Tag: M.W=150-200

Formula: C7H4Cl2O2. In 2019 TETRAHEDRON published article about C-H AMINATION; CARBON-NITROGEN BONDS; 1-NAPHTHYLAMINE DERIVATIVES; 8-AMINOQUINOLINE AMIDES; C5-H PHOSPHONATION; ARYL HALIDES; ACTIVATION; QUINOLINES; STRATEGY; SCOPE in [Ma, Yueyue; Shi, Yaqi; Yang, Fan; Wu, Yangjie] Zhengzhou Univ, Key Lab Appl Chem Henan Univ, Henan Key Lab Chem Biol & Organ, Coll Chem & Mol Engn, Zhengzhou 450052, Henan, Peoples R China; [Wu, Yusheng] TetranovBiophann LLC, Zhengzhou 450001, Henan, Peoples R China; [Wu, Yusheng] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 35. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

A practical and efficient protocol for Ag/Ru-cocatalyzed regioselective C-H amination of 8-hydroxyquinoline esters with pyrazoles was developed, This reaction proceeded smoothly via a photoredox-mediated direct C-H/N-H oxidative coupling process. The remarkable features of this reaction include the wide substrate scope, mild reaction conditions and high regioselectivity at the C4 site of the quinolinyl moiety. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Ma, YY; Shi, YQ; Yang, F; Wu, YS; Wu, YJ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about METAL-FREE SYNTHESIS; ONE-POT SYNTHESIS; SELECTIVE INHIBITORS; COPPER; 1,2,4-OXADIAZOLES; ARYLATION; DESIGN; MILD; DISCOVERY; LIGANDS, Saw an article supported by the . Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Reddy, MLC; Khan, FRN; Saravanan, V. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Product Details of 50-84-0

A divergent approach has been successfully developed for the synthesis of N-1,2,4-oxadiazole substituted sulfoximines starting from N-cyano sulfoximines. This method has a wide degree of substrate scope that includes aryl, heteroaryl, alkyl, fluoroalkyl and saturated heterocyclic compounds. Excellent functional group tolerability was also observed. Extension of this methodology to nucleosides, amino acids and dipeptides was found to be successful. A gram scale reaction was also established. The major part of this method is metal free and the utility of environmentally friendly solvents such as 2-methyl THF and ionic liquids is an added advantage.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Reddy, MLC; Khan, FRN; Saravanan, V or concate me.. Product Details of 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Authors Chi, YH; Yeh, TK; Ke, YY; Lin, WH; Tsai, CH; Wang, WP; Chen, YT; Su, YC; Wang, PC; Chen, YF; Wu, ZW; Yeh, JY; Hung, MC; Wu, MH; Wang, JY; Chen, CP; Song, JS; Shih, C; Chen, CT; Chang, CP in AMER CHEMICAL SOC published article about SMALL-MOLECULE INHIBITORS; N-MYC; CANCER; DESIGN; IDENTIFICATION; TRANSITION; STRATEGY; PRODRUGS; INDUCE; TARGET in [Chi, Ya-Hui; Yeh, Teng-Kuang; Ke, Yi-Yu; Lin, Wen-Hsing; Tsai, Chia-Hua; Wang, Wan-Ping; Chen, Yen-Ting; Su, Yu-Chieh; Wang, Pei-Chen; Chen, Yan-Fu; Wu, Zhong-Wei; Yeh, Jen-Yu; Hung, Ming-Chun; Wu, Mine-Hsine; Wang, Jing-Ya; Chen, Ching-Ping; Song, Jen-Shin; Shih, Chuan; Chen, Chiung-Tong; Chang, Chun-Ping] Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Taiwan; [Chi, Ya-Hui] China Med Univ, Grad Inst Biomed Sci, Taichung 40402, Taiwan; [Chang, Chun-Ping] Chung Yuan Christian Univ, Dept Chem, Taoyuan 320314, Taiwan in 2021, Cited 45. Safety of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

The A-type Aurora kinase is upregulated in many human cancers, and it stabilizes MYC-family oncoproteins, which have long been considered an undruggable target. Here, we describe the design and synthesis of a series of pyrimidine-based derivatives able to inhibit Aurora A kinase activity and reduce levels of cMYC and MYCN. Through structure-based drug design of a small molecule that induces the DFG-out conformation of Aurora A kinase, lead compound 13 was identified, which potently (IC50 < 200 nM) inhibited the proliferation of high-MYC expressing small-cell lung cancer (SCLC) cell lines. Pharmacokinetic optimization of 13 by prodrug strategies resulted in orally bioavailable 25, which demonstrated an 8-fold higher oral AUC (F = 62.3%). Pharmacodynamic studies of 25 showed it to effectively reduce cMYC protein levels, leading to >80% tumor regression of NCI-H446 SCLC xenograft tumors in mice. These results support the potential of 25 for the treatment of MYC-amplified cancers including SCLC.

Safety of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chi, YH; Yeh, TK; Ke, YY; Lin, WH; Tsai, CH; Wang, WP; Chen, YT; Su, YC; Wang, PC; Chen, YF; Wu, ZW; Yeh, JY; Hung, MC; Wu, MH; Wang, JY; Chen, CP; Song, JS; Shih, C; Chen, CT; Chang, CP or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

COA of Formula: C7H4Cl2O2. In 2020 EUR J MED CHEM published article about CARRIER PROTEIN REDUCTASE; MYCOLIC ACID BIOSYNTHESIS; CRYSTAL-STRUCTURE; CONDENSING ENZYMES; ENOYL REDUCTASE; ACP REDUCTASE; INHA; TARGET; FAS; IDENTIFICATION in [Faion, Leo; Pintiala, Catalin; Bourbiaux, Kevin; Piveteau, Catherine; Herledan, Adrien; Biela, Alexandre; Leroux, Florence; Deprez, Benoit; Willand, Nicolas; Flipo, Marion] Univ Lille, Inst Pasteur Lille, Drugs & Mol Living Syst U1177, INSERM, F-59000 Lille, France; [Djaout, Kamel; Frita, Rosangela; Moune, Martin; Vandeputte, Alexandre; Baulard, Alain R.] Univ Lille, CIIL Ctr Infect & Immun Lille, Inst Pasteur Lille, CHU Lille,U1019,UMR 9017,CNRS,Inserm, F-59000 Lille, France; [Cantrelle, Francois-Xavier; Hanoulle, Xavier] Univ Lille, Inst Pasteur Lille, INSERM,CHU Lille, U1167,RID AGE Risk Factors & Mol Determinants Agi, F-59000 Lille, France; [Cantrelle, Francois-Xavier; Hanoulle, Xavier] CNRS, Integrat Struct Biol ERL9002, F-59000 Lille, France; [Kremer, Laurent; Blaise, Mickael] Univ Montpellier, Inst Rech Infectiol Montpellier IRIM, CNRS, UMR 9004, F-34293 Montpellier, France; [Kremer, Laurent] Inst Rech Infectiol Montpellier, INSERM, Montpellier, France; [Tanina, Abdalkarim; Wintjens, Rene] Univ Libre Bruxelles, Fac Pharm, Dept RD3, Unite Microbiol Chim Bioorgan & Macromol CP206 04, B-1050 Brussels, Belgium in 2020, Cited 58. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Mycobacterium tuberculosis (M.tb), the etiologic agent of tuberculosis, remains the leading cause of death from a single infectious agent worldwide. The emergence of drug-resistant M.tb strains stresses the need for drugs acting on new targets. Mycolic acids are very long chain fatty acids playing an essential role in the architecture and permeability of the mycobacterial cell wall. Their biosynthesis involves two fatty acid synthase (FAS) systems. Among the four enzymes (MabA, HadAB/BC, InhA and KasA/B) of the FAS-II cycle, MabA (FabG1) remains the only one for which specific inhibitors have not been reported yet. The development of a new LC-MS/MS based enzymatic assay allowed the screening of a 1280 fragment-library and led to the discovery of the first small molecules that inhibit MabA activity. A fragment from the anthranilic acid series was optimized into more potent inhibitors and their binding to MabA was confirmed by F-19 ligand-observed NMR experiments. (C) 2020 Elsevier Masson SAS. All rights reserved.

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Faion, L; Djaout, K; Frita, R; Pintiala, C; Cantrelle, FX; Moune, M; Vandeputte, A; Bourbiaux, K; Piveteau, C; Herledan, A; Biela, A; Leroux, F; Kremer, L; Blaise, M; Tanina, A; Wintjens, R; Hanoulle, X; Deprez, B; Willand, N; Baulard, AR; Flipo, M or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about METHYL KETONES; INTRAMOLECULAR CYCLIZATION; ELECTROPHILIC CYCLIZATION; MICHAEL ADDITION; ACCESS; STRATEGY; ANILINES; HYDROCHLORIDE; DERIVATIVES; INDOLES, Saw an article supported by the Foundation of Guizhou Educational Committee [qianjiaohe KY zi [2019] 081]; Natural Science Foundation of Guizhou Province [1141]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Zhou, XY; Chen, X. The CAS is 50-30-6. Through research, I have a further understanding and discovery of 2,6-Dichlorobenzoic acid. Quality Control of 2,6-Dichlorobenzoic acid

Iodine-catalyzed oxidative C(sp(3))-H acyloxylation of acetone with carboxylic acids has been developed. The method employs iodide-as catalyst and sodium chlorite as oxidant. Substituted benzoic acids, naphthoic acids and heteroaromatic carboxylic acids can be used, and 2-oxopropyl carboxylates are obtained with good to excellent yields.

Quality Control of 2,6-Dichlorobenzoic acid. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, XY; Chen, X or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Dong, LL; Shen, SQ; Chen, W; Lu, HZ; Xu, DD; Jin, SH; Yang, Q; Zhang, JJ in [Dong, Lili; Shen, Shengqiang; Lu, Huizhe; Xu, Dongdong; Jin, Shuhui; Zhang, Jianjun] China Agr Univ, Coll Sci, Dept Appl Chem, Beijing, Peoples R China; [Chen, Wei; Yang, Qing] Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100193, Peoples R China published Glycosyl triazoles as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors: Design, synthesis, molecular docking and MD simulations in 2019, Cited 36. COA of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

The insect enzyme GH20 beta-N-acetyl-D-hexosaminidase OfHex1 represents an important chitinolytic enzyme found in the agricultural pest Ostrinia furnacalis (Guenee) and inhibition of this enzyme has been considered a promising strategy for the development of eco-friendly pesticides. In this article, based on the structure of the catalytic domains of OfHex1, a series of novel glycosyl triazoles were designed and synthesized via Cu-catalyzed azide-alkyne [3+ 2] cycloaddition reaction. To investigate the potency and selectivity of these glycosyl triazoles, the inhibition activities towards OfHex1 and HsHexB (human beta-N-acetylhexosaminidase B) were studied. Particularly compound 17c (OfHex1, K-i= 28.68 mu M; HsHexB, K-i > 100 mu M) exhibited a suitable activity and selectivity against OfHex1. Furthermore, the possible inhibitory mechanisms of 17c with OfHex1 were studied using molecular docking and MD simulations. The structure-activity relationship results as well as the formed binding patterns may provide promising insights into the further development of novel OfHex1 inhibitors.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dong, LL; Shen, SQ; Chen, W; Lu, HZ; Xu, DD; Jin, SH; Yang, Q; Zhang, JJ or concate me.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo published in 2020, Reprint Addresses Liu, XH; Shi, JB (corresponding author), Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

Paeonol has been proved to have potential anti-inflammatory activity, but its clinical application is not extensive due to the poor anti-inflammatory activity (14.74% inhibitory activity at 20 mu M). In order to discover novel lead compound with high anti-inflammatory activity, series of paeonol derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. Structure-activity relationships (SARs) have been fully concluded, and finally (E)-N-(4-(2-acetyl-5-methoxyphenoxy)phenyl)-3-(3,4,5-trimet-hoxyphenyl) acrylamide (compound 1 la) was found to be the best active compound with low toxicity, which showed 96.32% inhibitory activity at 20 mu M and IC50 value of 6.96 mu M against LPS-induced over expression of nitric oxide (NO) in RAW 264.7 macrophages. Preliminary mechanism studies indicated that it could inhibit the expression of TLR4, resulting in inhibiting of NF-kappa B and MAPK pathways. Further studies have shown that compound 11a has obvious therapeutic effect against the adjuvant-induced rat arthritis model.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Hu, YS; Han, X; Yu, PJ; Jiao, MM; Liu, XH; Shi, JB or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2019.0 CHEMISTRYSELECT published article about COUPLING REACTIONS; C5 HALOGENATION; BOND FORMATION; COPPER; QUINOLINES; CHEMISTRY; HALIDES; FLUORINE in [Guan, Dan; Luan, Huo-Xin; Patiguli, Maimaiti; Jiao, Qiu-Ju; Yun, Qing-Qing; Chen, Quan-Sheng; Xu, Chong-Jun; Nie, Xiao-Bin] Xinjiang Lab Petr Reserve Conglomerate, Kalamay 834000, Peoples R China; [Guan, Dan; Luan, Huo-Xin; Patiguli, Maimaiti; Jiao, Qiu-Ju; Yun, Qing-Qing; Chen, Quan-Sheng; Xu, Chong-Jun; Nie, Xiao-Bin] Petrochina Co Ltd, Exp & Testing Res Xinjiang Oilfield Co, Res Inst Enhance Oil Recovery, Kelamayi 834000, Xinjiang, Peoples R China; [Hu, Fang-Peng; Huang, Guo-Sheng] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Dept Chem, Lanzhou 730000, Gansu, Peoples R China in 2019.0, Cited 40.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6. Product Details of 50-30-6

An efficient, metal-free C-H halogenated method for the synthesis of beta-halogenated carboxamides using non-corrosive NXS (X=Cl, Br) as the halogenated source and ammonium sulfocyanide (NH4SCN) as the additive was proposed and accomplished. Various substituted 2-oxazolines efficiently afforded the corresponding beta-halogenated carboxamides via a ring-opening reaction in good yields. The characteristic features of this reaction include readily available materials, mild reaction conditions and functional groups tolerance.

Product Details of 50-30-6. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Guan, D; Luan, HX; Patiguli, M; Jiao, QJ; Yun, QQ; Chen, QS; Xu, CJ; Nie, XB; Hu, FP; Huang, GS or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Dodean, RA; Kancharla, P; Li, YX; Melendez, V; Read, L; Bane, CE; Vesely, B; Kreishman-Deitrick, M; Black, C; Li, QG; Sciotti, RJ; Olmeda, R; Luong, TL; Gaona, H; Potter, B; Sousa, J; Marcsisin, S; Caridha, D; Xie, LS; Vuong, C; Zeng, Q; Zhang, J; Zhang, P; Lin, HL; Butler, K; Roncal, N; Gaynor-Ohnstad, L; Leed, SE; Nolan, C; Huezo, SJ; Rasmussen, SA; Stephens, MT; Tan, JC; Cooper, RA; Smilkstein, MJ; Pou, S; Winter, RW; Riscoe, MK; Kelly, JX in [Dodean, Rozalia A.; Kancharla, Papireddy; Li, Yuexin; Winter, Rolf W.; Riscoe, Michael K.; Kelly, Jane X.] Portland State Univ, Dept Chem, Portland, OR 97201 USA; [Dodean, Rozalia A.; Li, Yuexin; Smilkstein, Martin J.; Pou, Sovitj; Winter, Rolf W.; Riscoe, Michael K.; Kelly, Jane X.] Dept Vet Affairs Med Ctr, Portland, OR 97239 USA; [Melendez, Victor; Read, Lisa; Bane, Charles E.; Vesely, Brian; Kreishman-Deitrick, Mara; Black, Chad; Li, Qigui; Sciotti, Richard J.; Olmeda, Raul; Thu-Lan Luong; Gaona, Heather; Potter, Brittney; Sousa, Jason; Marcsisin, Sean; Caridha, Diana; Xie, Lisa; Vuong, Chau; Zeng, Qiang; Zhang, Jing; Zhang, Ping; Lin, Hsiuling; Butler, Kirk; Roncal, Norma; Gaynor-Ohnstad, Lacy; Leed, Susan E.; Nolan, Christina] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA; [Huezo, Stephanie J.; Rasmussen, Stephanie A.; Cooper, Roland A.] Dominican Univ Calif, Dept Nat Sci & Math, San Rafael, CA 94901 USA; [Stephens, Melissa T.; Tan, John C.] Univ Notre Dame, Genom Core Facil, Notre Dame, IN 46556 USA; [Tan, John C.] Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA published Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials in 2019, Cited 53. SDS of cas: 50-84-0. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-stage activity against both liver stage and blood-stage malaria. Several lead compounds generated from structural optimization of a large library of novel acridones exhibit efficacy in the following systems: (1) picomolar inhibition of in vitro Plasmodium falciparum blood-stage growth against multidrug-resistant parasites; (2) curative efficacy after oral administration in an erythrocytic Plasmodium yoelii murine malaria model; (3) prevention of in vitro Plasmodium berghei sporozoite-induced development in human hepatocytes; and (4) protection of in vivo P. berghei sporozoite-induced infection in mice. This study offers the first account of liver-stage antimalarial activity in an acridone chemotype. Details of the design, chemistry, structure-activity relationships, safety, metabolic/pharmacokinetic studies, and mechanistic investigation are presented herein.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dodean, RA; Kancharla, P; Li, YX; Melendez, V; Read, L; Bane, CE; Vesely, B; Kreishman-Deitrick, M; Black, C; Li, QG; Sciotti, RJ; Olmeda, R; Luong, TL; Gaona, H; Potter, B; Sousa, J; Marcsisin, S; Caridha, D; Xie, LS; Vuong, C; Zeng, Q; Zhang, J; Zhang, P; Lin, HL; Butler, K; Roncal, N; Gaynor-Ohnstad, L; Leed, SE; Nolan, C; Huezo, SJ; Rasmussen, SA; Stephens, MT; Tan, JC; Cooper, RA; Smilkstein, MJ; Pou, S; Winter, RW; Riscoe, MK; Kelly, JX or concate me.. SDS of cas: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Solvent-Dependent Chemoselective and Stereoselective Approach to Synthesis of Spiro-gamma-Lactams with Potent Anticancer Activity WOS:000644469700001 published article about 3-ISOTHIOCYANATO OXINDOLES; SPIROOXINDOLES; CYCLOADDITIONS; CONSTRUCTION; CYCLIZATION; MALEIMIDES; BENZAMIDES; ALKALOIDS; SCAFFOLDS; DISCOVERY in [Lei, Jie; He, Liu-Jun; Tang, Dian-Yong; Chen, Zhong-Zhu; Xu, Zhi-Gang] Chongqing Univ Arts & Sci, Coll Pharm, Natl & Local Joint Engn Res Ctr Targeted & Innova, IATTI, Chongqing 402160, Peoples R China; [Lei, Jie; Yan, Wei; Li, Hong-yu] Univ Arkansas Med Sci, Dept Pharmaceut Sci, Coll Pharm, Little Rock, AR 72205 USA; [Wen, Jingyuan] Univ Auckland, Sch Pharm, Auckland 1023, New Zealand in 2021, Cited 41. Safety of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Chemoselective approaches were developed for derivatizing diastereoselective chromanone spiro-gamma-lactams through the Michael-type addition by using amide as a weak nucleophile to construct the spiro-carbon center under basic conditions. To expand the scope of this post-Ugi cascade reaction, a new series of oxidized chromone derivatives was synthesized by altering solvent from EtOH to DMF. Compounds 7 a and 7 b which could be synthesized in one day, demonstrated comparable anticancer activities with legendary anticancer drug paclitaxel in the PANC and U87 cell lines. This methodology offers a new approach to construct spiro-carbon centers with functionalized chromanones or chromones under mild reaction conditions.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Lei, J; He, LJ; Tang, DY; Wen, JY; Yan, W; Li, HY; Chen, ZZ; Xu, ZG or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics