Category: 99-60-5

Rong, Guangwei; Liu, Defu; Yan, Hong; Chen, Jie; Zheng, Yang; Zhang, Guoqi; Mao, Jincheng published an article in 2015, the title of the article was A Practical Way to Prepare Isobutyronitrile Amides through Reactions between Carboxylic Acids and Azobisisobutyronitrile.Safety of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

A practical and efficient synthesis of N-isobutyronitrile amides R1C(O)N(R2)C(CN)(R3)R4 (R1 = 2-BrC6H4, 4-H3CC6H4CH:CH, furan-2-yl, naphthalen-1-yl, etc.; R2 = H, C(O)CH(CH3)2, C(O)C6H5, C(O)CH(CH3)CH2CH3; R3 = R4 = Me, Et) has been achieved through the direct condensation of carboxylic acids bearing variously substituted Ph rings/cinnamic acid/phenylpropiolic acid and azobisisobutyronitrile (AIBN). A radical pathway was proposed and the methodol. requires no catalysts and additives, and represents the first practical approach to a variety of valuable amides containing the isobutyronitrile structural unit. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Safety of 2-Chloro-4-nitrobenzoic acid

The Article related to isobutyronitrile amide preparation green chem, carboxylic acid azobisisobutyronitrile condensation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 5, 2018, Pandey, Archana; Verma, Chandrabhan; Singh, B.; Ebenso, Eno E. published an article.Related Products of 99-60-5 The title of the article was Synthesis, characterization and corrosion inhibition properties of benzamide-2-chloro-4-nitrobenzoic acid and anthranilic acid-2-chloro-4-nitrobenzoic acid for mild steel corrosion in acidic medium. And the article contained the following:

The present study deals with the synthesis of two new compounds namely, benzamide – 2-chloro-4-nitrobenzoic acid (BENCNBA) and anthranilic acid-2-chloro-4-nitrobenzoic acid (AACNBA) using solid phase reactions. The phase diagram studies revealed that formation of the studied compounds occurs in 1:1 molar ratio. The synthesized compounds were characterized using several spectral techniques such as FT-IR, 1H and 13C NMR, UV-Vis, powder x-ray diffraction (PXRD). Single crystal x-ray diffraction (SCXRD) study showed that both BENCNBA and AACNBA compounds crystallize in triclinic crystal system with P-1 space group. Further, the presence of intermol. hydrogen bonding between the constituent components was also supported by single crystal x-ray diffraction (SCXRD) method. Heat of mixing, entropy of fusion, roughness parameter, interfacial energy and excess thermodn. functions were computed using the enthalpy of fusion values derived from differential scanning calorimeter (DSC) study. The inhibition effect of BENCNBA and AACNBA on the mild steel corrosion in hydrochloric acid solution was tested using electrochem. methods. Electrochem. impedance spectroscopy (EIS) study revealed that both BENCNBA and AACNBA behaved as interface corrosion inhibitors and showed maximum inhibition efficiencies of 95.71% and 96.42%, resp. at 400 ppm (1.23 × 10-3 M) concentration Potentiodynamic polarization (PDP) measurements suggested that BENCNBA and AACNBA acted as mixed type corrosion inhibitors. EIS and PDP results showed that BENCNBA and AACNBA act as efficient corrosion inhibitors for mild steel and their inhibition efficiencies enhances on increasing their concentrations The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5

The Article related to steel corrosion benzamidechloronitrobenzoate anthranilic acid chloronitrobenzoate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Related Products of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 2021, Li, Ting; Cheng, Xinpeng; Qian, Pengcheng; Zhang, Liming published an article.Product Details of 99-60-5 The title of the article was Gold-catalysed asymmetric net addition of unactivated propargylic C-H bonds to tethered aldehydes. And the article contained the following:

The asym. one-step net addition of unactivated propargylic C-H bonds to aldehydes such as 7-(dimethyl(phenyl)silyl)hept-6-ynal, 4-(benzyloxy)-7-(tert-butyldimethylsilyl)hept-6-ynal, 7-(tert-Butyldimethylsilyl)-2-phenylhept-6-ynal, etc. leads to an atom-economic construction of versatile chiral homopropargylic alcs. e.g., I, but has not yet been realized. Here, implementation in an intramol. manner under mild reaction conditions have been showed. This chem.-via cooperative gold catalysis enabled by chiral bifunctional phosphine ligands (1R/1S)-II (R = Me, Cy; R1 = H, Me)-achieves asym. catalytic deprotonation of propargylic C-H (pKa > 30) by a tertiary amine group (pKa ≈ 10) of the ligand in the presence of much more acidic aldehydic α-hydrogens (pKa ≈ 17). The reaction exhibits a broad scope and readily accommodates various functional groups. The cyclopentane/cyclohexane-fused homopropargylic alc. products e.g., III are formed with excellent enantiomeric excesses and high trans-selectivities with or without a preexisting substrate chiral center. D. functional theory studies of the reaction support the conceived reaction mechanism and the calculated energetics corroborate the observed stereoselectivity and confirm addnl. metal-ligand cooperation. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Product Details of 99-60-5

The Article related to chiral fused homopropargylic alc preparation enantioselective density functional theory, propargylic aldehyde intramol addition gold bifunctional phosphine ligand catalyst and other aspects.Product Details of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 2020, Wang, Guangcheng; Liu, Wenjing; Tang, Juan; Ma, Xue; Gong, Zipeng; Huang, Yong; Li, Yongjun; Peng, Zhiyun published an article.Recommanded Product: 99-60-5 The title of the article was Design, synthesis and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors. And the article contained the following:

A series of (phenyl)(4-methoxynaphthalen-1-yl)methanones I [Ar = Ph, 4-FC6H4, naphthalen-2-yl, etc.] was designed, synthesized via reaction of 1-methoxynaphthalene with aromatic carboxylic acids and evaluated for their antiproliferative activity against human breast cancer cell line (MCF-7). Most of the tested derivatives I showed good to moderate cytotoxicity against MCF-7 cell line, among which compound I [Ar = 3-OH-4-MeOC6H3] (IC50 = 1.47 ± 0.14μM) was found to be the most active compound, which was more active than the standard drug cisplatin (IC50 = 15.24 ± 1.27μM). In vitro tubulin polymerization inhibition assay, EBI competition assay, cell cycle anal. and cell apoptosis assay identified that compound I [Ar = 3-OH-4-MeOC6H3] was a new tubulin polymerization inhibitor by targeting the colchicine binding site. Mol. docking study showed that compound I [Ar = 3-OH-4-MeOC6H3] possessed high binding affinities with the colchicine binding site of tubulin through hydrogen bond, cation-π, and hydrophobic interaction. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to phenyl methoxynaphthalenyl methanone preparation sar tubulin polymerization antitumor human, anticancer activity, benzophenone, naphthalene, tubulin polymerization inhibitors and other aspects.Recommanded Product: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kim, Sooyeon; Fujitsuka, Mamoru; Tohnai, Norimitsu; Tachikawa, Takashi; Hisaki, Ichiro; Miyata, Mikiji; Majima, Tetsuro published an article in 2015, the title of the article was The unprecedented J-aggregate formation of rhodamine moieties induced by 9-phenylanthracenyl substitution.Synthetic Route of 99-60-5 And the article contains the following content:

The authors report a substitution of 9-phenylanthracenyl group into rhodamine derivatives that can induce the J-aggregate formation of rhodamine moieties in the aqueous solution upon the addition of a halide ion. From x-ray crystallog. anal., the dramatic red shift in the absorption band (i.e. apparatus 100 nm) originates from the cooperative slipped-stacking of rhodamine and anthracene mols. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5

The Article related to unprecedented j aggregate rhodamine moieties phenylanthracenyl substitution, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Synthetic Route of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 2020, Milisiunaite, Vaida; Kadlecova, Alena; Zukauskaite, Asta; Dolezal, Karel; Strnad, Miroslav; Voller, Jiri; Arbaciauskiene, Egle; Holzer, Wolfgang; Sackus, Algirdas published an article.Category: chlorides-buliding-blocks The title of the article was Synthesis and anthelmintic activity of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives. And the article contained the following:

A series of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives I [R1 = Me, Ph; R2 = H, F; R3 = H, F, Cl, etc.; R4 = H, F] were synthesized from readily available 1-phenyl- and 1-methyl-1H-pyrazol-3-ols by sequentially employing O-acylation, Fries rearrangement and potassium carbonate-induced cyclization. The anthelmintic properties of the obtained compounds were investigated in-vivo in a model nematode, Caenorhabditis elegans. Five compounds, I [R1 = Ph, R2 = R3 = R4 = H; R1 = Ph, R2 = R4 = H, R3 = F; R1 = Ph, R2 = R4 = H, R3 = Cl; R1 = Ph, R2 = R4 = H, R3 = Br; R1 = Ph, R2 = F, R3 = R4 = H] altered the development of C. elegans. While the activities of I [R1 = Ph, R2 = R3 = R4 = H; R1 = Ph, R2 = F, R3 = R4 = H] were rather modest, compounds I [R1 = Ph, R2 = R4 = H, R3 = F; R1 = Ph, R2 = R4 = H, R3 = Cl; R1 = Ph, R2 = R4 = H, R3 = Br] inhibited the growth of the worms at concentrations of approx. 1-3μM. At these concentrations, the compounds did not kill the worms, but they strongly inhibited their development, with the majority of larvae never progressing past the L1 stage. Moreover, testing in non-cancer human cell lines showed that, with exception of 7-bromo derivative I [R1 = Ph, R2 = R4 = H, R3 = Br], the active compounds showed favorable toxicity profiles. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Category: chlorides-buliding-blocks

The Article related to benzopyranopyrazolone preparation anthelmintic activity cytotoxicity sar, anthelmintic activity, benzopyrano[2,3-c]pyrazol-4(2h)-ones, caenorhabditis elegans, cytotoxicity, pyrazole and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 5, 2020, Ryabchuk, Pavel; Leischner, Thomas; Kreyenschulte, Carsten; Spannenberg, Anke; Junge, Kathrin; Beller, Matthias published an article.Product Details of 99-60-5 The title of the article was Cascade Synthesis of Pyrroles from Nitroarenes with Benign Reductants Using a Heterogeneous Cobalt Catalyst. And the article contained the following:

A bifunctional 3d-metal catalyst for the cascade synthesis of diverse pyrroles from nitroarenes is presented. The optimal catalytic system Co/NGr-C@SiO2-L is obtained by pyrolysis of a cobalt-impregnated composite followed by subsequent selective leaching. In the presence of this material, (transfer) hydrogenation of easily available nitroarenes and subsequent Paal-Knorr/Clauson-Kass condensation provides >40 pyrroles in good to high yields using dihydrogen, formic acid, or a CO/H2O mixture (WGSR conditions) as reductant. In addition to the favorable step economy, this straightforward domino process does not require any solvents or external co-catalysts. The general synthetic utility of this methodol. was demonstrated on a variety of functionalized substrates including the preparation of biol. active and pharmaceutically relevant compounds, for example, (+)-Isamoltane. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Product Details of 99-60-5

The Article related to pyrrole preparation cascade reaction, nitroarenes hydrogenation paal knorr clauson kass condensation supported co, cobalt, heterogeneous catalysis, hydrogenation, nitroarene, pyrrole and other aspects.Product Details of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 31, 2017, Nechipadappu, Sunil Kumar; Tekuri, Venkatadri; Trivedi, Darshak R. published an article.Reference of 2-Chloro-4-nitrobenzoic acid The title of the article was Pharmaceutical Co-Crystal of Flufenamic Acid: Synthesis and Characterization of Two Novel Drug-Drug Co-Crystal. And the article contained the following:

Two novel pharmaceutical co-crystals of anti-inflammatory drug flufenamic acid (FFA) with 2-chloro-4-nitrobenzoic acid (CNB) and ethenzamide (ETZ) have been synthesized by solvent evaporation method as well as by solvent drop-assisted grinding method. The synthesized co-crystals were characterized thoroughly by various spectroscopic methods and crystal structures were determined by single-crystal x-ray diffraction technique. In FFA-CNB co-crystal, robust supramol. acid-acid homosynthon was observed FFA-ETZ co-crystal is formed via robust supramol. acid-amide heterosynthon. In FTIR spectra, a significant shift in the carbonyl stretching frequency was observed for the co-crystals due to the presence of intermol. hydrogen bond. 1H NMR study suggests the presence of hydrogen bond in the solution state of FFA-ETZ co-crystal; however, it was absent for FFA-CNB co-crystal. Solubility study in Millipore water revealed that the solubility of FFA is increased by 2-fold when it is in the form of FFA-CNB co-crystal and no increment in the solubility of FFA was observed in FFA-ETZ co-crystal. About 5-fold increment in the solubility of FFA was observed in both the co-crystals in 0.1 N HCl (pH 1) solution The synthesized co-crystals were found to be non-hygroscopic at ∼75% relative humidity and stable for a period of 6 mo at ambient temperature (∼25°C). The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Reference of 2-Chloro-4-nitrobenzoic acid

The Article related to pharmaceutical solid flufenamic acid chloro nitrobenzoic acid ethenzamide cocrystal, co-crystal, crystal engineering, hygroscopicity, pharmaceutical co-crystal, solubility, stability and other aspects.Reference of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sharma, Sushila; Kumar, Manoranjan; Sharma, Shruti; Nayal, Onkar S.; Kumar, Neeraj; Singh, Bikram; Sharma, Upendra published an article in 2016, the title of the article was Microwave assisted synthesis of phenanthridinones and dihydrophenanthridines by vasicine/KOtBu promoted intramolecular C-H arylation.Quality Control of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

A simple, efficient, rapid and transition metal-free methodol. has been developed by utilizing vasicine (a natural product), as a catalyst for the synthesis of phenanthridinones and dihydrophenanthridines. The reaction proceeds through intramol. C-H arylation with aryl halides in the presence of KOtBu as a base under microwave irradiation in sulfolane as a solvent. The reaction proceeds well with various aryl iodides, bromides and more remarkably with less reactive aryl chlorides for 15 min, providing the corresponding products in 45-90% yields. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Quality Control of 2-Chloro-4-nitrobenzoic acid

The Article related to phenanthridinone hydrophenanthridine synthesis vasicine potassium butoxide intramol arylation microwave, aryl halide intramol arylation phenanthridinone hydrophenanthridine synthesis and other aspects.Quality Control of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2020, Thakral, Samridhi; Narang, Rakesh; Kumar, Manoj; Singh, Vikramjeet published an article.Recommanded Product: 2-Chloro-4-nitrobenzoic acid The title of the article was Synthesis, molecular docking and molecular dynamic simulation studies of 2-chloro-5-[(4-chlorophenyl)sulfamoyl]-N-(alkyl/aryl)-4-nitrobenzamide derivatives as antidiabetic agents. And the article contained the following:

A series of title compounds I (R = Pr, 4-pyridyl, 2-bromophenyl, etc.) has been synthesized. The results of in vitro antidiabetic study against α-glucosidase indicated that compound I (R = 2-methyl-5-nitrophenyl) bearing 2-CH3-5-NO2 substituent on Ph ring was found to be the most active compound against both enzymes. The electron donating (CH3) group and electron withdrawing (NO2) group on a Ph ring highly favored the inhibitory activity against these enzymes. The docking simulations study revealed that these synthesized compounds displayed hydrogen bonding, electrostatic and hydrophobic interactions with active site residues. The structure activity relationship studies of these compounds were also corroborated with the help of mol. modeling studies. Mol. dynamic simulations have been done for top most active compound for validating its α-glucosidase and α-amylase inhibitory potential, and RMSD anal. of ligand protein complex suggested the stability of top most active compound I (R = 2-methyl-5-nitrophenyl) in binding site of target proteins. In silico ADMET results showed that synthesized compounds were found to have negligible toxicity, good solubility and absorption profile as the synthesized compounds fulfilled Lipinski’s rule of 5 and Veber’s rule. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 2-Chloro-4-nitrobenzoic acid

The Article related to chlorophenylsulfamoyl nitrobenzamide alkyl aryl preparation mol docking antidiabetic pharmacokinetic, admet, molecular docking, molecular dynamic simulations, α-amylase, α-glucosidase and other aspects.Recommanded Product: 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics