Tag: M.W=200-250

Sun, Bin published the artcilePhotocatalyst-, metal- and additive-free regioselective radical cascade sulfonylation/cyclization of benzimidazole derivatives with sulfonyl chlorides induced by visible light, Name: Coumarin-6-sulfonyl chloride, the publication is Organic Chemistry Frontiers (2022), 9(14), 3669-3676, database is CAplus.

Herein, an environmentally friendly and practical protocol for the visible-light-triggered regioselective radical cascade sulfonylation/cyclization of unactivated alkenes towards the synthesis of polycyclic benzimidazoles containing the sulfone group has been developed. Notably, the control experiments demonstrated that a radical pathway was involved in this reaction, and a sulfonyl radical center was initially generated via self-homolysis of sulfonyl chloride upon irradiation Moreover, this protocol features a wide substrate scope, high atom economy, and excellent regioselectivity, and is easy to scale up.

Organic Chemistry Frontiers published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H21NO3, Name: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ying-Hong published the artcileNovel 12N-substituted matrinanes as potential anti-coxsackievirus agents, COA of Formula: C9H5ClO4S, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(4), 829-833, database is CAplus and MEDLINE.

A series of novel 12N-substituted matrinane derivatives were synthesized and evaluated for their activities against coxsackievirus type B3 (CVB3) taking compound I as the lead. SAR anal. indicated that the introduction of a suitable heteroaromatic ring on the 12N-atom might be beneficial for the activity. Among them, compound II exhibited the highest potency against all CVB serotypes as well as CVA16 with IC₅₀ values ranging from 2.02 μM to 7.41 μM, indicating a broad-spectrum anti-coxsackieviruse effect. Furthermore, compound II demonstrated a good safety profile in vivo. Thus, we consider 12N-substituted matrinanes to be a promising family of anti-coxsackievirus agents, and compound II to be a promising drug candidate in the treatment of various diseases related to coxsackievirus infection.

Bioorganic & Medicinal Chemistry Letters published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Hualing published the artcileCatalytic Asymmetric Reduction of α-Trifluoromethylated Imines with Catecholborane by BINOL-Derived Boro-phosphates, HPLC of Formula: 5860-95-7, the publication is Journal of Organic Chemistry (2021), 86(5), 4336-4345, database is CAplus and MEDLINE.

A catalytic enantioselective reduction of α-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral α-trifluoromethylated amines in high yields and with excellent enantioselectivities (up to 98% yield and 96% ee) under mild conditions.

Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ciganek, M. published the artcileModification of glass capillary inner surface for chromatography, Product Details of C9H20Cl2Si, the publication is Chemical Papers (1991), 45(1), 81-9, database is CAplus.

Conditions of glass capillary (50 μm inner diameter) inner surface modification by an aqueous solution of ammonia were studied. The resulting silica gel porous layer was modified chem. by methyloctyldichlorosilane. Under given etching conditions (temperature 250-300° for 16 h), a 5-10 volume% aqueous solution of ammonia was optimal. The static way of silylation by 10 volume% silane solution in toluene for 16 h at 250-280° with the column filled to 50-70% of its volume is optimal. This method provides a mech. stable porous layer 1-10 μm thick.

Chemical Papers published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Matsuo, Y. published the artcilePreparation and characterization of silylated graphite oxide, Quality Control of 14799-93-0, the publication is Carbon (2005), 43(14), 2875-2882, database is CAplus.

Graphite oxide was silylated by various alkylchlorosilanes in the presence of butylamine and toluene, and new intercalation compounds were obtained. The silylating reagents with two or three Cl atoms at Si in them reacted with graphite oxide, while no reaction occurred when silylating reagents with only one Cl atom was used. The silylating reagent mainly reacted with hydroxyl group of graphite oxide, forming Si-O bonding. The role of butylamine was not only exfoliating graphite oxide layer but also scavenging HCl mol. which caused the decomposition of silylated graphite oxide. The Si content was almost constant �.6 mol/graphite oxide for the samples silylated by alkyltrichlorosilane with shorter alkyl chain lengths. It increased with the increase of alkyl chain length and reached 1.7 mol/graphite oxide. The higher Si content could be ascribed to further silylation on hydroxyl groups formed at Si atoms of silylating reagent bonded to graphite oxide, bridging two silylating reagents.

Carbon published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Quality Control of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Aspin, Samuel J. published the artcile9-Silafluorenyl dichlorides as chemically ligating coupling agents and their application in peptide synthesis, Related Products of chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2016), 55(44), 13833-13837, database is CAplus and MEDLINE.

A fundamentally simple, mild, and practical procedure for peptide bond formation is reported that employs a stoichiometric amount of easy-to-access 9-silafluorenyl dichlorides as the coupling agent. Without initial preactivation or elaboration of the carboxylic acid or amine termini of the amino acids, the developed reagent is proposed to act through an unprecedented chem. ligation mechanism, bringing the two coupling partners together before being subsequently eliminated. The desired amides or peptide bonds are thus furnished in good yields and with low to no epimerization.

Angewandte Chemie, International Edition published new progress about 1451393-45-5. 1451393-45-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (2-Bromo-4-chlorophenyl)boronic acid, and the molecular formula is C6H5BBrClO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shigano, Miyuki published the artcileThe effect of aging on the repeated-dose liver micronucleus assay, SDS of cas: 637-07-0, the publication is Genes and Environment (2021), 43(1), 37, database is CAplus and MEDLINE.

Abstract: Background: The liver micronucleus (MN) assay is an effective and important in vivo test for detecting genotoxic compounds In particular, the repeated-dose liver MN (RDLMN) assay which greatly facilitates incorporation of the liver MN assay into the general toxicity study has been developed. Usefulness of the RDLMN assay was appraised highly in the 7th International Workshops on Genotoxicity Testing (2017 in Tokyo) in that sufficient numbers and types of chems. were studied and easy integration into the general toxicity study is preferred from the 3Rs point of view. However, it was pointed out that it is necessary to evaluate the effect of age at the start of 4-wk repeated administration, since there are limited data, where only those of rats of 6 wk of age at the start of administration are available. In this study, we conducted the 4-wk RDLMN assay using rats of 6 and 8 wk of age (at the start of administration) to investigate the effect of age on the liver MN inducibility. Clofibrate, a weak inducer of liver MN, was used in this study to detect the slight difference in the liver MN induction. Results: The liver MN induced by clofibrate was detected in both rats of 6 and 8 wk of age at the start of administration. However, the liver MN induction was lower in rats of 8 wk of age compared to rats of 6 wk of age at the start of administration. Conclusion: These results suggest that the liver MN inducibility decreases with age. Therefore, we recommend the use of rats of 6 wk of age at start of administration to reliably detect the liver MN induction in the RDLMN assay.

Genes and Environment published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H17NS2, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sharapova, T. published the artcileReduced hepatic global hydroxymethylation in mice treated with non-genotoxic carcinogens is transiently reversible with a methyl supplemented diet, Related Products of chlorides-buliding-blocks, the publication is Toxicology and Applied Pharmacology (2021), 115439, database is CAplus and MEDLINE.

Non-genotoxic carcinogens (NGCs) are known to cause perturbations in DNA methylation, which can be an early event leading to changes in gene expression and the onset of carcinogenicity. Phenobarbital (PB) has been shown to alter liver DNA methylation and hydroxymethylation patterns in mice in a time dependent manner. The goals of this study were to assess if clofibrate (CFB), a well-studied rodent NGC, would produce epigenetic changes in mice similar to PB, and if a Me donor supplementation (MDS) would modulate epigenetic and gene expression changes induced by phenobarbital. CByB6F1 mice were treated with 0.5% clofibrate or 0.14% phenobarbital for 7 and 28 days. A subgroup of PB treated and control mice were also fed MDS diet. Liquid Chromatog.-Ionization Mass Spectrometry (LC-MS) was used to quantify global liver 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) levels. Gene expression anal. was conducted using Affymetrix microarrays. A decrease in liver 5hmC but not 5mC levels was observed upon treatment with both CFB and PB with varying time of onset. We observed moderate increases in 5hmC levels in PB-treated mice when exposed to MDS diet and lower expression levels of several phenobarbital induced genes involved in cell proliferation, growth, and invasion, suggesting an early modulating effect of Me donor supplementation. Overall, epigenetic profiling can aid in identifying early mechanism-based biomarkers of non-genotoxic carcinogenicity and increases the quality of cancer risk assessment for candidate drugs. Global DNA methylation assessment by LC-MS is an informative first step toward understanding the risk of carcinogenicity.

Toxicology and Applied Pharmacology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C4H7BN2O2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagarajan, K. published the artcileAntiimplantation agents: part I – 1-arylthiosemicarbazides, Formula: C7H6ClF3N2, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1984), 23B(12), 1243-57, database is CAplus.

1-Arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines were prepared and examined for their antiimplantation activity in rats. Among the active compounds, MeNHCSNHNHC₆H₃(CF₃)₂-3,5 (C2696-Go) and the corresponding 4,4-di-Me, Et, n-Bu, and allyl derivatives completely inhibit implantation at doses of 10, 3, 20, 20 and 30 mg/kg resp. The 3,4-dichlorophenyl analog is effective at a dose of 30 mg/kg. Hydrazinothiazoline I (n = 1) and the corresponding dihydrothiazine I (n = 2) show a weaker activity. The biol. profile of C2696-Go was determined and it prevents implantation by its antiuretotropic activity and ability to inhibit desiduoma formation.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 1869-22-3. 1869-22-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Hydrazine,Amine,Benzene, name is 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, and the molecular formula is C7H6ClF3N2, Formula: C7H6ClF3N2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kiso, Yoshihisa published the artcileSilicon hydrides and nickel complexes. IV. Preparation of silicon-nickel complexes by the reaction of silicon hydrides with σ-alkyl-nickel complexes, Synthetic Route of 14799-93-0, the publication is Journal of Organometallic Chemistry (1974), 76(1), 95-103, database is CAplus.

Three silicon-nickel complexes, Ni(bipy)(SiX3)2 (I,X3 = Cl3; II, X3 = MeCl2, bipy = 2,2′-bipyridyl) and Ni(h1-C5H5 )-(PPh3)(SiCl3) (III, C5H5 = cyclopentadienyl), were prepared by treatment of silicon hydrides with appropriate alkyl-nickel complexes, Ni(bipy)R2 (IV, R = Me, V, R = Et) and Ni(h1-C5H5)(PPh3)Et (VI), resp. Both complexes I and III reacted with HCl or DCl to give the corresponding chlorosilane HSiX3 (or DSiX3) and Ni(bipy)Cl2, in good yields. II reacted with tetracyanoethylene to afford MeCl2SiSiCl2Me, but in low yield. III reacted with MeI to form MeSiCl3 (23.5% yield). The silicon-nickel complex I was inactive as catalyst for hydrosilylation of olefins, whereas the alkyl complexes V and VI were active.

Journal of Organometallic Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics