Tag: M.W=200-250

Aktar, Bedriye Seda Kursun; Sicak, Yusuf; Tatar, Gizem; Oruc-Emre, Emine Elcin published the artcile< Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities>, Quality Control of 162046-61-9, the main research area is benzoyl hydrazone preparation antioxidant activity enzyme inhibition SAR; mol modeling.

Hydrazone compounds have high capacity in terms of antioxidant activity and enzyme inhibition activities such as anticholinesterase, tyrosinase, and urease. In this study, benzoyl hydrazones compounds RC(O)NHN=CHR1 (R = 4-ClC6H4, 2-F3CC6H4, 3,5-(CF3)2C6H3, etc.; R1 = 4-hydroxy-3,5-dimethoxyphenyl) were synthesized starting from 3,5-dimethoxy-4-hydroxybenzaldehyde. Antioxidant activity of the synthesized compounds was evaluated. In the β-carotene-linoleic acid and ABTS cation radical scavenging activities, compounds RC(O)NHN=CHR1 (R = 3,5-(CF3)2C6H3, R1 = 4-hydroxy-3,5-dimethoxyphenyl; R = 4-CH3OC6H4, R1 = 4-hydroxy-3,5-dimethoxyphenyl; R = 4-CF3OC6H4, R1 = 4-hydroxy-3,5-dimethoxyphenyl) stood out as the most active compounds, resp. In the anticholinesterase enzyme inhibition activity results, compound RC(O)NHN=CHR1 (R = 4-O2NC6H4, R1 = 4-hydroxy-3,5-dimethoxyphenyl) exhibited the best activity against AChE and BChE enzymes in the synthesis series. In addition, mol. docking anal. was performed to understand the inhibition mechanism of the synthesized compounds with target enzymes at the at. level. In the light of biol. activity and in silico studies, it has the potential to guide studies for the development of new drugs for Alzheimer disease in the future.

Turkish Journal of Chemistry published new progress about Antioxidants. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Quality Control of 162046-61-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Suzuki, Takayoshi; Khan, Mohammed Naseer Ahmed; Sawada, Hideyuki; Imai, Erika; Itoh, Yukihiro; Yamatsuta, Katsura; Tokuda, Natsuko; Takeuchi, Jun; Seko, Takuya; Nakagawa, Hidehiko; Miyata, Naoki published the artcile< Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors>, COA of Formula: C8H8BrCl, the main research area is anilinobenzamide preparation selective sirtuin inhibitor; phenethyloxyanilinobenzamide preparation selective inhibition SIRT2; structure anilinobenzamide inhibition selectivity human sirtuin isoform.

Anilinobenzamides such as I [R = H, PhNHCO, PhNMeCO, PhCH2NHCO, PhCH2NMeCO, PhCH2CONH, PhCH2CONMe, cyclohexylmethoxy, Me2CHCH2O, PhCH2O, PhCH2CH2O, R2CH2CH2O, PhCH2CH2CH2O; R2 = 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 2-F3CC6H4, 3-F3CC6H4, 4-F3CC6H4, 2-FC6H4, 3-FC6H4, 4-FC6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 2-BrC6H4, 3-BrC6H4, 4-BrC6H4; R1 = H, (E)-PhCH:CH, (Z)-PhCH:CH, PhCH2CH2, PhNMeCO, PhNHCO, PhCONMe, PhCONH, R3CONH; R3 = Me, Me2CH, cyclohexyl, 4-piperidinyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl] were prepared as selective inhibitors of human sirtuin 2 (SIRT2), a deacetylase with potential involvement in neurodegenerative diseases such as Parkinson’s and Huntington’s diseases. In particular, phenethyloxyanilinobenzamides such as I (R = R2CH2CH2O; R1 = H; R2 = Ph, 3-FC6H4) were potent and selective SIRT2 inhibitors, with 3.5-fold greater SIRT2 inhibition and more than 35-fold greater selectivity for SIRT2 over SIRT1 and SIRT3 than the previously known dichlorophenylfuranylpropenamide SIRT2 inhibitor AGK2. I (R = PhCH2CH2; R1 = H) dose-dependently inhibited SIRT2 in human colon cancer HCT116 cells.

Journal of Medicinal Chemistry published new progress about Aromatic amides Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, COA of Formula: C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fotsch, Christopher; Biddlecome, Gloria; Biswas, Kaustav; Chen, Jian Jeff; D’Amico, Derin C.; Groneberg, Robert D.; Han, Nianhe Bruce; Hsieh, Feng-Yin; Kamassah, Augustus; Kumar, Gondi; Lester-Zeiner, Dianna; Liu, Qingyian; Mareska, David A.; Riahi, Babak Bobby; Wang, Yueh-Ju Judy; Yang, Kevin; Zhan, James; Zhu, Joe; Johnson, Eileen; Ng, Gordon; Askew, Benny C. published the artcile< A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core>, COA of Formula: C7H6Cl2O2S, the main research area is bradykinin receptor antagonist piperidine tetralin preparation SAR.

The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. In this report, we describe a new class of B1 receptor antagonists that contain the piperidine acetic acid tetralin core. A structure-activity relationship for these analogs is described in this paper. The most potent compounds from this class have IC50s < 20 nM in a B1 receptor functional assay. One of these compounds, I, shows modest oral bioavailability in rats. Bioorganic & Medicinal Chemistry Letters published new progress about Bradykinin B1 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, COA of Formula: C7H6Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xia, Yuehan; Yu, Mingcheng; Zhao, Yunpeng; Xia, Li; Huang, Yafei; Sun, Nannan; Song, Meiqi; Guo, Huimin; Zhang, Yunyi; Zhu, Di; Xie, Qiong; Wang, Yonghui published the artcile< Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists>, Formula: C8H8BClO4, the main research area is tetrahydroquinoline benzomorpholine orphan retinoic acid receptor agonist cancer immunotherapy; Benzomorpholines; Cancer immunotherapy; Functional switch; RORγt agonists; Tetrahydroquinolines.

The retinoic acid receptor-related orphan receptor γt (RORγt) is an important nuclear receptor that regulates the differentiation of Th17 cells and production of interleukin 17(IL-17). RORγt agonists increase basal activity of RORγt and could provide a potential approach to cancer immunotherapy. Herein, hit compound I was identified as a weak RORγt agonist during inhouse library screening. Changes in LHS core of I led to the identification of tetrahydroquinoline compound II as a partial RORγt agonist (maximum act. = 39.3%). Detailed structure-activity relationship on substituent of the LHS core, amide linker and RHS arylsulfonyl moiety was explored and a novel series of tetrahydroquinolines and benzomorpholines was discovered as potent RORγt agonists. Tetrahydroquinoline compound III (EC50 = 8.9 ± 0.4 nM, maximum act. = 104.5%) and benzomorpholine compound IV (EC50 = 7.5 ± 0.6 nM, maximum act. = 105.8%) were representative compounds with high RORγt agonistic activity in dual FRET assay, and they showed good activity in cell-based Gal4 reporter gene assay and Th17 cell differentiation assay (104.5% activation at 300 nM of III; 59.4% activation at 300 nM of IV). The binding modes of III and IV as well as the two RORγt inverse agonists accidentally discovered were also discussed.

European Journal of Medicinal Chemistry published new progress about Cancer immunotherapy. 603122-80-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BClO4, Formula: C8H8BClO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lindsley, Craig W.; Zhao, Zhijian; Leister, William H.; O’Brien, Julie; Lemaire, Wei; Williams, David L. Jr.; Chen, Tsing-Bau; Chang, Raymond S. L.; Burno, Maryann; Jacobson, Marlene A.; Sur, Cyrille; Kinney, Gene G.; Pettibone, Douglas J.; Tiller, Philip R.; Smith, Sheri; Tsou, Nancy N.; Duggan, Mark E.; Conn, P. Jeffrey; Hartman, George D. published the artcile< Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides>, Quality Control of 162046-61-9, the main research area is antipsychotic piperidinylmethylbenzamide preparation SAR glycine transporter.

An iterative analog library synthesis approach was employed to develop SAR for the title compounds Analog I was thus identified as a novel, centrally active GlyT1 inhibitor. I enhanced prepulse inhibition in a rodent behavioral model sensitive to antipsychotic treatment.

ChemMedChem published new progress about Antipsychotics. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Quality Control of 162046-61-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Warner, Andrew J.; Lawson, James R.; Fasano, Valerio; Ingleson, Michael J. published the artcile< Formation of C(sp2)-boronate esters by borylative cyclization of alkynes using BCl3>, Quality Control of 16799-05-6, the main research area is cyclization borylative alkyne aryl boron trichloride preparation cyclic alkenylboronate; fluorenyl azafluorenyl boronate preparation dipropargyl compound cyclization boron trichloride; intramol borylation arylalkyne arene boron trichloride preparation diaryl vinylboronate; alkynes; boron; cyclizations; heterocycles; synthetic methods.

Arylpropargyl compounds R1C6H4YCH2CCR2 undergo cyclization in a reaction with BCl3 and pinacol, yielding cyclic alkenylboronates I (2, R1 = H, Me, MeO, Cl; Y = CH2, NTs, O; R2 = Ph, ClC6H4, C6F5, 3-CF3C6H4, 4-NCC6H4, MeC6H4, Br, Me, 1-naphthyl, PhCH:CH, 4-NO2C6H4, 4-EtO2CC6H4). Diynes R3CCCH2YCH2CCR3 gave boronates II (R3 = Ph, 10a,b; Y = CH2, NTs) or III (11, R3 = H, Y = CH2). BCl3 is an inexpensive electrophile which induces the borylative cyclization of a wide range of substituted alkynes to regioselectively form polycycles containing synthetically versatile C(sp2)-boronate esters. It proceeds rapidly, with good yields and is compatible with a range of functional groups and substitution patterns. Intermol. 1,2-carboboration of alkynes Ar1CCMe is also achieved using BCl3 and arene Ar2H to generate trisubstituted vinyl boronate esters Ar1Ar2C:CMe(Bpin) (12, Ar1 = Ph, Ar2 = 5-methyl-2-thienyl).

Angewandte Chemie, International Edition published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Quality Control of 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jiwen; Fu, Zice; Wang, Yingcai; Schmitt, Mike; Huang, Alan; Marshall, Derek; Tonn, George; Seitz, Lisa; Sullivan, Tim; Lucy Tang, H.; Collins, Tassie; Medina, Julio published the artcile< Discovery and optimization of CRTH2 and DP dual antagonists>, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride, the main research area is phenylacetic acid derivative preparation prostanoid CRTH2 DP dual antagonist.

A series of phenylacetic acid derivatives was discovered as CRTH2 antagonists. Modification of the series led to compounds that are also antagonists of DP. Since activation of CRTH2 and DP are believed to play key roles in mediating responses of asthma and other immune diseases, this series was optimized to increase the dual antagonistic activities and improve pharmacokinetic properties. These efforts led to selection of AMG 009 as a clin. candidate.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiasthmatics. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Molchanov, A. P.; Pecheritsyna, Ya. P.; Kostikov, R. R. published the artcile< Synthesis and thermal transformations of adducts of dihalocarbenes with cyclopentadiene and spiro[2.4]hepta-4,6-diene dimers>, Safety of 3-Chlorophenethyl Bromide, the main research area is cyclopentadiene dimer cyclopropanation dihalocarbene; spiroheptadiene dimer cyclopropanation dihalocarbene; tetracycloundecene dihalo preparation thermolysis; cyclopropanespirotetracycloundecenespirocyclopropane dihalo preparation thermolysis.

Reaction of the title dimers with CHCl3 or with CHBrXY (X = Y = Br; X, Y = Cl, Br; X = F, Y = Br) in hexane containing KOCMe3 gave 12-33% cyclopropanated adducts I and II (X = Y = Cl, Br; X = Y = Cl, Br; X = F, Y = Br). Thermal decomposition of I gave tricyclic dihalo compounds III via ring cleavage, whereas II gave 62-73% 3-XC6H4CH2CH2Y by a retro-Diels-Alder route.

Zhurnal Organicheskoi Khimii published new progress about Cyclopropanation. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Safety of 3-Chlorophenethyl Bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics