Tag: M.W=250-300

Khare, R. K. published the artcileSynthesis and fungicidal activity of some 5-methylene-2-[5′-aryl-1′,3′,4′-oxa(thia)diazol-2′-yl]amino-4-thiazolones, Computed Properties of 18791-02-1, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1995), 34B(9), 828-31, database is CAplus.

N¹-(5-aryl-1,3,4-oxa(thia)diazol-2-yl)thioureas undergo regioselective cyclocondensation with 2,3-dibromopropionyl chloride to give 5-methylene-2-[5′-aryl-1′,3′,4′-oxa(thia)diazol-2′-yl]amino-4-thiazolones. These thiazolones have been tested in vitro for their antifungal activity against Aspergillus niger and Fusarium oxysporium and results compared with their parent thioureas. Attempts have also been made to correlate structural features of tested compounds with their activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Computed Properties of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Balaganesh, Muthiah published the artcilePhotodissociation of CH₂BrCHBrC(O)Cl at 248 nm: probing Br₂ as the primary fragment using cavity ring-down spectroscopy, Name: 2,3-Dibromopropionylchloride, the publication is Physical Chemistry Chemical Physics (2021), 23(39), 22492-22500, database is CAplus and MEDLINE.

The photodissociation of 2,3-dibromopropionyl chloride (CH₂BrCHBrC(O)Cl, 2,3-DBPC) at 248 nm was carried out to study Br₂ as the primary mol. product in the B³Î ⁺_0u â†?X¹Î£⁺_g transition using cavity ring-down absorption spectroscopy. The rotational spectra (v” = 0-2) were acquired and assigned with the aid of spectral simulation. It is verified that the obtained Br2 fragment is attributed to the one-photon dissociation of 2,3-DBPC and is free from contributions of secondary reactions. The vibrational ratio of the Br2 population of v(0):v(1):v(2) is equal to 1:(0.58 ± 0.12):(0.23 ± 0.09), corresponding to the Boltzmann vibrational temperature of 623 ± 38 K. The quantum yield of Br₂ eliminated from 2,3-DBPC is estimated to be 0.09 ± 0.04. The dissociation pathways of 2,3-DBPC and its potential energy surfaces were calculated using d. functional theory. By employing the CCSD(T)//M062X/6-31+g(d,p) level of theory, transition state barriers and corresponding reaction energies were calculated for the Br, Cl, Br₂, BrCl, HBr and HCl elimination channels. The unimol. rate constant for Br₂ elimination was determined to be 2.09 x 10⁵ s^-1 using Rice-Ramsperger-Kassel-Marcus (RRKM) theory, thus explaining the small quantum yield of the Br₂ channel.

Physical Chemistry Chemical Physics published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Name: 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Van Tilborg, W. J. M. published the artcileThe electrochemical Wittig-Horner reaction; evidence of a stepwise cleavage of a four-membered ring Wittig intermediate, Application In Synthesis of 866-23-9, the publication is Recueil des Travaux Chimiques des Pays-Bas (1980), 99(6), 202-6, database is CAplus.

Electroreduction of diethyl(trichloromethyl)phosphonate in the presence of aldehydes or ketones replaces the O atom of the carbonyl group by a dichloromethylene group. The yield of 1,1-dichloroethene product decreases substantially if the carbonyl compound carries strongly acidic hydrogen. In several cases the conversion of the 4-membered ring Wittig intermediate into its corresponding carbanion by heterolytic P-C bond cleavage was observed The intermediate carbanion is sufficiently stable to be intercepted by proton abstraction. These observations suggest that the decomposition of the Wittig 4-membered ring intermediate occurs along a 2-step pathway.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C24H20Ge, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gotsko, Maxim D. published the artcileTopochemical mechanoactivated phosphonylethynylation of pyrroles with chloroethynylphosphonates on solid Al₂O₃ or K₂CO₃ media, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Tetrahedron Letters (2015), 56(32), 4657-4660, database is CAplus.

Dialkyl 2-(1H-pyrrol-2-yl)ethynylphosphonates have been synthesized from their resp. pyrroles by a transition metal-free, topochem. mechanoactivated phosphonylethynylation (room temperature, 24-48 h) using chloroethynylphosphonates on solid Al₂O₃ (40-58% yield) or K₂CO₃ (38-43% yield).

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tomashevskii, A. A. published the artcileReaction of (α-haloalkyl)thiiranes with nucleophilic reagents. I. Reaction with morpholine, HPLC of Formula: 18791-02-1, the publication is Zhurnal Organicheskoi Khimii (1994), 30(10), 1528-36, database is CAplus.

D-labeling experiments showed that (chloromethyl)thiirane reacts with morpholine by a mechanism involving initial ring cleavage and subsequent recyclization. In the case of (bromomethyl)thiirane, direct substitution of Br competes with this mechanism. Reactions of morpholine with 2-(chloromethyl)-2-methylthiirane, 3-(chloromethyl)-2,2-dimethylthiirane, and diastereoisomers of (1-chloroethyl)thiirane were also examined

Zhurnal Organicheskoi Khimii published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C5H5BrN2, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Tae-Kyung published the artcileSynthesis of a novel bridge compound having hetero-bi-functional reactive groups. Part 1: its adsorption properties, HPLC of Formula: 18791-02-1, the publication is Dyes and Pigments (2005), 65(3), 261-266, database is CAplus.

A novel heterobifunctional compound containing two different reactive groups, α,β-dibromopropionylamino and dichloro-s-triazinyl groups, was synthesized. The α,β-dibromopropionylamino group had considerable reactivity towards amines or amino groups under acidic conditions and high temperature The dichloro-s-triazinyl group had reactivity towards hydroxyl groups under alk. conditions and room temperature The compound was used as a bridge to fix dyes containing amino groups (e.g. 1-amino-4-hydroxyanthraquinone) to cellulosic substrates (e.g. cotton textiles). The effects of temperature, pH, neutral salt, treatment time and concentration on chemisorption of the bridge compound to cotton fibers were investigated. The heterobifunctional compound provided the 1-amino-4-hydroxyanthraquinone-dyed cotton textile with a color strength of 14.73, while the dyed untreated textile had a color strength of 0.78.

Dyes and Pigments published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Hai published the artcileStructural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase, Quality Control of 866-23-9, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(6), 1651-1654, database is CAplus and MEDLINE.

Low brain levels of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) lead to convulsions. Inhibition of GABA aminotransferase increases the concentration of GABA and can terminate the convulsions. Earlier we reported the synthesis of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid (2), which is 186 times more potent an inactivator of GABA aminotransferase than the epilepsy drug S-vigabatrin. The corresponding dichloromethylene analog of 2 (compound 3) has been made, but it shows only weak reversible inhibition of GABA aminotransferase. However, the tetrazole isostere of 2 (compound 4) has been found to be a time-dependent inactivator of GABA aminotransferase. Although it is 20 times less potent than carboxylic acid 2, it is 2.5 times more potent than S-vigabatrin. A calculation of the Clog P values indicates that 4 is the most lipophilic of the three, being 69 times more lipophilic than 2 and 55 times more lipophilic than S-vigabatrin, indicating potential for improved bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C26H41N5O7S, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pachl, Petr published the artcileStructure-Based Optimization of Bisphosphonate Nucleoside Inhibitors of Human 5′(3′)-deoxyribonucleotidases, Application of Diethyltrichloromethylphosphonate, the publication is European Journal of Organic Chemistry (2018), 2018(37), 5144-5153, database is CAplus.

Cellular 5′-nucleotidases, enzymes regulating nucleotide/nucleoside pools, are capable of dephosphorylating phosphomonoesters of important nucleoside analog drugs, thus decreasing their therapeutic efficacy. Human cytosolic (cdN) as well as mitochondrial (mdN) variants of this enzyme represent interesting targets for development of inhibitory compounds In this work, bisphosphonate nucleoside derivatives were designed by using a structure-based approach. A second phosphonate group was attached onto a base moiety and by optimization of the linker an increased inhibitor potency towards mdN and cdN was attained. The best compound exhibited inhibition of both enzymes in a nanomolar range, making it the most potent inhibitor of these enzymes prepared to date. In addition, the compounds showed selectivity towards the cdN variant. A series of crystal structures were solved for several inhibitors in the complex with mdN or cdN that provided a structural basis for understanding the inhibition profile of bisphosphonate compounds

European Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Exner, O. published the artcileThe inductive effect. IV. Transmission of the inductive effect through the furan and thiophene nuclei, Formula: C5H10Cl3O3P, the publication is Collection of Czechoslovak Chemical Communications (1964), 29(9), 2016-22, database is CAplus.

cf. CA 61, 562g. The apparent dissociation constants of substituted (R = H, Me, OH, OMe, OPh, SH, SO₂Ph, NMe₃Cl) 5-methylpyromucic (I) and 5-methylthiophene-2-carboxylic (II) acids were determined in 80% Me Cello-solve. The relative sensitivity to substitution in both series is believed to represent the value of the mobility of the π-electrons and indirectly the measure of the aromatic character of the skeleton which decreases in the order benzene > thiophene > furan.

Collection of Czechoslovak Chemical Communications published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ruefenacht, Kurt published the artcilePhosphoric acid esters and thiophosphoric acid esters with some heterocyclic substitutions. 7. Thio- and dithiophosphoric acid esters of the GS 13005 type with some analog or homolog heterocyclic rings, Product Details of C3H3Br2ClO, the publication is Helvetica Chimica Acta (1973), 56(7), 2186-204, database is CAplus.

Analogs of the pesticide GS 13005 were prepared, including pyrazolinones of the type I, (R = Cl, OH), pyrazoles II, (R = H, Me, Cl; R1 = H, Cl, Br, NO2; R2 = H, Me, iso-Pr; R3 = Cl, OH), pyridazinones III, (R = H, Cl, Br, Me, Et; R1 = H, Cl, Me; R2 = H, Cl, Me; R3 = Cl, OH), thiadiazinones IV, (R = Me, Et; R1 = Cl, OH), and their mono- and dithiophosphates. The preparation, of analogous thiadiazepinones failed, giving instead pyrazolidinone derivatives Approx. 100 compounds were prepared

Helvetica Chimica Acta published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Product Details of C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics