Tag: 200-300

GC-MS analysis of essential oil from flowers of Melia toosendan was written by Wei, Ping;Qu, Qinghui;Jiang, Huimin;Cirenyangzong;Wang, Junxian. And the article was included in Xibei Yaoxue Zazhi in 2014.Application In Synthesis of 1-Chlorooctadecane This article mentions the following:

The aim is to analyze the chem. constituents of the essential oil from the fresh and the dried flowers of Melia toosendan. The chem. components of the essential oil were analyzed by GC-MS. 22 Peaks were separated totally, and 16 compounds were identified from the fresh flowers, which accounted for 72.73%. The oil contained mainly alkanes, also contained nitrogen and chlorine compounds 41 Peaks were separated totally, and 33 compounds were identified from the dried ones, which accounted for 80.49%. The oil contained mainly alc. and acid compounds, and didn’t contain nitrogen and chlorine compounds The relative content of each component was calculated by peak area normalization method. It was the first time to extract and analyze the essential oil from the dried and the fresh flowers of Melia toosendan. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Application In Synthesis of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Modulating the Asymmetry of the Active Layer in Pursuit of Nanofiltration Selectivity via Differentiating Interfacial Reactions of Piperazine was written by Gao, Yawei;Zhao, Yangying;Wang, Xiao-mao;Tang, Chuyang;Huang, Xia. And the article was included in Environmental Science & Technology in 2022.Electric Literature of C9H3Cl3O3 This article mentions the following:

Nanofiltration (NF), highly prospective for drinking water treatment, faces a challenge in simultaneously removing emerging contaminants while maintaining mineral salts, particularly divalent cations. To overcome this challenge, NF membranes possessing small pores concomitant with highly neg. charged surfaces were synthesized via a two-step fabrication strategy. The key is to generate a polyamide active layer having a loose and carboxyl group-abundant segment on top and a dense barrier segment underneath. This was achieved by restrained interfacial polymerization between trimesoyl chloride and partly protonated piperazine to form a highly depth-heterogeneous polyamide network, followed by second amidation in an organic environment to remove untethered polyamide fragments and associate malonyl chlorides with reserved amine groups to introduce more neg. charges. Most importantly, on first-principle engineering the spatial architecture of the polyamide layer, amplifying asym. charge distribution was paired with the thinning of the vertical structure. The optimized membrane exhibits high salt/organic rejection selectivity and water permeance superior to most NF membranes reported previously. The rejections of eight emerging contaminants were in the range of 66.0-94.4%, much higher than the MgCl₂ rejection of 41.1%. This new fabrication strategy, suitable for various diacyl chlorides, along with the new membranes so produced, offers a novel option for NF in potable water systems. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Electric Literature of C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, Synthesis, and Biological Activity of Novel Fungicides Containing a 1,2,3,4-Tetrahydroquinoline Scaffold and Acting as Laccase Inhibitors was written by Zhang, Xiaoming;Xu, Huan;Su, Huifei;Yang, Xinling;Sun, Tengda;Lu, Xingxing;Shi, Fasheng;Duan, Hongxia;Liu, Xili;Ling, Yun. And the article was included in Journal of Agricultural and Food Chemistry in 2022.Formula: C7H4ClF3O2S This article mentions the following:

In this work, PMDD-5Y was selected as a lead compound, designed and used to synthesize a series of novel sulfonyl hydrazide derivatives containing the natural product scaffold 1,2,3,4-tetrahydroquinoline I (R¹ = H, 6-Me, 2-Me; R² = 2-chlorophenyl, 4-nitrophenyl, Bu, etc.; X = O, S) . The new compounds I had antifungal activities against several fungi, especially Valsa mali and Sclerotinia sclerotiorum. One compound I (R¹ = H, R¹ = 4-chlorophenyl, X = S) displayed very good in vitro activity against S. sclerotiorum and V. mali, with EC50 values of 3.32 and 2.78渭g/mL, resp. The results of an enzyme activity assay showed that compound I (R¹ = H, R¹ = 4-tert-butylphenyl, X = S) had the best inhibitory activity against laccase, with an EC50 value of 14.85渭g/mL. This was more active than the lead compound PMDD-5Y and the pos. control cysteine. Using a mol. docking method, the binding mode of the title compounds I with laccase was studied . The structural features of these new laccase inhibitors as fungicides will advance research and impact the field of discovering more potent fungicides to control diseases in agriculture. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ring-Expansion Reactions of Epoxy Amides and Enamides: Functionalized Azetidines, Dihydrofurans, Diazocanes, or Dioxa-3-azabicyclonon-4-enes? was written by Suraj;Swamy, K. C. Kumara. And the article was included in Journal of Organic Chemistry in 2022.Product Details of 777-44-6 This article mentions the following:

Functionalized azetidines I [R¹ = Ph, 4-MeC₆H₄, 2-naphthyl, etc.; R² = Ph, 2-BrC₆H₄, 2-IC₆H₄, etc.], 2,3-dihydrofurans II [R³ = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.] or the unorthodox dioxa-3-azabicyclonone-4-ene motifs III [R⁴ = Ph, 4-BrC₆H₄, 2-naphthyl, etc.; R⁵ = Ph, 4-MeC₆H₄, 2-BrC₆H₄, etc.] were the products from transition metal-free reaction between N-oxiranylmethyl benzenesulfonamide and 尾-chloro-cinnamaldehyde, depending on whether one uses either NaI/K₂CO₃ or LiBr/K₂CO₃. These ring expansion reactions involved enamide (X-ray evidence) derived from N-oxiranylmethyl benzenesulfonamide and 尾-chloro-cinnamaldehyde as an intermediate. The N-oxiranylmethyl benzenesulfonamide itself upon heating gave readily separable and crystalline isomeric diazocanes that could be characterized by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Product Details of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Improvement of mechanical properties and heat distortion temperature of polylactic acid by highly aromatic hyperbranched polyamide was written by Sun, Jianjian;Huang, Yansong;Jin, Yujuan;Tian, Huafeng;Men, Shuang. And the article was included in Journal of Applied Polymer Science in 2022.HPLC of Formula: 4422-95-1 This article mentions the following:

The highly aromatic hyperbranched polyamide (HBPA) was synthesized and used as a modifier in order to enhance the phys. performance of polylactic acid (PLA). The results showed that compared to the neat PLA, the tensile strength of the PLA/HBPA blends increased by 41.8%; fracture energy increased by 42.8% when the content of HBPA was 1.0 phr. The addition of HBPA can significantly improve the thermal deformation temperature of PLA. The polarized optical microscope images suggested that HBPA can act as a nucleating agent for PLA during the isothermal crystallization This research indicated HBPA exhibits excellent reinforcing effect for PLA, due to the formation of hydrogen bonds and/or chem. crosslinking between HBPA and PLA. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1HPLC of Formula: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli was written by Chan, Michael;Lao, Fitzgerald S.;Chu, Paul J.;Shpigelman, Jonathan;Yao, Shiyin;Nan, Jason;Sato-Kaneko, Fumi;Li, Vicky;Hayashi, Tomoko;Corr, Maripat;Carson, Dennis A.;Cottam, Howard B.;Shukla, Nikunj M.. And the article was included in Journal of Medicinal Chemistry in 2019.Category: chlorides-buliding-blocks This article mentions the following:

Agents that safely induce, enhance, or sustain multiple innate immune signaling pathways could be developed as potent vaccine adjuvants or coadjuvants. Using high-throughput screens with cell-based nuclear factor 魏B (NF-魏B) and interferon stimulating response element (ISRE) reporter assays, we identified a bis-aryl sulfonamide bearing compound 1 that demonstrated sustained NF-魏B and ISRE activation after a primary stimulus with lipopolysaccharide or interferon-伪, resp. Here, we present systematic structure-activity relationship (SAR) studies on the two Ph rings and amide nitrogen of the sulfonamide group of compound 1 focused toward identification of affinity probes. The murine vaccination studies showed that compounds 1 and 33 when used as coadjuvants with monophosphoryl lipid A (MPLA) showed significant enhancement in antigen ovalbumin-specific Ig responses compared to MPLA alone. SAR studies pointed to the sites on the scaffold that can tolerate the introduction of aryl azide, biotin, and fluorescent rhodamine substituents to obtain several affinity and photoaffinity probes which will be utilized in concert for future target identification and mechanism of action studies. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Category: chlorides-buliding-blocks).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Exploring ibuprofen derivatives as 伪-glucosidase and lipoxygenase inhibitors: Cytotoxicity and in silico studies was written by Daud, Saima;Abid, Obaid-ur-Rahman;Sardar, Asma;Abdullah, Shawana;Shahid, Wardah;Ashraf, Muhammad;Ejaz, Syeda Abida;Saeed, Amna;Shah, Basit Ali;Niaz, Basit. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2022.Synthetic Route of C7H3Cl2NS This article mentions the following:

This study reports the synthesis of a series of ibuprofen derivatives, including thiosemicarbazides 4a-f, 1,3,4-oxadiazoles 5a-f, 1,3,4-thiadiazoles 6a-f, 1,2,4-triazoles 7a-f, and their S-alkylated derivatives 8a-d. All of the newly synthesized derivatives were analyzed using 1H NMR, 13C NMR spectroscopy, and high-resolution mass spectra (electron ionization) spectrometry. These synthetic mols. were examined for their in vitro baking yeast 伪-glucosidase and soybean 15-lipoxygenase (15-LOX) inhibition and cell viability studies. The results revealed that the compounds N-(3,4-dichlorophenyl)-5-[1-(4-isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5f (IC50 3.05 卤 1.23 渭M) and N-(3-fluorophenyl)-5-[1-(4-isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5b (IC50 3.12 卤 1.21 渭M) were the most potent with respect to the 伪-glucosidase enzyme while in case of 15-LOX, the compound 4-(2,4-dichlorophenyl)-1-[2-(4-isobutylphenyl)propanoyl]thiosemicarbazide 4e showed potent inhibition with an IC50 value of 55.41 卤 0.41 渭M. All these compounds were found least toxic by displaying a blood mononuclear cell viability value of 69.2%-97.8% by the MTT assay compared to the standards when assayed at 0.25 mM concentration Mol. docking analyses were conducted to evaluate the inhibition profiles of these derivatives against the said enzymes and the data supported the in vitro profiles. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Synthetic Route of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives was written by Bagul, Suresh D.;Rajput, Jamatsing D.;Tadavi, Samina K.;Bendre, Ratnamala S.. And the article was included in Research on Chemical Intermediates in 2017.HPLC of Formula: 777-44-6 This article mentions the following:

Abstract: Sulfonamides have enormous importance in biol. sciences. In the present investigation, the fundamental energetic group, hydrazide-based sulfonamide, has been incorporated into a naturally occurring phenolic monoterpenoid, carvacrol (5-isopropyl-2-methylphenol) moiety, with the aim of combining the active groups to generate more potent antimicrobial and anti-oxidant agents. Series of hydrazide-based sulfonamide derivatives (IV a-g) have been synthesized and characterized by modern sophisticated techniques such as ¹H NMR, ¹³C NMR and LC-MS. The newly synthesized derivatives were screened for their antimicrobial activities against three fungal (Aspergillus niger, A. flavus and A. fumigatus) and three bacterial (Escherichia coli, Staphylococcus aureus and Bacillus subtilis) species, of which compounds IVc and IVd were found to have good antifungal activity and compounds IVd and IVg exhibited decent antibacterial activities. Antioxidant activity was performed by DPPH radical scavenging assay. Compound IVd has been found to be more active in comparison to standard ascorbic acid and compounds IVa, IVb, and IVc demonstrated excellent antioxidant activity. Graphical Abstract: [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient Syntheses of Benzothiazepines as Antagonists for the Mitochondrial Sodium-Calcium Exchanger: Potential Therapeutics for Type II Diabetes was written by Pei, Yazhong;Lilly, Michael J.;Owen, David J.;D’Souza, Lawrence J.;Tang, Xiao-Qing;Yu, Jinghua;Nazarbaghi, Ramina;Hunter, Andrew;Anderson, Christen M.;Glasco, Susan;Ede, Nicholas J.;James, Ian W.;Maitra, Uday;Chandrasekaran, S.;Moos, Walter H.;Ghosh, Soumitra S.. And the article was included in Journal of Organic Chemistry in 2003.Computed Properties of C11H14ClNO2 This article mentions the following:

Type II diabetes mellitus is a chronic metabolic disorder that can lead to serious cardiovascular, renal, neurol., and retinal complications. While several drugs are currently prescribed to treat type II diabetes, their efficacy is limited by mechanism-related side effects (weight gain, hypoglycemia, gastrointestinal distress), inadequate efficacy for use as monotherapy, and the development of tolerance to the agents. Consequently, combination therapies are frequently employed to effectively regulate blood glucose levels. We have focused on the mitochondrial sodium-calcium exchanger (mNCE) as a novel target for diabetes drug discovery. We have proposed that inhibition of the mNCE can be used to regulate calcium flux across the mitochondrial membrane, thereby enhancing mitochondrial oxidative metabolism, which in turn enhances glucose-stimulated insulin secretion (GSIS) in the pancreatic 尾-cell. In this paper, we report the facile synthesis of benzothiazepines, e.g., I, and derivatives by S-alkylation using 2-aminobenzhydrols. The syntheses of other bicyclic analogs based on benzothiazepine, benzothiazecine, benzodiazecine, and benzodiazepine templates are also described. These compounds have been evaluated for their inhibition of mNCE activity, and the results from the structure-activity relationship (SAR) studies are discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Computed Properties of C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and properties of 2-guanidinopurines was written by Cesnek, Michal;Masojidkova, Milena;Holy, Antonin;Solinova, Veronika;Koval, Dusan;Kasicka, Vaclav. And the article was included in Collection of Czechoslovak Chemical Communications in 2006.Recommanded Product: 203436-45-7 This article mentions the following:

2-Guanidinopurines were prepared as derivatives of 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]-9H-purine (PMEDAP) (I), which shows an important antiviral activity. It completes earlier described synthesis of 6-guanidinopurine derivatives The title compounds were obtained by the reaction of the corresponding 2-chloropurines with guanidine. 2- And 6-guanidinopurines were used as model compounds for determination of dissociation constants (pK_a) of their ionogenic groups by capillary zone electrophoresis. The pK_a values of ionogenic groups of the above compounds were compared with those of the corresponding aminopurines. The pK_a of guanidino group at the purine moiety varies from 7.77 to 10.32. There is no protonation of N¹-position in contrast to aminopurines. None of these compounds showed any antiviral activity. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Recommanded Product: 203436-45-7).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 203436-45-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics