Tag: M.W=300-350

Shi, Feng published the artcileA novel and convenient process for the selective oxidation of naphthalenes with hydrogen peroxide, SDS of cas: 23616-79-7, the publication is Advanced Synthesis & Catalysis (2007), 349(3), 303-308, database is CAplus.

A practical Ru phase-transfer catalyst (Ru-PTC) system for the oxidation of naphthalene derivatives was developed. Substituted 1,4-quinones were obtained in good selectivity and yield in H₂O without the addition of any organic solvent and acid. By applying the optimized conditions the feed additive menadione (vitamin K₃) was obtained from 2-methylnaphthalene with 64% yield and 73% selectivity. Oxidation of phenanthrene is also described.

Advanced Synthesis & Catalysis published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C10H20O2, SDS of cas: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haraguchi, Naoki published the artcileAsymmetric transfer hydrogenation of imines catalyzed by a polymer-immobilized chiral catalyst, COA of Formula: C19H34ClN, the publication is Organic & Biomolecular Chemistry (2009), 7(1), 69-75, database is CAplus and MEDLINE.

The asym. transfer hydrogenation of imines was performed with the use of a polymer-immobilized chiral catalyst. The chiral catalyst, prepared from crosslinked polystyrene-immobilized chiral 1,2-diamine monosulfonamide, was effective in the asym. transfer hydrogenation of N-benzyl imines in CH₂Cl₂ to give a chiral amine in high yield and good enantioselectivity. Furthermore, an amphiphilic polymeric catalyst prepared from crosslinked polystyrene containing sulfonated groups successfully catalyzed the asym. transfer hydrogenation of cyclic imines in water. Enantioenriched secondary amines with up to 94% ee were obtained by using a polymeric catalyst.

Organic & Biomolecular Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akazawa, Masako published the artcilePhotoresponsive dithienylethene-urea-based organogels with “reversed” behavior, HPLC of Formula: 219537-97-0, the publication is Organic & Biomolecular Chemistry (2008), 6(9), 1544-1547, database is CAplus and MEDLINE.

Dithienylperhydrocyclopentene-bisurea-based low mol. weight gelators are described that function as photoresponsive organogels that show a remarkable gel-to-liquid transition upon irradiation The two series of derivatives, with and without alkyl spacers between the urea hydrogen bonding groups and the photochromic unit, show different gelation behavior. Upon UV irradiation of the gels, a gel liquefied at only 1.4% conversion of the photochromic unit. Transmission electron microscopy (TEM) shows that the gel fibers consist of thin ribbons. Semi-empirical (PM3) calculations indicate that the hydrogen bonding between the open-ring isomer (o) mols. is weak, and that formation of the closed-ring isomer (c) destabilizes the hydrogen bonding further. The results indicate that a small amount of the closed-ring isomer will disrupt the intermol. hydrogen-bonding, leading to disintegration of the gel fiber ribbons and hence reversible liquefication.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, HPLC of Formula: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mizuno, Noritaka published the artcileA Flexible Nonporous Heterogeneous Catalyst for Size-Selective Oxidation through a Bottom-Up Approach, HPLC of Formula: 23616-79-7, the publication is Angewandte Chemie, International Edition (2010), 49(51), 9972-9976, S9972/1-S9972/19, database is CAplus and MEDLINE.

The nonporous ([(Bu)₄N]₄[γ-SiW₁₀O₃₄(H₂O)₂]·H₂O, 1.H₂O) synthesized through a bottom-up approach sorbs EtOAc, which is highly mobile in the solid bulk of the compound, probably contributing to the easy co-sorption of olefins and H₂O₂. 1 Heterogeneously catalyzes size-selective oxidation (small olefins are much more preferentially epoxidized than large olefins) of various organic substances including olefins, sulfides, and silanes with aqueous H₂O₂ in EtOAc. 1 Can easily be separated by filtration and reused several times with retention of its high catalytic activity and is the 1st example for the heterogeneously catalyzed size-selective liquid-phase oxidation with H₂O₂ by a POM-based catalyst.

Angewandte Chemie, International Edition published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Feng published the artcileSelective oxidation of naphthalene derivatives with ruthenium catalysts using hydrogen peroxide as terminal oxidant, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Journal of Molecular Catalysis A: Chemical (2007), 270(1-2), 68-75, database is CAplus.

The selective oxidation of naphthalene and its derivatives to give naphthoquinones has been investigated in detail. The reaction can be carried out effectively in the presence of a catalytic amount of Ru complexes (0.2 mol %) and phase transfer catalysts using H₂O₂ as the terminal oxidant and water as the solvent. The effects of different ruthenium complexes, phase transfer catalysts, and the concentration of hydrogen peroxide were studied. Compared to previous procedures for this type of reaction, acidic solvents and high concentration of hydrogen peroxide are not necessary, which makes the reaction more environmentally friendly.

Journal of Molecular Catalysis A: Chemical published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C25H34N4O2S, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Rong published the artcilePeptide-cross-linked protein-imprinted polymers: easy template removal and excellent imprinting effect, Quality Control of 42074-68-0, the publication is CCS Chemistry (2019), 1(5), 544-552, database is CAplus.

Mol. imprinting of proteins remains a huge challenge because of two major obstacles: difficulty in template removal and low imprinting efficiency. Herein, we propose a new strategy to simultaneously overcome these two challenges by creating molecularly imprinted polymers (MIPs) with nanoscale shape-memorable imprint cavities. These novel MIPs were developed by simply crosslinking the polymers with a peptide cross-linker instead of commonly used cross-linkers. Due to the unique pH-induced helix- coil transition of the peptide cross-linker, adjusting the pH from 5.5 to 7.4 leads to an expansion of the imprint cavities, thus facilitating template removal. Returning the pH back to 5.5 restores the original size and shape of the imprint cavities due to the precise refolding of peptide. A template protein can therefore be readily removed under mild conditions, while simultaneously achieving a significantly improved imprinting effect.

CCS Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C7H3IN2O2, Quality Control of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Peltenburg, Hester published the artcileSorption of structurally different ionized pharmaceutical and illicit drugs to a mixed-mode coated microsampler, Quality Control of 23616-79-7, the publication is Journal of Chromatography A (2016), 1-8, database is CAplus and MEDLINE.

The mixed-mode (C18/strong cation exchange-SCX) solid-phase microextraction (SPME) fiber has recently been shown to have increased sensitivity for ionic compounds compared to more conventional sampler coatings such as polyacrylate and polydimethylsiloxane (PDMS). However, data for structurally diverse compounds to this (prototype) sampler coating are too limited to define its structural limitations. The authors determined C18/SCX fiber partitioning coefficients of nineteen cationic structures without hydrogen bonding capacity besides the charged group, stretching over a wide hydrophobicity range (including amphetamine, amitriptyline, promazine, chlorpromazine, triflupromazine, difenzoquat), and eight basic pharmaceutical and illicit drugs (pKa >8.86) with addnl. hydrogen bonding moieties (MDMA, atenolol, alprenolol, metoprolol, morphine, nicotine, tramadol, verapamil). In addition, sorption data for three neutral benzodiazepines (diazepam, temazepam, and oxazepam) and the anionic NSAID diclofenac were collected to determine the efficiency to sample non-basic drugs. All tested compounds showed nonlinear isotherms above 1 mmol/L coating, and linear isotherms below 1 mmol/L. The affinity for C18/SCX-SPME for tested organic cations without H-bond capacities increased with longer alkyl chains, ranging from logarithmic fiber-water distribution coefficients (log D_fw) of 1.8 (benzylamine) to 5.8 (triflupromazine). Amines smaller than benzylamine may thus have limited detection levels, while cationic surfactants with alkyl chain lengths >12 carbon atoms may sorb too strong to the C18/SCX sampler which hampers calibration of the fiber-water relationship in the linear range. The log D_fw for these simple cation structures closely correlates with the octanol-water partition coefficient of the neutral form (K_ow,N), and decreases with increased branching and presence of multiple aromatic rings. Oxygen moieties in organic cations decreased the affinity for C18/SCX-SPME. Log D_fw values of neutral benzodiazepines were an order of magnitude higher than their log K_ow,N. Results for anionic diclofenac species (log K_ow,N 4.5, pKa 4.0, log D_fw 2.9) indicate that the C18-SCX fiber might also be useful for sampling of organic anions. This data supports the authors’ theory that C18-based coatings are able to sorb ionized compounds through adsorption and demonstrates the applicability of C18-based SPME in the measurement of freely dissolved concentrations of a wide range of ionizable compounds

Journal of Chromatography A published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Quality Control of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kleinwaechter, Michael published the artcileOxidative and reductive cyclization in stiff dithienylethenes, HPLC of Formula: 219537-97-0, the publication is Beilstein Journal of Organic Chemistry (2018), 2812-2821, database is CAplus and MEDLINE.

The electrochem. behavior of stiff dithienylethenes, undergoing double bond isomerization in addition to ring-closure, has been investigated. Electrochromism was observed in almost all cases, with the major pathway being the oxidatively induced cyclization of the open isomers. The influence of the ring size (to lock the reactive antiparallel conformation) as well as substituents (to modulate the redox potential) on the electrocyclization was examined In the series of derivatives with 6-membered rings, both the E- and the Z-isomer convert to the closed isomer, whereas for the 7-membered rings no cyclization from the E-isomer was observed For both stiff and normal dithienylethenes bearing benzonitrile substituents an addnl. and rare reductive electrocyclization was observed The mechanism underlying both observed electrocyclization pathways has been elucidated.

Beilstein Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, HPLC of Formula: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kobatake, Seiya published the artcileAcid-induced photochromic system switching of diarylethene derivatives between P- and T-types, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Chemical Communications (Cambridge, United Kingdom) (2007), 1698-1700, database is CAplus and MEDLINE.

Diethylamino-substituted diarylethenes can switch between P-type photochromism (P-type = thermally stable isomers) and T-type (thermally unstable isomers) photochromism upon addition of trifluoromethanesulfonic acid. The protonated closed-form photoinduced color isomers return to open-ring isomers at a fast rate at elevated temperature such as 160° C. The protonation and deprotonation of the open- and closed isomers was reversible. Such photochromic materials could be used as reversible switching materials for write-by-light/erase-by-heat recording.

Chemical Communications (Cambridge, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fushimi, Nobuhiko published the artcileDesign, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1), Product Details of C19H34ClN, the publication is Bioorganic & Medicinal Chemistry (2013), 21(3), 748-765, database is CAplus and MEDLINE.

Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of therapeutic options for postprandial hyperglycemia. Previously, we reported potent and selective SGLT1 inhibitors 1 and 2 showing efficacy in oral carbohydrate tolerance tests in diabetic rat models. In a pharmacokinetic (PK) study of glycoside I (R = OH), excessive systemic exposure to metabolites of I (R = OH) was observed, presumably due to the high permeability of its aglycon. To further improve SGLT1 inhibitory activity and reduce aglycon permeability, a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranoside derivatives, e.g. I (R = NH₂), bearing novel hydrophilic substitution groups on the Ph ring were synthesized and their inhibitory activity toward SGLTs was evaluated. Optimized compound II showed an improved profile satisfying both higher activity and lower permeability of its aglycon. Moreover, the superior efficacy of II in various carbohydrate tolerance tests in diabetic rat models was confirmed compared with acarbose, an α-glucosidase inhibitor (α-GI) widely used in the clinic.

Bioorganic & Medicinal Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Product Details of C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics