Tag: M.W=200-250

Washburn, Alex; Abdeen, Sanofar; Ovechkina, Yulia; Ray, Anne-Marie; Stevens, Mckayla; Chitre, Siddhi; Sivinski, Jared; Park, Yangshin; Johnson, James; Hoang, Quyen Q.; Chapman, Eli; Parish, Tanya; Johnson, Steven M. published the artcile< Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections>, Reference of 22952-32-5, the main research area is benzoxazolylphenyl phenylbenzoxazolyl sulfonamide preparation; inhibition GroEL ES chaperonin PtpB benzoxazolylphenyl phenylbenzoxazolyl sulfonamide; antimycobacterial activity toxicity benzoxazolylphenyl phenylbenzoxazolyl sulfonamide; Antibiotics; Chaperonin; GroEL; GroES; HSP10; HSP60; Molecular chaperone; Mycobacterium tuberculosis; Phosphatases; Polypharmacology; Proteostasis; Small molecule inhibitors.

Benzoxazolylphenyl sulfonamides I (R = Me, Ph, 2-thienyl, 2-FC6H4, 3-FC6H4, 4-FC6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 5-chloro-2-thienyl, 2-F3CC6H4, 3-F3CC6H4, 4-F3CC6H4, 3,4-Cl2C6H3, 4-F-3-F3CC6H3, 4-Cl-3-F3CC6H3, 4-Cl-3-O2NC6H3, 5-Cl-2-MeOC6H3, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-EtC6H4, 4-H2C:CHC6H4, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-HOC6H4, 3-HOC6H4, 4-HOC6H4) and phenylbenzoxazolyl sulfonamides II (R = Me, Ph, 2-thienyl, 2-FC6H4, 3-FC6H4, 4-FC6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 5-chloro-2-thienyl, 2-F3CC6H4, 3-F3CC6H4, 4-F3CC6H4, 3,4-Cl2C6H3, 4-F-3-F3CC6H3, 4-Cl-3-F3CC6H3, 4-Cl-3-O2NC6H3, 5-Cl-2-MeOC6H3, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-EtC6H4, 4-H2C:CHC6H4, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-HOC6H4, 3-HOC6H4, 4-HOC6H4) were prepared as dual inhibitors of GroEL/ES and the virulence factor protein tyrosine phosphatase B (PtpB) for the treatment of Mycobacterium tuberculosis infection at all stages of bacterial infection.

Bioorganic & Medicinal Chemistry Letters published new progress about Benzoxazoles Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Reference of 22952-32-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lian, Chang; Yue, Guanglu; Zhang, Haonan; Wei, Liyan; Liu, Danyang; Liu, Sichen; Fang, Huayi; Qiu, Di published the artcile< Synthesis of arylstannanes by palladium-catalyzed desulfitative coupling reaction of sodium arylsulfinates with distannanes>, Product Details of C7H6Cl2O2S, the main research area is palladium catalyzed desulfitative cross coupling reaction arylsulfinate hexaalkyl distannane; arylstannane functionalized preparation.

A novel Pd-catalyzed desulfitative cross-coupling reaction of Na arylsulfinates with hexaalkyl distannanes is realized, allowing the facile synthesis of functionalized arylstannanes with moderate to excellent yields. The successful implement of gram-scale synthesis and tandem Stille coupling reaction demonstrates the potential applications of this method in organic synthesis.

Tetrahedron Letters published new progress about Arylation. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Product Details of C7H6Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chupak, Louis S.; Zheng, Xiaofan; Hu, Shuanghua; Huang, Yazhong; Ding, Min; Lewis, Martin A.; Westphal, Ryan S.; Blat, Yuval; McClure, Andrea; Gentles, Robert G. published the artcile< Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase>, Computed Properties of 351003-34-4, the main research area is benzylic glycine sulfonamide preparation diacylglycerol lipase inhibitor structure activity; 2-Arachidonoylglycerol; Diacylglycerol; Endocannabinoid; Glycine; Lipase inhibitor; Sulfonamide.

N-Benzylic-substituted glycine sulfonamides that reversibly inhibit diacylglycerol (DAG) lipases are reported. Detailed herein are the structure activity relationships, profiling characteristics and physico-chem. properties for the first reported series of DAG lipase (DAGL) inhibitors that function without covalent attachment to the enzyme. Highly potent examples are presented that represent valuable tool compounds for studying DAGL inhibition and constitute important leads for future medicinal chem. efforts.

Bioorganic & Medicinal Chemistry published new progress about Diglycerides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 351003-34-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H5ClF2O3S, Computed Properties of 351003-34-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yu, Yuye published the artcile< Microwave-assisted synthesis and biological activity of 2,5-disubstituted-1,3,4-thiadiazole>, SDS of cas: 70057-67-9, the main research area is carboxylic acid thiosemicarbazide cyclocondensation phosphoryl chloride dehydrating agent; thiadiazole preparation antifungal activity.

The reaction of substitute aryl and alkyl acid with thiosemicarbazide in the presence of dehydrating agent POCl3, affords a series of 2-amino-5-aryl-1,3,4-thiadiazoles under microwave irradiation 2,5-Disubstituted-1,3,4-thiadiazoles have attracted much attention due to their diverse biol. activities, such as antimicrobial, antibacterial, anesthetic, anticonvulsant and antiinflammatory activities. Compared with classical methods, this method has the advantages of high yields, short reaction time, easy preparation and mild reaction conditions. The preliminary biol. test showed that the synthesized compound has weak antifungal activity to G. zeae Petch, B. cinerea Pers, Phytophthora infestans (Mont.) de Bary, Botryosphaeria berengeriana f. sp. piricola (Nose) koganezawa et Sakuma, Fusarium oxysporum f.sp. cucumerinum and Cercospora arachidicola. The structures of compounds were characterized by m.ps., 1H NMR and IR.

Asian Journal of Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, SDS of cas: 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gummidi, Lalitha; Kerru, Nagaraju; Awolade, Paul; Raza, Asif; Sharma, Arun K.; Singh, Parvesh published the artcile< Synthesis of indole-tethered [1,3,4]thiadiazolo and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids as anti-pancreatic cancer agents>, Synthetic Route of 70057-67-9, the main research area is indole tethered thiadiazolo oxadiazolopyrimidinone hydrid preparation antitumor agent; Indole; Molecular hybridization; Pancreatic cancer; Pyrimidinone; [4+2] Cycloaddition reaction.

New indole-tethered [1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one (e.g. I) and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids (e.g. II) were synthesized using [4+2] cycloaddition reactions of functionalized 1,3-diazabuta-1,3-dienes with indole-ketenes. All mol. hybrids were structurally characterized by spectroscopic techniques (IR, NMR, and HRMS) and screened for their anti-pancreatic cancer activity in vitro. The [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids showed stronger anti-pancreatic cancer activity than the [1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one hybrids against the PANC-1 cell line. II bearing an ortho-chlorophenyl moiety emerged as the most potent anti-pancreatic cancer agent with an IC50 value of 7.7 ± 0.4μM, much superior to the standard drug Gemcitabine (IC50 > 500μM). The discovery of these [1,3,4]thiadiazolo and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids elicits their potentials as pursuable candidates for pancreatic cancer chemotherapy.

Bioorganic & Medicinal Chemistry Letters published new progress about [4+2] Cycloaddition reaction. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Synthetic Route of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Lu; Zhu, Chuan; Bi, Peijia; Feng, Chao published the artcile< Ni-catalyzed migratory fluoro-alkenylation of unactivated alkyl bromides with gem-difluoroalkenes>, Recommanded Product: 3-Chlorophenethyl Bromide, the main research area is aralkyl bromide aryl difluoroalkene nickel catalyst stereoselective regioselective fluoroalkenylation; diaryl fluoroalkene preparation.

Nickel-catalyzed highly regio- and stereoselective migratory fluoro-alkenylation of unactivated alkyl bromides was reported. Catalytic cycle merged alkyl nickel chain-walking and defluorinative coupling enabled the introduction of a broad array of fluoroalkenyl moieties into carbon chains. Control experiments with other halogenated alkenes demonstrated the essential role of fluorine atoms in this reaction. The reaction proceeded under mild conditions and allowed for the synthesis of a variety of valuable monofluoroalkenes.

Chemical Science published new progress about Alkenylation catalysts, stereoselective. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Recommanded Product: 3-Chlorophenethyl Bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dukat, Ma-lgorzata; Abdel-Rahman, Ashraf A.; Ismaiel, Abd M.; Ingher, Stacy; Teitler, Milt; Gyermek, Lazlo; Glennon, Richard A. published the artcile< Structure-Activity Relationships for the Binding of Arylpiperazines and Arylbiguanides at 5-HT3 Serotonin Receptors>, Quality Control of 16799-05-6, the main research area is arylpiperazine arylbiguanide preparation serotonin receptor binding.

Arylpiperazines are nonselective agents that bind at 5-HT3 serotonin receptors with moderate to high affinity, whereas 1-phenylbiguanide is a low-affinity but more selective 5-HT3 agonist. In an attempt to enhance the affinity of the latter agent, and working with the assumption that similarities might exist between the binding of the two types of agents, we formulated structure-activity relationships for the binding of the arylpiperazines and then incorporated those substituents, leading to high affinity for the arylpiperazines, into 1-phenylbiguanide. A subsequent investigation examined the structure-activity relationships of the arylbiguanides and identified arylguanidines as a novel class of 5-HT3 ligands. Although curious similarities exist between the structure-activity relationships of the arylpiperazines, arylbiguanides, and arylguanidines, it cannot be concluded that all three series of compounds are binding in the same manner. Furthermore, upon investigating pairs of compounds in the three series, the arylpiperazines behaved as 5-HT3 antagonists (von Bezold-Jarisch assay) whereas the arylbiguanides and arylguanidines acted as 5-HT3 agonists.

Journal of Medicinal Chemistry published new progress about 5-HT3 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Quality Control of 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Edman, Karl; Furber, Mark; Hemsley, Paul; Johansson, Cristian; Pairaudeau, Garry; Petersen, Jens; Stocks, Michael; Tervo, Anu; Ward, Alison; Wells, Edward; Wissler, Lisa published the artcile< The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger>, SDS of cas: 42413-03-6, the main research area is MMP MMP7 selectivity trigger.

MMP7 inhibitors employing a novel selectivity trigger.

ChemMedChem published new progress about Enzyme inhibitors. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, SDS of cas: 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boechat, Nubia; Santos da Costa, Jorge Carlos; de Souza Mendonca, Jorge; Mello de Oliveira, Pedro Santos; Nora De Souza, Marcus Vinicius published the artcile< A simple reduction of methyl aromatic esters to alcohols using sodium borohydride-methanol system>, COA of Formula: C8H6Cl2O2, the main research area is benzyl alc preparation aromatic ester reduction sodium borohydride methanol.

Several aromatic esters were reduced to the corresponding benzyl alc. by using a sodium borohydride-methanol system. The reduction was completed within 2.0-4.0 h after refluxing in THF. The alc. products were isolated after aqueous workup in good yields (88-97%).

Tetrahedron Letters published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, COA of Formula: C8H6Cl2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics