Tag: M.W=250-300

Burger, L. L. published the artcileUranium and plutonium extraction by organophosphorus compounds, Safety of Diethyltrichloromethylphosphonate, the publication is Journal of Physical Chemistry (1958), 590-3, database is CAplus.

Organic phosphates, phosphonates, phosphinates, and phosphine oxides were compared as solvents for U and Pu nitrates. Distribution coefficients for U(VI), Pu(IV), and Pu(VI) indicated a large difference in solvent strength among these groups of compounds The introduction of an electroneg. group greatly reduced the solvent strength. The P-O stretching frequency was correlated with solvent strength for these compounds Some solid complexes of the organophosphorus compounds with UO₂(NO₃)₂ were isolated.

Journal of Physical Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Yu published the artcileThe Copper-Catalyzed Reaction of 2-(1-Hydroxyprop-2-yn-1-yl)phenols with Sulfonyl Azides Leading to C3-Unsubstituted N-Sulfonyl-2-iminocoumarins, Application In Synthesis of 21286-54-4, the publication is Journal of Organic Chemistry (2021), 86(13), 9155-9162, database is CAplus and MEDLINE.

An operationally simple synthesis of Z-configured and C3-unsubstituted N-sulfonyl-2-iminocoumarins I [R¹ = H, 6-Br, 6-Cl, 6-Me; R² = H, Me; R³ = Me, Ph, 4-ClC₆H₄, etc.] was achieved by reacting 2-(1-hydroxyprop-2-yn-1-yl)phenols with sulfonyl azides. The cascade process involved likely starts with a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. This was followed by ring-opening of the resulting metalated triazole (with accompanying loss of nitrogen), reaction of the ensuing ketenimine with the pendant phenolic hydroxyl group and finally dehydration of the (Z)-N-(4-hydroxychroman-2-ylidene)sulfonamide so formed.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C3H5BN2O2, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Tonghao published the artcileCopper-catalyzed radical reactions of 2-azido-N-arylacrylamides with 1-(trifluoromethyl)-1,2-benziodoxole and 1-azidyl-1,2-benziodoxole, Related Products of chlorides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2016), 14(13), 3376-3384, database is CAplus and MEDLINE.

The reactions of 2-azido-N-arylacrylamides with trifluoromethyl radicals and azidyl radicals were investigated by using Togni’s reagent and Zhdankin’s reagent as the source of these radicals. Under the catalysis of CuI, Togni’s reagent was firstly converted into the trifluoromethyl radical, which then reacted with 2-azido-N-arylacrylamides to afford the corresponding α-(arylaminocarbonyl)iminyl radicals. The cyclization of the iminyl radicals delivered quinoxalin-2(1H)-one products in moderate yields. A similar reaction took place between 2-azido-N-arylacrylamides and the azidyl radical. In the latter cases, the reaction produced 3-azidomethyl and 3-cyano-substituted quinoxalin-2(1H)-ones. This study not only helps to elucidate the factors influencing the cyclization of α-(arylaminocarbonyl)iminyl radicals, but also provided a new approach towards quinoxalin-2-ones.

Organic & Biomolecular Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C26H26N4O7, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Zhenzhen published the artcileCopper-Catalyzed Carbotrifluoromethylation of Unactivated Alkenes Driven by Trifluoromethylation of Alkyl Radicals, Formula: C5H10Cl3O3P, the publication is Chinese Journal of Chemistry (2019), 37(5), 452-456, database is CAplus.

Herein an unprecedented protocol for radical carbotrifluoromethylation of unactivated alkenes is reported. With Cu(OTf)₂ as the catalyst, the reaction of unactivated alkenes, TMSCF₃ and activated alkyl chlorides at room temperature provides the corresponding carbotrifluoromethylation products in satisfactory yields. Directed by trifluoromethylation of alkyl radicals, the method exhibits an excellent regioselectivity that is opposite to those driven by CF₃ radical addition

Chinese Journal of Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C6H8O6, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Bangkui published the artcilePalladium-Catalyzed Ring-Closing Reaction for the Synthesis of Saturated N-Heterocycles with Aminodienes and N,O-Acetals, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2021), 86(11), 7849-7863, database is CAplus and MEDLINE.

An efficient palladium-catalyzed ring-closing reaction of aminodienes e.g., (E)-N-(2-(benzylamino)ethyl)-4-methyl-N-(penta-2,4-dien-1-yl)benzenesulfonamide with N,O-acetals RN(R¹)CH₂OCH₃ [R = n-Bu, Bn, (4-bromophenyl)methyl, etc.; R¹ = n-Bu, Bn, (4-bromophenyl)methyl, etc.; RR¹ = -(CH₂)₂O(CH₂)₂-] for the synthesis of saturated N-heterocycles e.g., (E)-N,N-dibenzyl-3-(1-benzyl-4-tosyl-1,4-diazepan-6-yl)prop-2-en-1-amine is described. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups with volatile MeOH as the sole byproduct. This method provides rapid and practical access to a broad range of saturated N-heterocycles e.g., (E)-N,N-dibenzyl-3-(1-benzyl-4-tosyl-1,4-diazepan-6-yl)prop-2-en-1-amine with diverse structural backbones that are useful building blocks in natural product synthesis and drug discovery.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C12H14BNO2, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mao, Liu-Liang published the artcileVisible-light-induced sulfonylation/cyclization of vinyl azides: one-pot construction of 6-(sulfonylmethyl)phenanthridines, Application In Synthesis of 21286-54-4, the publication is Organic Chemistry Frontiers (2018), 5(2), 232-236, database is CAplus.

Visible-light-induced sulfonylation/cyclization of vinyl azides were developed for the synthesis of 6-(sulfonylmethyl)phenanthridines. This facile and efficient approach used simple and readily available sulfonyl chlorides as the sulfonylation reagent for the construction of C-S bonds and triggered the formation of the C-N bond with mild conditions, broad substrate scope and high functional group tolerance.

Organic Chemistry Frontiers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Renxiang published the artcileModified and Scalable Synthesis of N-Tosyl-4-Chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor): Direct Imidation of Sulfinyl Chlorides with Chloramine-T Trihydrate, Category: chlorides-buliding-blocks, the publication is Organic Process Research & Development (2022), 26(2), 380-386, database is CAplus.

A general and practical method for the preparation of N-Tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) and its adaptation to a large scale was disclosed. Starting from readily available 4-chlorobenzenesulfonyl chloride, chloramine-T trihydrate and potassium fluoride, SulfoxFluor was prepared on a hectogram scale in 63% overall yield with simple purification techniques. The use of chloramine-T trihydrate (instead of anhydrous chloramine-T) was a significant improvement over previous work, which streamlined the process and avoided the risk of explosion during drying or heating. This research not only established a reliable method for the scale-up synthesis of SulfoxFluor but also provided an insight into the imidation of sulfinyl chlorides with chloramine-T in the presence of water.

Organic Process Research & Development published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Lixin published the artcilePalladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles, SDS of cas: 21286-54-4, the publication is Organic Letters (2017), 19(17), 4600-4603, database is CAplus and MEDLINE.

A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)indoles, e.g., I, and 2-(2-aminoethyl)pyrrolidines, e.g., II (X-rays single crystal structures for both compounds shown), which are important building blocks in synthetic organic chem. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gong, Kai published the artcileFrom symmetrical tetrasulfides to trisulfide dioxides via photocatalysis, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Green Chemistry (2021), 23(24), 9865-9869, database is CAplus.

A straightforward strategy involving photocatalysis has been established for accessing trisulfide dioxides R¹SSSO₂R² (R¹ = Et, t-Bu, 1-adamantyl, 2-MeC₆H₄, etc.; R² = cyclopropyl, Ph, 4-FC₆H₄, 2-thienyl, etc.) from readily achieved sym. tetrasulfides R¹S₄R¹ and sulfinic acids R²SO₂H. Stern-Volmer anal. and radical quenching experiments demonstrated the occurrence of a single electron transfer between the photocatalyst and sulfinic acid. Bioactive mols. such as the antihypertensive drug captopril, allicin derivatives, amino acids and terpenes were efficiently and reversibly linked through sulfur-sulfur covalent bonds. Furthermore, flow-setup syntheses of trisulfide dioxides were successfully achieved on the gram scale, indicating the great potential of the developed protocol for practical industrial applications.

Green Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhou, Xian-yan published the artcileDT-GC-MS analysis on environmental risk of poplar engineering biocomposites, Synthetic Route of 18585-06-3, the publication is Advanced Materials Research (Zuerich, Switzerland) (2010), 129-131(Pt. 2), 780-783, database is CAplus.

Poplar engineering biocomposites are new engineering material. In order to evaluate its potential environmental risk to human, the volatile organic compounds of poplar engineering biocomposites were adsorbed and determined by TD-GC-MS. The result were: (1) The main constituents of volatiles at 40°C were bicyclo[2.2.1]heptan-2-one, 1,7,7- trimethyl-, (1r)-(31.55%), 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester(14.94%), 2,6,10,14,18,22-tetracosahexaene, 2,6,10,15,19,23-hexamethyl-(7.34%), [1,1′:3′,1″-terphenyl]-2′-ol(5.97%), cedrol (5.29%), caryophyllene(5.26%), 3-[(1z)-1,3-butadienyl]-4-vinylcyc lopentene(3.92%), etc. (2) The main constituents of volatiles at 60°C were 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester(17.13%), [1,1′:3′,1″-terphenyl]-2′-ol(9.11%), camphor(8.6%), 4-imidazolidinone, 5-(phenylmethyl)-2-thioxo- (7.6%), cedrol(7.26%), 2,5-cyclohexadiene-1,4-dione, 2,5-diphenyl-(4.58%), 1h-indole, 5-methyl- 2-phenyl-(3.94%), 2,6,10,14,18,22-tetracosahexaene, 2,6,10,15,19,23-hexamethyl- (3.63%), phenol,2,4-bis(1,1-dimethylethyl) (3.56%), etc. So the poplar engineering biocomposites was safe under 40-60°C.

Advanced Materials Research (Zuerich, Switzerland) published new progress about 18585-06-3. 18585-06-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Amine,Benzene,Amide, name is Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate, and the molecular formula is C22H28ClN7O3S, Synthetic Route of 18585-06-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics