Tag: 800-900

Gupta, Saswata; Sabbasani, Venkata R.; Su, Siyuan; Wink, Donald J.; Lee, Daesung published their research in ACS Catalysis in 2021. The article was titled 《Alkene-Chelated Ruthenium Alkylidenes: A Missing Link to New Catalysts》.Name: Benzylidenebis(tricyclohexylphosphine)dichlororuthenium The article contains the following contents:

A variety of heteroatom-chelated Ru alkylidenes were developed as metathesis-active catalysts. Alkene-chelated Ru alkylidenes, however, were not considered as a viable alternative because alkene coordination is a necessary step in the catalytic cycle. Relying on common design principles with varying steric and electronic factors, structurally diverse alkene-chelated Ru alkylidene complexes were prepared by trapping the intermediates of enyne ring-closing metathesis (RCM) of 1,n-enynes and diynes with a stoichiometric amount of an initiator Ru complex. One of the crucial structural elements that promotes the formation of 1,5-alkene-chelates is the exo-Thorpe-Ingold effect, exerted by a gem-dialkyl moiety. These alkene-chelated complexes show a trans relation between the N-heterocyclic carbene (NHC) ligand and the chelated alkene. However, η3-vinyl alkylidene complexes were generated from the RCM of ynamide-tethered 1,n-enynes. The presence of an ynamide moiety with a right connectivity is essential for the formation of these rare η3-vinyl alkylidene complexes with a cis relation between the N-heterocyclic carbene (NHC) ligand and the chelated alkene. The stability and reactivity of these alkene-chelated Ru alkylidenes could be finely tuned to show characteristic behaviors in RCM, cross-metathesis (CM), and ring-opening metathesis polymerization (ROMP) reactions. In the part of experimental materials, we found many familiar compounds, such as Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Name: Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Name: Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Single-Component Polycondensation of Bis(alkoxycarbonyldiazomethyl)aromatic Compounds To Afford Poly(arylene vinylene)s with an Alkoxycarbonyl Group on Each Vinylene Carbon Atom》 was written by Shimomoto, Hiroaki; Moriya, Taka-aki; Mori, Takeshi; Itoh, Tomomichi; Kanehashi, Shinji; Ogino, Kenji; Ihara, Eiji. HPLC of Formula: 172222-30-9 And the article was included in ACS Omega in 2020. The article conveys some information:

The original synthetic strategy for a new type of poly(arylene vinylene) (PAV) is presented, where the C=C-bond-forming coupling of bis(alkoxycarbonyldiazomethyl)aromatic compounds is utilized as propagation. The strategy is unique in that the resulting PAVs have an alkoxycarbonyl group as an electron-withdrawing substituent on each vinylene carbon atom in the polymer main chain. Among the transition-metal catalysts examined in this study, RuCl(cod)Cp* (cod = 1,5-cyclooctadiene, Cp* = pentamethylcyclopentadienyl) is the most efficient, affording PAVs from a series of bis(alkoxycarbonyldiazomethyl)aromatic compounds with a high trans-C=C-forming selectivity of up to 90%. A PAV sample with a fluorenylene framework as an arylene moiety prepared by the Ru catalyst exhibited a hole mobility of 4 × 10-6 cm2 V-1 s-1. In the experimental materials used by the author, we found Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9HPLC of Formula: 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.HPLC of Formula: 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of Benzylidenebis(tricyclohexylphosphine)dichlororutheniumIn 2022 ,《Polymers from organosilicon derivatives of 5-norbornene-2-methanol for membrane gas separation》 appeared in Polymer. The author of the article were Adreyanov, Fedor A.; Alentiev, Dmitry A.; Lunin, Artyom O.; Borisov, Ilya L.; Volkov, Alexey V.; Finkelshtein, Eugene Sh; Ren, Xiang-Kui; Bermeshev, Maxim V.. The article conveys some information:

In this work, we have proposed a new strategy to the synthesis of norbornene-type monomers with Si-O-C structural motifs via a straightforward and selective dehydrogenative addition reaction between 5-norbornene-2-methanol and trialkylsilanes. As a result, a set of monomers with various trilalkylsiloxy groups (alkyl – CH3, C2H5, and n-C3H7) was synthesized with the yields of 89-90%. These monomers exhibited a high reactivity in both metathesis and vinyl-addition polymerization, affording high-mol.-weight products in yields up to 90%. The metathesis polymers were rubbery with glass transition temperatures from -29 to +23°C, while related isomeric vinyl-addition polynorbornenes were glassy polymers. Permeability (P) and diffusion (D) coefficients for these polymers were systematically evaluated for permanent gases (He, H2, O2, N2, and CO2) and C1-C4 alkanes. Studying their gas transport properties allowed to establish new structure-property relationships. Particularly, the length of alkyl fragments in trilalkylsiloxy group affected differently gas permeability of metathesis (rubbery) and vinyl-addition (glassy) polymers. Besides, it was shown that the method of linking the Si-O-C-containing group to the main chains of polymers played very important role: Alk3SiO-substituted polynorbornenes are more permeable than isomeric (AlkO)Alk2Si-substituted ones. For the metathesis polynorbornenes, P(CO2) were in the range of 152-226 Barrer, and ideal selectivity (α) of CO2/N2 – 13-16; for the vinyl-addition polynorbornenes, P(CO2) = 230-500 Barrer, and α(CO2/N2) = 14-17. Among studied polymers, promising results for ethane/methane separation was demonstrated by metathesis polynorbornene bearing tri(n-propyl)siloxymethyl substituents: P(C2H6) = 138 Barrer and α(C2H6/CH4) = 2.4. The obtained polymers were also characterized by using TGA, WAXD, and nitrogen adsorption-desorption methods. The experimental part of the paper was very detailed, including the reaction process of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Application In Synthesis of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Application In Synthesis of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Nepal, Prabin; Kalapugama, Suneth; Shevlin, Michael; Naber, John R.; Campeau, Louis-Charles; Pezzetta, Cristofer; Carlone, Armando; Cobley, Christopher J.; Bergens, Steven H. published an article in ACS Catalysis. The title of the article was 《Polycationic Rh-JosiPhos Polymers Supported on Phosphotungstic Acid/Al2O3 by Multiple Electrostatic Attractions》.Electric Literature of C43H72Cl2P2Ru The author mentioned the following in the article:

Cationic Rh-JosiPhos complexes were tethered to crowded, ring-opening olefin metathesis (ROMP)-active norbornene groups. These monomers underwent facile, alternating ROMP (alt-ROMP) with cyclooctene as the co-monomer catalyzed by RuCl2(:CHPh)(PCy3)2 to form linear, polycationic copolymers. The polymers were readily absorbed by phosphotungstic acid (PTA) on Al2O3 via multiple electrostatic attractions between the cationic Rh centers in the polymer and the PTA anions on the Al2O3 support. The enantioselective hydrogenation of di-Me itaconate occurred with 100% conversion, 5000 turnovers per run, with up to 96% ee, and without significant Rh leaching over 10 reuses of the catalyst. The results came from multiple reactions, including the reaction of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Electric Literature of C43H72Cl2P2Ru)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Electric Literature of C43H72Cl2P2Ru

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kaden, Felix; Metz, Peter published their research in Organic Letters in 2021. The article was titled 《Enantioselective Total Synthesis of the Guaianolide (-)-Dehydrocostus Lactone by Enediyne Metathesis》.HPLC of Formula: 172222-30-9 The article contains the following contents:

The hydroazulene core of the bioactive sesquiterpenoid (-)-dehydrocostus lactone was generated by domino enediyne metathesis. A triple hydroboration/oxidation of the resultant conjugated triene installed three out of four stereogenic centers of the target in a single step. The enantiopure acyclic metathesis substrate was readily available by an asym. anti aldol reaction. Masking of the γ-lactone as an acetal allowed for an efficient completion of the synthesis through late-stage double carbonyl olefination. In the experimental materials used by the author, we found Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9HPLC of Formula: 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.HPLC of Formula: 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

He, Hengxi; Qiu, Guirong; Wang, Weixiang; Gu, Haibin published an article in 2021. The article was titled 《Micelles of ferrocene/aldehyde-containing triblock polynorbornene: Preparation, biocompatibility, dual-cargo-loading and oxidation/pH-sensitive release behavior》, and you may find the article in Materials Letters.Quality Control of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium The information in the text is summarized as follows:

Using the ring-opening metathesis polymerization, a new amphipathic triblock polynorbornene-based copolymer containing reactive aldehyde, redox-active ferrocene, and dendritic oligoethylene glycols units (PNCHO-PNFc-PNTEG), was controllably synthesized and exhibited the dual-cargo loading capacity with the oxidation/pH stimuli-responsive behavior. PNCHO-PNFc-PNTEG could conjugate the amino-containing doxorubicin (DOX) by the acid-sensitive Schiff base reaction. The DOX-grafted PNCHO-PNFc-PNTEG could further self-assemble into spherical nanoscale polymeric micelles that can encapsulate the second model cargo rhodamine B (RhB). The step-by-step release behavior of the loaded two cargos was observed Namely, the loaded RhB could be firstly released under the stimulus of oxidant, and the grafted DOX could be then released under acidic condition. Moreover, PNCHO-PNFc-PNTEG micelles showed excellent biocompatibility both in in vitro L929 cell test and in vivo zebrafish embryo toxicity experiments Thus, PNCHO-PNFc-PNTEG as polymeric carrier has great application potential in the medical field for controllable drug release. The results came from multiple reactions, including the reaction of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Quality Control of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Quality Control of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth》 was written by Bouclier, Celine; Simon, Matthieu; Laconde, Guillaume; Pellerano, Morgan; Diot, Sebastien; Lantuejoul, Sylvie; Busser, Benoit; Vanwonterghem, Laetitia; Vollaire, Julien; Josserand, Veronique; Legrand, Baptiste; Coll, Jean-Luc; Amblard, Muriel; Hurbin, Amandine; Morris, May C.. Category: chlorides-buliding-blocks And the article was included in Theranostics in 2020. The article conveys some information:

CDK4/cyclin D kinase constitutes an attractive pharmacol. target for development of anticancer therapeutics, in particular in KRAS-mutant lung cancer patients, who have a poor prognosis and no targeted therapy available yet. Although several ATP-competitive inhibitors of CDK4 have been developed for anticancer therapeutics, they suffer from limited specificity and efficacy. As an alternative to ATP-competitive inhibitors we have designed a stapled peptide to target the main interface between CDK4 and cyclin D, and have characterized its physico-chem. properties and affinity to bind cyclin D1. We have validated a pos. correlation between CDK4/cyclin D level and KRAS mutation in lung cancer patients. The stapled peptide enters cells rapidly and efficiently, and inhibits CDK4 kinase activity and proliferation in lung cancer cells. Its intrapulmonary administration in mice enables its retention in orthotopic lung tumors and complete inhibition of their growth when co-administered with Abemaciclib. The stapled peptide targeting the main interface between CDK4 and cyclin D provides promising therapeutic perspectives for patients with lung cancer. The results came from multiple reactions, including the reaction of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Category: chlorides-buliding-blocks)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Swart, Marthinus R.; Marais, Charlene; Erasmus, Elizabeth published an article in 2021. The article was titled 《Comparison of the Spectroscopically Measured Catalyst Transformation and Electrochemical Properties of Grubbs’ First- and Second-Generation Catalysts》, and you may find the article in ACS Omega.Application In Synthesis of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium The information in the text is summarized as follows:

According to UV-visible spectroscopy (0.10 mM, CH2Cl2 at 25°), the catalyst transformation (which could possibly include ligand dissociation with active catalyst formation, dimer formation, and decomposition) rate constants (kobs) of Grubbs’ 1st (1) and 2nd (2) generation catalysts are 7.48 × 10-5 and 1.52 x 10-4 s-1, resp. From 31P NMR (0.1M, CD2Cl2, at 25°), the catalyst transformation was 5.1% for 1 and 16.5% for 2 after 72 h. However, due to the larger concentrations of the NMR samples compared to the UV-visible samples, the extent of transformation did not correspond. The oxidation potential of the Ru(II)/Ru(III) couple of 2 (E°’ = 27.5 mV at v = 200 mV s-1) was considerably lower than that of 1 (E°’ = 167 mV at v = 200 mV s-1). In the case of 1, a 2nd reduction peak appeared at slow scan rates. This may probably be ascribed to an electrochem. active compound that was formed from the intermediate cation 1•+ and the subsequent reduction of the latter. The oxidation/reduction of 1 proceeds according to an ErCi electrochem. mechanism (Er = electrochem. reversible step, Ci = chem. irreversible step), whereas 2 proceeds according to an ErCr electrochem. mechanism (Er = electrochem. reversible step, Ci = chem. reversible step). The experimental part of the paper was very detailed, including the reaction process of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Application In Synthesis of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Application In Synthesis of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kotha, Sambasivarao; Pulletikurti, Sunil; Fatma, Ambareen; Dhangar, Gopal; Naidu, Gonna Somu published an article in 2021. The article was titled 《Synthesis of Polycycles and Oxacycles via Tandem Metathesis of endo -Norbornene Derivatives》, and you may find the article in Synthesis.Computed Properties of C43H72Cl2P2Ru The information in the text is summarized as follows:

Here, the presence of a carbonyl group at C7 position prevents the olefin metathesis of endo-norbornene derivatives due to complexation of the metal alkylidene has been demonstrated. Time-dependent NMR studies showed the presence of new proton signals in the metal alkylidene region, which indicate the formation of metal complex with the carbonyl group of the substrate. These observations were further proved by ESI-MS anal. Whereas computational studies showed that the catalyst was interacting with the C7 carbonyl group and aligned perpendicular to that of norbornene olefin. These endo-keto norbornene derivatives were reduced to hydroxyl derivatives diastereoselectively. Ring-rearrangement metathesis (RRM) of these hydroxyl derivatives, produced the [6/5/6], and [5/6/5] carbo-tricyclic cores of natural products in one step. Whereas the RRM of O-allyl derivatives, delivered the oxa-tricyclic compounds in a single step with excellent yields. The results came from multiple reactions, including the reaction of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Computed Properties of C43H72Cl2P2Ru)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Computed Properties of C43H72Cl2P2Ru

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sui, Xuelin; Gutekunst, Will R. published an article in ACS Macro Letters. The title of the article was 《Cascade Alternating Metathesis Cyclopolymerization of Diynes and Dihydrofuran》.Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium The author mentioned the following in the article:

Ruthenium alkoxymethylidene complexes have recently come into view as competent species for metathesis copolymerization reactions when coupled with appropriate comonomer targets. Here, we explore the ability of Fischer-type carbenes to participate in cascade alternating metathesis cyclopolymn. (CAMC) through facile terminal alkyne addition The combination of diyne monomers and an equal feed ratio of low-strain dihydrofuran leads to a controlled chain-growth copolymerization with high degrees of alternation (>97% alternating diads) and produces degradable polymer materials with low dispersities and targetable mol. weights When combined with enyne monomers, this method is amenable to the synthesis of alternating diblock copolymers that can be fully degraded to short oligomer fragments under aqueous acidic conditions. This work furthers the potential for the generation of functional metathesis materials via Fischer-type ruthenium alkylidenes.Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium) was used in this study.

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics