Category: 99-60-5

On August 8, 2016, Esvan, Yannick J.; Zeinyeh, Wael; Boibessot, Thibaut; Nauton, Lionel; Thery, Vincent; Knapp, Stefan; Chaikuad, Apirat; Loaec, Nadege; Meijer, Laurent; Anizon, Fabrice; Giraud, Francis; Moreau, Pascale published an article.Recommanded Product: 99-60-5 The title of the article was Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. And the article contained the following:

The design and synthesis of new pyrido[3,4-g]quinazoline derivatives is described as well as their protein kinase inhibitory potencies toward five CMGC family members (CDK5, CK1, GSK3, CLK1 and DYRK1A). The interest for this original tricyclic heteroaromatic scaffold as modulators of CLK1/DYRK1A activity was validated by nanomolar potencies (compounds 10-nitropyrido[3,4-g]quinazolin-2-amine and Pyrido[3,4-g]quinazoline-2,10-diamine). CLK1 co-crystal structures with two inhibitors revealed the binding mode of these compounds within the ATP-binding pocket. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to pyridoquinazoline derivative preparation cmgc protein kinase inhibitor, clk1 pyridoquinazolineamine cocrystal structure, clk1 binding mode, cmgc family, kinase inhibitors, pyrido[3,4-g]quinazoline, ser/thr kinases and other aspects.Recommanded Product: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 1, 2019, Gotoh, Kazuma; Ishida, Hiroyuki published an article.COA of Formula: C7H4ClNO4 The title of the article was Crystal structures of the two isomeric hydrogen-bonded cocrystals 2-chloro-4-nitrobenzoic acid-5-nitroquinoline (1/1) and 5-chloro-2-nitrobenzoic acid-5-nitroquinoline (1/1). And the article contained the following:

The structures of two isomeric compounds of 5-nitroquinoline with chloro- and nitro-substituted benzoic acid, namely, 2-chloro-4-nitrobenzoic acid-5-nitroquinoline (1/1), (I), and 5-chloro-2-nitrobenzoic acid-5-nitroquinoline (1/1), (II), both C7H4ClNO4·C9H6N2O2, have been determined at 190 K. In each compound, the acid and base mols. are held together by an O-H···N hydrogen bond. In the crystal of (I), the hydrogen-bonded acid-base units are linked by a C-H···O hydrogen bond, forming a tape structure along [1 [inline formula omitted] 0]. The tapes are stacked into a layer parallel to the ab plane via N-O···π interactions between the nitro group of the base mol. and the quinoline ring system. The layers are further linked by other C-H···O hydrogen bonds, forming a three-dimensional network. In the crystal of (II), the hydrogen-bonded acid-base units are linked into a wide ribbon structure running along [1 [inline formula omitted] 0] via C-H···O hydrogen bonds. The ribbons are further linked via another C-H···O hydrogen bond, forming a layer parallel to (110). Weak π-π interactions [centroid-centroid distances of 3.7080 (10) and 3.7543 (9) Å] are observed between the quinoline ring systems of adjacent layers. Hirshfeld surfaces for the 5-nitroquinoline mols. of the two compounds mapped over shape index and dnorm were generated to visualize the weak intermol. interactions. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to chloro nitrobenzoic acid nitroquinoline isomeric hydrogen bond crystal structure, 2-chloro-4-nitro­benzoic acid, 5-chloro-2-nitro­benzoic acid, 5-nitro­quinoline, hirshfeld surface, crystal structure, hydrogen bond and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 31, 2021, Navidpour, Latifeh; Shabani, Shabnam; Heidari, Alireza; Bashiri, Manouchehr; Ebrahim-Habibi, Azadeh; Shahhosseini, Soraya; Shafaroodi, Hamed; Abbas Tabatabai, Sayyed; Toolabi, Mahsa published an article.Recommanded Product: 99-60-5 The title of the article was 5-[Aryloxypyridyl (or nitrophenyl)]-4H-1,2,4-triazoles as novel flexible benzodiazepine analogues: Synthesis, receptor binding affinity and lipophilicity-dependent anti-seizure onset of action. And the article contained the following:

A new series of 5-(2-aryloxy-4-nitrophenyl)-4H-1,2,4-triazoles and 5-(2-aryloxy-3-pyridyl)-4H-1,2,4-triazoles, possessing C-3 thio or alkylthio substituents, was synthesized and evaluated for their benzodiazepine receptor affinity and anti-seizure activity. These analogs revealed similar to significantly superior affinity to GABAA/benzodiazepine receptor complex (IC50 values of 0.04-4.1 nM), relative to diazepam as the reference drug (IC50 value of 2.4 nM). To determine the onset of anti-seizure activity, the time-dependent effectiveness of i.p. administration of compounds on pentylenetetrazole induced seizure threshold was studied and a very good relationship was observed between the lipophilicity (cLogP) and onset of action of studied analogs (r2 = 0.964). The min. ED of the compounds, determined at the time the analogs showed their highest activity, was demonstrated to be 0.025-0.1 mg/kg, relative to diazepam (0.025 mg/kg). The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to triazol flexible benzodiazepine derivative preparation lipophilicity antiseizure activity, 1,2,4-triazole, flexible benzodiazepines, gabaa/benzodiazepine receptor complex, onset of action, ptz induced seizure threshold and other aspects.Recommanded Product: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 5, 2020, Scheepers, Matthew C.; Lemmerer, Andreas published an article.Name: 2-Chloro-4-nitrobenzoic acid The title of the article was Synthesis and Characterization of a Series of Sulfamethazine Multicomponent Crystals with Various Benzoic Acids. And the article contained the following:

Nine multi-component crystals consisting of sulfamethazine (sz) with HOBz and its derivatives were synthesized and characterized. Eight of the 9 multi-component crystals are co-crystals, while 1 is a mol. salt. The co-formers used to form multi-component crystals with sz include: 2-chloro-4-nitrobenzoic acid (2c4n), 2-chloro-5-nitrobenzoic acid (2c5n), salicylic acid (2hba), 3-hydroxybenzoic acid (3hba), 4-hydroxybenzoic acid (4hba), 4-bromobenzoic acid (4Brba), HOBz (ba), cinnamic acid (ca) and toluic acid (ta). These multi-component crystals were characterized by single-crystal x-ray diffraction (SC-XRD), Powder X-ray diffraction (PXRD) and Differential Scanning Calorimetry (DSC). SC-XRD showed that 8 of the co-formers that interacted with sz formed the amidine-carboxyl synthon; with the only exception to this were sz+4hba which formed the imidine-carboxyl synthon formed instead. PXRD confirmed that the single crystals were representative of the bulk material. DSC showed most of the multi-component crystals to have only a melting phase transition, which differed from the m.ps. of the co-formers. The only exceptions were sz+4brba and sz+ca, where an addnl. endothermic peak was observed, which corresponds to an amorphous phase transition before melting. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Name: 2-Chloro-4-nitrobenzoic acid

The Article related to sulfamethazine benzoic acid derivative multicomponent synthesis hydrogen bond, crystal structure sulfamethazine benzoic acid derivative multicomponent, mol structure sulfamethazine benzoic acid derivative multicomponent and other aspects.Name: 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 1, 2018, Zhou, Qian; You, Chaoqun; Zheng, Cong; Gu, Yawen; Gu, Hongchao; Zhang, Rui; Wu, Hongshuai; Sun, Baiwang published an article.Quality Control of 2-Chloro-4-nitrobenzoic acid The title of the article was 3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents. And the article contained the following:

DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogs have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clin. usage and the mechanisms of action are not fully understood. Novel acridine derivatives are needed for effective cancer therapy. A series of novel 3-nitroacridine-based derivatives were synthesized, their DNA binding and anticancer activities were evaluated. The chem. modifications at position 9 of the 3-nitroacridine were crucial for DNA affinity, thus optimizing anticancer activity. UV-Vis and CD (CD) spectroscopy indicated interaction of compounds with DNA, and the binding modes were intercalation and groove binding. MTT assay and clonogenic assay showed that compounds 1, 2 and 3 had obvious cell growth inhibition effect. They induced cell apoptosis in human breast cancer cells in a dose-dependent manner, and exhibited anticancer effect via DNA damage as well as cell cycle arrest at G0/G1 phage. Using confocal fluorescent microscope, the apoptotic features were observed The results suggested that compounds 1-3 with high DNA binding affinity and good inhibitory effect of cancer cell proliferation can be developed as prime candidates for further chem. optimization. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Quality Control of 2-Chloro-4-nitrobenzoic acid

The Article related to breast cancer dna target anticancer agent 3 nitroacridine derivative, apoptosis cell cycle arrest g1 g0 phase, acridine derivatives, anticancer activity, apoptosis, dna binding, structure-activity relationship (sar), synthesis and other aspects.Quality Control of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 30, 2016, Al-Ghorbani, Mohammed; Pavankumar, G. S.; Naveen, P.; Thirusangu, Prabhu; Prabhakar, B. T.; Khanum, Shaukath Ara published an article.COA of Formula: C7H4ClNO4 The title of the article was Synthesis and an angiolytic role of novel piperazine-benzothiazole analogues on neovascularization, a chief tumoral parameter in neoplastic development. And the article contained the following:

A novel series of benzoic acid N’-[2-(4-benzothiazol-2-yl-piperazin-1-yl)-acetyl]-hydrazides (6a-j) were synthesized and characterized by IR, 1H, 13C NMR, elemental and mass spectral analyses. The in-vitro cytotoxicity and cell viability assay of the synthesized compounds 6a-j were evaluated against Dalton’s lymphoma ascites (DLA) cells. The authors’ results showed that compound 3-bromobenzoic acid N’-[2-(4-benzothiazol-2-yl-piperazin-1- yl)-acetyl]-hydrazide (6c) with a bromo group on Ph ring has showed promising antiproliferative efficacy. Further investigation of compound (6c) on in-vivo treatment model depicts the increased tumor suppression through inhibition of angiogenesis. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to piperazine benzothiazole analog preparation antitumor neovascularization structure activity, antiproliferative angiogenesis piperazine benzothiazole analog, angiogenesis, antiproliferative, dla cells, piperazine–benzothiazole and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bihdan, Oleksii A.; Parchenko, Volodymyr V. published an article in 2018, the title of the article was Some aspects of synthesis 3-(2-fluorophenyl)-6-R1-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole and 3-(2-,3-fluorophenyl)-6-R3-7h[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines.Safety of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

The synthesis of new 3-(2-fluorophenyl)-6-R1-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles I (R1 = Ph, 2-bromo-5-methoxyphenyl, furan-2-yl, etc.) and 3-(2-fluorophenyl, 3-fluorophenyl)-6-R3-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines II (R2 = 2-F, 3-F; R3 = Me, Ph, 4-fluorophenyl, 4-methoxyphenyl) and the passage of cyclization reaction have been described. By using the compound 5-(2-fluorophenyl)-4-amino-1,2,4-triazol-3-thiol, the reaction of its cyclization in the presence of corresponding aryl, heterocarboxylic acids in POCl3 medium has been investigated. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Safety of 2-Chloro-4-nitrobenzoic acid

The Article related to triazolothiadiazole fluorophenyl preparation, carboxylic acid aminotriazole thiol fluorophenyl heterocyclization, triazolothiadiazine fluorophenyl preparation, bromoketone aminotriazole thiol fluorophenyl heterocyclization and other aspects.Safety of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2018, Kaur, Avneet; Pathak, Dharam P.; Sharma, Vidushi; Narasimhan, Balasubramanian; Sharma, Prateek; Mathur, Rajani; Wakode, Sharad published an article.SDS of cas: 99-60-5 The title of the article was Synthesis, biological evaluation and docking study of N-(2-(3,4,5-trimethoxybenzyl)benzoxazole-5-yl) benzamide derivatives as selective COX-2 inhibitor and anti-inflammatory agents. And the article contained the following:

A series of N-(2-(3,4,5-trimethoxybenzyl)-benzoxazole-5-yl)benzamide derivatives (3a-3n) was synthesized and evaluated for its in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50 < 1 μM), were evaluated in vivo for their anti-inflammatory and ulcerogenic potential. Out of the fourteen newly synthesized compounds; 3b (N-(2-(3,4,5-trimethoxybenzyl)benzoxazol-5-yl)-4-chlorobenzamide), 3d (N-(2-(3,4,5-trimethoxybenzyl)benzoxazol-5-yl)-2-chlorobenzamide), 3e, 3h, 3l and 3m were found to be most potent COX-2 inhibitors in in vitro enzymic assay with IC50 in the range of 0.14-0.69 μM. In vivo anti-inflammatory activity of these six compounds (3b, 3d, 3e, 3h, 3l and 3m) was assessed by carrageenan induced rat paw edema method. The compound 3b (79.54%), 3l (75.00%), 3m (72.72%) and 3d (68.18%) exhibited significant anti-inflammatory activity than standard drug ibuprofen (65.90%). Ulcerogenic activity with histopathol. studies was performed, and the screened compounds demonstrated significant gastric tolerance than ibuprofen. Mol. Docking study was also performed with resolved crystal structure of COX-2 to understand the interacting mechanisms of newly synthesized inhibitors with the active site of COX-2 enzyme and the results were found to be in line with the biol. evaluation studies of the compounds The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).SDS of cas: 99-60-5

The Article related to trimethoxybenzylbenzoxazoleyl benzamide derivative preparation cox2 inhibitor antiinflammatory docking, anti-inflammatory activity, cox-1, cox-2, histopathology, n-(3,4,5-trimethoxybenzyl)benzoxazole, ulcerogenic activity and other aspects.SDS of cas: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 3, 2016, Yu, Haiqing; Li, Yanxia; Ge, Yang; Song, Zhendong; Wang, Changyuan; Huang, Shanshan; Jin, Yue; Han, Xu; Zhen, Yuhong; Liu, Kexin; Zhou, Youwen; Ma, Xiaodong published an article.Computed Properties of 99-60-5 The title of the article was Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines. And the article contained the following:

With the aim of overcoming gefitinib resistance, a series of novel quinazoline derivatives bearing an adamantyl group on the aniline ring were synthesized as potent epidermal growth factor receptor (EGFR) inhibitors. Most of these analogs are comparable to gefitinib in their ability to inhibit non-small cell lung cancer (NSCLC) cell lines, and several also exhibited significantly enhanced anti-tumor potency. Specifically, compound I, with an IC50 value of 2.06 μM against A431 cells with the wild-type EGFR and of 0.009 μM against the gefitinib-sensitive cells, displayed approx. 5-fold higher potency than the lead compound to inhibit the cells harboring the EGFRT790M mutant. In addition, the mol. simulation and Western blot anal. results also indicated that these compounds effectively interfered with the EGFRT790M activity, and may serve as a new alternative structure to develop more effective antitumor agents. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Computed Properties of 99-60-5

The Article related to adamantyl anilinoquinazoline preparation epidermal growth factor receptor inhibitor, egfr inhibitor adamantyl anilinoquinazoline preparation, quinazoline adamantyl preparation egfr inhibitor, adamantyl, egfr, nsclc, quinazoline, t790m and other aspects.Computed Properties of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 2018, Ghorbani, Mahdi; Shams, Alireza; Seyedin, Orkideh; Afshar Lahoori, Nahid published an article.HPLC of Formula: 99-60-5 The title of the article was Magnetic ethylene diamine-functionalized graphene oxide as novel sorbent for removal of lead and cadmium ions from wastewater samples. And the article contained the following:

In this paper, magnetic ethylene diamine-functionalized graphene oxide (MDFGO) as a novel sorbent was synthesized and applied for removal of Pb(II) and Cd(II) from real wastewater samples. The morphol. and mol. structure of MDFGO were studied by different anal. methods. The effective parameters in adsorption efficiency of Pb(II) and Cd(II) were studied and optimized using exptl. design. Under the optimal condition, the effective parameters including pH, sorbent dosage, shaking rate, and adsorption time were 6.2, 33.0 mg, 500 rpm, and 11 min, resp. Mechanism of adsorption kinetic was investigated using the Lagergren pseudo-first-order, pseudo-second-order, and intraparticle diffusion models. It was found that adsorption of lead and cadmium ions in the MDFGO sorbent followed from pseudo-first-order and pseudo-second-order models, resp. Thermodn. parameters (ΔG°, ΔH°, and ΔS°) for the lead and cadmium ions uptake onto the MDFGO sorbent were calculated and indicated that the adsorption processes were spontaneous and endothermic in nature for both cations. In order to investigate the isotherm model for adsorption of Pb(II) and Cd(II), the exptl. data were studied using the Langmuir, Freundlich, and Harkins-Jura isotherm models. The results fitted well with Freundlich model for both metal ions. The new sorbent (MDFGO) was applied to remove Pb(II) and Cd(II) from battery wastewater and electroplating wastewater. The removal percentage of Pb(II) and Cd(II) were 99.6±0.5 and 99.4±0.6, resp., and demonstrated that the new sorbent was very suitable for removal of lead and cadmium ion from the real wastewater samples. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).HPLC of Formula: 99-60-5

The Article related to ethylene diamine graphene oxide adsorption lead cadmium wastewater treatment, adsorption, batteries wastewater samples, electroplating wastewater samples, magnetic ethylene diamine-functionalized graphene oxide, removal of lead and cadmium ions and other aspects.HPLC of Formula: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics