Tag: M.W=300-350

Bhat, Navya Subray published the artcileHydrochloric acid-catalyzed coproduction of furfural and 5-(chloromethyl)furfural assisted by a phase transfer catalyst, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Carbohydrate Research (2020), 108105, database is CAplus and MEDLINE.

Furfural has been produced in 53% isolated yield from D-xylose within an aqueous HCl-1,2-dichloroethane biphasic reaction mixture using benzyltributylammonium chloride (BTBAC) as a phase transfer catalyst. The use of BTBAC noticeably improved the yield of furfural compared to that in the control reaction. The reaction was optimized on the reaction temperature, duration, concentration of HCl, and the loading of BTBAC. Furfural and 5-(chloromethyl)furfural (CMF) have also been coproduced from a mixture of pentose and hexose sugars. Under optimized conditions (100°C, 3 h, 20.2% HCl, 10 wt% BTBAC), CMF and furfural were isolated in 17% and 53% yield, resp., from a mixture of glucose and xylose. In addition, levulinic acid was isolated from the aqueous layer in 31% yield.

Carbohydrate Research published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gadakh, Bharat published the artcileBase substituted 5′-O-(N-isoleucyl)sulfamoyl nucleoside analogs as potential antibacterial agents, HPLC of Formula: 42074-68-0, the publication is Bioorganic & Medicinal Chemistry (2014), 22(10), 2875-2886, database is CAplus and MEDLINE.

Aminoacyl-sulfamoyl adenosines are well-known nano-molar inhibitors of the corresponding prokaryotic and eukaryotic tRNA synthetases in vitro. Inspired by the aryl-tetrazole containing compounds of Cubist Pharmaceuticals and the modified base as found in the natural antibiotic albomycin, the selectivity issue of the sulfamoylated adenosines prompted us to investigate the pharmacophoric importance of the adenine base. We therefore synthesized and evaluated several isoleucyl-sulfamoyl nucleoside analogs with either uracil, cytosine, hypoxanthine, guanine, 1,3-dideaza-adenine (benzimidazole) or 4-nitro-benzimidazole as the heterocyclic base. Based on the structure and antibacterial activity of microcin C, we also prepared their hexapeptidyl conjugates in an effort to improve their uptake potential. We further compared their antibacterial activity with the parent isoleucyl-sulfamoyl adenosine (Ile-SA), both in in vitro and in cellular assays. Surprisingly, the strongest in vitro inhibition was found for the uracil containing analog. Unfortunately, only very weak growth inhibitory properties were found as of low uptake. The results are discussed in the light of previous literature findings.

Bioorganic & Medicinal Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Presa, Andreu published the artcilePhotoactivation of the Cytotoxic Properties of Platinum(II) Complexes through Ligand Photoswitching, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Inorganic Chemistry (2018), 57(7), 4009-4022, database is CAplus and MEDLINE.

The development of photoactivatable metal complexes with potential anticancer properties is a topical area of current investigation. Photoactivated chemotherapy (PACT) using coordination compounds is typically based on photochem. processes occurring at the metal center. In the present study, an innovative approach is applied that takes advantage of the remarkable photochem. properties of diarylethenes. Following a proof-of-concept study with two complexes, namely C1 and C2, a series of addnl. platinum(II) complexes from dithienylcyclopentene-based ligands have been designed and prepared Like C1 and C2, these new coordination compounds exhibit two thermally stable, interconvertible photoisomers that display distinct properties. The photochem. behavior of ligands L3-L7 has been analyzed by 1H NMR and UV-vis spectroscopy. Subsequently, the corresponding platinum(II) complexes C3-C7 have been synthesized and fully characterized, including by X-ray diffraction for some of them. Next, the interaction of each photoisomer (i.e., containing the open or closed ligand) of the metal complexes with DNA has been examined thoroughly using various techniques, revealing their distinct DNA-binding modes and affinities, as observed for the earlier compounds C1 and C2. The antiproliferative activity of the two forms of the complexes has then been assessed with five cancer cell lines and compared with that of C1 and C2, which supported the use of such diarylethene-based systems for the generation of a new class of potential photochemotherapeutic metallodrugs.

Inorganic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

de Lucas, Ana I. published the artcileScaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor, Computed Properties of 1860005-05-5, the publication is ACS Omega (2021), 6(35), 22997-23006, database is CAplus and MEDLINE.

Glutamate hyperfunction is implicated in multiple neurol. and psychiatric diseases. Activation of the mGlu2 receptor results in reduced glutamate release and decreased excitability representing a promising novel therapeutic agent for the treatment of disorders such as epilepsy, schizophrenia, mood, anxiety, and other neuropsychiatric disorders. We have previously reported substantial efforts leading to potent and selective mGlu2 PAMs from different chem. series. Herein, the discovery and optimization of a novel series of imidazopyrazinone mGlu2 PAMs are reported. This new scaffold originated from computational searching of fragment databases and comparison with our previously explored scaffolds. Optimization guided by our robust understanding of SAR from former series led to potent, selective, and brain-penetrant compounds

ACS Omega published new progress about 1860005-05-5. 1860005-05-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronate Esters, name is 2-(3-Chloro-4-(cyclopropylmethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C16H22BClO3, Computed Properties of 1860005-05-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Castellanos, Sonia published the artcileGating charge recombination rates through dynamic bridges in tetrathiafulvalene-fullerene architectures, HPLC of Formula: 219537-97-0, the publication is Angewandte Chemie, International Edition (2013), 52(52), 13985-13990, database is CAplus and MEDLINE.

In summary, we have prepared new mol. constructs composed of electron-donating tetrathiafulvalene (TTF) and p-extended-TTF derivatives covalently connected to electron-accepting pyrrolidino[3,4:1,2] fullerene through photo-switchable dithienylethene bridges. By exposure to a light stimulus the bridge can be interconverted between a decoupled ring-open and a coupled ring-closed form and, hence, enables external control of electronic communication between the donor and acceptor units. In the resulting architectures, incoming photons give rise to efficient charge separation and, furthermore, allow modulation of the lifetimes of the charge-separated states over two orders of magnitude by variation of their wavelength. The photoresponsive, dynamic bridge provides a means for (self-)regulation through a reversible activation-deactivation mechanism for solar energy conversion in artificial photosynthetic systems.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, HPLC of Formula: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhong, Yu-Wu published the artcileDithienylcyclopentenes-Containing Transition Metal Bisterpyridine Complexes Directed toward Molecular Electronic Applications, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Inorganic Chemistry (2009), 48(3), 991-999, database is CAplus and MEDLINE.

There is continuing interest in the design and synthesis of functional materials for applications in mol. electronics and information storage. Of particular interest are systems that can provide multiple means for controlling transport through well-defined and stable electronic and/or redox states. The authors report herein the synthesis and characterization of a system containing transition-metal complexes along with dithienylethene (DTE) units so as to achieve photo and redox control of transport. A facile synthetic methodol. was developed to assemble and couple metal terpyridine (M-tpy) complexes with the photochromic DTE unit in a linear structure with M-DTE-M or DTE-M-DTE arrangements, with emphasis on the latter series. The photochromic properties of these assemblies were examined by monitoring the changes in their UV/visible spectra upon irradiation at specific wavelengths capable of triggering the open/closed isomerization in the DTE units. Their electrochromic properties were studied via cyclic voltammetry and controlled potential electrolysis experiments Complexes 10 (PhDTE-Fe-DTEPh) and 11 (PhDTE-Co-DTEPh) with phenyl-ending groups are both photochromic and electrochromic, so they represent excellent candidates for further elaborations. The Fe(II)-containing complex 8 (ClDTE-Fe-DTECl) with chloride-ending groups was photochromically inactive but could undergo the electrochem. induced open-to-closed isomerization. On the contrary, the electrochromically inactive complex 9 (ClDTE-Co-DTECl) underwent cyclization under UV irradiation

Inorganic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C12H10F2Si, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhong, Yu-Wu published the artcileDinuclear Transition-Metal Terpyridine Complexes with a Dithienylcyclopentene Bridge Directed toward Molecular Electronic Applications, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Inorganic Chemistry (2007), 46(25), 10470-10472, database is CAplus and MEDLINE.

Dinuclear metal terpyridine (M-tpy; M = Ru, Os, Fe, and Co) complexes with a photochromic dithienylethene bridge were designed and synthesized through either a convergent or a divergent approach. The open forms of the complexes containing Ru^II and Fe^II centers are inert to UV photoirradiation but could be cyclized electrochem. as revealed by a cyclic voltammetric study. On the contrary, the Co^II complex underwent efficient photochem. but not electrochem. cyclization. The corresponding Os^II complex was neither photochromic nor electrochromic.

Inorganic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C19H14O2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yannian published the artcileReversible Light-Directed Red, Green, and Blue Reflection with Thermal Stability Enabled by a Self-Organized Helical Superstructure, Application In Synthesis of 219537-97-0, the publication is Journal of the American Chemical Society (2012), 134(23), 9573-9576, database is CAplus and MEDLINE.

Adding external, remote, and dynamic control to self-organized superstructures with desired properties is an important leap necessary in leveraging the fascinating mol. subsystems for employment in applications. Here two novel light-driven dithienylethene chiral mol. switches possessing remarkable changes in helical twisting power during photoisomerization as well as very high helical twisting powers were found to experience photochem. reversible isomerization with thermal stability in both isotropic organic solvents and anisotropic liquid crystal media. When doped into a com. available achiral liquid crystal host, the chiral switch was able to either immediately induce an optically tunable helical superstructure or retain an achiral photoresponsive liquid crystal phase whose helical superstructure was induced and tuned reversibly upon light irradiation Moreover, reversible light-directed red, green, and blue reflection colors with thermal stability in a single thin film were demonstrated.

Journal of the American Chemical Society published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yannian published the artcileSynthesis and Characterization of Light-Driven Dithienylcyclopentene Switches with Axial Chirality, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Organic Chemistry (2011), 76(17), 7148-7156, database is CAplus and MEDLINE.

Dithienylcyclopentenes such as I and its enantiomer were prepared as photochem. reversible but thermally stable switches with axial stereochem. All three compounds prepared exhibited photochem. reversible isomerization between their open forms and closed forms and were thermally stable in the open and closed forms both in organic solvents and in a liquid crystal host. Dithienylcyclopentenes such as I acted not only as chiral dopants, inducing helical superstructures in achiral liquid crystal hosts, but also reversibly and dynamically tuned the transmittance and reflection of the resulting chiral phases upon light irradiation The helical twisting powers, transmittance, and reflection spectra of photoswitchable cholesteric liquid crystals were measured. I exhibited an unusually high helical twisting power, which is significantly larger than those of the known chiral diarylethenes reported as chiral dopants so far.

Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rameshbabu, Krishnamurthy published the artcileSynthesis and Characterization of Thermally Irreversible Photochromic Cholesteric Liquid Crystals, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Physical Chemistry B (2011), 115(13), 3409-3415, database is CAplus and MEDLINE.

Three thermally irreversible photochromic chiral liquid crystal dithienylcyclopentenes were found not only to be able to self-organize into a phototunable helical superstructure, i.e., cholesteric phase, but also to be able to induce a photoresponsive helical superstructure in an achiral liquid crystal host. The cholesteric phase in the three chiral compounds went into a glassy phase without crystallization upon cooling. All the materials exhibited reversible photochromism with thermal stability in both solution and thin film, and their fluorescence was shifted to longer wavelength upon UV irradiation while the shifted fluorescence was recovered upon visible light irradiation The enhanced fluorescence emission with the addition of fluoride anions was observed, and its reverse process happened with the addition of an equivalent proton.

Journal of Physical Chemistry B published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics