Tag: 500-600

Zhu, Chenghao; Chu, Haoke; Li, Gen; Ma, Shengming; Zhang, Junliang published their research in Journal of the American Chemical Society on December 11 ,2019. The article was titled 《Pd-Catalyzed Enantioselective Heck Reaction of Aryl Triflates and Alkynes》.Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) The article contains the following contents:

The first palladium-catalyzed asym. Heck reaction between aryl triflates and alkynes to give trisubstituted allenes with high er under mild reaction conditions is described. The key to the success is the discovery and fine-tuning of the different N-substituents of Xu-Phos, which ensure the enantioselectivity and reactivity. Synthetic transformation of the chiral allenes with high chirality transfer was also demonstrated. In the experiment, the researchers used many compounds, for example, Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

da Cunha, Gislaine A.; de Souza, Ronan F. F.; de Farias, Renan L.; Moreira, Mariete B.; Silva, Debora E. S.; Zanetti, Renan D.; Garcia, Daniel M.; Spindola, Daniel G.; Michelin, Luis F. G.; Bincoletto, Claudia; de Souza, Aline A.; Antunes, Alyne A.; Judice, Wagner A. de S.; Leitao, Renan C. F.; Deflon, Victor M.; Mauro, Antonio E.; Netto, Adelino V. G. published their research in Journal of Inorganic Biochemistry on February 29 ,2020. The article was titled 《Cyclopalladated compounds containing 2,6-lutidine: Synthesis, spectral and biological studies》.Product Details of 18987-59-2 The article contains the following contents:

Bridge splitting reactions between [Pd(C2,N-dmba)(μ-X)]2 (dmba = N,N-dimethylbenzylamine; X = Cl, I, N3, NCO) and 2,6-lutidine (lut) in the 1:2 molar ratio at room temperature afforded cyclopalladated compounds of general formulas [Pd(C2,N-dmba)(X)(lut)] {X = Cl- (1), I- (2), NNN- (3), NCO- (4)}, which were characterized by elemental analyses and IR, 1H NMR spectroscopy. The mol. structures of all synthesized palladacycles have been solved by single-crystal x-ray crystallog. The cytotoxicity of the cyclopalladated compounds has been evaluated against a panel of murine {mammary carcinoma (4T1) and melanoma (B16F10-Nex2)} and human {melanoma (A2058, SK-MEL-110 and SK-MEL-5)} tumor cell lines. All complexes were about 10 to 100-fold more active than cisplatin, depending on the tested tumor cell line. For comparison purposes, the cytotoxic effects of 1-4 towards human lung fibroblasts (MRC-5) have also been tested. The late apoptosis-inducing properties of 1-4 compounds in SK-MEL-5 cells were verified 24 h incubation using annexin V-Fluorescein isothiocyanate (FITC)/propidium iodide (PI). The binding properties of the model compound 1 on human serum albumin (HSA) and calf thymus DNA (ct-DNA) have been studied using CD and fluorescence spectroscopy. Docking simulations have been carried out to gain more information about the interaction of the palladacycle and HSA. The ability of compounds 1-4 to inhibit the activity of cathepsin B and L has also been investigated in this work.Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Product Details of 18987-59-2) was used in this study.

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Product Details of 18987-59-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,European Journal of Inorganic Chemistry included an article by Werle, Christophe; Karmazin, Lydia; Bailly, Corinne; Djukic, Jean-Pierre. Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II). The article was titled 《Effect of Enhanced Electron Withdrawal on the Cohesion of Cr-Pd Hemichelates》. The information in the text is summarized as follows:

Bimetallic chromium-palladium and trimetallic dichromium-palladium fluorenyl hemichelates I (4a, M absent, Q = CH2, R = Me, X = H; 4b, M = (CO)3Cr, Q = CH2, R = Me, X = H; 5a, M absent, R2NQ = 4-tert-butyl-2-pyridyl, X = NMe2; 5b, M = (CO)3Cr, R2NQ = 4-tert-butyl-2-pyridyl, X = NMe2) were synthesized and fully characterized. Their mol. structures obtained by X-ray diffraction anal. do not show major differences – in interat. bond lengths within the Pd coordination sphere – when compared to previously reported bimetallic analogs. Theor. investigations were performed using methods of the D. Functional Theory (ZORA-PBE-D3(BJ)/all electron TZP level, EDA, ETS-NOCV and QTAIM-IQA) to analyze the influence of a second Cr(CO)3 moiety in the process of formation of the Cr-Pd hemichelate. Theory shows that despite the extensive charge delocalization in the anion of trans-bistricarbonylchromium(fluorene), the formation of a stable hemichelate is still possible albeit requiring a moderate energy payload to funnel charge d. towards the formation of the benzylic carbon-palladium bond. IQA analyses of hemichelates show the important role of attractive electrostatic interactions in the dominantly noncovalent Cr(CO)3-Pd interactions. In the experiment, the researchers used Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2020,Chemical Communications (Cambridge, United Kingdom) included an article by Tao, Mengna; Li, Wenbo; Zhang, Junliang. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II). The article was titled 《Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization of norbornene and norbornadiene》. The information in the text is summarized as follows:

A highly enantioselective Pd/Xiang-Phos-catalyzed carboheterofunctionalization of norbornene is described, giving a direct access to various chiral norbornane-fused dihydrofurans and dihydropyrroles. This synthetic methodol. provides the first example of asym. carboetherification of norbornene, and also tolerates norbornadiene well. The experimental part of the paper was very detailed, including the reaction process of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis and characterization of a cyclometallated palladium(II) complex with (2-diphenylphosphino)ethylamine》 were Elsegood, Mark R. J.; Han, Jiabao; Smith, Martin B.; Wu, Shimeng. And the article was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2019. Category: chlorides-buliding-blocks The author mentioned the following in the article:

Reaction of com. available Ph2PCH2CH2NH2 with {PdCl(C9H12N)}2 (2:1) in CH2Cl2 afforded, instead of Pd(Cl)(P-Ph2PCH2CH2NH2)(C9H12N) , the cationic complex [Pd(P,N-Ph2PCH2CH2NH2)(C9H12N)]Cl which was characterized by single crystal x-ray crystallog. The lack of reactivity of towards Rhodamine 6G can therefore be rationalized. In the part of experimental materials, we found many familiar compounds, such as Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Category: chlorides-buliding-blocks)

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics