Category: 99-60-5

On November 5, 2015, Zeng, Xiao-Ping; Ming, Mei published an article.COA of Formula: C7H4ClNO4 The title of the article was Tuning the structures of three coordination polymers incorporating ZnII and 2,2′-dichloro-4,4′-azodibenzoic acid via selective auxiliary ligands. And the article contained the following:

By tuning the auxiliary ligands in the assembling reaction, three ZnII coordination polymers of [Zn(Cl-adc)(phen)(H2O)](DMF) (1), [Zn(Cl-adc)(DMA)](DMA) (2), and [Zn(Cl-adc)(dip)](DMF)0.5 (3) (Cl-H2adc = 2,2′-dichloro-4,4′-azodibenzoic acid, phen = 1,10-phenanthroline, dip = 1,3-di(imidazole)propane) were successfully synthesized and characterized by single-crystal x-ray diffraction study, elemental anal., IR spectra, TGA analyses, solid-state fluorescent property, and powder X-ray diffraction (PXRD). Single crystal x-ray diffraction reveals that 1 and 2 displays a 1-dimensional polymeric chain and 2-dimensional sql layered net with the presence of chelated phen and terminal DMA ligands, resp. By incorporating dip linker, 3 exhibits a 2-dimensional + 2-dimensional → 3-dimensional entangled network, with each 2-dimensional net portraying wavelike sql layered structure. Their structural divergences should be properly attributed to fact that, the structural topologies can be well regulated by using three auxiliary ligands incorporating different coordination function. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to zinc dichloroazodibenzoato phenanthroline propanebisimidazole complex preparation crystal structure fluorescence, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 1, 2020, Karmakar, Mainak; Chattopadhyay, Shouvik published an article.Product Details of 99-60-5 The title of the article was Synthesis, structure and nitroaromatic sensing ability of a trinuclear zinc complex with a reduced Schiff base ligand: Assessment of the ability of the ligand to sense zinc ion. And the article contained the following:

A trinuclear zinc complex, [Zn{Zn(N3)L}2] {H2L = 2,2′-[(1-ethyl-1,3-propanediyl)bis(iminomethylene)]bis[6-ethoxyphenol]},has been synthesized and characterized. Its structure has been confirmed by X-ray crystallog. anal. The complex acts as a sensor for the detection of nitroaroms. in CH3CN solution via turn-off fluorescence response. The solution phase sensing phenomenon has been studied and a strong quenching efficiency has been observed with a quenching constant (KSV) 13.7952 × 102 M-1 for 2-chloro-4-nitrobenzoic acid. H2L displayed high specificity, sensitivity as well as selectivity for zinc ion in its turn-on fluorescence activity. The mechanism of fluorescence enhancement has been proposed, while the metal-ligand binding stoichiometry and binding constant have also been determined The detection limit of zinc ion is 7.74 × 10-7 M., with the binding constant K = 2.857 × 105 M-1. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Product Details of 99-60-5

The Article related to zinc azide ethylpropanediyliminomethyleneethoxyphenol complex preparation fluorescent sensor, crystal structure zinc azide ethylpropanediyliminomethyleneethoxyphenol, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Product Details of 99-60-5

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Karmakar, Mainak; Roy, Sourav; Chattopadhyay, Shouvik published an article in 2019, the title of the article was A series of trinuclear zinc(II) complexes with reduced Schiff base ligands: turn-off fluorescent chemosensors with high selectivity for nitroaromatics.Formula: C7H4ClNO4 And the article contains the following content:

A facile method for synthesizing trinuclear Zn(II) complexes with compartmental reduced Schiff bases was described. Five such complexes, [{(N3)Zn(L1)}2Zn] (1), [{(SCN)Zn(L1)}2Zn] (2), [{(SCN)Zn(L2)}2Zn] (3), [{(N3)Zn(L2)}2Zn] (4) and [{(N3)Zn(L3)}2Zn]·CH2CL2 (5) where H2L1 = 2,2′-[(1,3-propanediyl)bis(iminomethylene)]bis[6-ethoxyphenol], H2L2 = 2,2′-[(2,2-dimethyl-1,3-propanediyl)bis(iminomethylene)]bis[6-methoxyphenol] and H2L3 = 2,2′-[(2,2-dimethyl-1,3-propanediyl)bis(iminomethylene)]bis[6-ethoxyphenol], were synthesized and characterized by elemental and spectral analyses. X-ray crystallog. analyses confirmed their structures. All complexes may be used as sensors for the detection of nitroaroms. in DMF via turn-off fluorescence response. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Formula: C7H4ClNO4

The Article related to crystal structure zinc trinuclear complex reduced schiff base, zinc trinuclear schiff base preparation fluorescence response nitroarom compound, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Formula: C7H4ClNO4

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2015, Wang, Yang; Lei, Fan; Li, Xiaolong; He, Yi; Li, Jue; Qiu, Rui; Wu, Xueying; Hai, Li; Wu, Yong published an article.Computed Properties of 99-60-5 The title of the article was Structure-based design, synthesis and anti-influenza A virus activities of substituted phenyl-coupled heterocyclic ethylamide derivatives. And the article contained the following:

A series of new substituted phenyl-coupled heterocyclic ethylamide derivatives was designed and synthesized as anti-influenza agents. In vitro anti-influenza A(A/PR/8/34 H1N1 strain) activities of these compounds were investigated and compared to those of the com. antiviral drugs(Arbidol and Ribavirin) against the influenza. Specifically, among these twelve compounds exhibiting moderate levels of antiviral activity against influenza A, compounds 30c and 30d are the most effective ones, and as efficacious as the pos. control Ribavirin and much more effective than Ingavirin and Arbidol, indicating that they are prospective candidates for further exploration. These results are also consistent with the docking study results in terms of the design of compounds targeting influenza A via viral nucleoprotein. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Computed Properties of 99-60-5

The Article related to phenyl coupled heterocyclic ethylamide derivative antiinfluenzaa virus activity, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Computed Properties of 99-60-5

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Mu, Shuai; Niu, Duan; Liu, Ying; Zhang, Dashuai; Liu, Dengke; Liu, Changxiao published an article in 2015, the title of the article was An Improved, Scalable and Impurity-Free Process for Lixivaptan.Synthetic Route of 99-60-5 And the article contains the following content:

An optimized synthetic method in high efficiency has been developed for the synthesis of lixivaptan from 2-nitrobenzyl bromide and pyrrole-2-carboxaldehyde. The byproducts among this procedure and an unknown impurity in crude product were investigated. The byproducts were speculated by 1H NMR or MS. The unknown impurity was characterized by 1H NMR, 13C NMR, and HRMS, confirming the structures as N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-N-(5-fluoro-2-methylbenzoyl)-5-fluoro-2-methylbenzamide. Afterwards, the impurity was synthesized to make comparisons. The target product lixivaptan was obtained with 47.6% overall yield and 99.93% purity. This cost-effective and environmentally friendly process is suitable for scale-up production The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5

The Article related to lixivaptan improved scalable impurity free synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Synthetic Route of 99-60-5

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anand, Keshav; Wakode, Sharad published an article in 2018, the title of the article was Synthesis, characterization and biological evaluation of benzimidazole derivatives.HPLC of Formula: 99-60-5 And the article contains the following content:

A series of benzimidazole derivatives were synthesized by a single step process by reacting o-phenylenediamine and benzoic acid. The purity and structure confirmation of the synthesized compounds were done by TLC and 1H-NMR. The compounds were evaluated for anti-microbial, anti-fungal and antioxidant activity. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).HPLC of Formula: 99-60-5

The Article related to benzimidazole preparation antibacterial antioxidant antifungal activity, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.HPLC of Formula: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 31, 2021, Neupane, Umesh; Rai, R. N. published an article.COA of Formula: C7H4ClNO4 The title of the article was Co-crystals formation specified from binary phase diagram studies; Their thermochemical, spectroscopic and optical properties. And the article contained the following:

A thermodn. investigation on co-crystals formed by the complexation in binary systems involving 2-amino-5-chloropyridine (ACP) as electron donor with electron acceptors; 3-nitrobenzoic acid (NBA) and 2-chloro-4-nitrobenzoic acid (CNBA) have been studied sep. by establishing the phase diagram. The solvent-free synthesis method has been adopted to prepare various compositions of binary mixtures A co-crystal is formed at 1:1 mol ratio and two eutectics are formed, one on either side of co-crystal, in each system. The thermal properties of co-crystals, eutectics and parent components have been studied by DSC method. The various thermodn. parameters of co-crystal and eutectics are also studied based on heat of fusion values obtained from DSC. The co-crystals have been characterized by FT-IR, powder XRD and UV-vis. absorption techniques. The FT-IR study revealed the ionic interaction followed by hydrogen bonding (N-H…O) in both co-crystals. Powder XRD study ascertained the particle sizes and crystalline nature of co-crystals. Besides phase diagram, DSC and PXRD studies, the UV-vis. absorption study also has confirmed the complexation between parent mols. to form the co-crystals. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to cocrystal formation binary phase diagram thermochem spectroscopic optical property, Thermodynamics, Thermochemistry, and Thermal Properties: Thermochemical Properties and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2020, Zhou, Shiyang; Huang, Gangliang published an article.Related Products of 99-60-5 The title of the article was Design, synthesis and biological evaluation of novel 7H-benzo[c][1,3]dioxolo[4,5-f]chromen-7-one derivatives with potential anti-tumor activity. And the article contained the following:

In this study, a series of novel 7H-benzo[c][1,3]dioxolo[4,5-f]chromen-7-one derivatives I (R1 = H, NH2, NO2; R2 = H, Me, Et, i-Pr, COMe) were obtained by structural modification of the lead compounds with Fissitungfine B. A total 15 compounds were designed, synthesized and evaluated as tumor inhibitors. These target compounds have the novel chem. structures that named three six-membered rings including one lactone six-membered ring. In vitro assay, the results showed that the target compounds have a broad spectrum and strong anti-tumor activity. The inhibitory activity of the compound I (R1 = NO2; R2 = i-Pr) to MCF-7 was IC50 = 0.35 +/- 0.01μM, to A-549 was IC50 = 0.37 +/- 0.01μM, to Hela was IC50 = 0.56 +/- 0.02μM, to MDC-803 was IC50 = 0.53 +/- 0.02μM and COLO-205 was IC50 = 0.50 +/- 0.02μM in vitro. At the same time, in vivo anti-tumor activity assay results showed that the target compounds had a good inhibitory effect on tumor growth. Among them, the target compound I (R1 = NO2; R2 = i-Pr) had the best anti-tumor activity, it could inhibit tumor growth well at a low dose. The target compound I (R1 = NO2; R2 = i-Pr) could be used as a candidate drug for further research and development, in order to be used as early as application in the clin. treatment of tumors. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5

The Article related to benzodioxolochromenone preparation antitumor human, anti-tumor activity, design, fissitungfine b, synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Related Products of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 5, 2021, Yokoyama, Akihiro; Ishii, Arisa; Ohishi, Tomoyuki; Kikkawa, Shoko; Azumaya, Isao published an article.Synthetic Route of 99-60-5 The title of the article was Synthesis of a coronene analogue containing an amide bond by Pd-mediated intramolecular C-C bond formation of 2-halogenated 4-(alkylamino)benzoic acid cyclic trimer. And the article contained the following:

A coronene analog containing amide linkage was synthesized from a halogenated cyclic triamide by palladium-mediated intramol. C-C bond formation (I → II). The cyclic triamide was formed from the condensation of 2-chloro-4-(isobutylamino)benzoic acid in the presence of dichlorotriphenylphosphorane in 1,1,2,2-tetrachloroethane. By contrast, the condensation of 2-bromo counterpart required silicon tetrachloride in pyridine. The intramol. C-C bond formation, which yielded the target coronene analog, occurred during the reaction of bromo-substituted cyclic triamide with palladium(II) acetate, triphenylphosphine, and potassium carbonate in N,N-dimethylformamide. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5

The Article related to coronene amide synthesis palladium mediated intramol cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Synthetic Route of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 2, 2020, Berzins, Agris; Kons, Artis; Sarsuns, Kristaps; Belyakov, Sergey; Actins, Andris published an article.Synthetic Route of 99-60-5 The title of the article was On the Rationalization of Formation of Solvates: Experimental and Computational Study of Solid Forms of Several Nitrobenzoic Acid Derivatives. And the article contained the following:

Anal. of crystal structures, mol. properties, interaction strength in solution, and computationally generated nonsolvated form crystal structure landscapes of 5 chloronitrobenzoic acid isomers and 2 addnl. 2-substituted 4-nitrobenzoic acids were used to rationalize the obtained solvate landscape of these compounds Screening of the solid forms was performed for each of the compounds, and crystal structures of the obtained nonsolvated forms and selected solvates were determined Mol. conformation, intermol. interactions, and packing efficiency of nonsolvated forms and solvates were analyzed to understand factors contributing to structure stabilization and determining the formation of the observed crystal structures. Computationally generated crystal structure landscapes of nonsolvated forms were tested for the possibility to predict the propensity to form solvates and identify polymorphic compounds Most of the solvates were obtained with solvents acting as strong H bond acceptors and/or able to form aromatic interactions. Solute-solvent association Gibbs energy representing interaction strength is the most apparent identifiable factor explaining the solvate formation of the studied compounds, and using this tool, the existence of 3 new multicomponent phases was successfully predicted. Solid form screening and crystal structure anal. of 7 nitrobenzoic acid derivatives showed that these compounds form solvates with solvents acting as strong H bond acceptors and/or able to form aromatic interactions. Solute-solvent association Gibbs energy representing interaction strength is the most apparent identifiable factor explaining the solvate formation of the studied compounds The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5

The Article related to nitro benzoate derivative structure intermol interaction strength stabilization gibbs, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Synthetic Route of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics