Tag: 100-200

Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria was written by Alkhaibari, Ibrahim S.;Kc, Hansa Raj;Roy, Subrata;Abu-gazleh, Mohd. K.;Gilmore, David F.;Alam, Mohammad A.. And the article was included in Molecules in 2021.SDS of cas: 2613-34-5 This article mentions the following:

The design, synthesis, and antimicrobial studies of 30 novel pyrazole derivatives I (R = C₆H₅, 3-FC₆H₄, 3,4-(F₂)C₆H₃, etc.) have been described. Most of the synthesized compounds I are potent growth inhibitors of planktonic Gram-pos. bacteria with min. inhibitory concertation (MIC) values as low as 0.25渭g/mL. Further studies led to the discovery of several lead compounds, which are bactericidal and potent against MRSA persisters. Compounds I (R = 4-BrC₆H₄, 3,5-(Cl)₂-4-FC₆H₂, 4-Br-3-Cl-2-FC₆H₂) are potent against S. aureus biofilms with min. biofilm eradication concentration (MBEC) values as low as 1渭g/mL. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5SDS of cas: 2613-34-5).

3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 2613-34-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives was written by Li, Yu;Shi, Qiuyan;Shao, Jiajia;Yuan, Yaping;Yang, Zhigang;Chen, Shizhen;Zhou, Xin;Wen, Shijun;Jiang, Zhong-Xing. And the article was included in European Journal of Medicinal Chemistry in 2018.HPLC of Formula: 1711-11-1 This article mentions the following:

To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool mol. Using a K-ras cellular model, salinomycin and its derivatives showed different mol. mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactions of perfluoroalkanesulfonyl chlorides with silyl enol ethers catalyzed by a ruthenium(II) phosphine complex was written by Kamigata, Nobumasa;Udodaira, Kumiko;Shimizu, Toshio. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 1997.Product Details of 7476-66-6 This article mentions the following:

Reactions of trifluoromethane- and tridecafluorohexanesulfonyl chlorides with silyl enol ethers have been investigated in the presence of a ruthenium(II) phosphine complex. Perfluoroalkylation and chlorination occurred depending on the substituent on the silyl enol ether, i.e., perfluoroalkylated compound was selectively obtained in the reactions with silyl enol ether possessing an electron-withdrawing group while chlorinated compounds were selectively formed in the reaction with a silyl enol ether possessing an electron-donating group. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Product Details of 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity was written by Marcyk, Paul T.;LeBlanc, Emmanuelle V.;Kuntz, Douglas A.;Xue, Alice;Ortiz, Francisco;Trilles, Richard;Bengtson, Stephen;Kenney, Tristan M. G.;Huang, David S.;Robbins, Nicole;Williams, Noelle S.;Krysan, Damian J.;Prive, Gilbert G.;Whitesell, Luke;Cowen, Leah E.;Brown, Lauren E.. And the article was included in Journal of Medicinal Chemistry in 2021.Synthetic Route of C8H6ClFO2 This article mentions the following:

The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics has been precluded by human host toxicities and suppression of immune responses. We recently described resorcylate aminopyrazoles (RAPs) as the first class of Hsp90 inhibitors capable of discriminating between fungal (Cryptococcus neoformans, Candida albicans) and human isoforms of Hsp90 in biochem. assays. Here, we report an iterative structure-property optimization toward RAPs capable of inhibiting C. neoformans growth in culture. In addition, we report the first X-ray crystal structures of C. neoformans Hsp90 nucleotide binding domain (NBD), as the apoprotein and in complexes with the non-species-selective Hsp90 inhibitor NVP-AUY922 and three RAPs revealing unique ligand-induced conformational rearrangements, which reaffirm the hypothesis that intrinsic differences in protein flexibility can confer selective inhibition of fungal vs. human Hsp90 isoforms. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Synthetic Route of C8H6ClFO2).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C8H6ClFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and thermal decomposition mechanism of rare earth complexes with 5-chloro-2-methoxybenzoic acid and 1,10-phenanthroline was written by Zhang, Jie;Wang, Juan-Fen;Zhang, Jian-Jun. And the article was included in Wuli Huaxue Xuebao in 2012.Reference of 3438-16-2 This article mentions the following:

Three rare earth complexes of [Ln(5-Cl-2MOBA)₃phen]₂ (Ln = Nd(1), Eu(2), Ho(3); 5-Cl-2MOBA: 5-chloro-2-methoxybenzoate; phen: 1,10-phenanthroline) were synthesized and characterized by elemental anal., TG-differential TG-DSC (TG-DTG-DSC), IR spectra, UV spectra, and molar conductance techniques. The fluorescence spectra showed that complex 2 emitted a characteristic fluorescence of the Eu³⁺ ions. The thermal properties are discussed by TG – DSC / FTIR (TG-DSC/FTIR) techniques. And the three-dimensional IR accumulation spectra for the three complexes were also analyzed. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Reference of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An improved method for the synthesis of phenylacetic acid derivatives via carbonylation was written by Li, He;Zhang, Yijun;Liu, Dinghua;Liu, Xiaoqin. And the article was included in Journal of Chemical Research in 2019.Computed Properties of C8H9Cl This article mentions the following:

A series of phenylacetic acid derivatives RCH₂CO₂H [R = 2-ClC₆H₄, 4-MeC₆H₄, 2,4-Cl₂C₆H₃, etc.] was synthesized via bistriphenylphosphine palladium dichloride catalyzed carbonylation reaction of benzyl chloride derivatives in presence of tetraethylammonium chloride and sodium hydroxide as reagents and xylene as solvent at 80掳C under a CO atm. 2,4-Dichlorophenylacetic acid was obtained in a maximum yield of 95% from 2,4-dichlorobenzyl chloride using the same reaction system. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Computed Properties of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of high-affinity 5-HT₃ receptor antagonists. 1. Initial structure-activity relationship of novel benzamides was written by Youssefyeh, R. D.;Campbell, H. F.;Klein, S.;Airey, J. E.;Darkes, P.;Powers, M.;Schnapper, M.;Neuenschwander, K.;Fitzpatrick, L. R.. And the article was included in Journal of Medicinal Chemistry in 1992.Recommanded Product: 3438-16-2 This article mentions the following:

Novel benzamides, e.g. I (X = H, Cl, Br, n = 1; X = Cl, n = 2), II (R = Me, Me₂CHCH₂, CH₂:CHCHMe, MeCOCHMe), and S–III which are orally active, highly potent, specific antagonists of serotonin 5-HT₃ receptors were prepared and the structure-activity relationships that led to these novel structures with improved potency in selectivity are described. (S)-III was identified and selected for further evaluation as a 5-HT₃ receptor antagonist. Compared with 5-HT₃ antagonists such as GR 38032F, BRL 43694, and metoclopramide, (S)-III was most active in (a) inhibiting binding to 5-HT₃ receptor binding sites in rat entorhinal cortex with a K_i value of 0.19 nM and (b) blocking cisplatin-induced emesis in the ferret with an ED₅₀ value determined to be 9 mg/kg, i.d. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Recommanded Product: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Furanyl-1,3-thiazol-2-yl and benzoxazol-5-ylacetic acid derivatives: novel classes of heparanase inhibitor was written by Courtney, Stephen M.;Hay, Philip A.;Buck, Richard T.;Colville, Claire S.;Phillips, David J.;Scopes, David I. C.;Pollard, Faye C.;Page, Martin J.;Bennett, James M.;Hircock, Margaret L.;McKenzie, Edward A.;Bhaman, Maina;Felix, Robert;Stubberfield, Colin R.;Turner, Paul R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Product Details of 1711-11-1 This article mentions the following:

Using a furanylthiazoleacetic acid as a starting point, a novel series of benzoxazol-5-ylacetic acid derivatives have been identified as heparanase inhibitors. Several compounds, such as I, possess an IC₅₀ of 鈭?00 nM against heparanase. Several of the compounds show antiangiogenic properties. Improvement to the DMPK profile has provided compounds of potential use in in vivo models. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Product Details of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage ranges was written by Nishiyama, Hiroyuki;Ono, Masahiro;Sugimoto, Takuya;Sasai, Toshio;Asakawa, Naoyuki;Yaegashi, Takashi;Nagaoka, Masato;Matsuzaki, Takeshi;Kogure, Noriyuki;Kitajima, Mariko;Takayama, Hiromitsu. And the article was included in MedChemComm in 2012.Synthetic Route of C8H4ClNO This article mentions the following:

4-Chlorocolchicine derivatives were synthesized with a view of developing new anticancer agents. The derivatives were examined for their potent activity and effective dosage range in mice, as well as favorable metabolic stability. As a result, several compounds bearing an 伪-hydroxyalkanoyl group on the C-7 amino function, were revealed to exhibit potent activities with broad effective dosage ranges. The title compounds thus formed included a colchicine amide derivative (I) and related substances. The title compounds were evaluated against N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide (colchicine). The synthesis of the target compounds was achieved using (7S)-7-amino-4-chloro-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one (4-chlorodeacetylcolchicine) as a starting material. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Synthetic Route of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics