Tag: M.W=300-350

Jamal Ahamed, V. S. published the artcileRadical polymerization of methyl methacrylate (MMA) initiated by KHSO₅-BTBAC system – a kinetic study, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Journal of Polymer Research (2012), 19(2), 1-8, database is CAplus.

Kinetics of free radical polymerization of Me methacrylate using potassium peroxomonosulfate as initiator in the presence of benzyltributylammonium chloride (BTBAC) as phase transfer catalyst was studied. The polymerization reactions were carried out under nitrogen atm. and unstirred conditions at a constant temperature of 60°C in Et acetate/water bi-phase system. The role of concentrations of monomer, initiator, catalyst, temperature, acid and ionic strength on the rate of polymerization (R_p) was ascertained. The orders with respect to monomer, initiator and phase transfer catalyst were found to be 1.5, 0.5 and 0.5 resp. The rate of polymerization (R_p) is independent of ionic strength and pH. Based on the kinetic results, a suitable mechanism is proposed.

Journal of Polymer Research published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corpas-Lopez, Victoriano published the artcileO-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2020), 63(11), 5734-5751, database is CAplus and MEDLINE.

Leishmania (L.) infantum causes visceral, cutaneous, and mucosal leishmaniasis in humans and canine leishmaniasis in dogs. Herein, we describe that O-alkyl hydroxamate derivatives displayed potent and selective in vitro activity against the amastigote stage of L. infantum while no activity was observed against promastigotes. Compound PhNHCO(CH₂)₆CONHOCPh₃ (I)showed potent in vivo activity against L. infantum. Moreover, the combination of compound 5 supported on gold nanoparticles and meglumine antimoniate was also effective in vivo and improved the activity of these compounds compared to that of the individual treatment. Docking studies showed that compound 5 did not reach highly conserved pocket C and established interactions with the semiconserved residues V44, A45, R242, and E243 in pocket A of LiSIR2rp1. The surface space determined by these four amino acids is not conserved in human sirtuins. Compound I represents a new class of selective ligands with antileishmanial activity.

Journal of Medicinal Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Junji published the artcileSoft mimic gear-shift with a multi-stimulus modified diarylethene, Formula: C15H14Cl2S2, the publication is Journal of Materials Chemistry (2009), 19(32), 5726-5729, database is CAplus.

A novel gated photochromic compound 1,8-naphthalimidepiperazine-tethered dithienylethene (Nap-Pip-DTE) was prepared to mimic a soft gear-shift based on alternative UV/Vis irradiation, protonation/deprotonation and copper(II) ion complexation/dissociation The fluorescence and absorption spectra were used as output signals. Copper(II) ion was introduced to mimic the parking (P) state by complexation with two intramol. piperazine moieties of Nap-Pip-DTE, transforming diarylethene moieties into the photoinactive parallel form.

Journal of Materials Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C17H18N3NaO3S, Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Al Musaimi, Othman published the artcileCombining solid phase synthesis and chromatographic purification for efficient peptide manufacture, Application In Synthesis of 42074-68-0, the publication is Chimica Oggi (2020), 38(2), 18-21, database is CAplus.

In recent years, peptides have gained an important position in the drug arena for a variety of treatments. Solid-phase peptide synthesis (SPPS) continues to have a significant impact in both R&D as well as in production of com. peptides. The combination of SPPS with reverse-phase (RP) chromatog. separations allowed for the peptides to be purified to levels suitable for drug usage. Thanks to their chem. and phys. stability to high pressure, chems., temperature and oxidising reagents, polystyrene / divinyl benzene (PS/DVB) resins are the main solid support for peptide synthesis as well as being suitable for the chromatog. purification of the peptides by RP and ion exchange (IEX). Depending on the application, the optimal crosslinking changes, as do the optimal particle size, the uniformity in particle size distribution and the porosity of the resin. The characteristics and applications of the PS/DVB resins are explored in this paper for the synthesis and purification of peptides of com. interest.

Chimica Oggi published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Application In Synthesis of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Koronkiewicz, Brian published the artcileShallow distance dependence for proton-coupled tyrosine oxidation in oligoproline peptides, Application In Synthesis of 42074-68-0, the publication is Journal of the American Chemical Society (2020), 142(28), 12106-12118, database is CAplus and MEDLINE.

We have explored the kinetic effect of increasing electron transfer (ET) distance in a biomimetic, proton-coupled electron-transfer (PCET) system. Biol. ET often occurs simultaneously with proton transfer (PT) in order to avoid the high-energy, charged intermediates resulting from the stepwise transfer of protons and electrons. These concerted proton-electron-transfer (CPET) reactions are implicated in numerous biol. ET pathways. In many cases, PT is coupled to long-range ET. While many studies have shown that the rate of ET is sensitive to the distance between the electron donor and acceptor, extensions to biol. CPET reactions are sparse. The possibility of a unique ET distance dependence for CPET reactions deserves further exploration, as this could have implications for how we understand biol. ET. We therefore explored the ET distance dependence for the CPET oxidation of tyrosine in a model system. We prepared a series of metallopeptides with a tyrosine separated from a Ru(bpy)₃²⁺ complex by an oligoproline bridge of increasing length. Rate constants for intramol. tyrosine oxidation were measured using the flash-quench transient absorption technique in aqueous solutions The rate constants for tyrosine oxidation decreased by 125-fold with three added proline residues between tyrosine and the oxidant. By comparison, related intramol. ET rate constants in very similar constructs were reported to decrease by 4-5 orders of magnitude over the same number of prolines. The observed shallow distance dependence for tyrosine oxidation is proposed to originate in part from the requirement for stronger oxidants, leading to a smaller hole-transfer effective tunneling barrier height. The shallow distance dependence observed here and extensions to distance-dependent CPET reactions have potential implications for long-range charge transfers.

Journal of the American Chemical Society published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Application In Synthesis of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Parvathy, Kattera S. published the artcileUltrasound-assisted reaction of 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide with potassium salt of curcumin under PTC conditions, Application In Synthesis of 23616-79-7, the publication is Ultrasonics Sonochemistry (2008), 15(4), 571-577, database is CAplus and MEDLINE.

Reaction of 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide with potassium salt of curcumin [bis-1,7-(3′-methoxy-4′-hydroxy)phenyl-5-hydroxy-1,4,6-heptatrien-3-one] under either thermal or high pressure conditions affect the labile substrate, curcumin, thus resulting in drastic reduction in the yields of the glucosides. This drawback could be effectively overcome by carrying out the biphasic reaction in the presence of a phase transfer catalyst under the effect of ultrasound. The reaction under the sonochem. conditions was faster and resulted in the increased yield of the glucoside products. The reaction was investigated in detail with a view to optimizing the yield of the glucosides. The detailed study clearly indicated the important role of the nature and quantity of the phase transfer catalyst employed in the reaction. Also, the selectivity with respect to the formation of mono- or di-β-glucosides under both mono- and biphasic reaction conditions was clearly discernable. The study establishes a simple synthetic protocol for the glucoside derivatives of curcumin in high yields and selectivity using ultrasonic waves.

Ultrasonics Sonochemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Application In Synthesis of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Escribano, Alejandra published the artcileWhy Are Dithienylethene-Linked Biscobaltocenes so Hard to Photoswitch?, Computed Properties of 219537-97-0, the publication is ChemPhysChem (2017), 18(6), 596-609, database is CAplus and MEDLINE.

Attaching an organometallic unit to a dithienylethene (DTE) mol. switch can allow one to vary its switching and spectroscopic properties, and to create switchable magnetic properties. In this work, two different dithienylethene mol. switches are used as a bridge between two cobalt sandwich units. The only difference between the switching cores is in the size of the cycloalkene ring connecting both thiophene rings. The complexes present different oxidation states for the cobalt atoms, which are demonstrated to determine the switching reaction. The UV/Vis measurements show that while the Co(I) complexes undergo the switching reaction, the Co(II,III) complexes switch poorly. Kohn-Sham d. functional theory calculations indicate diabatic ring-closure mechanisms and a large number of excited states hindering the cyclization reaction and favoring the relaxation to the open form of the mol. switch.

ChemPhysChem published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bianchini, Giulio published the artcilePhotomodulable phosphines incorporating diarylethene moieties, Category: chlorides-buliding-blocks, the publication is RSC Advances (2015), 5(14), 10795-10798, database is CAplus.

Incorporation of the dithienylethene moiety as a substituent provides new ‘switchable’ phosphine ligands whose electronic properties are reversibly modulated by light. The presence of electron-withdrawing substituents in the photochromic unit increases the σ-donation gap between the photo-modulated open and closed phosphine isomers.

RSC Advances published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Menglei published the artcileHighly efficient selective extraction of Mo with novel hydrophobic deep eutectic solvents, Quality Control of 23616-79-7, the publication is Journal of the Air & Waste Management Association (2021), 71(12), 1492-1501, database is CAplus and MEDLINE.

Recycling of valuable metals from spent catalysts in a green way is gaining extensive interest for economic and environment reasons. In this study, we developed novel hydrophobic deep eutectic solvents to extract Mo from spent catalysts. The hydrophobic DESs have been designed and synthesized by mixing one molar of the quaternary ammonium salt and two molars of various saturated fatty acids with different carbon chain lengths. The extraction ability and extraction mechanism of these DESs were studied, some factors influencing the extraction efficiency, including the structure of hydrogen bond acceptors and hydrogen bond donors, initial aqueous pH, reaction time and temperature, phase ratios were investigated. It is found that the synthesized hydrophobic DESs exhibit excellent extraction performance toward Mo, where the Mo distribution ratio is more than 2200 in the presence of other metals, corresponding to an extraction efficiency of 99% at optimal reaction conditions. This work reveals a distinct class of materials, guiding an effective and green way for spent catalyst treatment. Implications: Novel hydrophobic deep eutectic solvents have been developed to extract Mo from spent catalysts, the synthesized hydrophobic DESs possess several advantages, such as green, low price, low toxicity, and biodegradability. It exhibits excellent extraction performance under an optimized extraction condition. This work reveals a distinct class of materials, guiding a promising way for green and economical utilization of spent catalysts.

Journal of the Air & Waste Management Association published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C8H5F3O2S, Quality Control of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kuang, Jing published the artcileiRGD Modified Chemo-immunotherapeutic Nanoparticles for Enhanced Immunotherapy against Glioblastoma, Application of 2-Chlorotrityl chloride, the publication is Advanced Functional Materials (2018), 28(17), n/a, database is CAplus.

Glioblastoma is the most common primary brain tumor in adults and still remains incurable, due to the limited accumulation of drugs in the tumor area. Herein, iRGD-modified nanoparticles, DOX@MSN-SS-iRGD&1MT, are developed for simultaneous delivery of chemotherapeutic agents (doxorubicin, DOX) and immune checkpoint inhibitor (1-methyltryptophan, 1MT) into orthotopic glioma. The nanoparticles are comprised of mesoporous silica nanoparticles loaded with DOX, combined with Asp-Glu-Val-Asp (DEVD) connected 1MT, and finally modified by iRGD. These nanoparticles show the capability of penetrating through blood brain barrier into the tumor area, and significantly improve accumulation of drugs in orthotopic brain tumors with minimal side effects. The nanoparticles also activate cytotoxic CD8⁺ T lymphocytes and inhibit CD4⁺ T cells in both GL261 cells cocultured with splenocytes in vitro and GL261-luc orthotopic tumors in vivo. Moreover, the expression of antitumor cytokines IFNα/β, IFN-γ, TNF, IL-17, STING, and GrzB is upregulated while protumor proteins p-STAT3 and IL-10 are downregulated in the brain tumor area. This study demonstrates the advantages of chemo-immunotherapeutic nanoparticles accumulated in the brain tumor area and their effectively inhibiting tumor proliferation, which establishes a delivery platform to promote antitumor immunity against glioblastoma.

Advanced Functional Materials published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Application of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics