the new advance to synthesis of bioactive compounds is illustrated through two representative applications: an eight-step, 15% overall yield, and completely Z-selective route leading to an intermediate that may be used in synthesis of stagonolide E (vs 11 steps, 4% overall yield and 91% Z, previously), and a five-step, 25% overall yield sequence to access a precursor to dihydrocompactin (vs 13 steps and 5% overall yield, formerly). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Computed Properties of 98946-18-0

The Article related to unsaturated ester carboxylic acid amide stereoselective preparation, ruthenium catechithiolate complex preparation stereoselective cross metathesis catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 98946-18-0

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 27, 2019, Leung, Leo; Niculescu-Duvaz, Dan; Smithen, Deborah; Lopes, Filipa; Callens, Cedric; McLeary, Robert; Saturno, Grazia; Davies, Lawrence; Aljarah, Mohammed; Brown, Michael; Johnson, Louise; Zambon, Alfonso; Chambers, Tim; Menard, Delphine; Bayliss, Natasha; Knight, Ruth; Fish, Laura; Lawrence, Rae; Challinor, Mairi; Tang, HaoRan; Marais, Richard; Springer, Caroline published an article.Related Products of 98946-18-0 The title of the article was Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships. And the article contained the following:

Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase that cross-links collagens and elastin in the extracellular matrix and is a critical mediator of tumor growth and metastatic spread. LOX is a target for cancer therapy, and thus the search for therapeutic agents against LOX has been widely sought. We report herein the medicinal chem. discovery of a series of LOX inhibitors bearing an aminomethylenethiophene (AMT) scaffold. High-throughput screening provided the initial hits. Structure-activity relationship (SAR) studies led to the discovery of AMT inhibitors with sub-micromolar half-maximal inhibitory concentrations (IC50) in a LOX enzyme activity assay. Further SAR optimization yielded the orally bioavailable LOX inhibitor CCT365623 (I) with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Related Products of 98946-18-0

The Article related to aminomethylenethiophene derivative preparation structure activity relationship, anti metastatic inhibitor lysyl inhibitor aminomethylenethiophene compound, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics