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Synthesis and properties of high-temperature mesomorphic polysiloxane (MEPSIL) solvents: biphenyl- and terphenyl-based nematic systems was written by Apfel, M. A.;Finkelmann, H.;Janini, G. M.;Laub, R. J.;Luehmann, B. H.;Price, A.;Roberts, W. L.;Shaw, T. J.;Smith, C. A.. And the article was included in Analytical Chemistry in 1985.Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) This article mentions the following:

Mesomorphic (liquid-crystalline) side-chain siloxanes were prepared for evaluation as stationary phases in gas chromatog. by hydrosilylation of 4-(allyloxy)benzoate esters by Me hydrogen siloxanes in the presence of a dicyclopentadienylplatinum (II)chloride  [12083-92-0] catalyst. The products were characterized by IR, NMR, gas chromatog., DSC, elemental anal., and hot-stage, polarized optical microscopy. Their selectivity was substantially different from that of other common gas chromatog. solvents. The one best suited for use in gas chromatog. had m.p. 139°, nematic-isotropic transition temperature 319°, and practical operating limits of 150 to >300°. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Botting, Nigel P. published the artcile1-(5-Chloro-2,4-dihydroxyphenyl)-2-(4-ethoxyphenyl)ethanone, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Acta Crystallographica, Section E: Structure Reports Online (2008), 64(10), o2030, o2030/1-o2030/8, database is CAplus and MEDLINE.

The structure of the title compound, C₁₆H₁₅ClO₄, contains aryl rings which are inclined by 75.6 (1)° to each other. It displays intramol. O-H…O hydrogen bonding between the 2-hydroxy and carbonyl groups, forming a six-membered ring. Furthermore, the 4-hydroxy group, acting as a hydrogen-bond donor, is bound to the O atom of the 2-hydroxy group of another mol. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brandt, Krystyna published the artcileReactions of diethyl trichloromethylphosphonate with metallic zinc, COA of Formula: C5H10Cl3O3P, the publication is Journal of Organometallic Chemistry (1974), 70(3), 309-12, database is CAplus.

Complexes of tetrachloroethylenediphosphonic acid tetraethyl ester and diethyl trichloromethylphosphonate (DETCMP) with ZnCl2 are formed in the reaction of DETCMP with metallic Zn. The complexes undergo dealkylation and condensation reactions leading to the formation of zinc polypyrophosphonate (I). Alc. solvents cause an increase of reaction rate.

Journal of Organometallic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, COA of Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hosek, Petr published the artcileAuxin transport at cellular level: new insights supported by mathematical modelling, Computed Properties of 33697-81-3, the publication is Journal of Experimental Botany (2012), 63(10), 3815-3827, database is CAplus and MEDLINE.

The mol. basis of cellular auxin transport is still not fully understood. Although a number of carriers have been identified and proved to be involved in auxin transport, their regulation and possible activity of as yet unknown transporters remain unclear. Nevertheless, using single-cell-based systems it is possible to track the course of auxin accumulation inside cells and to specify and quantify some auxin transport parameters. The synthetic auxins 2,4-dichlorophenoxyacetic acid (2,4-D) and naphthalene-1-acetic acid (NAA) are generally considered to be suitable tools for auxin transport studies because they are transported specifically via either auxin influx or efflux carriers, resp. Our results indicate that NAA can be metabolized rapidly in tobacco BY-2 cells. The predominant metabolite has been identified as NAA glucosyl ester and it is shown that all NAA metabolites were retained inside the cells. This implies that the transport efficiency of auxin efflux transporters is higher than previously assumed. By contrast, the metabolism of 2,4-D remained fairly weak. Moreover, using data on the accumulation of 2,4-D measured in the presence of auxin transport inhibitors, it is shown that 2,4-D is also transported by efflux carriers. These results suggest that 2,4-D is a promising tool for determining both auxin influx and efflux activities. Based on the accumulation data, a math. model of 2,4-D transport at a single-cell level is proposed. Optimization of the model provides estimates of crucial transport parameters and, together with its validation by successfully predicting the course of 2,4-D accumulation, it confirms the consistency of the present concept of cellular auxin transport.

Journal of Experimental Botany published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Computed Properties of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Jun published the artcileCoordinating Activation Strategy-Induced Selective C-H Trifluoromethylation of Anilines, Related Products of chlorides-buliding-blocks, the main research area is trifluoromethyl aniline preparation coordinating activation trifluoromethylation picolinamide.

A simple protocol for the synthesis of 2-(trifluoromethyl)aniline derivatives through a coordinating activation strategy was developed. The reaction showed good reactivity and gave the target products in moderate to good yields. Pleasingly, the directing group could be recovered in excellent yield. Furthermore, this strategy allowed efficient access to the synthesis of floctafenine. A single-electron-transfer mechanism was proposed to be responsible for this trifluoromethylation reaction.

ChemCatChem published new progress about Anilines Role: SPN (Synthetic Preparation), PREP (Preparation) (trifluoromethyl). 62593-17-3 belongs to class chlorides-buliding-blocks, name is 2,4-Dichloro-6-(trifluoromethyl)aniline, and the molecular formula is C7H4Cl2F3N, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 3-Chlorophenylacetic acid.

Ho, Tuan H.;Phan, Nhu T. A.;Ho, Thuyen T. C.;Tran, Duyen L. M.;Nguyen, Tung T.;Phan, Nam T. S. research published 《 Elemental Sulfur Mediated Synthesis of Pyrrolo[1,2-a ]quinoxalines from 1-(2-Nitroaryl)pyrroles》, the research content is summarized as follows. A simple coupling of 1-(2-nitroaryl)pyrroles and arylacetic acids, in the presence of elemental sulfur, to furnish the fused heterocycles I [R = H, 7-F, 7-MeO, etc.; R¹ = Ph, 4-MeC₆H₄, 2-thienyl, etc.] in good yields was described. The conditions were compatible with many functionalities including ester, nitrile, halogen and nitro groups. Use of benzyl alcs. and picoline coupling reagents was also attempted.

Recommanded Product: 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C15H17ClFNO4S《Activation of TLR4 induces inflammatory muscle injury via mTOR and NF-κB pathways in experimental autoimmune myositis mice》 was published in 2022. The authors were Zhang, Hongya;He, Fangyuan;Zhou, Linfu;Shi, Ming;Li, Fangming;Jia, Hongge, and the article was included in《Biochemical and Biophysical Research Communications》. The author mentioned the following in the article:

Idiopathic inflammatory myopathy (IIM) is an autoimmune disease that invades skeletal muscle; however, the etiol. of IIM is still poorly understood. Toll-like receptor (TLR) 4 has been widely reported to take part in the autoimmune inflammation of IIMs. The mammalian target of rapamycin, mTOR, is a key central substance which mediates immune responses and metabolic changes, and also has been confirmed to be involved in the pathogenesis of IIMs. However, the interconnectedness between TLR4 and mTOR in IIM inflammation has not been fully elucidated. We hypothesized that TLR4 may play an important role in IIM inflammatory muscle injury by regulating mTOR. Mice were divided into four groups: a normal control group, IIM animal model (exptl. autoimmune myositis, EAM) group, TAK242 intervention group and rapamycin (RAPA) intervention group. The results of EAM mice showed that TLR4, mTOR, nuclear factor-kappa B (NF-κB) and inflammatory factors interleukin-17A (IL-17A) and interferon γ (IFN-γ) mRNA levels were significantly upregulated. These factors were pos. correlated with the degree of muscle inflammatory injury. When EAM mice were given the antagonist TAK242 to inhibit the TLR4 pathway, the results demonstrated that both mTOR and NF-κB were downregulated in the muscle of the mice. Muscle staining showed that the inflammatory injury was alleviated and the EAM mouse muscle strength was improved. Then, RAPA was used to inhibit the mTOR pathway, and the inflammatory factors IL-17A and IFN-γ were downregulated in EAM mouse muscle and serum. Consistently, muscle inflammatory injury was significantly reduced, and muscle strength was significantly improved. Our results suggest that TLR4 may regulate inflammatory muscle injury in EAM by activating the mTOR and NF-κB pathways, which provides both an exptl. complement for the pathol. mechanism of IIM and an encouraging target for the selection of effective treatments. And (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) was used in the research process.

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) can reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs).Computed Properties of C15H17ClFNO4S Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. COA of Formula: C7H4Cl2O.

Devi, Lagudu;Robert, Alice R.;Ganja, Himavathi;Maddila, Suresh;Jonnalagadda, Sreekantha B. research published 《 A rapid, sustainable and environmental friendly protocol for the catalyst-free synthesis of 2-methyl-5-oxo-hexahydroquinoline-3-carboxylate via ultrasonic irradiation》, the research content is summarized as follows. A facile, economic, highly valuable and sustainable protocol for the synthesis of substituted 2-methyl-5-oxo-hexahydroquinoline-3-carboxylate derivatives I [R = 2-FC₆H₄, 2-BrC₆H₄, 4-N(Me)₂C₆H₄, etc.] was developed via one-pot, the multicomponent reaction of various benzaldehydes, 1,3-cyclohexanedione, benzyl acetoacetate and ammonium acetate in EtOH under ultrasound irradiation at room temperature condition. Employment of green solvent and catalyst-free conditions made this approach very fascinating from cost-effective and eco-friendly viewpoints. Mainly, this protocol offered various benefits such as easy handling, cleaner reaction, operational simplicity, simple work-up system, excellent yields (92-98%), rapid reaction time and condensed environmental consequences.

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., COA of Formula: C7H4Cl2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 6276-54-6,Some common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-chloropropylamine hydrochloride (5.0 g, 38.5 mmol) in water (15 mL) wasslowly added a solution of NaN3 (7.5 g, 115.3 mmol) in water (30 mL). The resulting solution washeated at 80 C for 18 h. After cooling to room temperature, about 1/2 to 2/3 of the water was removedunder vacuum. The remaining residue was diluted with ether (50 mL). This biphasic mixture wascooled in an ice bath for 5 min and KOH (2.0 g) was added. The phases were separated and theaqueous phase was extracted with diethyl ether (2 x 50 mL). The organic layers were combined, driedwith Na2SO4, and concentrated to give the 3-azidopropylamine as light yellow oil (2.9 g, 29.0 mmol)in 75% yield. 1H-NMR (CDCl3): delta3.39-3.36 (t, 2H), 2.82-2.79 (t, 2H), 1.77-1.70 (m, 2H), 1.45 (bs, 2H).ESI-MS: m/z calcd for C3H9N4: 100.1, found 101.1 [M + H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloropropan-1-amine hydrochloride, its application will become more common.

Reference:
Article; Guo, Zhide; Gao, Mengna; Song, Manli; Shi, Changrong; Zhang, Pu; Xu, Duo; You, Linyi; Zhuang, Rongqiang; Su, Xinhui; Liu, Ting; Du, Jin; Zhang, Xianzhong; Molecules; vol. 21; 6; (2016);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 933190-51-3, name is 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 8-Bromo-6-chloroimidazo[1,2-b]pyridazine

A mixture of 8-bromo-6-chloroimidazo[1,2-b]pyridazine (300 mg, 1.3 mmol), 6-(3-methylcyclopentyl)pyridin-2-amine (277 mg, 1.56 mmol), Pd2(dba)3 (75 mg, 0.13 mmol), BINAP (324 mg, 0.52 mmol), Cs2CO3 (1272 mg, 3.9 mmol) and dioxane (20 mL) was heated to 100 C. with stirring for 16 h under N2. The solvent was removed in vacuo and the resulting mixture was purified by chromatography (silica gel, 200-300 mesh, petroleum ether:ethyl acetate=5:1) to give 6-chloro-N-(6-(3-methylpyrrolidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine (301 mg, 70%) as a yellow solid. LC-MS: [M+H]+, 329.1, tR=1.949 min.

According to the analysis of related databases, 933190-51-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoffmann-La Roche Inc.; Hermann, Johannes Cornelius; Kuglstatter, Andreas; Lucas, Matthew C.; Padilla, Fernando; Wanner, Jutta; Zhang, Xiaohu; US2013/109661; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics