Tag: M.W=150-200

Jessop, Theodore C. published the artcileLead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors, HPLC of Formula: 209919-30-2, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(23), 6784-6787, database is CAplus and MEDLINE.

A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series with a high throughput screening hit to afford a highly potent, selective and orally bioavailable inhibitor, compound 10. This compound showed dose dependent inhibition of deoxycytidine kinase in vivo.

Bioorganic & Medicinal Chemistry Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, HPLC of Formula: 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roy, Aroop K. published the artcileThe First Alkene-Platinum-Silyl Complexes: Lifting the Hydrosilation Mechanism Shroud with Long-Lived Precatalytic Intermediates and True Pt Catalysts, Safety of Dichloro(hexyl)(methyl)silane, the publication is Journal of the American Chemical Society (2002), 124(32), 9510-9524, database is CAplus and MEDLINE.

The synthesis, characterization, and exploratory chem. of two classes of alkene-platinum-silyl complexes, which have been postulated as hydrosilation intermediates, are described in this report. The unique dimeric complexes 1, [R₃Si(μ-Cl)(η²-COD)Pt]₂ {R₃Si = Et₃Si, MeCl₂Si, Me₂ClSi, “(EtO)₃Si”, PhMe₂Si, and (Me₃SiO)Me₂Si; COD = cycloocta-1,5-diene}, and the bis-silyl complexes 2, (η⁴-COD)Pt(SiR₃)₂ (R₃Si = Cl₃Si, MeCl₂Si, Me₂ClSi, PhMe₂Si), are formed from the sequential reaction of 2 and 4 equivalent of the corresponding hydrosilanes, resp., with Pt(COD)Cl₂ in the presence of a small excess of COD. Complexes 1 are stable for many days in solution at room temperature but decompose via slow elimination of chlorosilane. Some of the bis-silyl compounds 2 are stable for extended periods under inert atm. and especially below 0°, either in the solid state or in solution (in the presence of a small excess of free COD). Complexes 2 display catalytic activity as discrete, mol., and mononuclear species for hydrosilation and isomerization reactions. Compound 2c (R₃Si = MeCl₂Si) was fully characterized via multinuclear NMR spectroscopy and x-ray crystal structure anal. The facile H-transfer rather than Si-transfer to bound COD provides exptl. support for the sequence of insertive steps in the Chalk-Harrod catalytic cycle, at least for Pt-catalyzed hydrosilation.

Journal of the American Chemical Society published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Safety of Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Greguric, Ivan published the artcileDiscovery of [¹⁸F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Journal of Medicinal Chemistry (2009), 52(17), 5299-5302, database is CAplus and MEDLINE.

The high melanoma uptake and rapid body clearance displayed by our series of [¹²³I]iodonicotinamides prompted the development of [¹⁸F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide, a novel radiotracer for PET melanoma imaging. Significantly, unlike fluorobenzoates, [¹⁸F]fluorine incorporation on the nicotinamide ring is one step, facile, and high yielding. [¹⁸F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide displayed high tumor uptake, rapid body clearance via predominantly renal excretion, and is currently being evaluated in preclin. studies for progression into clin. trials to assess the responsiveness of therapeutic agents.

Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yoshihira, Kunitoshi published the artcileStereochemistry. XL. Rearrangement and trans-elimination contrary to the Chugaev reaction rule. 4. Thermal treatment on thionobenzoates, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Yakugaku Zasshi (1969), 89(9), 1225-35, database is CAplus and MEDLINE.

Thermal treatment of xanthates bearing an anchimeric group causes rearrangement to dithiocarbonates or trans elimination depending on their conformation (contrary to the Chugaev reaction). Thiobenzoates, e.g. I, were similarly treated and the analogous conclusion was reached concerning results and mechanisms. The identification of 2-(dialkylamino)alkanethiols produced in this series was reexamined and Hansen’s report on the same problem was corrected with respect to isothiuronium salt formation and desulfurization by Raney Ni.

Yakugaku Zasshi published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C11H11BFNO4, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tanaka, Nobuyuki published the artcileRelationship between Stereochemistry and the β₃-Adrenoceptor Agonistic Activity of 4′-Hydroxynorephedrine Derivative as an Agent for Treatment of Frequent Urination and Urinary Incontinence, Computed Properties of 33697-81-3, the publication is Journal of Medicinal Chemistry (2003), 46(1), 105-112, database is CAplus and MEDLINE.

This report proposes a β₃-adrenoceptor (AR) selective agonist, 2-[2-chloro-4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]acetic acid (I), as a novel agent for treating urinary bladder dysfunction. This compound and its relatives have a unique feature among β₃-AR agonists: two chiral carbons are adjacently structured on the left side of the mol. To study the relationship between the stereoconfiguration of the vicinal chiral carbons in I and β-AR agonistic activity, the four stereoisomers were synthesized via oxazolidinone prepared by intracyclization involving inversion of the β-hydroxy group. The in vitro assays using rat atria for β₁-AR, rat uteri for β₂-AR, and ferret detrusor for β₃-AR showed that I possessed potent β₃-AR agonistic activity (EC₅₀ = 3.85 nM) and 3700- and 1700-fold selectivity for β₃-AR relative to β₁– and β₂-AR, resp. Comparison of the four isomers revealed that the (αS,βR)-compound (I) was not only the most potent agonist but was also the most selective for β₃-AR. In the anesthetized rat, i.v. administration of I brought about a sufficient decrement of the intrabladder pressure (ED₅₀ = 12 μg/kg), and intraduodenal administration of the Et ester of I, led to same result (ED₅₀ = 0.65 mg/kg). Moreover, no effects on the cardiovascular system were observed in either test.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C2H3N3, Computed Properties of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pendem, Venkata Bhavanarushi published the artcileIron-promoted sulfur sequestration for the substituent-dependent regioselective synthesis of tetrazoles and guanidines, SDS of cas: 3696-23-9, the publication is Journal of Sulfur Chemistry (2021), 42(5), 499-509, database is CAplus.

Herein, a facile and versatile synthetic methodol. for the construction of tetrazoles and guanidines in the presence of an eco-friendly, inexpensive and easily available iron reagent were established. Aromatic thioureas with electron-donating substituents produced their resp. target products in quant. yield. In contrast, when electron-withdrawing substituted aromatic thioureas were used, the expected products were obtained in reduced yield. However, the desired products were obtained in good yield at moderate temperature In addition, mechanistic studies revealed that the synthetic route involved iron-based subsequent reactions of addition and removal of sulfur.

Journal of Sulfur Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Penghui published the artcileBio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes, Quality Control of 209919-30-2, the publication is Nature Communications (2019), 10(1), 1-9, database is CAplus and MEDLINE.

A bio-inspired iron-catalyzed polymethylhydrosiloxane-promoted aerobic oxidation of methylarenes to arylaldehydes with high yields and selectivities was reported. Notably, this method can tolerate oxidation-labile and reactive boronic acid group, which is normally required to be transformed immediately after its introduction and represents a significant advance in the area of the chem. of organoboronic acids, including the ability to incorporate both aldehyde and ketone functionalities into unprotected arylboronic acids, a class that can be difficult to access by current means. The robustness of this protocol was demonstrated on the late-stage oxidation of complex bioactive mols., including dehydroabietic acid, Gemfibrozil, Tocopherol nicotinate, a complex polyol structure and structurally complex arylboronic acids.

Nature Communications published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Quality Control of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Reeves, Jonathan T. published the artcileDevelopment of an Enantioselective Hydrogenation Route to (S)-1-(2-(Methylsulfonyl)pyridin-4-yl)propan-1-amine, COA of Formula: C6H4ClNO2, the publication is Organic Process Research & Development (2014), 18(7), 904-911, database is CAplus.

A highly enantioselective enamide hydrogenation route to the title amine was developed. Highlights of the synthesis include an efficient two-step synthesis of a 2-sulfonyl 4-pyridyl Et ketone, a simple enamide synthesis by direct condensation of propionamide with a ketone, catalytic asym. enamide hydrogenation employing the inhouse-developed ligand MeO-BIBOP, and a mild epimerization-free deprotection of a propionamide using Koenig’s procedure.

Organic Process Research & Development published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Hong published the artcileSynthesis and characterization of branched polysilanes, HPLC of Formula: 14799-94-1, the publication is Sichuan Daxue Xuebao, Ziran Kexueban (2001), 38(6), 863-866, database is CAplus.

Synthesis of the monomers was improved by using the “sequential drop”. By this way, the yield of the monomers was increased, and drain of the materials was decreased as compared with “fully mixing”. Using Wurtz-type coupling of methylphenethyldichlorosilane and trichloromethylsilane branched polysilanes: P(MPES-to-MS) were synthesized by “pre-polymerization” and “mixing polymerization”.

Sichuan Daxue Xuebao, Ziran Kexueban published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, HPLC of Formula: 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bhattacherjee, Debojit published the artcileTrisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained H₂S release profiles, Product Details of C7H6Cl2, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(90), 13534-13537, database is CAplus and MEDLINE.

Temperature- and solvent-induced selective synthesis of trisulfides and disulfides is demonstrated. A remarkable selectivity was achieved using Na₂S as a sulfur-transfer agent under mild, greener, catalyst-free and additive-free conditions. This study reveals trisulfides as a better model than disulfides in general for a sustained release of H₂S and potent anti-cancer activities.

Chemical Communications (Cambridge, United Kingdom) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Product Details of C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics