Tag: M.W=250-300

Wang, Dungai published the artcileMetal- and base-free reductive coupling reaction of P(O)-H with aryl/alkyl sulfonyl chlorides: a novel protocol for the construction of P-S-C bonds, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Organic & Biomolecular Chemistry (2017), 15(3), 545-549, database is CAplus and MEDLINE.

Novel and efficient synthesis of S-aryl/alkyl phosphinothioates from P(O)-H and aryl/alkyl sulfonyl chlorides under metal- and base-free conditions is described. This reaction provides an alternative strategy for the construction of P-S-C bonds in moderate to excellent yields. Moreover, this method can be readily applied to gram-scale preparation

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C2H2N4O2, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, Ke-Liang published the artcileDesign, Synthesis, and Bioevaluation of Substituted Phenyl Isoxazole Analogues as Herbicide Safeners, Computed Properties of 3919-74-2, the publication is Journal of Agricultural and Food Chemistry (2020), 68(39), 10550-10559, database is CAplus and MEDLINE.

Herbicide safeners enhance herbicide detoxification in crops without affecting target weed sensitivity. To enhance crop tolerance to the toxicity-related stress caused by the herbicide acetochlor (ACT), a new class of substituted Ph isoxazole derivatives was designed by an intermediate derivatization method as herbicide safeners. Microwave-assisted synthesis was used to prepare the Ph isoxazole analogs, and all of the structures were confirmed via IR, ¹H NMR, ¹³C NMR, and HRMS. Compound (I) was further characterized by X-ray diffraction anal. Bioassay results showed that most of the obtained compounds provided varying degrees of safening against ACT-induced injury by increasing the corn growth recovery, glutathione content, and glutathione S-transferase activity. In particular, compound (II) showed excellent safener activity against ACT toxicity, comparable to that of the com. safener benoxacor. Gaussian calculations have been performed and the results indicated that the nucleophilic ability of compound II is higher than that of benoxacor, thus the activity is higher than that of benoxacor. These findings demonstrate that Ph isoxazole derivatives possess great potential for protective management in corn fields.

Journal of Agricultural and Food Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Computed Properties of 3919-74-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Zi-Wei published the artcileFragments recombination, design, synthesis, safener activity and CoMFA model of novel substituted dichloroacetylphenyl sulfonamide derivatives, Formula: C11H7ClFNO3, the publication is Pest Management Science (2021), 77(4), 1724-1738, database is CAplus and MEDLINE.

Isoxaflutole (IXF), as a kind of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, has been widely used in many kinds of plants. IXF can cause injury in corn including leaf and stem bleaching, plant height reduction or stunting, and reduced crop stand. Safeners are co-applied with herbicides to protect crops without compromising weed control efficacy. With the ultimate goal of addressing Zea mays injury caused by IXF, a series of novel substituted dichloroacetylphenyl sulfonamide derivatives was designed on the basis of scaffold hopping and active substructure splicing. A total of 35 compounds were synthesized via acylation reactions. All the compounds were characterized by IR (IR), proton and carbon-13 NMR (¹H-NMR and ¹³C-NMR), and high-resolution mass spectrometry (HRMS). The configuration of compound II-1 was confirmed by single crystal X-ray diffraction. The bioassay results showed that all the title compounds displayed remarkable protection against IXF via improved content of carotenoid. Especially compound II-1 which possessed better glutathione transferases (GSTs) activity and carotenoid content than the contrast safener cyprosulfamide (CSA). All the satisfied parameters suggested that the Comparative Mol. Field Anal. (CoMFA) model was reliable and stable [with a cross-validated coefficient (q²) = 0.527, r² = 0.995, r²_pred = 0.931]. The mol. docking simulation indicated that the compound II-1 and CSA could compete with diketonitrile (DKN) at the active site of HPPD, which is a hydrolyzed product of IXF in plants, causing the herbicide to be ineffective. The present work revealed that the compound II-1 deserves further attention as the candidate structure of safeners.

Pest Management Science published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C22H18O2, Formula: C11H7ClFNO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Liang-chen published the artcileAroma finishing of silk fabric grafted with α-bromoacrylamidoethyl cyclodextrin, Quality Control of 18791-02-1, the publication is Yinran (2009), 35(17), 5-9, database is CAplus.

α-Bromoacrylamidoethyl cyclodextrin (β-CD-2-EDBA) was prepared with β-cyclodextrin, p-toluenesulfonyl chloride and 2,3-dibromo-propionyl chloride. Aroma finishing of silk fabric grafted with 8-CD-2-EDBA was carried out. Optimum grafting process was pH value 9, grafting agent 16% (owf), sodium sulfate 8 g/L, liquor ratio 1:50, and treating at 90°C for 40 min. Grafting ratio of treated silk fabric was high, and fragrance storage and fragrance retention time enhanced significantly. Scanning electron microscope picture proved that B-CD-2-EDBA was successfully grafted onto silk surface. Grafting ratio was tested with phenolphthalein spectral probe method and gravimetric method sep., it was found that the former had higher grafting ratio, while the latter was more accurate.

Yinran published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Quality Control of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Liang-chen published the artcileThe synthesis of novel finishing agent mono-(2-(2,3-dibromopropionyl)ethylenediamino-2-deoxy)-β-cyclodextrin, SDS of cas: 18791-02-1, the publication is Donghua Daxue Xuebao, Ziran Kexueban (2010), 36(3), 237-243, database is CAplus.

Cyclodextrins can be grafted onto silk in fragrance finishing. Mono-(2-O-tosyl)-β-cyclodextrin (β-CD-2-OTs) was produced under a chem. reaction between β-cyclodextrin and TsCl with a mole ratio of 1:6 in alk. aqueous solution 2-ethylenediamio-β-cyclodextrin (β-CD-2-E) was synthesized under the reaction between β-CD-2-OTs and ethylenediamine at the temperature around 60 °C. Mono-(2-(2,3-dibromopropionyl)ethylenediamino-2-deoxy)-β-cyclodextrin was synthesized through the reaction between β-CD-2-E and 2,3-dibromopropionyl chloride. The synthesis process was proved to be successful through the anal. of FT-IR spectra and ¹H-NMR spectrum. The novel finishing agent was proved to graft onto silk successfully through the SEM pictures.

Donghua Daxue Xuebao, Ziran Kexueban published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, SDS of cas: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qian, Hui published the artcileOrganocatalytic Enantio- and Diastereoselective Synthesis of 1,2-Dihydronaphthalenes from Isobenzopyrylium Ions, Quality Control of 7080-50-4, the publication is Journal of the American Chemical Society (2015), 137(2), 560-563, database is CAplus and MEDLINE.

A highly efficient asym. synthesis of dihydronaphthalenes I [R¹ = H, 7-Me, 6-F, etc; R² = Ph, 4-Me-C₆H₄, 4-OMe-C₆H₄, etc; Ar = Ph, 4-OMe-C₆H₄, 4-Me-C₆H₄, etc.] is disclosed. The process represents a new addition to the limited asym. reactions of isobenzopyryliums, a family of versatile 10π-electron aromatic species. Excellent asym. induction is achieved for the first time without an anchoring group in the 4-position or a metal catalyst, both of which were required previously in these reactions. The success is attributed to the unusual chiral counteranion (meanwhile also the nucleophile) generated in situ from the chiral phosphate and the boronic acid as well as the leaving group. Preliminary control experiments provided important insight into the reaction mechanism.

Journal of the American Chemical Society published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Quality Control of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Wei published the artcileA hemicyanine fluorescent reactive cationic dye: synthesis and applications on wool fabrics, Name: 2,3-Dibromopropionylchloride, the publication is Coloration Technology (2015), 131(4), 316-321, database is CAplus.

A novel hemicyanine fluorescent reactive cationic dye was synthesized by the reaction between the free amino group of a hemicyanine fluorescent dye and 2,3-dibromopropionyl chloride. The dye was characterised by proton NMR spectroscopy, high-resolution mass spectrometry, UV-visible absorption spectrometry, and single-photon fluorescence spectrometry. The prepared dye was applied to wool fabrics to give fluorescent orange shades. The color fastness of the dyed wool fabrics was tested. Results show that dyed fabrics using the novel hemicyanine fluorescent reactive cationic dye could be used as fluorescent clothing.

Coloration Technology published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C13H9ClN2O4, Name: 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yuanfeng published the artcileAsymmetric Epoxidation of α,β-Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)-3,4-Diaminopyrrolidine Derived N4-Ligands with Camphorsulfonyl Sidearms, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Asian Journal of Organic Chemistry (2020), 9(4), 616-621, database is CAplus.

Three (R,R)-3,4-diaminopyrrolidine-based chiral N₄ ligands and corresponding iron complexes were synthesized. The complexes were applied to the asym. epoxidation of various α,β-unsaturated ketones with H₂O₂ as an oxidant and carboxylic acid as an auxiliary. Good to excellent enantioselectivity (up to 97%) was achieved in the case of 2,2-dimethylbutyric acid as an auxiliary.

Asian Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Wentian published the artcileDesign and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC), Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2019), 62(10), 5217-5241, database is CAplus and MEDLINE.

Despite advances in targeted anticancer therapies, there are still no small-mol.-based therapies available that specifically target colorectal cancer (CRC) development and progression, the second leading cause of cancer deaths. We previously disclosed the discovery of truncating adenomatous polyposis coli (APC)-selective inhibitor 1 (TASIN-1), a small mol. that specifically targets colorectal cancer cells lines with truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor gene through inhibition of cholesterol biosynthesis. Here, we report a medicinal chem. evaluation of a collection of TASIN analogs and activity against colon cancer cell lines and an isogenic cell line pair reporting on the status of APC-dependent selectivity. A number of potent and selective analogs were identified, including compounds with good metabolic stability and pharmacokinetic properties. The compounds reported herein represent a first-in-class genotype-selective series that specifically target apc mutations present in the majority of CRC patients and serve as a translational platform toward a targeted therapy for colon cancer.

Journal of Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C6H8O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xinyu published the artcileFluorocyclization of Allyl Alcohols and Amines to Access 3-Functionalized Oxetanes and Azetidines, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Organic Letters (2021), 23(9), 3674-3679, database is CAplus and MEDLINE.

An efficient method to prepare 3-functionalized oxetanes and azetidines I [R¹ = H, Me, Ph, etc.; R² = Me, Ph, 2-FC₆H₄, etc.; R¹R² = (CH₂)₄, (CH₂)₅, (CH₂)₂O(CH₂)₂, etc.; X = O, NC(O)Ph, NSO₂Ph, etc.] was realized by fluorocyclization of readily available 2-azidoallyl alcs. and amines. Notably, this was the first example applying the fluorocyclization strategy to construct four-membered heterocycles. The pendant electron-donating group (-N₃ or -OR) played a crucial role in polarizing the C=C double bond and facilitating the cyclization process, as verified by DFT and exptl. studies.

Organic Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics