Tag: M.W=150-200

Rowbottom, Martin W. published the artcileSynthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1), HPLC of Formula: 209919-30-2, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(14), 3439-3445, database is CAplus and MEDLINE.

A novel series of bis-aminopyrrolidine ureas containing either a 4-biphenylcarboxamide or 5-phenyl-2-thiophenecarboxamide group have been identified as potent and functional antagonists of the melanin-concentrating hormone receptor-1. Syntheses and SAR are described, which led to the discovery of compounds with high binding affinity (K_i = 1 nM) for the receptor. Preliminary in vitro metabolic stability data are also reported for key compounds

Bioorganic & Medicinal Chemistry Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, HPLC of Formula: 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rowbottom, Martin W. published the artcileSynthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1), Recommanded Product: (3-Chloro-5-cyanophenyl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(8), 2171-2178, database is CAplus and MEDLINE.

The design, synthesis, and SAR of a series of substituted spirohydantoins, e.g., I, are described. Optimization of an inhouse screening hit gave compounds that exhibited potent binding affinity and functional activity at MCH-R1.

Bioorganic & Medicinal Chemistry Letters published new progress about 915763-60-9. 915763-60-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (3-Chloro-5-cyanophenyl)boronic acid, and the molecular formula is C7H5BClNO2, Recommanded Product: (3-Chloro-5-cyanophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pundeer, Rashmi published the artcileGreen and expeditious synthesis of some 2-amino/arylamino-4-(1-naphthyl)thiazole derivatives using [hydroxy(tosyloxy)iodo]benzene, Application In Synthesis of 3696-23-9, the publication is Indian Journal of Heterocyclic Chemistry (2016), 25(3-4), 311-315, database is CAplus.

The synthesis of a series of 2-amino/arylamino-4-(1-naphthyl)thiazoles I (R = C₆H₅, 4-O₂NC₆H₄, 4-FC₆H₄, etc.) under solvent-free and eco-friendly conditions by applying ‘Grindstone Chem. Technique’ using [hydroxy(tosyloxy)iodo]benzene is described practicing the modified Hantzsch thiazole synthesis of α-tosyloxyacetonaphthone and thiourea/substituted thioureas.

Indian Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Epshtein, G. Yu. published the artcileHaloalkyl sulfides. II. Reaction of alkylene sulfides with halogens and sulfuryl chloride, HPLC of Formula: 1002-41-1, the publication is Zhurnal Obshchei Khimii (1964), 34(6), 1948-50, database is CAplus.

cf. CA 60, 7909h. Chlorination of alkylene sulfides in CCl₄ with ice cooling or treatment with SO₂Cl₂ in CCl₄ gave the following from the indicated starting materials: ClSCH₂CH₂Cl, 46% (from ethylene sulfide); ClSCH₂CH₂Br, 65% [from bis(2-bromoethyl)sulfide]; ClSCH₂CHMeCl, 42% (from propylene sulfide); ClSCH₂CHMeBr, 80% [from bis(2-bromopropyl)sulfide]; 2-chlorocyclohexylsulfenyl chloride, 44% (from cyclohexene sulfide); and (CICH₂CH₂)₂S₂, 63% (from ethylene sulfide and 1:2 proportion of either Cl or SO₂Cl₂). Reaction of appropriate halogens with alkylene sulfides in CCl₄ with ice cooling with 1:2 molar ratio of the reactants gave the following, also obtained similarly with SO₂Cl₂,: (BrCH₂CH₂S)₂, 63% (from ethylene sulfide); (ICH₂CH₂S)₂, 80% (from ethylene sulfide); (MeCHClCH₂S)₂, 63% (from propylene sulfide); (MeCHBrCH₂S)₂, 80% (from propylene sulfide); (MeCHICH₂S)₂, 80% (from propylene sulfide); and bis(2-chlorocyclohexyl) disulfide, 26% (from cyclohexene sulfide). 2-Chloropropylsulfenyl chloride treated with C₂H₄ 15 min. gave 70% ClCH₂CH₂SCH₂CHMeCl, b₅ 88°, d₁₄ 1.2426, n¹⁴_D 1.5221. This and chloramine-T in aqueous EtOH 25 hrs. gave 60% 2-chloroethyl 2-chloropropyl p-toluenesulfilimine, m. 136-7° (Fuson, et al., CA 41, 688d). The following constants were reported: ClSCH₂CH₂Cl, b₁₆ 52-4° d₂₀ 1.3851, n²⁰_D 1.5234; ClSCH₂CH₂Br, b₅ 60°, 1.7875, 1.5776; ClSCH₂CHMeCl, b₁₃ 40°, d₁₄ 1.3040, n¹⁴_D 1.5149; ClSCH₂CHMeBr, b₂ 55°, d₁₅ 1.6885, n¹⁵_D 1.5630; 2-chlorocyclohexylsulfenyl chloride, b₅ 104°, d₂₄ 1.2920, n²⁴_D 1.5455; (ClCH₂CH₂S)₂, b₅ 115° d₂₀ 1.3396, n²⁰_D 1.5662; (BrCH₂CH₂S)₂, m. 25-6°; (ICH₂CH₂S)₂, m. 45-6°; (MeCHClCH₂S)₂, b_2-3 121°, d₁₅ 1.2413, n¹⁵_D 1.5430; (MeCHBrCH₂S)₂, b₂ 137° d₁₆ 1.6602, n¹⁶_D 1.5852; (MeCHICH₂S)₂, undistillable, d₁₇ 1.9962, n¹⁷_D 1.6520; bis(2-chlorocyclohexyl) disulfide, b₂ 177-9°, d₂₈ 1.2280, n²⁸_D 1.5826.

Zhurnal Obshchei Khimii published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, HPLC of Formula: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Epshtein, G. Yu. published the artcileHaloalkyl sulfides. V. Reaction of alkylene sulfides with alkanesulfenyl chlorides and alkyl polythiochlorides, COA of Formula: C4H8Cl2S2, the publication is Zhurnal Obshchei Khimii (1964), 34(7), 2347-9, database is CAplus.

cf. CA 61, 8178c. Addition of RSCl to the appropriate alkylene sulfide in CCl₄ with cooling gave on distillation the indicated disulfides. Ethylene sulfide (I) and ClCH₂CH₂SCl gave (SCH₂CH₂Cl)₂; propylene sulfide (II) gave ClCH₂CH₂SSCH₂CHMeCl; isobutylene sulfide gave ClCH₂CH₂SSCMe₂CH₂Cl (III); I and BrCH₂CH₂SCl gave ClCH₂CH₂SSCH₂CH₂Br, b₄ 129-30°, d₁₉ 1.5683, n¹⁹_D 1.5897; 3-chloro-1,2-propylene sulfide and ClCH₂CH₂SCl gave ClCH₂CH₂SSCH₂CHClCH₂Cl, b₅ 151°, d₂₀ 1.4122, n²⁰_D 1.5752; II and ClSCH₂CHMeBr gave MeCHClCH₂SSCH₂CHMeBr, b₂ 127°, d₁₇ 1.4687, n¹⁷_D 1.5665; II and CCl₃SCl gave CCl₃SSCH₂CHMeCl, b₂ 122°, d₁₈ 1.4726, n¹⁸_D 1.5616; II and MeCHClCH₂SSCl gave (CHMeClCH₂S)₂S, b_1.5 126°, d₁₅ 1.2542, n¹⁵_D 1.5492; I similarly gave ClCH₂CH₂SSSCH₂CHMeCl, b_2.5 125°, d₁₆ 1.3000, n¹⁶_D 1.5634; II and CHMeClCH₂SSSCl gave (MeCHClCH₂SS)₂, undistillable, d₁₇ 1.3560, n¹⁷_D 1.6120; I and CHMeBrCH₂SCl gave ClCH₂CH₂SSCH₂CHMeBr, b_2.5 124°, d₁₇ 1.5462, n¹⁷_D 1.5808; I and CCl₃SCl gave CCl₃SSCH₂CH₂Cl, b₄ 115°, d₁₆ 1.4962, n¹⁶_D 1.4962; II and CHMeClCH₂SCl gave (MeCHClCH₂S)₂, b_2.5 118-26°, d₁₅ 1.2405, n¹⁵_D 1.5408; CHMeClCH₂SCl with 3-chloro-1,2-propylene sulfide gave CHMeClCH₂SSCH₂CHClCH₂Cl, b₁ 128°, d₂₁ 1.3574, n²¹_D 1.5625; isobutylene sulfide gave CHMeClCH₂SSCMe₂CH₂Cl, b_1.5 110°, d₁₆ 1.2153, n¹⁶_D 1.5412. III b_1.5 106-8°, d₁₅ 1.2724, n¹⁵_D 1.5558.

Zhurnal Obshchei Khimii published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, COA of Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grytsai, Oleksandr published the artcileSynthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2020), 104271, database is CAplus and MEDLINE.

Two series of compounds I (R = H, 2-Cl, 3-Br, etc.; X = CH or N) carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivs I (X = N). The biol. results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series I (R = 3-Br; X = CH or N) on several cell lines tested. Moreover, results point out an antiangiogenic activity of these compds I. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Campagnol, Nicolo published the artcileOn the electrochemical deposition of metal-organic frameworks, Product Details of C6H4ClNO2, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2016), 4(10), 3914-3925, database is CAplus.

The electrochem. deposition of Metal-Organic Frameworks (MOFs) is an interesting technique to synthesize adherent, microporous layers on top of conductive substrates. The technique can be subdivided in two approaches: anodic and cathodic deposition. While the mechanism of the cathodic approach has already been well studied, at least for MOF-5 not much is known about the anodic approach. A four-step mechanism is proposed to better understand the anodic deposition, and the same MOF used for the study, HKUST-1, is also deposited cathodically to compare the two approaches. This study focuses on how nucleation starts and proceeds, on the influence of the potential applied, the stresses in the growing layers, and the origin of defects like delamination and MOF detachment. The study is followed by critical considerations on the methods and on the technique, together with suggestions and guidelines to synthesize new MOF layers.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Smidt, Hauke published the artcileTranscriptional regulation of the cpr gene cluster in ortho-chlorophenol-respiring Desulfitobacterium dehalogenans, COA of Formula: C8H7ClO3, the publication is Journal of Bacteriology (2000), 182(20), 5683-5691, database is CAplus and MEDLINE.

To characterize the expression and possible regulation of reductive dehalogenation in halorespiring bacteria, a 11.5-kb genomic fragment containing the o-chlorophenol reductive dehalogenase-encoding cprBA genes of the gram-pos. bacterium Desulfitobacterium dehalogenans was subjected to detailed mol. characterization. Sequence anal. revealed the presence of eight designated genes with the order cprTKZEBACD and with the same polarity except for cprT. The deduced cprC and cprK gene products belong to the NirI/NosR and CRP-FNR families of transcription regulatory proteins, resp. CprD and CprE are predicted to be mol. chaperones of the GroEL type, whereas cprT may encode a homolog of the trigger factor folding catalysts. Northern blot anal., reverse transcriptase PCR, and primer extension anal. were used to elucidate the transcriptional organization and regulation of the cpr gene cluster. Results indicated halorespiration-specific transcriptional induction of the monocistronic cprT gene and the biscistronic cprBA and cprZE genes. Occasional read-through at cprC gives rise to a tetracistronic cprBACD transcript. Transcription of cprBA was induced 15-fold upon addition of the o-chlorophenolic substrate 3-chloro-4-hydroxyphenylacetic acid within 30 min with concomitant induction of dehalogenation activity. Putative regulatory protein binding motifs that to some extent resemble the FNR box were identified in the cprT-cprK and cprK-cprZ intergenic regions and the promoter at cprB, suggesting a role for FNR-like CprK in the control of expression of the cprTKZEBACD genes.

Journal of Bacteriology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C14H10O4, COA of Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Van Lerberghe, K. published the artcileThe improved silane method for the preparation of free paint and varnish films. 3, Application of Dichloro(hexyl)(methyl)silane, the publication is Double Liaison – Chimie des Peintures (1978), 339-45, database is CAplus.

The properties and utility of substituted silanes in the preparation of free films of coating materials by coating glass plates with silanes prior to application of the coating are described. The use of Me₂SiCl₂ [75-78-5] gave excellent free films from coating solutions, while EtSiMeCl₂ [4525-44-4] and Et₂SiCl₂ [1719-53-5] gave films from coating emulsions.

Double Liaison – Chimie des Peintures published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C11H14O4, Application of Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hendrickx, Eric published the artcilePhotorefractive Polysilanes Functionalized with a Nonlinear Optical Chromophore, Recommanded Product: Dichloro(hexyl)(methyl)silane, the publication is Macromolecules (1999), 32(7), 2232-2238, database is CAplus.

We have prepared various polysilane copolymers that were functionalized with the nonlinear optical chromophore N-methyl-p-nitroaniline. The glass transition temperature of the polysilanes was adjusted to room temperature by copolymerization of methylphenyldichlorosilane and n-hexylmethyldichlorosilane. Asym. two-beam coupling was observed at 633 nm, and a gain coefficient of 18 cm^-1 was measured at an externally applied field of 48 V μm^-1.

Macromolecules published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Recommanded Product: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics