Tag: 300-400

Characterization of triclosan-induced hepatotoxicity and triclocarban-triggered enterotoxicity in mice by multiple omics screening was written by Song, Yuchen;Zhang, Cui;Lei, Hehua;Qin, Mengyu;Chen, Gui;Wu, Fang;Chen, Chuan;Cao, Zheng;Zhang, Ce;Wu, Mengjing;Chen, Xiaoyu;Zhang, Limin. And the article was included in Science of the Total Environment in 2022.COA of Formula: C13H9Cl3N2O This article mentions the following:

Triclosan (2,4,4-trichloro-2-hydroxydiphenyl ether, TCS) and triclocarban (3,4,4-trichloro-carbanilide, TCC) are two antimicrobial agents commonly used for personal care products. Previous studies primarily focused on resp. harmful effects of TCS and TCC. In terms of their structural similarities and differences, however, the structure-toxicity relationships on health effects of TCS and TCC exposure remain unclear. Herein, global 1H NMR-based metabolomics was employed to screen the changes of metabolic profiling in various biol. matrixes including liver, serum, urine, feces and intestine of mice exposed to TCS and TCC at chronic and acute dosages. Metagenomics was also applied to analyze the gut microbiota modulation by TCS and TCC exposure. Targeted MS-based metabolites quantification, histopathol. examination and biol. assays were subsequently conducted to supply confirmatory information on resp. toxicity of TCS and TCC. We found that oral administration of TCS mainly induced significant liver injuries accompanied with inflammation and dysfunction, hepatic steatosis fatty acids and bile acids metabolism disorders; while TCC exposure caused marked intestine injuries leading to striking disruption of colonic morphol., inflammatory status and intestinal barrier integrity, intestinal bile acids metabolism and microbial community. These comparative results provide novel insights into structure-dependent mechanisms of TCS-induced hepatotoxicity and TCC-triggered enterotoxicity in mice. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2COA of Formula: C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fate, toxicity and effect of triclocarban on the microbial community in wastewater treatment systems was written by Wang, Hao;Yun, Hui;Li, Minghan;Cui, Hanlin;Ma, Xiaodan;Zhang, Yanqing;Pei, Xuanyuan;Zhang, Liying;Shi, Ke;Li, Zhiling;Liang, Bin;Wang, Aijie;Zhou, Jizhong. And the article was included in Journal of Hazardous Materials in 2022.Computed Properties of C13H9Cl3N2O This article mentions the following:

Triclocarban (TCC), one of the typical antimicrobial agents, is a contaminant of emerging concern commonly found in high concentration in water environments. However, the fate and toxicity of TCC in wastewater treatment systems remain poorly understood. Here, we investigated how TCC impacts COD and inorganic nitrogen transformation in a hydrolytic anaerobic-anoxic/oxic process. In the anaerobic section, the transformation of TCC was dominated by reductive dechlorination and supplemented by two amid bonds hydrolysis. In the anoxic and oxic sections, the hydrolysis of amid bonds dominated. The toxicity was reduced after the treatment (IC₅₀ from 0.09 to 0.54). TCC inhibited NH⁺₄-N removal in the anaerobic section and led to the NO^–₃-N accumulation (2.84-4.13 mg/L) after treatment, with the abundance of N-removal bacteria decreased by 6%. Furthermore, the original ecol. niche was gradually replaced by TCC-resistant/degradative bacteria, formating new microbial modules to resist the TCC stress. Importantly, fourteen genera including Methanosaeta, Longilinea, Dokdonella and Mycobacterium as potential bioindicators warning TCC and its intermediates were proposed. Overall, this study provides new insights into the fate of TCC in biol. wastewater treatment systems and suggests a great importance for TCC control to ensure the health and resilience of ecosystems. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Computed Properties of C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Age, gender, and racial/ethnic differences in the association of triclocarban with adulthood obesity using NHANES 2013-2016 was written by Uche, Uloma Igara;King, Christopher C.. And the article was included in Archives of Environmental & Occupational Health in 2022.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

This study examined the association between triclocarban and obesity among US adults and compared the pattern of this association across age, gender, and racial/ethnic groups. Study found triclocarban to be associated with obesity (OR: OR:1.123 95% CI: 1.046, 1.205) and this association remained among women (OR:1.14 95% CI: 1.031, 1.261). Study participants aged 60 years and older were more likely to be overweight (OR:1.131 95% CI: 1.022 1.251) and obese (OR:1.192 95% CI: 1.079, 1.317) when compared to other age groups. Likewise, non-Hispanic whites (OR:1.126 95% CI: 1.003, 1.263) and “other race including multi-racial” (OR:1.431 95% CI: 1.219, 1.679) were more likely to be obese when compared to other racial/ethnic groups. In conclusion, triclocarban is associated with obesity among US adults and there is evidence of gender, age, and racial/ethnicity differences in the association In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and properties of high-temperature mesomorphic polysiloxane (MEPSIL) solvents: biphenyl- and terphenyl-based nematic systems was written by Apfel, M. A.;Finkelmann, H.;Janini, G. M.;Laub, R. J.;Luehmann, B. H.;Price, A.;Roberts, W. L.;Shaw, T. J.;Smith, C. A.. And the article was included in Analytical Chemistry in 1985.Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) This article mentions the following:

Mesomorphic (liquid-crystalline) side-chain siloxanes were prepared for evaluation as stationary phases in gas chromatog. by hydrosilylation of 4-(allyloxy)benzoate esters by Me hydrogen siloxanes in the presence of a dicyclopentadienylplatinum (II)chloride聽聽[12083-92-0] catalyst. The products were characterized by IR, NMR, gas chromatog., DSC, elemental anal., and hot-stage, polarized optical microscopy. Their selectivity was substantially different from that of other common gas chromatog. solvents. The one best suited for use in gas chromatog. had m.p. 139掳, nematic-isotropic transition temperature 319掳, and practical operating limits of 150 to >300掳. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation and ligand displacement reactions of diene(polyfluorophenyl)platinum(II) complexes was written by Deacon, G. B.;Nelson-Reed, K. T.. And the article was included in Journal of Organometallic Chemistry in 1987.HPLC of Formula: 12083-92-0 This article mentions the following:

The complexes PtR₂(diene) [R = C₆F₅ or p-HC₆F₄; diene = cis,cis-cycloocta-1,5-diene (cod), dicyclopentadiene (dcy), norbornadiene (nbd), hexa-1,5-diene (hex)] have been prepared by the organolithium route. Reaction of PtCl₂(cod) with an equimolar amount of TlO₂CR (R = C₆F₅, p-HC₆F₄) in pyridine yields Pt(R)Cl(cod), which have been converted into Pt(R)X(cod) (X = Br or iodo) by halogen exchange reactions. Other decarboxylations result in diene displacement giving cis-Pt(C₆F₅)Cl(py)₂ and cis– and trans-Pt(C₆F₅)₂(py)₂. The complexes, cis-Pt(C₆F₅)₂L₂ (L = py or Ph₃P) and cis-Pt(p-HC₆F₄)₂(PPh₃)₂ are formed by ligand replacement reactions of PtR₂(cod), but Pt(C₆F₅)₂ (cod) does not react with N,N,N‘,N‘-tetramethylethylenediamine (tmed) nor Pt(C₆F₅)₂(nbd or dcy) with ethylenediamine (en). Diene displacement occurs more readily from PtR₂(hex) giving Pt(C₆F₅)₂L₂ [L₂ = cis-(NH₃)₂, en, tmed, 1,10-phenanthroline) and cis-Pt(p-HC₆F₄)₂(PPh₃)₂. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0HPLC of Formula: 12083-92-0).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 12083-92-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile fabrication of ternary MWCNTs/ZnO/Chitosan nanocomposite for enhanced photocatalytic degradation of methylene blue and antibacterial activity was written by Malekkiani, Mitra;Heshmati Jannat Magham, Abbas;Ravari, Fatemeh;Dadmehr, Mehdi. And the article was included in Scientific Reports in 2022.Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

Developing a cheap, stable and effective photocatalyst is necessary for remediation of persistent organic pollutants. To address this challenge, we proposed a unique interfacial engineering technique and proper bandgap matching strategy to synthesize MWCNTs/ZnO/Chitosan ternary nanocomposite for effective photocatalytic application. The features of the prepared samples were determined by FESEM, TEM, EDX, elemental mapping, AFM, FT-IR, XRD, UV-Vis spectroscopy and BET surface anal. The obtained results showed successful fabrication of synthesized nanocomposites with enhanced surface area. Degradation effect of nanostructures on methylene blue (MB) and antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) pathogenic strains were investigated. The proposed photocatalytic mechanism illustrated the electron transfer facilitated by MWCNTs/ZnO/Chitosan structure which results in spatial separation of electron-hole pairs. Compared with ZnO and ZnO/Chitosan, the prepared MWCNTs/ZnO/Chitosan ternary nanocomposite showed high usage of UV illumination and superior separation of photogenerated electron-hole pairs. MWCNTs/ZnO/Chitosan illustrated 86.26% adsorption rate and outstanding increased photocatalytic activity on MB degradation efficiency of 98.76% after 20 min. Stability of photocatalyst reached from 98.76% initial decolorization to 85% at the fourth cycle. In addition, the ternary nanocomposite also exhibited remarkable bactericidal activity against gram-pos. (S.聽aureus) and (B.聽subtilis) and gram-neg. (E.聽coli) bacteria strains. Due to the obtained results, the prepared nanocomposite would be an efficient candidate photocatalyst with antibacterial properties. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Age, gender, and racial/ethnic differences in the association of triclocarban with adulthood obesity using NHANES 2013-2016 was written by Uche, Uloma Igara;King, Christopher C.. And the article was included in Archives of Environmental & Occupational Health in 2022.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

This study examined the association between triclocarban and obesity among US adults and compared the pattern of this association across age, gender, and racial/ethnic groups. Study found triclocarban to be associated with obesity (OR: OR:1.123 95% CI: 1.046, 1.205) and this association remained among women (OR:1.14 95% CI: 1.031, 1.261). Study participants aged 60 years and older were more likely to be overweight (OR:1.131 95% CI: 1.022 1.251) and obese (OR:1.192 95% CI: 1.079, 1.317) when compared to other age groups. Likewise, non-Hispanic whites (OR:1.126 95% CI: 1.003, 1.263) and “other race including multi-racial” (OR:1.431 95% CI: 1.219, 1.679) were more likely to be obese when compared to other racial/ethnic groups. In conclusion, triclocarban is associated with obesity among US adults and there is evidence of gender, age, and racial/ethnicity differences in the association In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hydrosilylation conditions applied on alkenyl benzylated xyloses: selective reduction and isomerization was written by Hadad, Caroline;Bouquillon, Sandrine;Harakat, Dominique;Muzart, Jacques. And the article was included in Applied Organometallic Chemistry in 2009.Category: chlorides-buliding-blocks This article mentions the following:

In the presence of triethylsilane and different transition metal catalysts, the main reactive pathways observed from benzylated xyloses bearing an unsaturated tether were the reduction and the isomerization of the double bond without debenzylation of the sugar moiety. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Category: chlorides-buliding-blocks).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Occurrence of endocrine disrupting chemicals (EDCs) in river water, ground water and agricultural soils of India was written by Saha, S.;Narayanan, N.;Singh, N.;Gupta, S.. And the article was included in International Journal of Environmental Science and Technology in 2022.Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

Endocrine disrupting chems. are exogenous chems. which alter the functions of endocrine system. There are very few studies of occurrence and distribution of endocrine disrupting chems. in water, soil and their potential human health risks under Indian conditions. In the present work, occurrence of eleven endocrine disrupting chems. namely bisphenol-A, triclosan, triclocarbon, 4-nonylphenol, 4-tert octylphenol, Me paraben, Pr paraben, Bu paraben, benzyl Bu phthalate, di (2-ethylhexyl) phthalate and di-Bu phthalate have been investigated in 20 river water samples, 5 ground water samples and 23 agricultural soil samples collected from 26 sampling points of different agro-climatic zones of India during 2019-2020. Instrument detection and quantification limits of different endocrine disrupting chems. using LC-MS/MS varied from 0.001 to 0.05 and 0.005-0.1 μg/mL, resp. Detection frequencies of bisphenol A, 4-nonylphenol, 4-tert octylphenol and di-Bu phthalate were 100% in river water samples. In ground water samples di-Bu phthalate, benzyl Bu phthalate, di (2-ethylhexyl) phthalate, triclosan, triclocarbon, 4-tert octylphenol, 4-nonylphenol, Pr paraben and Bu paraben and in soils 4-tert octylphenol, 4-nonylphenol, bisphenol-A and di-Bu phthalate were detected in 100% sample. High mean concentrations of di (2-ethylhexyl) phthalate were recorded in river waters (2706.135 μg/L), ground waters (3203.33 μg/L) and agricultural soils (1005.490 ng/g). Other chems. detected in high concentrations were 4-tert octylphenol (180.680-829.93 μg/L), di-Bu phthalate (117.492-182.29 μg/L) and bisphenol-A (13.99-228.03 μg/L). Widespread distribution and high concentrations of these chems. in water and soil is a cause of concern and, therefore, continued monitoring of these chems. in different environmental matrixes is the need of the hour. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Line ferries and cargo ships for the monitoring of marine contaminants of emerging concern: Application along a Europe-Arctic transect was written by Brumovsky, Miroslav;Becanova, Jitka;Sanka, Ondrej;Loeken, Katharina Bjarnar;Baho, Didier L.;Soerensen, Kai;Nizzetto, Luca. And the article was included in Journal of Hazardous Materials in 2022.Recommanded Product: 101-20-2 This article mentions the following:

Contaminants of emerging concern (CEC) are a focus in marine protection. Several CECs are released with wastewater effluents to coastal environments and their offshore occurrence has been recently documented. Routine monitoring is key for implementing marine protection acts, however infrastructural, financial, and tech. limitations hinder this task along broad spatial transects. Here we show the efficacy of a new infrastructure enabling unmanned sampling of surface water from ships of opportunity in providing reliable and cost-effective routine monitoring of CECs along a Europe-Arctic transect. The distribution and long-range transport of several pharmaceuticals and personal care products, artificial food additives, and stimulants were assessed. Validation of operations through strict procedural and anal. quality criteria is presented. A framework to estimate a compound-specific spatial range (SR) index of marine long-range transport based on monitoring results and information on source spatial distribution, is introduced. Estimated SR values ranged 50-350 km depending on compound, yielding a ranking of long-range transport potential which reflected expectations based on degradation half-lives. SR values were used to calculate prior maps of detection probability that can be used to plan future routine monitoring in the region. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Recommanded Product: 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics