Tag: M.W=150-200

Vallejo-Montesinos, Javier published the artcileSynthesis and properties in solution of Gaussian homo asymmetric polysiloxanes with a bulky side group, Recommanded Product: Dichloro(hexyl)(methyl)silane, the publication is Journal of Inorganic and Organometallic Polymers and Materials (2012), 22(6), 1332-1340, database is CAplus.

The ring opening polymerization (ROP) of 1,3,5-trihexyl-1,3,5-trimethylcyclotrisiloxane (D⁶₃) and 1,3,5-triheptyl-1,3,5-trimethylcyclotrisiloxane (D⁷₃) was promoted by acid-treated synthetic silica-alumina to obtain Gaussian homo asym. polysiloxanes. The M_w was > 70 kg/mol, and the polymers were characterized using ²⁹Si NMR. The polymers were also characterized by measuring the refractive index, second virial coefficient (A₂), radius of gyration, weight-average mol. weight, number-average mol. weight and polydispersity using a gel permeation chromatog./light scattering (GPC/LS) coupled system. The A₂ exptl. value for the two polymers (between 4 and 6.5 × 10^-4 mol/mL g²) indicated that toluene was a good solvent.

Journal of Inorganic and Organometallic Polymers and Materials published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C6H4ClNO2, Recommanded Product: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roedl, Carmen B. published the artcileMulti-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is European Journal of Medicinal Chemistry (2014), 302-311, database is CAplus and MEDLINE.

Eicosanoids like leukotrienes and prostaglandins play a considerable role in inflammation. Produced within the arachidonic acid (AA) cascade, these lipid mediators are involved in the pathogenesis of pain as well as acute and chronic inflammatory diseases like rheumatoid arthritis and asthma. With regard to the lipid cross-talk within the AA pathway, a promising approach for an effective anti-inflammatory therapy is the development of inhibitors targeting more than one enzyme of this cascade. Within this study, thirty N-4-diaryl-1,3-thiazole-2-amine based compounds with different substitution patterns were synthesized and tested in various cell-based assays to investigate their activity and selectivity profile concerning five key enzymes involved in eicosanoid metabolism (5-, 12-, 15-lipoxygenase (LO), cyclooxygenase-1 and -2 (COX-1/-2)). With compound ST-1355, 2-(4-phenylthiazol-2-ylamino)phenol, a multitarget ligand targeting all tested enzymes is presented, whereas compound ST-1705, 2-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol, represents a potent and selective 5-LO and COX-2 inhibitor with an IC₅₀ value of 0.9±0.2 μM (5-LO) and a residual activity of 9.1±1.1% at 10 μM (COX-2 product formation). The promising characteristics and the addnl. noncytotoxic profile of both compounds reveal new lead structures for the treatment of eicosanoid-mediated diseases.

European Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shelly, Kevin P. published the artcileGeneral acid catalysis in the enolization of acetone, Application In Synthesis of 6249-56-5, the publication is Canadian Journal of Chemistry (1989), 67(8), 1274-82, database is CAplus.

Iodometry was used to study the enolization of acetone in water catalyzed by HCl, MeSO₃H, 24 aliphatic monocarboxylic acids, nine aromatic monocarboxylic acids, eight aliphatic dicarboxylic acids, and 20 monoanions of dicarboxylic acids. The log k-pK profile for unbuffered solutions of strong and moderately strong acids shows a maximum near pK â‰?0. The Broensted α value for a set of eight aliphatic monocarboxylic acids in which effects of bulk, charge, and polarizability are at a min. is 0.56. Steric effects, probably augmented by polarizability effects in some cases, cause pos. deviations form the Broensted line drawn with respect to these standard acids. Anionic carboxylic acids are also more reactive than would be predicted from their equilibrium acid strengthens, whereas cationic acids tend to be less reactive. Using D₂O as solvent has only a small effect on the rate of carboxylic acid catalysis. Using acetone-d₆ gives values of k_H/k_D in the range of 7.0-8.0 at 25°, values consistent with a proton or deuteron being transferred between two bases of comparable strength, the carboxylate anion and the enol form of acetone.

Canadian Journal of Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C8H5F3O3, Application In Synthesis of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Selvakumari, S. published the artcileDonor acceptor groups effect, polar protic solvents influence on electronic properties and reactivity of 2-Chloropyridine-4-carboxylic acid, Quality Control of 6313-54-8, the publication is Journal of the Indian Chemical Society (2022), 99(6), 100478, database is CAplus.

The computational reckoning of 2-Chloropyridine-4-carboxylic acid (2CP4CA) was accomplished employing DFT/B3LYP with the root set as 6-311++G(d, p). The impact of polar protic solvents which are eco-friendly solvents (water, methanol, ethanol, 1-propanol) on 2CP4CA were analyzed. To examine the solvent effect, vibrational investigations and NLO reports of 2CP4CA in dissimilar solvents were executed. Geometrical properties were also established in gas phase for 2CP4CA. Exercising VEDA program, the entire vibrational assignment was accomplished. Donor-acceptor exchanges were ascertained utilizing NBO scrutiny technique. Thermodn. properties of 2CP4CA were analyzed at different temperatures By applying TD – DFT approach, theoretic UV-Vis absorption spectrum was procured in different solvents. In order to evaluate the complete electron concentration and sensitive spots of 2CP4CA, MEP coupled with FMO analyzes were employed. HOMO along with LUMO orbitals and energy band gap were acquired for 2CP4CA employing dissimilar polar protic solvents. Addnl., ELF, LOL and charge transfer studies were also executed. RDG anal. has been exercised for revealing non-covalent interactions.

Journal of the Indian Chemical Society published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C14H31NO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chittiboyina, Amar G. published the artcileDesign and Synthesis of the First Generation of Dithiolane Thiazolidinedione- and Phenylacetic Acid-Based PPARγ Agonists, COA of Formula: C8H7ClO3, the publication is Journal of Medicinal Chemistry (2006), 49(14), 4072-4084, database is CAplus and MEDLINE.

A series of novel derivatives of potent antioxidant vitamin, α-lipoic acid, and related analogs were designed, synthesized, and evaluated for their PPARγ agonist activities. Compounds I and the water soluble analog II (R = COCH₂NH₂.HCl) were found to be potent PPARγ agonists. I appeared to have a significant role in improving insulin sensitivity and reducing triglyceride levels in fa/fa rats as well as inhibited proliferation of a variety of normal and neoplastic cultured human cell types. These novel compounds may prove efficacious not only in the treatment of Type 2 diabetes, but also atherosclerosis, prevention of vascular restenosis, and inflammatory skin diseases.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Balin, A. I. published the artcileAminodisulfides as additives to lubricating materials, Synthetic Route of 1002-41-1, the publication is Khimiya i Tekhnologiya Topliv i Masel (1980), 10-11, database is CAplus.

Refluxing (RCHClCH₂)₂S₂ (R is Ph [29184-39-2], octyl [74639-15-9], C_5-8 alkyl, or C_8-12 alkyl) with NH(CH₂CH₂OH)₂ [111-42-2] in H₂O or dioxane gave a series of [RCH[N(CH₂CH₂OH)₂]CH₂]₂S₂ derivatives which are used as antiwear additives in lubricating oils. The refluxing was carried out at 105-127° depending on solvent and reactants for 1-7 h. The yields were 76-90.5%. The products contained â‰?.2% Cl and were not corrosive.

Khimiya i Tekhnologiya Topliv i Masel published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Synthetic Route of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gabor, Krisztina published the artcileCharacterization of CprK1, a CRP/FNR-type transcriptional regulator of halorespiration from Desulfitobacterium hafniense, Related Products of chlorides-buliding-blocks, the publication is Journal of Bacteriology (2006), 188(7), 2604-2613, database is CAplus and MEDLINE.

The recently identified CprK branch of the CRP (cAMP receptor protein)-FNR (fumarate and nitrate reduction regulator) family of transcriptional regulators includes proteins that activate the transcription of genes encoding proteins involved in reductive dehalogenation of chlorinated aromatic compounds Here we report the characterization of the CprK1 protein from Desulfitobacterium hafniense, an anaerobic low-G+C gram-pos. bacterium that is capable of reductive dechlorination of 3-chloro-4-hydroxyphenylacetic acid (Cl-OHPA). The gene encoding CprK1 was cloned and functionally overexpressed in Escherichia coli, and the protein was subsequently purified to homogeneity. To investigate the interaction of CprK1 with three of its predicted binding sequences (dehaloboxes), we performed in vitro DNA-binding assays (electrophoretic mobility shift assays) as well as in vivo promoter probe assays. These results show that CprK1 binds its target dehaloboxes with high affinity (dissociation constant, 90 nM) in the presence of Cl-OHPA and that transcriptional initiation by CprK1 is influenced by deviations in the dehaloboxes from the consensus TTAAT—-ATTAA sequence. A mutant CprK1 protein was created by a Val→Glu substitution at a conserved position in the recognition α-helix that gained FNR-type DNA-binding specificity, recognizing the TTGAT—-ATCAA sequence (FNR box) instead of the dehaloboxes. CprK1 was subject to oxidative inactivation in vitro, most likely caused by the formation of an intermol. disulfide bridge between Cys11 and Cys200. The possibility of redox regulation of CprK1 by a thiol-disulfide exchange reaction was investigated by using two Cys→Ser mutants. These results indicate that a Cys11-Cys200 disulfide bridge does not appear to play a physiol. role in the regulation of CprK1.

Journal of Bacteriology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Maurya, Hardesh K. published the artcileStudies on substituted benzo[h]quinazolines, benzo[g]indazoles, pyrazoles, 2,6-diarylpyridines as anti-tubercular agents, Formula: C5H13Cl2N, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(21), 5844-5849, database is CAplus and MEDLINE.

Various substituted 5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine, 1-(3-(4-alkoxyphenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)ethanone, pyrazole and 2,6-diarylpyridine derivatives have been synthesized in good yields by an efficient methodol. The synthesized compounds were evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv strain. Compounds I (R = piperidin-1-yl, NMe₂), II, and III (R¹ = Br, H) exhibited significant anti-tubercular activity at MIC values 50, 100, 50, 25 and 100 μM concentration In vitro cytotoxicity data using THP-1 cells indicated that most active compound III (R¹ = Br) is safe as its MIC value is much lower than the cytotoxic value.

Bioorganic & Medicinal Chemistry Letters published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kumar, Puneet published the artcileMetal-Free Direct Transformation of Aryl Boronic Acid to Primary Amines, COA of Formula: C7H8BClO2, the publication is European Journal of Organic Chemistry (2022), 2022(27), e202200508, database is CAplus.

In this work, a transition-metal free approach for the construction of primary aromatic amines R/R¹NH₂ (R = 4-chlorophenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.)/(R¹ = Ph, 4-methylphenyl, 4-hydroxyphenyl, 4-chlorophenyl, 2-cyanophenyl) from aryl boronic acids RB(OH)₂ and esters R¹Bpin with N-Boc-O-tosylhydroxylamine as an amine surrogate was reported. Bench stable TsONHBoc is easy to use and it produces a non-interfering water-soluble byproduct. The protocol is operative for both electron-rich and electron-deficient aryl boronic acids under acidic conditions, wherein, the former arenes affords a better yield of the desired product. Even, sterically hindered and halogenated substrates are easily amenable under this reaction condition. The current protocol can be scaled up to produce gram-scale primary aromatic amines.

European Journal of Organic Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, COA of Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rowbottom, Martin W. published the artcileSynthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1), Computed Properties of 145349-62-8, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(14), 3439-3445, database is CAplus and MEDLINE.

A novel series of bis-aminopyrrolidine ureas containing either a 4-biphenylcarboxamide or 5-phenyl-2-thiophenecarboxamide group have been identified as potent and functional antagonists of the melanin-concentrating hormone receptor-1. Syntheses and SAR are described, which led to the discovery of compounds with high binding affinity (K_i = 1 nM) for the receptor. Preliminary in vitro metabolic stability data are also reported for key compounds

Bioorganic & Medicinal Chemistry Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics