Tag: M.W=250-300

Ravn, Anne K. published the artcileCarbon Isotope Labeling Strategy for β-Amino Acid Derivatives via Carbonylation of Azanickellacycles, COA of Formula: C7H13ClNNaO5S, the publication is Journal of the American Chemical Society (2019), 141(30), 11821-11826, database is CAplus and MEDLINE.

A series of 4-membered azametallacycles have been prepared by the oxidative addition of Ni(0) with aziridines. Stoichiometric ¹³C-labeled carbon monoxide could be efficiently incorporated via Ni-C bond insertion to generate air stable and isolable cyclic Ni-acyl complexes. Upon subjection to a range of C-, N-, O-, and S-nucleophiles, ¹³C-labeled β-amino acids and derivatives thereof, as well as β-aminoketones, could be rapidly accessed. The methodol. proved highly adaptable for the synthesis of the antidiabetic drug, sitagliptin, with a single carbon isotope label.

Journal of the American Chemical Society published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, COA of Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chandrasekhar, T. published the artcileSynthesis and biological evaluation of some new aryl acid N’-(1H-indazole-3-carbonyl)-hydrazide derivatives, Formula: C11H7ClFNO3, the publication is Journal of Chemical and Pharmaceutical Research (2012), 4(5), 2795-2802, database is CAplus.

Amide coupling of 1H-indazole-3-carboxylic acid hydrazide with substituted aryl acids affords thirteen novel Aryl acid N’-(1H-indazole-3-carbonyl)-hydrazide derivatives The acid hydrazide was synthesized by the hydrazine reaction with 1-H-indazole-3-carboxylic acid Me ester which was obtained by esterification of indazole-3-carboxylic acid.

Journal of Chemical and Pharmaceutical Research published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Formula: C11H7ClFNO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lashkhi, V. L. published the artcileAntiwear action of organophosphorus and chloroorganophosphorus compounds in lubricating oils, Category: chlorides-buliding-blocks, the publication is Khimiya i Tekhnologiya Topliv i Masel (1975), 47-50, database is CAplus.

Antiwear additives with high thermal adsorption properties, such as CCl3(CH2)6PO(OEt)2 [53280-04-9] were effective for friction at low contact loads and low sliding rates. Others, such as CCl3PO(OEt)2 [866-23-9], PhPO(OCH2CCl3)2 [18255-20-4], and CCl3PO(OBu)2 [5887-93-4], forming strong superficial films, were effective for high sp. loads and high velocities. The additive CCl3C6H4PO(OEt)2 [28652-49-5], had simultaneously high thermal adsorption and gave strong films. The higher the work function of the metal electron, the higher was the efficiency of the additive. The esters of phosphonic acids, with or without Cl and having low chem. activity for a metal, were ineffective antiwear additives.

Khimiya i Tekhnologiya Topliv i Masel published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sanin, P. I. published the artcileInteraction of antiwear additives with friction surfaces, Product Details of C5H10Cl3O3P, the publication is Wear (1974), 30(2), 249-56, database is CAplus.

A study of the effects of phosphonic acid esters on frictional wear under diverse loads and sliding speeds indicated that the efficiency of such phosphonates (I) as antiwear additives depends on their structure and varies with the frictional modes. Principal I were grouped as esters which are ineffective under both high and low loads (esters with no Cl atoms); esters effective under both high and low loads (CCl3-group containing esters); and esters effective under high or low loads. The interaction of I with steel has been studied. Dissimilarity in the efficiency of esters as lubricating oil additives is explained by their different adsorption and chem. actions.

Wear published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosh, Harisadhan published the artcileSynthesis of axially chiral 1,8-diarylnaphthalene ligands and application in asymmetric catalysis: an intriguing fluorine effect, HPLC of Formula: 21286-54-4, the publication is Tetrahedron: Asymmetry (2015), 26(2-3), 79-84, database is CAplus.

A fluorinated and a non-fluorinated axially chiral 1,8-diarylnaphthalene ligand have been synthesized through an Ullmann and Suzuki coupling reaction based strategy. A practical methodol. for the successful chiral resolution of the newly synthesized catechol based moiety is presented. The authors also disclose the preliminary application of these axially chiral mols. as ligands in asym. transformation reactions. The synthesis of the target compounds was achieved by a reaction of 1,8-diiodonaphthalene with 1,2,3,4,5-pentafluoro-6-(iodo)benzene and formation of 1-iodo-8-(pentafluorophenyl)naphthalene. A Suzuki coupling of this aryl iodide with (2,3,6-trimethoxyphenyl)boronic acid gave a biaryl which was deprotected and resolved to deliver axially chiral biaryls 4-methoxy-3-[(1S)-8-(pentafluorophenyl)-1-naphthalenyl]-1,2-benzenediol and 4-methoxy-3-[(1R)-8-(pentafluorophenyl)-1-naphthalenyl]-1,2-benzenediol which was transformed into chiral titanium complexes.

Tetrahedron: Asymmetry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jayasundara, Chathurika R. K. published the artcileA Catalytic Borylation/Dehalogenation Route to o-Fluoro Arylboronates, Application of 2-(5-Chloro-2-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Organic Letters (2014), 16(23), 6072-6075, database is CAplus and MEDLINE.

A two-step Ir-catalyzed borylation/Pd-catalyzed dehalogenation sequence allows for the net synthesis of fluoroarenes where the boronic ester is ortho to fluorine. Key elements of this approach include the use of a halogen para to the fluorine to block meta Ir-catalyzed borylation and the chemoselective Pd-catalyzed dehalogenation by KF activated polymethylhydrosiloxane (PMHS).

Organic Letters published new progress about 1638847-73-0. 1638847-73-0 belongs to chlorides-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is 2-(5-Chloro-2-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H17BClFO2, Application of 2-(5-Chloro-2-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mayer, W. published the artcileThe pharmaceutical characterization and spectroscopy of AWD 26-06, Recommanded Product: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Pharmazie (1990), 45(8), 565-7, database is CAplus and MEDLINE.

Data are given on the TLC, stability, assay, and spectroscopic characteristics of the antiulcer drug AWD 26-06 (I). Brief TLC data are also given on 4 other compounds formed during the synthesis (not reported here) of I.

Pharmazie published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Recommanded Product: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gazizov, T. Kh. published the artcileReaction of dialkyl trimethylsilylphosphites with carbon tetrachloride, COA of Formula: C5H10Cl3O3P, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1984), 1830-2, database is CAplus.

The reaction of (EtO)₂POSiMe₃ with CCl₄ gave (EtO)₂P(O)Cl, (EtO)₂P(O)CCl₃, Me₃SiCl, Me₃SiCCl₃, disilacyclobutane I and HCCl₃. (RO)₂POSiMe₃ (R = Me, Pr) reacted similarly.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, COA of Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Spielmann, Kim published the artcileDiastereoselective Palladium-Catalyzed (3 + 2)-Cycloadditions from Cyclic Imines and Vinyl Aziridines, Computed Properties of 7080-50-4, the publication is Organic Letters (2018), 20(5), 1444-1447, database is CAplus and MEDLINE.

The synthesis of fused imidazolidines, e.g., I (x-ray single crystal structure shown), via two N-C bond-forming sequences has been developed. The transformation goes through a (3 + 2)-cycloaddition reaction in the presence of catalytic amounts of palladium by combining several vinyl aziridines and cyclic N-sulfonyl imines. Interestingly, the use of LiCl as additive allowed the improvement of diastereoselectivities when less encumbered substrates were used. The imidazolidine derivatives that bear aminal cores are isolated in high yields (15 examples, up to 96% yield) and diastereoselectivities (up to >20:1).

Organic Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C8H19NO2, Computed Properties of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tesfaldet, Zeriet O. published the artcileSequential injection spectrophotometric determination of trace amounts of iodide by its catalytic effect on the 4,4′-methylenebis(N,N-dimethylaniline)-chloramine-T reaction, Category: chlorides-buliding-blocks, the publication is Talanta (2004), 64(5), 1213-1219, database is CAplus and MEDLINE.

A simple and sensitive sequential injection spectrophotometric procedure is proposed for the determination of trace amounts of iodide in pharmaceutical preparations The method was based on the catalytic effect of iodide on the (tetra base) 4,4′-methylene bis(N,N-dimethylaniline)chloramine-T reaction in acidic solution The method involves a sequential aspiration of 255 μl sample/standard followed by 170 μl tetra base and then 128 μl chloramine-T solutions into a carrier stream to be stacked inside a holding coil and flow reversed through a reaction coil towards a detector. The resulting colored compound was measured at 600 nm using an UV/Vis-spectrophotometer. All the parameters that affected the reaction were evaluated and the calibration curve was linear over a range of 0.1-6.0 μg l^-1 of iodide concentration with detection limit of 0.05 μg l^-1. A sample throughput of 80 samples per h and relative standard deviation of less than 2.0% was achieved. The method was successfully applied for the determination of iodide in three different samples (tablets).

Talanta published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C3H12Cl2N2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics