Tag: 100-200

Synthesis and bioactivities of phenazine-1-carboxylic piperazine derivatives was written by Han, Fei;Yan, Ru;Zhang, Min;Xiang, Zhu;Wu, Qinglai;Li, Junkai. And the article was included in Natural Product Research in 2020.Application of 620-19-9 This article mentions the following:

Phenazine-1-carboxylic acid (PCA) as a natural product which has significant inhibition effects against many soil-borne fungal phytopathogens in agricultural application and has been registered in China as the fungicide against rice sheath blight. In order to find new higher fungicidal activities lead compounds and develop new eco-friendly agrochems., we introduced substructure piperazines which also have high biol. activity into PCA, designed and synthesized a series of phenazine-1-carboxylic piperazine derivatives, and their structures were confirmed by ¹H NMR and HRMS. Most compounds exhibited certain in vitro fungicidal activities. In particular, Compounds exhibited the activity against all the tested pathogenic fungi, such as Rhizoctonia solani, Alternaria solani, Fusarium oxysporum, Fusarium graminearum, Pyricularia oryzae Cavgra, with the EC₅₀ value of 24.6渭M, 42.9渭M, 73.7渭M, 73.8渭M, 34.2渭M, resp., more potent activities than PCA (33.2渭M, 81.5渭M, 186.5渭M, 176.4渭M, 37.3渭M). This result provided a highly active lead compound for the further structure optimization design. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iodide-Catalyzed Carbonylation-Benzylation of Benzyl Chlorides with Potassium Aryltrifluoroborates under Ambient Pressure of Carbon Monoxide was written by Han, Wei;Chen, Junjie;Jin, Fengli;Yuan, Xiaorong. And the article was included in Synlett in 2018.Electric Literature of C8H9Cl This article mentions the following:

The novel transition-metal free synthesis of a wide range of 1,2,3-triarylpropan-1-ones R¹CH₂CHR¹C(O)R² (R¹ = Ph, 3,4-Cl₂C₆H₃, 3-MeOC₆H₄, etc.; R² = Ph, 4-FC₆H₄, 2-naphthyl, etc.) in high yields was developed via tetrabutylammonium iodide-catalyzed carbonylation-benzylation of unactivated benzyl chlorides R¹CH₂Cl with potassium aryltrifluoroborates R²BF₃K using CO gas under ambient pressure. This protocol provides an inexpensive and operationally simple method for synthesis of 1,2,3-triarylpropan-1-ones and represented a significant improvement over the traditional palladium-catalyzed carbonylation. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Electric Literature of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions was written by Magnus, Christopher J.;Lee, Peter H.;Atasoy, Deniz;Su, Helen H.;Looger, Loren L.;Sternson, Scott M.. And the article was included in Science (Washington, DC, United States) in 2011.Category: chlorides-buliding-blocks This article mentions the following:

Ionic flux mediates essential physiol. and behavioral functions in defined cell populations. Cell type-specific activators of diverse ionic conductances are needed for probing these effects. We combined chem. and protein engineering to enable the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharmacol. selectivity and divergent functional properties. The LGICs and their small-mol. effectors were able to activate a range of ionic conductances in genetically specified cell types. LGICs constructed for neuronal perturbation could be used to selectively manipulate neuron activity in mammalian brains in vivo. The diversity of ion channel tools accessible from this approach will be useful for examining the relationship between neuronal activity and animal behavior, as well as for cell biol. and physiol. applications requiring chem. control of ion conductance. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Category: chlorides-buliding-blocks).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

1-(2-Thienyl)-2-phenylethylamines as potential non-stimulant anorectics was written by Mrongovius, R. I.;Ghosh, P.;Bolt, A. G.;Ternai, B.. And the article was included in Arzneimittel-Forschung in 1981.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Thirty-one 1-(2-thienyl)-2-phenylethylamines I (R = H, Cl, F, Br, CF₃, Me, OMe, or NO₂; R¹ = H or Et; and R² = H, Et, Ac, iso-Pr, or benzyl) were prepared and tested for anorectic and motor-stimulating activity. About half of the compounds produced anorexia and only one of these active agents increased motor activity. The 3 most potent anorectics without motor-stimulating activity were 1-(2-thienyl)-2-(4-chlorophenyl)ethylamine-HCl聽聽[80154-70-7], N-isopropyl-1-(2-thienyl)-2-(4-chlorophenyl)ethylamine-HCl聽聽[80154-71-8], and N-isopropyl-1-(2-thienyl)-2-(4-fluorophenyl)ethylamine-HCl聽聽[80154-82-1]. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyclic tertiary sulfamates: Selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives was written by De Monte, Celeste;Carradori, Simone;Secci, Daniela;D’Ascenzio, Melissa;Vullo, Daniela;Ceruso, Mariangela;Supuran, Claudiu T.. And the article was included in European Journal of Medicinal Chemistry in 2014.Recommanded Product: 697-73-4 This article mentions the following:

Carbonic anhydrase (hCA) IX and XII isoforms are over-expressed both in primary and in metastatic cell lines of hypoxic tumors and are innovative targets for cancer diagnosis and treatment. On the basis of the importance of the pharmacophoric sulfamate moiety (bioisostere of the sulfonamide group) present in the structure of recent human CA inhibitors, the authors designed N-alkylated I [R = CH₂:CH, MeC(O), EtO₂C, etc.] and O-alkylated derivatives II of acesulfame, a cyclic tertiary sulfamate, assessing the inhibitory activity against the ubiquitous isoforms hCA I and II and the cancer-related isoforms hCA IX and XII. All derivatives were nanomolar inhibitors, with some of them possessing an outstanding selectivity towards the tumor-associated hCA IX and/or hCA XII isoforms. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient synthesis of (R)-ochratoxin alpha, the key precursor to the mycotoxin ochratoxin A was written by Lenz, Cesar Antonio;Rychlik, Michael. And the article was included in Tetrahedron Letters in 2013.Recommanded Product: 3438-16-2 This article mentions the following:

Two new routes for the synthesis of enantiomerically pure ochratoxin 伪 (I) ((3R)-OT伪) are presented, which is the key intermediate for the synthesis of ochratoxin A (OTA) by coupling reaction with the amino acid L-phenylalanine. The key step of both routes is the one pot directed ortho-metalation/alkylation/lactonization of unprotected and suitably functionalized aromatic carboxylic acids, using lithium tetramethylpiperidide (LTMP) and (R)-propylene oxide. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Recommanded Product: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper (II) immobilized on magnetically separable L-arginine-尾-cyclodextrin ligand system as a robust and green catalyst for direct oxidation of primary alcohols and benzyl halides to acids in neat conditions was written by Nejad, Masoumeh Jadidi;Salamatmanesh, Arefe;Heydari, Akbar. And the article was included in Journal of Organometallic Chemistry in 2020.Computed Properties of C8H9Cl This article mentions the following:

Copper (II) immobilized on L-arginine-尾-cyclodextrin-functionalized magnetite nanoparticles (nano-Fe₃O₄@L-arginine-CD-Cu(II)) were successfully synthesized and fully characterized using FT-IR, XRD, SEM, EDX, ICP, TGA and VSM techniques. The catalytic activity of these magnetically retrievable nanoparticles was evaluated in the direct oxidation of primary alcs. and benzyl halides to acids in neat conditions that was observed to proceed well and products were obtained in good yields. In addition to showing good catalytic activity, the magnetic catalyst is easy to synthesize and could be recycled at least five times with little loss in activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Computed Properties of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The organocatalytic enantiodivergent fluorination of 尾-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters was written by Xie, Shaolei;He, Zhi-Juan;Zhang, Ling-Hui;Huang, Bo-Lun;Chen, Xiao-Wei;Zhan, Zong-Song;Zhang, Fu-Min. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Synthetic Route of C9H9ClO2 This article mentions the following:

Com. available cinchona alkaloids that can catalyze the enantiodivergent fluorination of 尾-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A meta-selective C-H borylation directed by a secondary interaction between ligand and substrate was written by Kuninobu, Yoichiro;Ida, Haruka;Nishi, Mitsumi;Kanai, Motomu. And the article was included in Nature Chemistry in 2015.Safety of 3-Cyanobenzoyl chloride This article mentions the following:

Regioselective C-H bond transformations are potentially the most efficient method for the synthesis of organic mols. However, the presence of many C-H bonds in organic mols. and the high activation barrier for these reactions make these transformations difficult. Directing groups in the reaction substrate are often used to control regioselectivity, which has been especially successful for the ortho-selective functionalization of aromatic substrates. Here, authors describe an iridium-catalyzed meta-selective C-H borylation of aromatic compounds using a newly designed catalytic system. The bipyridine-derived ligand that binds iridium contains a pendant urea moiety. A secondary interaction between this urea and a hydrogen-bond acceptor in the substrate places the iridium in close proximity to the meta-C-H bond and thus controls the regioselectivity. ¹H NMR studies and control experiments support the participation of hydrogen bonds in inducing regioselectivity. Reversible direction of the catalyst through hydrogen bonds is a versatile concept for regioselective C-H transformations. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Safety of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy was written by Amato, George;Roeloffs, Rosemarie;Rigdon, Greg C.;Antonio, Brett;Mersch, Theresa;McNaughton-Smith, Grant;Wickenden, Alan D.;Fritch, Paul;Suto, Mark J.. And the article was included in ACS Medicinal Chemistry Letters in 2011.HPLC of Formula: 1711-11-1 This article mentions the following:

A series of N-pyridyl benzamide KCNQ2/Q3 potassium channel openers were identified and found to be active in animal models of epilepsy and pain. The best compound 12 [ICA-027243, N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide] has an EC₅₀ of 0.38 渭M and is selective for KCNQ2/Q3 channels. This compound was active in several rodent models of epilepsy and pain but upon repeated dosing had a number of unacceptable toxicities that prevented further development. On the basis of the structure-activity relationships developed around 12, a second compound, 51, [N-(2-chloro-pyrimidin-5-yl)-3,4-difluoro-benzamide, ICA-069673], was prepared and advanced into a phase 1 clin. study. Herein, we describe the structure-activity relationships that led to the identification of compound 12 and to the corresponding pyrimidine 51. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics