Tag: 200-300

Thin-film composite membranes with programmable in-plane heterostructure for high degree-of-freedom performance control was written by Jiang, Chi;Ma, Xiupeng;Zhang, Liping;Tian, Lei;Li, Peng;Hou, Yingfei;Niu, Q. Jason. And the article was included in Journal of Membrane Science in 2022.Recommanded Product: 4422-95-1 This article mentions the following:

Ultra-efficient membrane separation technologies are needed to reduce the cost of mol. separations However, the two-dimensional isotropy of conventional selective membrane limits the freedom for deep optimization of separation process. In addition, the membrane separation properties, e.g. permeability, are difficult to be accurately pre-determined according to actual needs of applications, because membrane fabrication is largely empirical and lacks highly-controllable structure variable. Herein, we develop a novel thin-film composite membrane with high controllability, where two kinds of polyamides differing in structural and physicochem. properties are integrated into a unity according to pre-designed proportion and distribution, by generating heterogeneous polymerization interface with the help of inkjet printing. The separation performance of the heterostructure (HS) membranes show function relationships with the fabrication parameters (the essence is the ratio of different structures). The separation properties of every point (micron scale) of membrane can be individually managed. Thus, the HS design not only enables programmable, pre-determined membrane separation properties, but also opens the door to controlling their spatial distribution within membrane plane. Furthermore, the membrane with gradient permeability is proposed to solve the problem of flux imbalance within membrane elements, showing the great potential of the HS design in ultra-efficient membrane separation process. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Non-Nucleoside Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus NS5B Polymerase: Inhibition of Subgenomic Hepatitis C Virus RNA Replicons in Huh-7 Cells was written by Beaulieu, Pierre L.;Bousquet, Yves;Gauthier, Jean;Gillard, James;Marquis, Martin;McKercher, Ginette;Pellerin, Charles;Valois, Serge;Kukolj, George. And the article was included in Journal of Medicinal Chemistry in 2004.Computed Properties of C9H8ClNO4 This article mentions the following:

A previously disclosed series of nonnucleoside allosteric inhibitors of the NS5B polymerase of the hepatitis C virus (HCV) was optimized to yield novel compounds with improved physicochem. properties and activity in cell-based assays. Replacement of ionizable carboxylic acids with neutral substituents in lead compounds produced inhibitors with cellular permeability and antiviral activity in a cell-based assay of subgenomic HCV RNA replication (replicon EC₅₀ as low as 1.7 渭M). The improvement in potency in this ex vivo model of HCV RNA replication validates, in part, the mechanism by which this class of allosteric benzimidazole derivatives inhibits the polymerase and represents a significant step forward in the discovery of novel HCV therapeutics. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Computed Properties of C9H8ClNO4).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C9H8ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of oxidation of substituted 纬-ketoacid by N-chlorosaccharin in aqueous acetic acid medium was written by Farook, N. A. Mohamed;Alhaji, N. M. I.. And the article was included in International Journal of Chemical Sciences in 2004.Synthetic Route of C7H4ClNO3S This article mentions the following:

The kinetics of oxidation of a 纬-ketoacid namely, 4-oxo-4-(3′-4′-dimethylphenyl)butanoic acid by N-chlorosaccharin in aqueous acetic acid medium in the presence of perchloric acid have been investigated potentiometrically. The observed rate of oxidation is first order each in [KA], [NCSA] and [H⁺]. The main product of the oxidation is 3,4-dimethylbenzoic acid. The rate decreases with the addition of saccharin, one of the products of the reaction. Variation in ionic strength of the reaction medium has no significant effect on the rate of oxidation, but the rate of the reaction is enhanced by lowering the dielec. constant of the reaction medium. Hypochlorous acidium ion (H₂O⁺Cl), has been postulated as the reactive oxidizing species. A suitable mechanism consistent with the exptl. results has been proposed. The activation parameters have been computed with respect to slow step of the mechanism. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Synthetic Route of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly was written by Cole, Andrew G.;Kultgen, Steven G.;Mani, Nagraj;Ardzinski, Andrzej;Fan, Kristi Yi;Thi, Emily P.;Dorsey, Bruce D.;Stever, Kim;Chiu, Tim;Tang, Sunny;Daly, Owen;Phelps, Janet R.;Harasym, Troy;Olland, Andrea;Suto, Robert K.;Sofia, Michael J.. And the article was included in RSC Medicinal Chemistry in 2022.Product Details of 76-83-5 This article mentions the following:

Disruption of the HBV viral life cycle with small mols. that prevent the encapsidation of pregenomic RNA and viral polymerase through binding to HBV core protein is a clin. validated approach to inhibiting HBV viral replication. Herein we report the further optimization of clin. candidate AB-506 through core modification with a focus on increasing oral exposure and oral half-life. Maintenance of high levels of anti-HBV cellular potency in conjunction with improvements in pharmacokinetic properties led to multi-log₁₀ reductions in serum HBV DNA following low, once-daily oral dosing for key analogs in a preclin. animal model of HBV replication. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Product Details of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyclic amine sulfonamides as linkers in the design and synthesis of novel human 尾₃ adrenergic receptor agonists was written by Sum, Fuk-Wah;Wong, Victoria;Han, Stella;Largis, Elwood;Mulvey, Ruth;Tillett, Jeff. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Application of 1138-56-3 This article mentions the following:

Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human 尾₃ adrenergic receptor (尾₃-AR) agonists. The azetidine derivative, and piperidine derivatives were found to be potent 尾₃-AR agonists and have good selectivity against 尾₁– and 尾₂-AR. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Application of 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rare Medium-Sized Rings Prepared via Hydrolytic Imidazoline Ring Expansion (HIRE) was written by Osipyan, Angelina;Sapegin, Alexander;Novikov, Alexander S.;Krasavin, Mikhail. And the article was included in Journal of Organic Chemistry in 2018.Quality Control of Methyl 6-chloro-5-nitronicotinate This article mentions the following:

The hydrolytic imidazoline ring expansion (HIRE) methodol. was extended to readily available tetracyclic [1,4]thiazepines as well as sulfoxide and sulfone analogs thereof. The reactions resulted in the facile formation of a rare medium-sized [1,4,7]thiazecine ring system that has an emerging utility in bioactive compound design. Comparing the HIRE rates for representative compounds in the three groups of substrates allowed drawing some generalizations about the substituent effects on the course of the reaction. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Quality Control of Methyl 6-chloro-5-nitronicotinate).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of Methyl 6-chloro-5-nitronicotinate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Petroleum hydrocarbon fingerprints of water and sediment samples of Buffalo River Estuary in the Eastern Cape province, South Africa was written by Adeniji, A. O.;Okoh, O. O.;Okoh, A. I.. And the article was included in Journal of Analytical Methods in Chemistry in 2017.Safety of 1-Chlorooctadecane This article mentions the following:

Petroleum hydrocarbon status of the Buffalo River Estuary in East London, South Africa, was evaluated from Jan. to May, 2016. Surface water and sediment samples were collected from five points in the estuary and extracted using standard methods. The extracts were subsequently analyzed by gas chromatog.-flame ionization detection. Results showed that total petroleum hydrocarbon (TPH) varied from 7.65 to 477 渭g/L in the water and 12.59 to 1,100 mg/kg in the sediments, with mean values of 146.50 卤 27.96 渭g/L and 209.81 卤 63.82 mg/kg, resp. Concentrations of TPH in the sediments correlated significantly with organic carbon (OC) in both seasons. TPH and OC levels were sligthly lower in summer than in autumn in the two environmental matrixes, and the average amount of TPH in the water samples collected from all the sampling stations was generally lower than the EU standard limit of 300 渭g/L. However, the levels in the sediments exceeded the EGASPIN target value (50 mg/kg) for mineral oil but were below the intervention value (5,000 mg/kg), indicating a serious impact of industrial growth and urbanization on the area, although the n-alkane ratios and indexes used for source tracking revealed excessive flow from both natural and anthropogenic sources. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Safety of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sulfonylpiperazines based on a flavone as antioxidant and cytotoxic agents was written by Patel, Rahul V.;Mistry, Bhupendra M.;Syed, Riyaz;Parekh, Nikhil M.;Shin, Han-Seung. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2019.Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

Chrysin-based sulfonylpiperazines 7a-k were synthesized and investigated for their in vitro free radical scavenging potential as well as cytotoxic efficacies against selected cancer cell lines. Cytotoxicity of the new compounds toward noncancer cells was confirmed using the SRB assay against Madin-Darby Canine Kidney cells. Reaction of piperazine with different substituted benzenesulfonyl chlorides in triethylamine furnished sulfonylpiperazines (3a-k), which were then allowed to react with 7-(4-bromobutoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one (6) prepared reacting chrysin with 1,4-dibromobutane to give the final derivatives 7a-k. The results concluded that chrysin-sulfonylpiperazines exerted better antioxidant and anticancer efficacies than previously studied chrysin-piperazine precursors. For example, compounds 7h, 7j, and 7k with 4-OCF₃, 4-OCH₃, and 2,4-diOCH₃ groups exhibited the best antioxidant potential against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals. Moreover, halogenated analogs (7b, 7c, 7g, and 7h) demonstrated promising anticancer potential against SK-OV3, HeLa, and HT-29 cell lines, whereas those bearing a methoxy functional group (7j and 7k) had beneficial effects against the cell lines A-549 and HT-29. Thus, it can be confirmed from the bioassay results that the overall structural design as well as proper substitution is crucial to deliver the anticipated biol. effects. Spectroscopic techniques such as FT-IR, ¹H NMR, ¹³C NMR, mass and elemental anal. (CHN) were carried out to confirm the final structures. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and bioactivities of novel piperonylic acid derivatives containing a sulfonic acid ester moiety was written by Xie, Dandan;Hu, Xin;Ren, Xiaoli;Yang, Zaiping. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Related Products of 777-44-6 This article mentions the following:

In order to develop efficient, broad-spectrum and structurally simple agricultural bactericide, the structure of piperonylic acid was modified and a series of novel piperonylic acid derivatives I [R = Ph, 2-naphthyl, benzyl, etc.] containing a sulfonic acid ester moiety was synthesized. Bioassay results indicated the compounds I exhibited significantly antibacterial activities. Among them, compound I [R = phenyl] exhibited excellent antibacterial activities against Pseudomonas syringae pv. Actinidiae (Psa), with inhibitory value 99 and 85% at 100渭g/mL and 50渭g/mL, resp., which was higher than that of thiodiazole-copper (84 and 77%) and bismerthiazol (96 and 78%). In addition, some compounds also showed moderate insecticidal activity against Spodoptera frugiperda. The above mentioned results confirm the broadening of the application of piperonylic acid, with reliable support for the development of novel agrochem. bactericide. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Polyoxometalate-modified halloysite nanotubes-based thin-film nanocomposite membrane for efficient organic solvent nanofiltration was written by He, Hongru;Xu, Pan;Wang, Daming;Zhou, Hongwei;Chen, Chunhai. And the article was included in Separation and Purification Technology in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

Polyoxometalate-modified halloysite nanotubes (POM@MHNTs) were synthesized and doped into the polyamide (PA) matrix by interfacial polymerization to prepare doped POM@MHNTs thin-film nanocomposite (TFN) membranes for organic solvent nanofiltration (OSN). It is worth noting that the methanol flux of the TFN can be efficiently enhanced by tuning the contents of POM@MHNTs. The as-synthesized optimal sample (TFN-0.10) exhibits superior methanol flux of TFN-0.10 membrane of 14.80 L m^-2 h^-1 bar^-1 (1.76 times of that of undoped TFC membrane and 1.12 times of that of doped HNTs membrane (TFN-HNTs-0.10). These are mainly due to the tubular structure of POM@MHNTs providing addnl. solvent transfer channels and the ridge-valley morphol. of the membrane surface increasing the contact area between the membrane and the solvent. Meanwhile, the POM@MHNTs nanohybrids are similarly electrostatically attracted by the amide groups on the polyamide chains produced by interfacial polymerization, improving the compatibility of POM@MHNTs with polyamide membranes. TFN-0.10 OSN membrane showed stable chem. properties in medium polar organic (methanol, ethanol, THF), acid polar organic (acetonitrile), and strong polar organic (DMF) solvents. Prepared TFN OSN membranes exhibited strong long-term operation capability and organic solvent resistance after 80掳C DMF immersion for 7 days with inconspicuous separation performance changes. This work offers the prospect of using organic-inorganic hybrid modified nanomaterials to improve OSN performance. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics