Tag: M.W=200-300

Recommanded Product: 1968-05-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Ultrasensitivity dynamics of diverse aryl hydrocarbon receptor modulators in a hepatoma cell line. Author is Hoffman, Timothy E.; Acerbo, Evan R.; Carranza, Kasimir F.; Gilberto, Vincenzo S.; Wallis, Lyle E.; Hanneman, William H..

The aryl hydrocarbon receptor (AhR) is a nuclear receptor that facilitates a wide transcriptional response and causes a variety of adaptive and maladaptive physiol. functions. Such functions are entirely dependent on the type of ligand activating it, and therefore, the nuances in the activation of this receptor at the single-cell level have become a research interest for different pharmacol. and toxicol. applications. Here, we investigate the activation of the AhR by diverse classes of compounds in a Hepa1c1c7-based murine hepatoma cell line. The exogenous compounds analyzed produced different levels of ultrasensitivity in AhR activation as measured by XRE-coupled EGFP production and analyzed by both flow cytometric and computational simulation techniques. Interestingly, simulation experiments reported herein were able to reproduce and quantitate the natural single-cell stochasticity inherent to mammalian cell lines as well as the ligand-specific differences in ultrasensitivity. Classical AhR modulators 2,3,7,8-tetrachlorodibenzodioxin (10-1-105 pM), PCB-126 (10-1-107 pM), and benzo[a]pyrene (10-1-107 pM) produced the greatest levels of single-cell ultrasensitivity and most maximal responses, while consumption-based ligands indole-3-carbinol (103-109 pM), 3,3′-diindolylmethane (103-108 pM), and cannabidiol (103-108 pM) caused low-level AhR activation in more purely graded single-cell fashions. All compounds were tested and analyzed over a 24 h period for consistency. The comparative quant. results for each compound are presented within. This study aids in defining the disparity between different types of AhR modulators that produce distinctly different physiol. outcomes. In addition, the simulation tool developed for this study can be used in future studies to predict the quant. effects of diverse types of AhR ligands in the context of pharmacol. therapies or toxicol. concerns.

The article 《Ultrasensitivity dynamics of diverse aryl hydrocarbon receptor modulators in a hepatoma cell line》 also mentions many details about this compound(1968-05-4)Recommanded Product: 1968-05-4, you can pay attention to it or contacet with the author([email protected]) to get more information.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Penta, Dhanamjai; Mondal, Priya; Natesh, Jagadish; Meeran, Syed Musthapa researched the compound: 3,3′-Diindolylmethane( cas:1968-05-4 ).SDS of cas: 1968-05-4.They published the article 《Dietary bioactive diindolylmethane enhances the therapeutic efficacy of centchroman in breast cancer cells by regulating ABCB1/P-gp efflux transporter》 about this compound( cas:1968-05-4 ) in Journal of Nutritional Biochemistry. Keywords: dietary bioactive diindolylmethane centchroman breast cancer ABCB efflux transporter; ABCC1/MRP1; Breast cancer; Combinatorial therapy; Drug efflux; Molecular docking; P-glycoprotein. We’ll tell you more about this compound (cas:1968-05-4).

Overexpression of drug efflux transporters is commonly associated with multidrug-resistance in cancer therapy. Here for the first time, we investigated the ability of diindolylmethane (DIM), a dietary bioactive rich in cruciferous vegetables, in enhancing the efficacy of Centchroman (CC) by modulating the drug efflux transporters in human breast cancer cells. CC is a selective estrogen receptor modulator, having promising therapeutic efficacy against breast cancer. The combination of DIM and CC synergistically inhibited cell proliferation and induced apoptosis in breast cancer cells. This novel combination has also hindered the stemness of human breast cancer cells. Mol. docking anal. revealed that DIM had shown a strong binding affinity with the substrate-binding sites of ABCB1 (P-gp) and ABCC1 (MRP1) drug-efflux transporters. DIM has increased the intracellular accumulation of Hoechst and Calcein, the substrates of P-gp and MRP1, resp., in breast cancer cells. Further, DIM stimulates P-gp ATPase activity, which indicates that DIM binds at the substrate-binding domain of P-gp, and thereby inhibits its efflux activity. Intriguingly, DIM enhanced the intracellular concentration of CC by inhibiting the P-gp and MRP1 expression as well as activity. The intracellular retaining of CC has increased its efficacy against breast cancer. Overall, DIM, a dietary bioactive, enhances the anticancer efficiency of CC through modulation of drug efflux ABC-transporters in breast cancer cells. Therefore, DIM-based nutraceuticals and functional foods can be developed as adjuvant therapy against human breast cancer.

After consulting a lot of data, we found that this compound(1968-05-4)SDS of cas: 1968-05-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3,3′-Diindolylmethane(SMILESS: C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4,cas:1968-05-4) is researched.Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The article 《Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model》 in relation to this compound, is published in Molecular Immunology. Let’s take a look at the latest research on this compound (cas:1968-05-4).

Atopic dermatitis is a severe, chronic relapsing inflammatory disease of the skin with family clustering. It is characterized into acute phase, which is dominated by T helper 2-type immune responses, and chronic phase, which is dominated by T helper 1-type immune responses. Studies have shown that 3,3-diindolylmethane not only has antitumor effects but also can relieve symptoms of inflammatory diseases by inhibiting the nuclear factor-κB signaling pathway and regulating T cell differentiation. To study the effect of 3,3-diindolylmethane on atopic dermatitis and the underlying mechanism, a mouse model of acute atopic dermatitis was established using 2,4-dinitrofluorobenzene. After i.p. injection of 3,3-diindolylmethane, skin erythema and edema in mice were significantly alleviated. Furthermore, 3,3-diindolylmethane reduced immune activation, probably by inhibiting the secretion of thymic stromal lymphopoietin by keratinocytes. 3,3-Diindolylmethane also promoted the differentiation of regulatory T cells and inhibited the activation of T helper 2 and T helper 17 cells to reduce atopic dermatitis-related immune responses. However, it showed no significant effect on the differentiation of T helper 1 cells. These results indicate that 3,3-diindolylmethane has a significant inhibitory effect on T helper 2 cells in the acute phase of atopic dermatitis. Our findings may provide not only more insights into the pathol. mechanism of AD, but also a new candidate medicine for it.

The article 《Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model》 also mentions many details about this compound(1968-05-4)Recommanded Product: 3,3′-Diindolylmethane, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

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Chloride – Wikipedia,
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Recommanded Product: 3,3′-Diindolylmethane. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about (Thio)urea-catalyzed Friedel-Crafts Reaction: Synthesis of Bis(indolyl)- methanes. Author is Rivas-Loaiza, Juan A.; Reyes-Escobedo, Carlos E.; Lopez, Yliana; Rojas-Lima, Susana; Garcia-Merinos, Juan Pablo; Lopez-Ruiz, Heraclio.

Bis(indolyl)methane derivatives (BIMs) were synthesized in moderate to good yields by (thio)urea catalyzed electrophilic substitution of indole with various aldehydes. Reactions were performed under conventional and microwave (MW) heating, either using 1,2-dichloroetane as solvent or without solvent. The procedure using microwave heating was also applied to the synthesis of the natural products vibrindole A, arsindoline A, arundine and tris(1H-indol-3-yl)methane. Addnl., the synthesis of streptindole was carried out via 2,2-bis(3-indolyl)acetic acid. This methodol. is well suited for the synthesis of bis(indolyl)methanes: it offers good yields of products, low sensitivity to moisture and oxygen, high tolerance to different functional groups on the aldehydes such as alkynes and trimethylsilane, and simplicity in operation.

The article 《(Thio)urea-catalyzed Friedel-Crafts Reaction: Synthesis of Bis(indolyl)- methanes》 also mentions many details about this compound(1968-05-4)Recommanded Product: 3,3′-Diindolylmethane, you can pay attention to it, because details determine success or failure

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Chloride – Wikipedia,
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Computed Properties of C17H14N2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about 3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway. Author is Zhu, Peiyao; Yu, Huayun; Zhou, Kun; Bai, Yu; Qi, Ruiqun; Zhang, Shuguang.

Abstract: Background: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive tumors in the world. Aryl hydrocarbon receptor (AHR) has been reported to promote tumor metastasis and epithelial-mesenchymal transition (EMT) is a vital process of conferring cancer cells capabilities of migration and invasion. However, the mechanism by which modulation of AHR can inhibit tumor metastasis remains unknown. Thus, we aim to investigate the underlying mechanism regarding reversing EMT process of ESCC through modulation of AHR. Methods: We used AHR selective modulator 3,3′-diindolylmethane (DIM) to treat ESCC cell lines TE1 and KYSE150 so as to examine alterations of migration and invasion by wound healing and Transwell assay. Western blotting (WB) and qPCR were performed to detect relative genes and proteins changes regarding EMT process. Cell transfection was utilized for confirming pathways involved in DIM-induced reversal of EMT and in vivo assay was conducted for verification of the underlying mechanism. Co-IP assay was conducted for detecting protein-protein interactions. Results: AHR was overexpressed in ESCC and modulation of AHR by DIM could inhibit migration and invasion as well as downregulate mesenchymal cell markers β-Catenin, Vimentin and Slug and upregulate epithelial cell marker Claudin-1. Meanwhile, synergically overexpression of AHR, RhoA and ROCK1 correlated with poor clin. outcomes. DIM could inhibit COX2/PGE2 pathway by targeting AHR, and COX2 selective inhibitor Celecoxib could suppress EMT and metastasis. Results of PGE2 treatment were opposite to that of Celecoxib. Meanwhile, blockade of RhoA/ROCK1 pathway also exerted prohibitive effects on EMT and metastasis. WB results showed COX2/PGE2 pathway could be regulated by RhoA/ROCK1 pathway and DIM could inhibit RhoA/ROCK1 pathway through modulation of AHR. In vivo assay verified the results in vitro. Co-IP results showed DIM could modulate AHR to reverse EMT directly through inhibition of interaction between AHR and EGFR (epidermal growth factor receptor) so as to block RhoA/ROCK1-mediated COX2/PGE2 pathway which was connected by NF-κB. Conclusions: In brief, modulation of AHR by DIM can reverse EMT process and inhibit metastasis of ESCC through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway.

After consulting a lot of data, we found that this compound(1968-05-4)Computed Properties of C17H14N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 1968-05-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Rapid measurement of indole levels in Brassica vegetables using one millilitre binary organic extraction solvent and capillary electrophoresis-UV analysis.

Introduction : Brassica vegetables contain high levels of indole compounds which have been found to provide health benefits, especially as cancer-preventive agents. An efficient and rapid method using solvent extraction with capillary electrophoresis (CE) and UV detection was developed for the determination of four major indoles from four types of Brassica vegetables. Materials and Methods : Freeze-dried samples of four Brassica vegetables, i.e. broccoli, cauliflower, Chinese cabbage and cabbage, were selected. Hence, 1 mL of the binary solvent DMF (DMF)-methanol, 4:1 (volume/volume), was used for sample extraction The extracts were diluted with the running buffer and directly analyzed using CE with UV detection of four indole compounds Results : The binary solvent DMF-methanol, 4:1 (volume/volume) was selected from studies of the extraction efficiency of standard indoles spiked in ivy gourd (as the neg. control sample) and using diphenylamine as the internal standard Recovery was 80(±10)-120(±3)% for the four indoles: indole-3-carbinol (I3C), indole-3-acetonitrile (I3A), indole-3-acetic acid (IAA), and 3,3′-diindolylmethane (DIM). For direct anal. suitable dilution of the extract with the running buffer was required. The linear range of the quantitation is 0.75-25.0μg/mL, limit of detection (LOD) of 0.14-0.52μg/mL and r2 > 0.998. The amount of indole in the Brassica vegetables are in the order I3C > > IAA, I3A > DIM. Conclusion : A rapid method for extraction and quantitation of four indoles in four Brassica vegetables using CE with UV detection was developed. It has the potential as an efficient technique for generating data for use in agricultural and nutritional studies.

After consulting a lot of data, we found that this compound(1968-05-4)Application of 1968-05-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Cancer Letters (New York, NY, United States) called Novel COX1/2 and ERK1/2 inhibitor 3,3′-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2, Author is Tian, Xueli; Liu, KangDong; Zu, Xueyin; Ma, Fayang; Li, Zhi; Lee, MeeHyun; Chen, Hanyong; Li, Yan; Zhao, Yuzhou; Liu, Fangfang; Oi, Naomi; Bode, Ann M.; Dong, Zigang; Kim, Dong Joon, which mentions a compound: 1968-05-4, SMILESS is C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4, Molecular C17H14N2, Application In Synthesis of 3,3′-Diindolylmethane.

3,3′-Diindolymethane (DIM) is a dimeric condensation product of indole-3-carbinol (I3C) that is found in broccoli and cabbage. Although DIM has been reported to exhibit anticancer properties against multiple tumor types, the direct target proteins of DIM have not been fully investigated. In the present study, we report that DIM is a novel COX1/2 and ERK1/2 inhibitor that suppresses growth of colon cancer in vitro and in vivo. To identify possible mol. targets of DIM, 11 potential candidate proteins were validated by an in vitro kinase or enzyme assay. We found that DIM directly inhibits COX1/2 and ERK1/2 protein activities in vitro. Addnl., the PGE2 production (COX-mediated metabolite) and phosphorylated RSK expression (ERK1/2 direct downstream kinase) were strongly suppressed by DIM in colon cancer cells. The inhibition of cell growth by DIM is dependent on the expression of COX1/2 or ERK1/2 proteins. Notably, oral administration of DIM suppressed patient-derived xenograft colon tumor growth in an in vivo mouse model. Overall these results suggest that DIM is a potent and dual COX1/2 and ERK1/2 inhibitor that might be used for chemotherapy against colon cancer.

After consulting a lot of data, we found that this compound(1968-05-4)Application In Synthesis of 3,3′-Diindolylmethane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3,3′-Diindolylmethane(SMILESS: C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4,cas:1968-05-4) is researched.Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The article 《Indoles derived from glucobrassicin: cancer chemoprevention by indole-3-carbinol and 3,3′-diindolylmethane》 in relation to this compound, is published in Frontiers in Nutrition. Let’s take a look at the latest research on this compound (cas:1968-05-4).

Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3,3′-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clin. models and show promise in clin. trials. The pharmacokinetics/pharmacodynamics of DIM have been studied in both rodents and humans and urinary DIM is a proposed biomarker of dietary intake of cruciferous vegetables. Recent clin. studies at Oregon State University show surprisingly robust metabolism of DIM in vivo with mono- and di-hydroxylation followed by conjugation with sulfate or glucuronic acid. DIM has multiple mechanisms of action, the most well-characterized is modulation of aryl hydrocarbon receptor (AHR) signaling. In rainbow trout dose-dependent cancer chemoprevention by dietary I3C is achieved when given prior to or concurrent with aflatoxin B1, polycyclic aromatic hydrocarbons, nitrosamines or direct acting carcinogens such as N-methyl-N′-nitro-nitrosoguanidine. Feeding pregnant mice I3C inhibits transplacental carcinogenesis. In humans much of the focus has been on chemoprevention of breast and prostate cancer. Alteration of cytochrome P 450-dependent estrogen metabolism is hypothesized to be an important driver of DIM-dependent breast cancer prevention. The few studies done to date comparing glucobrassicin-rich crucifers such as Brussels sprouts with I3C/DIM supplements have shown the greater impact of the latter is due to dose. Daily ingestion of kg quantities of Brussels sprouts is required to produce in vivo levels of DIM achievable by supplementation. In clin. trials these supplement doses have elicited few if any adverse effects. Sulforaphane from glucoraphanin can act synergistically with glucobrassicin-derived DIM and this may lead to opportunities for combinatorial approaches (supplement and food-based) in the clinic.

Although many compounds look similar to this compound(1968-05-4)Product Details of 1968-05-4, numerous studies have shown that this compound(SMILES:C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C17H14N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Amelioration of hyperglycemia-induced nephropathy by 3,3′-diindolylmethane in diabetic mice. Author is Choi, Kyeong-Mi; Yoo, Hwan-Soo.

Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. Diabetic nephropathy is a major complication of hyperglycemia. 3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. In mice, STZ induced hyperglycemia, hunger, thirst, and abnormally increased kidney weight and serum creatinine, which is a renal functional parameter. DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. DIM also improved diabetic nephropathy by inhibiting the expression of PKC-a, the marker of albuminuria, and TGF-beta1, an indicator of renal hypertrophy, in diabetic mice. Our findings suggest that DIM may ameliorate hyperglycemia and diabetic nephropathy through the inhibition of PKC-a and TGF-beta1 signaling.

Although many compounds look similar to this compound(1968-05-4)COA of Formula: C17H14N2, numerous studies have shown that this compound(SMILES:C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Organic & Biomolecular Chemistry called Thiamine hydrochloride as a recyclable organocatalyst for the synthesis of bis(indolyl)methanes, tris(indolyl)methanes, 3,3-di(indol-3-yl)indolin-2-ones and biscoumarins, Author is Mathavan, Sivagami; Kannan, Keerthana; Yamajala, Rajesh B. R. D., which mentions a compound: 1968-05-4, SMILESS is C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4, Molecular C17H14N2, Synthetic Route of C17H14N2.

Thiamine hydrochloride was identified as an eco-friendly organocatalyst for the synthesis of bis(indolyl)methanes I [R1 = H, Ph, 2-HOC6H4, etc.; R2 = H, 5-OMe, 5-Br; R3 = H, Me; R4 = H, Et], 3,3-di(indol-3-yl)indolin-2-ones II [R5 = cyclohexyl, 2-oxoindolin-3-yl, R6 = H, 5-OMe, 5-Br; R7 = H, Me; R8 = H, Et] and biscoumarin derivatives III [R9 = Ph, 3-FC6H4, 4-NCC6H4, etc.] in good to excellent yields was reported. Green chem. matrix calculations for compound I [R1 = Ph; R2 = H; R3 = H; R4 = H] and III [R9 = Ph] showed high atom economy and a small E-factor for the reaction. Moreover the simple and easy operational protocol using a small amount of thiamine hydrochloride (1 mol%) made this procedure an alternative approach for this transformation industrially.

In some applications, this compound(1968-05-4)Synthetic Route of C17H14N2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics