Alghamdi, Saad et al. published their research in Latin American Journal of Pharmacy in 2022 |CAS: 99-60-5

The Article related to antimicrobial evaluation docking study, Placeholder for records without volume info and other aspects.Reference of 2-Chloro-4-nitrobenzoic acid

Alghamdi, Saad; Almehmadi, Mazen M.; Asif, Mohammad published an article in 2022, the title of the article was Antimicrobial evaluation and docking study of some 2-aryl-5-(pyridin-3-yl)-1,3,4-oxadiazole derivatives.Reference of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

1,3,4-Oxadiazoles are interesting compounds because of their valuable biol. effects. A new series of some 2-aryl-5-(pyridin-3-yl)-1,3,4-oxadiazole derivatives (3a-3h) were synthesized and screened for their antimicrobial activity. These compounds (3a-3h) were prepared from the reaction of nicotinic acid with Et alc. converted into Et nicotinate (1) by esterification. Compound (1) is converted to nicotinohydrazide (2) by treating with hydrazine hydrate. Compound 2 is converted to compounds 3a-3h by treating with appropriate aromatic carboxylic acids in the presence of POCl3. Confirm of structures of the synthesized compounds by using IR, 1HNMR, and MS spectroscopy. All the title compounds were tested for in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis (Gram-pos.), Pseudomonas aeruginosa, Escherichia coli (Gram-pos.) bacteria, and antifungal activity against Candida albicans and Aspergillus niger. Most of the compounds showed good activity against all the organisms. Compounds 3b, 3d, 3e, 3g, 3j, and 3l showed the highest activity against bacteria strains when compared to the standard ciprofloxacin. Compounds 3b, 3d, 3e, 3g, 3j, 3k, and 3l were showed better antifungal activity against fungal strains as compared to the standard drug griseofulvin. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Reference of 2-Chloro-4-nitrobenzoic acid

The Article related to antimicrobial evaluation docking study, Placeholder for records without volume info and other aspects.Reference of 2-Chloro-4-nitrobenzoic acid

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Liu, Jingbo et al. published their research in Chemical Research in Chinese Universities in 2016 |CAS: 99-60-5

The Article related to anthranilic diamide dihydroisoxazoline isoxazole biol activity, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Chloro-4-nitrobenzoic acid

On February 29, 2016, Liu, Jingbo; Li, Yuxin; Chen, Youwei; Wu, Changchun; Wan, Yingying; Wei, Wei; Xiong, Lixia; Zhang, Xiao; Yu, Shujing; Li, Zhengming published an article.Application In Synthesis of 2-Chloro-4-nitrobenzoic acid The title of the article was Design, synthesis and biological activities of novel anthranilic diamides containing dihydroisoxazoline and isoxazole. And the article contained the following:

Anthranilic diamides are one of the most important classes of modern agrochem. insecticides. To discover new structures with higher activity, lower toxicity and lower residue, a series of novel anthranilic diamides containing dihydroisoxazoline and isoxazole was designed and synthesized. Their structures were characterized by means of m.ps., proton NMR(1H NMR), 13C NMR and high resolution mass spectrometry(HRMS). According to the bioassay data, it was found that some of the title compounds exhibit moderate insecticidal activity and good antifungal activity. In particularly, compound 15b with a concentration of 50 mg/L shows a lethality rate of 60.0% against Mythimna separata Walker and a lethality rate of 50.0% against Culex pipiens pallens with a concentration of 1 mg/L. Moreover, compound 15b showed good antifungal activities(58.8%, 77.1%, 70.7%, 55.3%, 60.7%, 65.4%) when against all the tested fungi(Cercospora arachidicola Hori, Physalospora piricola, Rhizoctonia cerealis, Bipolaris maydis, Watermelon anthracnose, Fusarium moniliforme). The effects of compounds 14h, 14j and 15b on the concentration of intracellular calcium ion([Ca2+]i) in the central neurons of Mythimna sep. Walker were well investigated via calcium imaging technique. The results demonstrate that the novel compounds can elevate the calcium concentration in the neurons, denoting that some new structures are potential modulators of the insect ryanodine receptor(RyR). The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Application In Synthesis of 2-Chloro-4-nitrobenzoic acid

The Article related to anthranilic diamide dihydroisoxazoline isoxazole biol activity, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Chloro-4-nitrobenzoic acid

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Chlorides – an overview | ScienceDirect Topics

Vinolia, M. et al. published their research in Optical Materials (Amsterdam, Netherlands) in 2021 |CAS: 99-60-5

The Article related to nonlinear optics crystal growth hirshfeld analysis slow cooling technique, density functional theory, Placeholder for records without volume info and other aspects.Recommanded Product: 99-60-5

On December 31, 2021, Vinolia, M.; Kirupavathy, S. Shahil; Jerusha, Eunice; Muthu, S.; Shyam Kumar, M. Infant published an article.Recommanded Product: 99-60-5 The title of the article was Structure, hirshfeld surface studies, optical and mechanical analysis on a third-order nonlinear optical crystal 2-amino-6-methylpyridin-1-ium 2-chloro-4-nitrobenzoate (2A6M2C4N). And the article contained the following:

Organic third order nonlinear optical material, 2-Amino-6-methylpyridin-1-ium 2-chloro-4-nitrobenzoate (2A6M2C4N) was effectively synthesized and single crystals were developed by slow cooling solution growth method. The crystallog. structure of the grown crystal has been confirmed through single crystal X-ray diffraction anal. and it uncovers that the title material belongs to Triclinic crystal system with centrosym. space group of P-1. The crystalline phase formation was ascertained from powder X-ray diffraction measurements. The functional groups present in the compound were confirmed by Fourier transform IR anal. Optical anal. explicit that the grown crystal possess good transmittance in the wave length region of 200-800 nm. Photoluminescence spectroscopy analyzed by exciting the material at 320 nm supports that 2A6M2C4N crystal suits the requirements of optoelectronic devices. The thermal behavior of 2A6M2C4N exploited by TG-DTA measurements show that it is stable up to 160.04 °C. Third order nonlinear optical properties such as nonlinear refractive index and third order nonlinear optical susceptibility were calculated by employing the z-scan technique. The HOMO-LUMO, mol. electrostatic potential (MESP) and contour map of the mol. was examined at B3LYP/6-311++G (d, p) level by using DFT calculations The existence of the intermol. interactions in the mol. were confirmed by Hirshfeld surface studies. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to nonlinear optics crystal growth hirshfeld analysis slow cooling technique, density functional theory, Placeholder for records without volume info and other aspects.Recommanded Product: 99-60-5

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Liu, Yilin et al. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2022 |CAS: 99-60-5

The Article related to isoquinolinedione derivative synthesis cereblon modulator antitumor antiproliferative, anticancer, crbn, imids, nci-h929, Placeholder for records without volume info and other aspects.HPLC of Formula: 99-60-5

Liu, Yilin; Song, Yuming; Xu, Yingju; Jiang, Meixu; Lu, Haibin published an article in 2022, the title of the article was Design, synthesis, and biological evaluation of a novel series of 2-(2,6-dioxopiperidin-3-yl)isoquinoline-1,3(2H,4H)-dione derivatives as cereblon modulators.HPLC of Formula: 99-60-5 And the article contains the following content:

In the current study, we designed and synthesized a novel series of 2-(2,6-dioxopiperidin-3-yl)isoquinoline-1,3(2H,4H)-dione derivatives as cereblon (CRBN) modulators. The results of the CCK8 assay revealed potent antiproliferative activity for the selected compound against NCI-H929 (IC50=2.25 μM) and U239 (IC50=5.86 μM) cell lines. Compound also can inhibit the TNF-α level (IC50=0.76 μM) in LPS stimulated PMBC and showed nearly no toxicity to this normal human cell line. The TR-FRET assay showed compound having potent inhibitory activity against CRBN (IC50=4.83 μM), and the docking study confirmed a nice fitting of into the active sites of CRBN. Further biol. studies revealed compound can increase the apoptotic events, arrest the NCI-H929 cells at G0/G1 cell cycle, and induce the ubiquitination degradation of IKZF1 and IKZF3 proteins by CRL4CRBN. These preliminary results suggested that compound could serve as a potential antitumor drug and worthy of further investigation. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).HPLC of Formula: 99-60-5

The Article related to isoquinolinedione derivative synthesis cereblon modulator antitumor antiproliferative, anticancer, crbn, imids, nci-h929, Placeholder for records without volume info and other aspects.HPLC of Formula: 99-60-5

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Wen, Hui et al. published their research in Molecules in 2019 |CAS: 99-60-5

The Article related to arylamidine derivative serotonin norepinephrine reuptake inhibitor, antidepressant, dual reuptake inhibitors, norepinephrine, serotonin, Placeholder for records without volume info and other aspects.Related Products of 99-60-5

Wen, Hui; Qin, Wen; Yang, Guangzhong; Guo, Yanshen published an article in 2019, the title of the article was Design and synthesis of arylamidine derivatives as serotonin/norepinephrine dual reuptake inhibitors.Related Products of 99-60-5 And the article contains the following content:

To improve the in vivo antidepressant activity of previously reported serotonin (5-HT) and norepinephrine (NE) dual reuptake inhibitors, three series of arylamidine derivatives were designed and synthesized. The in vitro 5-HT and NE reuptake inhibitory activities of these compounds were evaluated, and compound II-5 was identified as the most potent 5-HT (IC50 = 620 nM) and NE (IC50 = 10 nM) dual reuptake inhibitor. Compound II-5 exhibited potent antidepressant activity in the rat tail suspension test and showed an acceptable safety profile in a preliminary acute toxicity test in mice. Our results show that these arylamidine derivatives exhibit potent 5-HT/NE dual reuptake inhibition and should be explored further as antidepressant drug candidates. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5

The Article related to arylamidine derivative serotonin norepinephrine reuptake inhibitor, antidepressant, dual reuptake inhibitors, norepinephrine, serotonin, Placeholder for records without volume info and other aspects.Related Products of 99-60-5

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Chlorides – an overview | ScienceDirect Topics

Blignaut, Jacques et al. published their research in Acta Crystallographica, Section E: Crystallographic Communications in 2018 |CAS: 99-60-5

The Article related to ammonium carboxylate mol salt crystal structure hydrogen bond, ammonium carboxyl­ate salts, crystal structure, graph set, hydrogen bonding, Placeholder for records without volume info and other aspects.Computed Properties of 99-60-5

On April 1, 2018, Blignaut, Jacques; Lemmerer, Andreas published an article.Computed Properties of 99-60-5 The title of the article was An investigation to elucidate the factors dictating the crystal structure of seven ammonium carboxylate molecular salts. And the article contained the following:

The crystal structures of seven ammonium carboxylate salts are reported, namely (RS)-1-phenylethan-1-aminium isonicotinate, (I), (RS)-1-phenylethan-1-aminium flurbiprofenate [or 2-(3-fluoro-4-phenylphenyl)propanoate], (II), (RS)-1-phenylethan-1-aminium 2-chloro-4-nitrobenzoate,(III), (RS)-1-phenylethan-1-aminium 4-iodobenzoate, (IV), (S)-1-cyclohexylethan-1-aminium 2-chloro-4-nitrobenzoate, (V), 2-(cyclohex-1-en-1-yl)ethan-1-aminium 4-bromobenzoate,(VI), and (S)-1-cyclohexylethan-1-aminium 4-bromobenzoate,(VII). Salts (II) to (VII) feature three N+-H···O- hydrogen bonds, which form one-dimensional hydrogen-bonded ladders. Salts (II), (III), (IV), (V) and (VII) have a type II ladder system despite the presence of halogen bonding and other intermol. interactions, whereas (VI) has a type III ladder system. Salt (I) has a unique hydrogen-bonded system of ladders, featuring both N+-H···O- and N+-H···N hydrogen bonds owing to the presence of the pyridine functional group. The presence of an addnl. hydrogen-bond acceptor on the carboxylate cation disrupts the formation of the ubiquitous type II and III ladder found predominately in ammonium carboxylate salts. Halogen bonding, however, has no influence on their formation. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Computed Properties of 99-60-5

The Article related to ammonium carboxylate mol salt crystal structure hydrogen bond, ammonium carboxyl­ate salts, crystal structure, graph set, hydrogen bonding, Placeholder for records without volume info and other aspects.Computed Properties of 99-60-5

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Chlorides – an overview | ScienceDirect Topics

Kaur, Harmeet et al. published their research in BMC Chemistry in 2019 |CAS: 99-60-5

The Article related to escherichia staphylococcus breast cancer colon carcinoma antimicrobial cytotoxicity, antimicrobial, cytotoxicity, diazenyl, docking, indole, Placeholder for records without volume info and other aspects.Recommanded Product: 99-60-5

On December 31, 2019, Kaur, Harmeet; Singh, Jasbir; Narasimhan, Balasubramanian published an article.Recommanded Product: 99-60-5 The title of the article was Indole hybridized diazenyl derivatives: synthesis, antimicrobial activity, cytotoxicity evaluation and docking studies. And the article contained the following:

In search of effective antimicrobial and cytotoxic agents, a series of indole hybridized diazenyl derivatives (DS-1 to DS-21) was efficiently prepared by condensation of diazotized p-aminoacetophenone with indole or nitroindole followed by reaction with different aromatic/heteroaromatic amines of biol. significance. The synthesized derivatives were characterized by various spectroscopic techniques. The antimicrobial evaluation of DS-1 to DS-23 was done by tube dilution method against various pathogenic bacterial and fungal strains. The active antimicrobial derivatives were further evaluated for cytotoxicity against human lung carcinoma cell line (HCT-116), breast cancer cell line (MDAMB231), leukemic cancer cell line (K562), and normal cell line (HEK293) by MTT assay using doxorubicin as the standard drug. The test derivatives were addnl. docked for the B-subunit of enzyme DNA gyrase from E. coli at the ATPase binding site to study the mol. interactions using Schrodinger maestro v11.5 software. Most of the synthesized derivatives have shown high activity against Gram-neg. bacteria particularly E. coli and K. pneumonia with MIC ranging from 1.95 to 7.81 μg/mL. The derivatives have demonstrated very less activity against tested Gram pos. bacterial and fungal strains. The derivatives DS-14 and DS-20 have been found to active against breast cancer cell line and human colon carcinoma cell line having IC50 in the range of 19-65 μg/mL. All the derivatives were found to less potent against leukemic cancer cell line. The synthesized derivatives have revealed their safety by exhibiting very less cytotoxicity against the normal cell line (HEK-293) with IC50 > 100 μg/mL. Most of the active derivatives have shown good docking scores in comparison to the standard drugs against DNA gyrase from E. coli. Further ADME predictions by Qikprop module of the Schrodinger confirmed these mols. have drug like properties. The derivatives DS-14 and DS-20 have shown potential against Gram-neg. bacteria and breast cancer cell line and can be used as a lead for rational drug designing of the antimicrobial and cytotoxic agents.[Figure not available: see fulltext.]. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to escherichia staphylococcus breast cancer colon carcinoma antimicrobial cytotoxicity, antimicrobial, cytotoxicity, diazenyl, docking, indole, Placeholder for records without volume info and other aspects.Recommanded Product: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Qian et al. published their research in Drug Development and Industrial Pharmacy in 2019 |CAS: 99-60-5

The Article related to dimethylnitroacridine breast cancer cell apoptosis dna, acridine derivatives, dna binding, anticancer activity, structure-activity relationship, synthesis, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Chloro-4-nitrobenzoic acid

Zhou, Qian; Wu, Hongshuai; You, Chaoqun; Gao, Zhiguo; Sun, Kai; Wang, Mingxin; Chen, Fanghui; Sun, Baiwang published an article in 2019, the title of the article was 1,3-dimethyl-6-nitroacridine derivatives induce apoptosis in human breast cancer cells by targeting DNA.Application In Synthesis of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

The acridine derivatives can interact with the double-stranded DNA, which is regarded as the biol. target of the anticancer drugs in cancer treatment. We designed and synthesized a new series of 1,3-dimethyl-6-nitroacridine derivatives as potential DNA-targeted anticancer agents. These compounds could partially intercalate into the calf thymus DNA, differing from the parent acridine. The results showed that the substitutions of the acridine ring had great effect on DNA binding affinity. The binding constants determined by UV-vis spectroscopy were found to be 105 M-1 grade. Anticancer activity of these compounds was screened using MTT assay. Most compounds inhibited 50% cancer cell growth at concentration below 30 μM, the results were consistent with the DNA binding ability. Compounds and were found to have more effective cytotoxicity, especially in human breast cancer cell lines. To investigate the action mechanism, we studied cell apoptosis, morphol. changes, and cell cycle distribution in MCF-7 and MDA-MB-231 cells. Compounds and caused MCF-7 and MDA-MB-231 cells death due to apoptosis, and induced cell apoptosis in a dose-dependent manner. They also had significant effect on cell cycle progression and arrested cell cycle at G2/M phase. The results demonstrated that compounds and are promising candidates for cancer treatment. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Application In Synthesis of 2-Chloro-4-nitrobenzoic acid

The Article related to dimethylnitroacridine breast cancer cell apoptosis dna, acridine derivatives, dna binding, anticancer activity, structure-activity relationship, synthesis, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Chloro-4-nitrobenzoic acid

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Chiarelli, Laurent R. et al. published their research in European Journal of Medicinal Chemistry in 2018 |CAS: 99-60-5

The Article related to arylfuranyl carboxylate preparation tuberculostatic sar mol docking, antimycobacterial drugs, drug design, iron, siderophores, tuberculosis, virtual screening, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Reference of 2-Chloro-4-nitrobenzoic acid

On July 15, 2018, Chiarelli, Laurent R.; Mori, Matteo; Barlocco, Daniela; Beretta, Giangiacomo; Gelain, Arianna; Pini, Elena; Porcino, Marianna; Mori, Giorgia; Stelitano, Giovanni; Costantino, Luca; Lapillo, Margherita; Bonanni, Davide; Poli, Giulio; Tuccinardi, Tiziano; Villa, Stefania; Meneghetti, Fiorella published an article.Reference of 2-Chloro-4-nitrobenzoic acid The title of the article was Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents. And the article contained the following:

The virtual screening, synthesis, and biol. evaluation of new furan derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI) was reported. A receptor-based virtual screening procedure was applied to screen the enamine database, identifying two compounds, I [R1 = Ph, 4-O2NC6H5, 4-F3CC6H5; R2 = H, Me] and II, endowed with a good enzyme inhibitory activity. Considering the most active compound I as starting point for the development of novel MbtI inhibitors, new derivatives based on the furan scaffold were prepared Among the SAR performed on this class, compound I [R1 = 4-O2NC6H5, R2 = H] emerged as the most potent MbtI inhibitor reported to date (Ki = 5.3 μM). Moreover, compound I [R1 = 4-O2NC6H5, R2 = H] showed a promising antimycobacterial activity (MIC99 = 156 μM), which is conceivably related to mycobactin biosynthesis inhibition. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Reference of 2-Chloro-4-nitrobenzoic acid

The Article related to arylfuranyl carboxylate preparation tuberculostatic sar mol docking, antimycobacterial drugs, drug design, iron, siderophores, tuberculosis, virtual screening, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Reference of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kan, Jian et al. published their research in Angewandte Chemie, International Edition in 2015 |CAS: 99-60-5

The Article related to carboxylic acid aromatic oxidative decarboxylative coupling minisci arene heteroarene, biaryl preparation, ch activation, heterocycles, oxidation, radicals, silver, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C7H4ClNO4

Kan, Jian; Huang, Shijun; Lin, Jin; Zhang, Min; Su, Weiping published an article in 2015, the title of the article was Silver-Catalyzed Arylation of (Hetero)arenes by Oxidative Decarboxylation of Aromatic Carboxylic Acids.Formula: C7H4ClNO4 And the article contains the following content:

The silver-catalyzed intermol. Minisci-type reaction of aromatic carboxylic acids was developed. With an inexpensive silver salt as a catalyst, this new reaction enabled a variety of aromatic carboxylic acids R1CO2H (R1 = 4-NCC6H4, 3-BrC6H4, 2-Cl-4-MeSO2C6H3, 2-chloro-3-pyridyl, etc.) to undergo decarboxylative coupling with electron-deficient arenes or heteroarenes R2H (R2 = Ph, 2,5-F2C6H3, pyridyl, etc.) regardless of the position of the substituents on the aromatic carboxylic acid, thus eliminating the need for ortho-substituted aromatic carboxylic acids, which were a limitation of previously reported methods. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Formula: C7H4ClNO4

The Article related to carboxylic acid aromatic oxidative decarboxylative coupling minisci arene heteroarene, biaryl preparation, ch activation, heterocycles, oxidation, radicals, silver, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics