Tag: M.W=250-300

Shi, Peng published the artcileRegio- and Stereoselective Chloro Sulfoximidations of Terminal Aryl Alkynes Enabled by Copper Catalysis and Visible Light, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Advanced Synthesis & Catalysis (2021), 363(10), 2552-2556, database is CAplus.

By visible-light photoredox catalysis with copper complexes, sulfoximidoyl chlorides add to terminal aryl alkynes to gave the corresponding (E)-β-chlorovinyl sulfoximines I [R = 2-thienyl, Ph, 2-naphthyl, etc.; R¹ = n-Pr, Ph, 4-MeC₆H₄, etc.] with exclusive regio- and stereoselectivities in high yields. Two representative products I [R = 4-BrC₆H₄, 4-t-BuC₆H₄; R¹ = Ph] had been characterized by X-ray crystal structure anal. Radicals appear was decisive intermediates. As demonstrated by two subsequent reactions, the products could be derivatized.

Advanced Synthesis & Catalysis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C9H21NO3, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Peng published the artcileVisible Light-Promoted Synthesis of β-Keto Sulfoximines from N-Tosyl-Protected Sulfoximidoyl Chlorides, Related Products of chlorides-buliding-blocks, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Under visible light, N-tosyl-protected sulfoximidoyl chlorides RSO(NTs)Cl (R = 4-CH₃C₆H₄, 4-CH₃OC₆H₅, 1-naphthyl, etc.) react with aryl alkynes R¹C₆H₄CC (R¹ = 4-Cl, 3-Br, 3-Me, etc.) to give β-keto sulfoximines I. The reaction is characterized by a high functional group tolerance and good yields. It can be improved by the presence of a ruthenium photocatalyst. Air is the source of the ketonic oxygen in the products.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H10BNO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ferrier, Robert J. published the artcileUnsaturated carbohydrates, part 28. Synthesis and photolysis of some carbohydrate 1,6-dienes, Related Products of chlorides-buliding-blocks, the publication is Carbohydrate Research (1985), 249-58, database is CAplus.

Several attempts to abbreviate author’s earlier syntheses of the prostaglandin intermediates I and II by photocyclization of carbohydrate-based 1,6-dienes III [R = R¹ = Cl, Br; RR¹ = S(CH₂)₃S; R = cyano, R¹ = NEt₂] and IV (R² = Me, OEt) did not yield the required bicyclo[3.2.0]heptane derivatives Photolysis of IV caused migration of the conjugated alkene bond.

Carbohydrate Research published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Murphy, Jaclyn M. published the artcileOne-Pot Synthesis of Arylboronic Acids and Aryl Trifluoroborates by Ir-Catalyzed Borylation of Arenes, HPLC of Formula: 929626-16-4, the publication is Organic Letters (2007), 9(5), 757-760, database is CAplus and MEDLINE.

The synthesis of arylboronic acids and aryl trifluoroborates in a one-pot sequence by Ir-catalyzed borylation of arenes is reported. To prepare the arylboronic acids, the Ir-catalyzed borylation is followed by oxidative cleavage of the boronic ester with NaIO₄ and to prepare the aryltrifluoroborate, the Ir-catalyzed borylation is followed by displacement of pinacol by KHF₂. These two-step sequences give products that are more reactive toward subsequent chem. than the initially formed pinacol boronates.

Organic Letters published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, HPLC of Formula: 929626-16-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hashimura, Kazuya published the artcileA stereocontrolled route to both enantiomers of the necine base dihydroxyheliotridane via intramolecular 1,3-dipolar addition using the same chiral precursor, Related Products of chlorides-buliding-blocks, the publication is Journal of the Chemical Society, Chemical Communications (1995), 2291-2, database is CAplus.

Diastereofacial selectivity in an enantiospecific intramol. 1,3-dipolar addition is controlled by adjusting the size of the tether between the dipole and the dipolarophile to give 2,3-disubstituted pyrrolidines enantiomeric with respect to the newly generated stereogenic 2,3-centers depending on the tether size; this leads to stereocontrolled synthesis of the (-)-(I) and (+)-enantiomers of the necine base dihydroxyheliotridane from chiral O-benzylglycidol.

Journal of the Chemical Society, Chemical Communications published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Binisti, Carine published the artcileStructure-activity relationships in platelet activating factor. 9. From PAF-antagonism to PLA₂ inhibition, Synthetic Route of 18791-02-1, the publication is Journal of Lipid Mediators and Cell Signalling (1997), 15(2), 125-144, database is CAplus and MEDLINE.

Novel acylated piperazines substituted at the 2-position by C_4-17 alkyl groups, analogs of known PAF-antagonists, were prepared by standard methods. These new compounds inhibited various secretory PLA₂s, with IC₅₀‘s in the μmol range. SAR evaluation showed that inhibition of secretory PLA₂ depends on the length of the alkyl chain, with an optimum for 13 to 17 carbons, which is in agreement with X-ray crystallog. and NMR (NMR) studies on the active site of PLA₂s, and that a free nitrogen on the piperazine ring is required to ensure a good inhibitory potency.

Journal of Lipid Mediators and Cell Signalling published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Synthetic Route of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cho, Jian-Yang published the artcileRemarkably selective iridium catalysts for the elaboration of aromatic C-H bonds, Name: Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, the publication is Science (Washington, DC, United States) (2002), 295(5553), 305-308, database is CAplus and MEDLINE.

Arylboron compounds have intriguing properties and are important building blocks for chem. synthesis. A family of Ir catalysts (IndIr(COD), (η⁶-mesitylene)Ir(BPin)₃ (4; HBPin = pinacolborane)) now enables the direct synthesis of arylboron compounds from aromatic hydrocarbons and boranes under solventless conditions. For example, a 98% yield of PhBPin was obtained in 15 h at 150° from benzene and HBPin (16:1 ratio) in the presence of 4 and PMe₃. The Ir catalysts are highly selective for C-H activation and do not interfere with subsequent in situ transformations, including Pd-mediated cross-couplings with aryl halides (e.g. 80% 3,5-dichloro-3′-methylbiphenyl). By virtue of their favorable activities and exceptional selectivities, these Ir catalysts impart the synthetic versatility of arylboron reagents to C-H bonds in aromatic and heteroaromatic hydrocarbons.

Science (Washington, DC, United States) published new progress about 408492-29-5. 408492-29-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronate Esters,Boronic acid and ester,, name is Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C14H18BClO4, Name: Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gramstad, Thor published the artcileStudies of hydrogen bonding. Part XXVIII. Hydrogen bond association of phenol with 5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinanes and diethylphosphonates, SDS of cas: 866-23-9, the publication is Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1977), B31(5), 345-53, database is CAplus.

The association constant and enthalpy of formation of the equilibrium between phenol and twelve 5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinanes I (R = Cl, CCl3, OMe, Ph, NMe2, etc.) and six diethylphosphonates (EtO)2P(O)R1 (R1 = CCl3, SMe, CPh3, etc.) were determined The association constant, enthalpy of association, half band width, ν1/2, of the complexed O-H bond, P(O) bond moment, μPO, and excess charge d., Δq, on the phosphoryl O give linear relations with the O-H frequency shift, ΔνOH. The calculated P(O) bond moment in the axial and equatorial position gives a linear correlation with the exptl. P(O) stretching frequency. Furthermore, the square root of the addnl. dipole moment, Δμ1/2, due to H bond formation, correlates linearly with the association constant, the O-H frequency shift, and with the half band width. A close relationship between band width of the complexed O-H bond and the strength and polarity of the H bonded complex is deduced.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pasha, Maira published the artcileCatalytic enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones: synthesis of tetrahydropyranones, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Heterocycles (2021), 103(1), 198-204, database is CAplus.

Diastereo- and enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones that afford tetrahydropyranone derivatives catalyzed by an amine-based catalyst system are reported. The major diastereomers of the tetrahydropyranone products obtained in these reactions had the relative stereochem. different from that of the previously synthesized tetrahydropyranone derivatives

Heterocycles published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yanagi, Tomoyuki published the artcileAsymmetric systematic synthesis, structures, and (chir)optical properties of a series of dihetero[8]helicenes, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Science (2021), 12(8), 2784-2793, database is CAplus and MEDLINE.

A series of dihetero[8]helicenes (P)/(M)/(rac)-I (R = O, S, NH, SO₂) have been systematically synthesized in enantiomerically enriched forms by utilizing the characteristic transformations of the organosulfur functionality. The synthetic route begins with assembling a ternaphthyl II common synthetic intermediate from 2-naphthol and 2,7-bis(phenethylsulfinyl)naphthalene through an extended Pummerer reaction followed by facile multi-gram-scale resolution The subsequent cyclization reactions into dioxa- and dithia[8]helicenes (P)/(M)/(rac)-I take place with excellent axial-to-helical chirality conversion. Dithia[8]helicenes (P)/(M)/(rac)-III are further transformed into the nitrogen (P)/(M)/(rac)-I and the carbon analogs (P)/(M)/(rac)-IV and (P)/(M)/(rac)-V by replacing the two endocyclic sulfur atoms via S_NAr-based skeletal reconstruction. The efficient systematic synthesis has enabled comprehensive evaluation of phys. properties, which has clarified the effect of the endocyclic atoms on their structures and (chir)optical properties as well as the unexpected conformational stability of the common helical framework.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15NO, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics