Extracurricular laboratory: Synthetic route of C7H4Cl2O2

Recommanded Product: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Popiol, J; Gunia-Krzyzak, A; Sloczynska, K; Koczurkiewicz-Adamczyk, P; Piska, K; Wojcik-Pszczola, K; Zelaszczyk, D; Krupa, A; Zmudzki, P; Marona, H; Pekala, E or concate me.

Recommanded Product: 2,4-Dichlorobenzoic acid. In 2021 INT J MOL SCI published article about IN-VITRO; BIOLOGICAL PROPERTIES; DERIVATIVES; ASSAY; PHOTOSTABILITY; MANGIFERIN; EXPRESSION; LIPOPHILICITY; MUTAGENICITY; PROTECTION in [Popiol, Justyna; Sloczynska, Karolina; Koczurkiewicz-Adamczyk, Paulina; Piska, Kamil; Wojcik-Pszczola, Katarzyna; Pekala, Elzbieta] Jagiellonian Univ Med Coll, Fac Pharm, Dept Pharmaceut Biochem, Med 9, PL-30688 Krakow, Poland; [Gunia-Krzyzak, Agnieszka; Zelaszczyk, Dorota; Marona, Henryk] Jagiellonian Univ Med Coll, Fac Pharm, Chair Organ Chem, Dept Bioorgan Chem, Med 9, PL-30688 Krakow, Poland; [Krupa, Anna] Jagiellonian Univ Med Coll, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, Med 9, PL-30688 Krakow, Poland; [Zmudzki, Pawel] Jagiellonian Univ Med Coll, Fac Pharm, Dept Med Chem, Med 9, PL-30688 Krakow, Poland in 2021, Cited 58. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of sunscreens containing UV filters. Currently used UV filters are characterized by some limitations including systemic absorption, endocrine disruption, skin allergy induction, and cytotoxicity. In the research centers all over the world new molecules are developed to improve the safety, photostability, solubility, and absorption profile of new derivatives. In our study, we designed and synthesized seventeen novel molecules by combining in the structures two chromophores: xanthone and (E)-cinnamoyl moiety. The ultraviolet spectroscopic properties of the tested compounds were confirmed in chloroform solutions. They acted as UVB or UVA/UVB absorbers. The most promising compound 9 (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate) absorbed UV radiation in the range 290-369 nm. Its photoprotective activity and functional photostability were further evaluated after wet milling and incorporation in the cream base. This tested formulation with compound 9 possessed very beneficial UV protection parameters (SPFin vitro of 19.69 +/- 0.46 and UVA PF of 12.64 +/- 0.32) which were similar as broad-spectrum UV filter tris-biphenyl triazine. Additionally, compound 9 was characterized by high values of critical wavelength (381 nm) and UVA/UVB ratio (0.830) thus it was a good candidate for broad-spectrum UV filter and it might protect skin against UVA-induced photoaging. Compound 9 were also shown to be photostable, non-cytotoxic at concentrations up to 50 mu M when tested on five cell lines, and non-mutagenic in Ames test. It also possessed no estrogenic activity, according to the results of MCF-7 breast cancer model. Additionally, its favorable lipophilicity (miLogP = 5.62) does not predispose it to penetrate across the skin after topical application.

Recommanded Product: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Popiol, J; Gunia-Krzyzak, A; Sloczynska, K; Koczurkiewicz-Adamczyk, P; Piska, K; Wojcik-Pszczola, K; Zelaszczyk, D; Krupa, A; Zmudzki, P; Marona, H; Pekala, E or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

New explortion of 2,4-Dichlorobenzoic acid

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Li, N; Song, XZ; Wang, L; Geng, XL; Wang, H; Tang, HY; Bian, ZY or concate me.

An article Single-Atom Cobalt Catalysts for Electrocatalytic Hydrodechlorination and Oxygen Reduction Reaction for the Degradation of Chlorinated Organic Compounds WOS:000537731900038 published article about NITROGEN-DOPED CARBON; HYDROGEN-PEROXIDE; ELECTROCHEMICAL OXIDATION; POROUS CARBON; WASTE-WATER; GRAPHENE; MECHANISM; ELECTROSYNTHESIS; IDENTIFICATION; COORDINATION in [Li, Ning; Song, Xiaozhe; Wang, Li; Geng, Xinle; Wang, Hui] Beijing Forestry Univ, Coll Environm Sci & Engn, Beijing 00083, Peoples R China; [Tang, Hanyu; Bian, Zhaoyong] Beijing Normal Univ, Coll Water Sci, Beijing 100875, Peoples R China in 2020, Cited 55. COA of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Electrochemical reduction-oxidation processes with the aid of cathode catalysts are promising technologies for the decomposition of organic compounds. High-efficiency and low-cost catalysts for electrochemical reductive dechlorination and two-electron oxygen reduction reaction (ORR) are vital to the overall degradation of chlorinated organic compounds. This study reports electrochemical dechlorination using a single-atom Co-loaded sulfide graphene (Co-SG) catalyst via atomic hydrogen generated from the electrochemical reduction of H2O and electrolysis of hydrogen. The Co-SG electrocatalyst exhibited a remarkable performance for H2O2 synthesis with a half-wave potential of 0.70 V (vs RHE) and selectivity over 90%. The high electrochemical performance was achieved for bifunctional electrocatalysis with regard to the smaller overpotentials, faster kinetics, and higher cycling stability compared to the noble metal-based electrocatalysts. In this study, 2,4-dichlorobenzoic acid was well degraded and the TOC concentration was effectively reduced. This work introduces the preparation of a new active site for high-performance single-atom catalysts and also promotes its application in the electrochemical degradation of chlorinated organic pollutants.

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Li, N; Song, XZ; Wang, L; Geng, XL; Wang, H; Tang, HY; Bian, ZY or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

What about chemistry interests you the most 2,4-Dichlorobenzoic acid

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chen, B; Lin, ZH; Wu, RH; Jin, SW; Dong, LF; Bai, LQ; Xu, WQ; Wang, DQ or concate me.

I found the field of Chemistry very interesting. Saw the article Nine Supramolecular Adducts of 4-dimethylaminopyridine and Carboxylic acids Assembled by Classical Hydrogen Bonds and Other Noncovalent Intermolecular Interactions published in 2021. COA of Formula: C7H4Cl2O2, Reprint Addresses Jin, SW (corresponding author), Zhejiang A&F Univ, Linan 311300, Peoples R China.; Jin, SW (corresponding author), Zhejiang A&F Univ, Jiyang Coll, Zhuji 311800, Zhejiang, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Cocrystallization of the widely available 4-dimethylaminopyridine, with a series of carboxylic acids gave nine molecular adducts 4-dimethylaminopyridinium trifluoroacetate (1) , 4-dimethylaminopyridinium glycolate glycolic acid (2) , 4-dimethylaminopyridinium 2-furoate dihydrate (3) , tri(4-dimethylaminopyridinium) tri(o-chlorobenzoate) tetrahydrate (4) , 4-dimethylaminopyridinium 4-bromobenzoate 4-bromobenzoic acid (5) , 4-dimethylaminopyridinium 4-formylbenzoate 4-formylbenzoic acid (6) , 4-dimethylaminopyridinium 2,4-dichlorobenzoate (7) , 4-dimethylaminopyridinium 2-aminobenzoate 2-aminobenzoic acid (8) and bis(4-dimethylaminopyridinium) 5-nitroisophthalate 5-nitroisophthalic acid methanol solvate (9) . The nine adducts have been characterised by X-ray diffraction, IR and elemental analysis, the melting points were also reported. Their structural and supramolecular aspects are fully analyzed. The result reveals that among the nine investigated crystals only the ring Ns in the 4-dimethylaminopyridine moieties are protonated when the carboxylic acids are deprotonated. The crystal packing is interpreted by the strong charge-assisted N-H center dot center dot center dot O hydrogen bond between the NH+ and the deprotonated acidic groups. Except the N-H center dot center dot center dot O hydrogen bonds, the charge assisted or neutral O-H center dot center dot center dot O hydrogen bonds were also found at 2-6, 8 and 9 . The COOH center dot center dot center dot COO- synthon has been at 2, 5-6 and 8-9. Further analysis of the crystal packing indicated that a different family of additional CH-O/CH2-O/CH3-O, F-F, Br-Br, CH-Cl, CH3-Cl, CH-pi/CH3-pi, C-H center dot center dot center dot C-pi, C-pi, Cl-O, O-C, O-pi and pi-pi contacts contribute to the stabilization and expansion of the total high-dimensional (2D-3D) framework structures. For the synergism of the various nonbonding contacts there created homo/hetero supramolecular synthons or both. (C) 2021 Elsevier B.V. All rights reserved.

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chen, B; Lin, ZH; Wu, RH; Jin, SW; Dong, LF; Bai, LQ; Xu, WQ; Wang, DQ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Something interesting about 50-84-0

SDS of cas: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Bano, K; Jain, A; Sarkar, R; Panda, TK or concate me.

In 2020 CHEMISTRYSELECT published article about ACIDIC IONIC LIQUIDS; BUTYL ACETATE SYNTHESIS; DUAL SOLVENT-CATALYSTS; FACILE SYNTHESIS; FISCHER ESTERIFICATION; ALDEHYDES; SYSTEM; GREEN; CYCLOALKANONES; KETONES in [Bano, Kulsum; Sarkar, Ratan; Panda, Tarun K.] Indian Inst Technol Hyderabad, Dept Chem, Sangareddy 502285, Telangana, India; [Jain, Archana] Mahatma Gandhi Inst Technol, Dept Phys & Chem, Hyderabad 500075, Telangana, India in 2020, Cited 78. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. SDS of cas: 50-84-0

Bronsted acidic ionic liquids (BAILs) have been used as catalyst and solvent in organic synthesis, due to their negligible volatility, remarkable solubility, good catalytic activity, and easily structurally tunable properties. In the present study, we have investigated the catalytic efficiency of economically viable ionic liquids bearing different cations pyridinium ([PyH](+) and triethylammonium [TEAH](+)) for the esterification of aromatic acid with various aliphatic alcohols and crossed aldol condensation of aromatic aldehydes with cyclohexanone under ambient condition. We also examined the effect of various process parameters on the yield of aromatic esters and alpha,alpha’-bis(arylidene)cycloalkanones.

SDS of cas: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Bano, K; Jain, A; Sarkar, R; Panda, TK or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Discovery of 2,4-Dichlorobenzoic acid

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dai, QZ; Chen, JW; Gao, CM; Sun, QS; Yuan, ZG; Jiang, YY or concate me.. Application In Synthesis of 2,4-Dichlorobenzoic acid

Recently I am researching about HYDROXAMIC ACID-DERIVATIVES; DNA-REPAIR; ANTIPROLIFERATIVE ACTIVITY; KINASE INHIBITORS; CANCER; BINDING; ROLES; DNMT, Saw an article supported by the Shenzhen Development and Reform Committee [20151961, 2019156]; Department of Science and Technology of Guangdong Province [2017B030314083]. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Dai, QZ; Chen, JW; Gao, CM; Sun, QS; Yuan, ZG; Jiang, YY. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Application In Synthesis of 2,4-Dichlorobenzoic acid

In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTF assays indicated that most of the compounds significantly inhibited multiple cancer cells proliferation. In addition, all the compounds displayed Topo II inhibition activity at 10 mol/L, and also possessed good PARP-1 inhibitory activities. Subsequent mechanistic studies showed that compound 9a induced remarkable apoptosis and caused prominent S cell cycle arrest in HCT116 cells. Our study suggested that 9a inhibiting Topo and PARP concurrently can be a potential lead compound for cancer therapy. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dai, QZ; Chen, JW; Gao, CM; Sun, QS; Yuan, ZG; Jiang, YY or concate me.. Application In Synthesis of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

You Should Know Something about 2,4-Dichlorobenzoic acid

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Neshat, A; Kakavand, M; Osanlou, F; Mastrorilli, P; Schingaro, E; Mesto, E; Todisco, S or concate me.. Safety of 2,4-Dichlorobenzoic acid

Safety of 2,4-Dichlorobenzoic acid. Recently I am researching about RECOVERABLE CATALYSTS; MOLECULAR-STRUCTURE; OXOCHROMIUM(V) CATIONS; SALEN COMPLEXES; EPOXIDATION; LIGANDS; OLEFINS; COORDINATION; CRYSTAL; DONOR, Saw an article supported by the Institute for Advanced Studies in Basic Sciences (IASBS) Research Council; Politecnico di Bari (FRA funds). Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Neshat, A; Kakavand, M; Osanlou, F; Mastrorilli, P; Schingaro, E; Mesto, E; Todisco, S. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Asymmetric Schiff base manganese(III) complexes involving salen ligands, N,N’-bis(salicylidene)2,3-diaminopyridine, N,N’-bis(3-methoxysalicylidene)2,3-diaminopyridine, N,N’-bis(3,5-di-tert-butylsalicylidene)2,3-diaminopyridine and N,N’-bis(3,5-di-chloro-salicylidene)2,3-diaminopyridine were prepared and their catalytic activity was investigated in the oxidation of some primary and secondary alcohols. During optimization of oxidation reactions, Mn-4, bearing electron withdrawing N,N’-Bis(3,5-di-chloro-salicylidene)2,3-diaminopyridine ligand, showed higher activity than other catalysts tested. The catalytic reactions were carried out in the presence of various oxidants such as oxygen, hydrogen peroxide or tert-butyl hydroperoxide (TBHP) and additives such as acetic acid and imidazole. The oxidant/additive combination of TBHP and imidazole was shown to be effective for the oxidation process and the degree of their impact on oxidation reaction was found highly dependent on a balanced ratio between them. Mn-4 was selected as the most effective catalyst under optimized reaction conditions and revealed efficient for the oxidation of secondary alcohols.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Neshat, A; Kakavand, M; Osanlou, F; Mastrorilli, P; Schingaro, E; Mesto, E; Todisco, S or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Chemistry Milestones Of 2,4-Dichlorobenzoic acid

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Popiol, J; Gunia-Krzyzak, A; Sloczynska, K; Koczurkiewicz-Adamczyk, P; Piska, K; Wojcik-Pszczola, K; Zelaszczyk, D; Krupa, A; Zmudzki, P; Marona, H; Pekala, E or concate me.. Category: chlorides-buliding-blocks

Authors Popiol, J; Gunia-Krzyzak, A; Sloczynska, K; Koczurkiewicz-Adamczyk, P; Piska, K; Wojcik-Pszczola, K; Zelaszczyk, D; Krupa, A; Zmudzki, P; Marona, H; Pekala, E in MDPI published article about IN-VITRO; BIOLOGICAL PROPERTIES; DERIVATIVES; ASSAY; PHOTOSTABILITY; MANGIFERIN; EXPRESSION; LIPOPHILICITY; MUTAGENICITY; PROTECTION in [Popiol, Justyna; Sloczynska, Karolina; Koczurkiewicz-Adamczyk, Paulina; Piska, Kamil; Wojcik-Pszczola, Katarzyna; Pekala, Elzbieta] Jagiellonian Univ Med Coll, Fac Pharm, Dept Pharmaceut Biochem, Med 9, PL-30688 Krakow, Poland; [Gunia-Krzyzak, Agnieszka; Zelaszczyk, Dorota; Marona, Henryk] Jagiellonian Univ Med Coll, Fac Pharm, Chair Organ Chem, Dept Bioorgan Chem, Med 9, PL-30688 Krakow, Poland; [Krupa, Anna] Jagiellonian Univ Med Coll, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, Med 9, PL-30688 Krakow, Poland; [Zmudzki, Pawel] Jagiellonian Univ Med Coll, Fac Pharm, Dept Med Chem, Med 9, PL-30688 Krakow, Poland in 2021, Cited 58. Category: chlorides-buliding-blocks. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of sunscreens containing UV filters. Currently used UV filters are characterized by some limitations including systemic absorption, endocrine disruption, skin allergy induction, and cytotoxicity. In the research centers all over the world new molecules are developed to improve the safety, photostability, solubility, and absorption profile of new derivatives. In our study, we designed and synthesized seventeen novel molecules by combining in the structures two chromophores: xanthone and (E)-cinnamoyl moiety. The ultraviolet spectroscopic properties of the tested compounds were confirmed in chloroform solutions. They acted as UVB or UVA/UVB absorbers. The most promising compound 9 (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate) absorbed UV radiation in the range 290-369 nm. Its photoprotective activity and functional photostability were further evaluated after wet milling and incorporation in the cream base. This tested formulation with compound 9 possessed very beneficial UV protection parameters (SPFin vitro of 19.69 +/- 0.46 and UVA PF of 12.64 +/- 0.32) which were similar as broad-spectrum UV filter tris-biphenyl triazine. Additionally, compound 9 was characterized by high values of critical wavelength (381 nm) and UVA/UVB ratio (0.830) thus it was a good candidate for broad-spectrum UV filter and it might protect skin against UVA-induced photoaging. Compound 9 were also shown to be photostable, non-cytotoxic at concentrations up to 50 mu M when tested on five cell lines, and non-mutagenic in Ames test. It also possessed no estrogenic activity, according to the results of MCF-7 breast cancer model. Additionally, its favorable lipophilicity (miLogP = 5.62) does not predispose it to penetrate across the skin after topical application.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Popiol, J; Gunia-Krzyzak, A; Sloczynska, K; Koczurkiewicz-Adamczyk, P; Piska, K; Wojcik-Pszczola, K; Zelaszczyk, D; Krupa, A; Zmudzki, P; Marona, H; Pekala, E or concate me.. Category: chlorides-buliding-blocks

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

More research is needed about 2,6-Dichlorobenzoic acid

About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Wang, R; Wu, WQ; Li, N; Shen, J; Liu, K; Yu, J or concate me.. Name: 2,6-Dichlorobenzoic acid

Name: 2,6-Dichlorobenzoic acid. In 2019.0 SYNLETT published article about O-GLYCOSYLATION METHODS; AT-METAL COMPLEXES; STEREOSELECTIVE-SYNTHESIS; INTERMOLECULAR HALOETHERIFICATION; SELECTIVE SYNTHESIS; RECENT PROGRESS; LEWIS-ACID; IODOACETOXYLATION; OLIGOSACCHARIDES; STRATEGY in [Wang, Rui; Wu, Wen-Qiang; Li, Na; Liu, Kun; Yu, Jie] Anhui Agr Univ, Dept Appl Chem, Hefei 230036, Anhui, Peoples R China; [Shen, Jia] Anhui Acad Agr Sci, Tobacco Res Inst, Hefei 230031, Anhui, Peoples R China in 2019.0, Cited 101.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6.

BrOnsted acids of anionic chiral Co(III) complexes were found to act as efficient phase-transfer catalysts for the diastereoselective iodoglycosylation or iodocarboxylation of glycals with a variety of alcohols or carboxylic acids, respectively, with N -iodosuccinimide as the iodo cation source. The corresponding 2-deoxy-2-iodoglycosides, including monosaccharides and disaccharides, and 2-deoxy-2-iodoglycosyl carboxylates, which are of high synthetic and biological importance, were obtained in high yields (up to 88%) with good diastereoselectivities (up to 9:1 dr).

About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Wang, R; Wu, WQ; Li, N; Shen, J; Liu, K; Yu, J or concate me.. Name: 2,6-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

The Absolute Best Science Experiment for 2,6-Dichlorobenzoic acid

Recommanded Product: 50-30-6. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact He, ZY; Wang, ZJ; Ru, JX; Wang, YL; Liu, TT; Zeng, Z or concate me.

Recommanded Product: 50-30-6. Recently I am researching about HIGHLY EFFICIENT SYNTHESIS; CROSS-COUPLING REACTIONS; CARBOXYLIC-ACIDS; DECARBONYLATIVE BORYLATION; AMIDES; REDUCTION; ESTERS; CHLORIDES; TRANSAMIDATION; HYDROGENATION, Saw an article supported by the Science and Technology Planning Project of Guangdong Province [2017A010103017]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51703069, 21272080]; Special Innovation Projects of Common Universities in Guangdong Province [20178S0182]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: He, ZY; Wang, ZJ; Ru, JX; Wang, YL; Liu, TT; Zeng, Z. The CAS is 50-30-6. Through research, I have a further understanding and discovery of 2,6-Dichlorobenzoic acid

We report the catalytic reduction of both active esters and amides by selective C(acyl)-X (X=O, N) cleavage to access aldehyde functionality via a palladium-catalyzed strategy. Reactions are promoted by hydrosilanes as reducing reagents with good to excellent yields and with excellent chemoselectivity for C(acyl)-N and C(acyl)-O bond cleavage. Carboxylic acid C(acyl)-O bonds are activated by 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) to form triazine ester intermediates, which further react with hydrosilanes to yield aldehydes in one-pot two-step procedures. We demonstrate that C(acyl)-O cleavage/formylation offers higher yields and broader substrate scopes compared with C(acyl)-N cleavage under the same reaction conditions.

Recommanded Product: 50-30-6. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact He, ZY; Wang, ZJ; Ru, JX; Wang, YL; Liu, TT; Zeng, Z or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An overview of features, applications of compound:2,4-Dichlorobenzoic acid

Name: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Lv, LY; Lu, JC; Zhang, HY; Wang, XD; Su, GY; Piao, HR; Zhao, YQ or concate me.

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Acylation of 25-hydroxyprotopanaxatriol with aromatic acids increases cytotoxicity published in 2019. Name: 2,4-Dichlorobenzoic acid, Reprint Addresses Piao, HR (corresponding author), Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Coll Pharm, Yanji 133002, Peoples R China.; Zhao, YQ (corresponding author), Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang, Liaoning, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

20(R)-25-hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound showing a variety of anti-tumor effects. In an attempt to search for a new anti-cancer compound with higher antitumor activities, we designed and synthesized a series of 25-OH-PPD derivatives. Cytotoxicity assay of these derivatives towards MCF-7, A549, U87, HO-8901, Hela cancer cell lines and normal IOSE144 cell lines were tested by MTF assay. Results showed that compared with compound 25-OH-PPD, Compounds 4, 5, 6, 10, 11 showed strong anticancer activity, and all compounds showed low toxicity or no toxicity for normal cells. In particular, compound 6 exhibited the best anti-tumor activity in all cancer cell lines (MCF-7, A549, U87, HO-8901, and Hela) with IC50 values of 5.04 mu M, 1.36 mu M, 3.24 mu M, 3.47 mu M, 4.57 mu M, respectively. Among the five cell lines, all the compounds showed strong inhibition on A549 cells. Further studies showed that Compound 6 significantly inhibited the proliferation of A549 cells by inducing apoptosis. Our results indicate that Compound 6 is a potential anticancer inhibitor and provides a theoretical basis for further research.

Name: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Lv, LY; Lu, JC; Zhang, HY; Wang, XD; Su, GY; Piao, HR; Zhao, YQ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics