Tag: M.W=600-700

Yaremchuk, A. A. published the artcileDevelopment of novel pharmaceutical forms of decamethoxin, Quality Control of 38146-42-8, the publication is Fiziologicheski Aktivnye Veshchestva (1991), 40-2, database is CAplus.

Decamethoxin, a quaternary ammonium compound, displayed high antibacterial activity against gram-pos. and gram-neg. pathogenic bacteria as well as anaerobic microorganisms, including Clostridium species. Decamethoxin was more active than other surface-active agents such as ethonium, thionium, dodecylpyridinium, cetylpyridinium, dodecylbenzalkonium, and cetylbenzalkonium. Decamethoxin may be used in the form of ointment and aerosol for treatment of skin and mucous membrane infections.

Fiziologicheski Aktivnye Veshchestva published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C9H21NO3, Quality Control of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lisetski, L. N. published the artcileEffects of membranotropic agents on mono- and multilayer structures of dipalmitoylphosphatidylcholine, SDS of cas: 38146-42-8, the publication is European Biophysics Journal (2002), 31(7), 554-558, database is CAplus and MEDLINE.

We have studied the action of some membranotropic agents (MTAs) on the parameters of mono- and multilayers of dipalmitoylphosphatidylcholine (DPPC). The MTAs used included an antimicrobial drug, decamethoxinum, the model amphiphilic agent stearoyl-L-α-alanine, and cholesterol as a reference substance. Using differential scanning calorimetry and the Langmuir monolayer technique, we measured the temperature and enthalpy of the main phase transition of DPPC, the mean mol. area, the collapse pressure and the free energy of the mixed monolayers of DPPC and MTA. A good correlation has been obtained between the structure of the MTA used and changes in the parameters of both mono- and multilayers. Thus, for cholesterol, its well-known condensing effect in the L_α phase correlates with its behavior in the mixed monolayers. The disturbing action of decamethoxinum (depression of the phase transition in DPPC multilayers and relatively high free energy of mixing in monolayers) is presumably connected with interaction of its charged ammonium moieties with polar phospholipid heads. At the same time, stearoyl-L-α-alanine condensed the lipid layers and increased the m.p. of DPPC, owing to its interaction with both polar and non-polar lipid moieties. One can conclude that the three MTAs used can really be considered as representative examples of three different types of behavior in mono- and multilayers.

European Biophysics Journal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, SDS of cas: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gerashchenko, I. I. published the artcileStabilization of proteases in solutions of some bis-tetraammonium compounds, Computed Properties of 38146-42-8, the publication is Farmatsevtichnii Zhurnal (Kiev) (1996), 112-114, database is CAplus.

It was found that ethonium and decamethoxin stabilized proteases (trypsin, chymotrypsin) in solutions at high temperature and high concentration of urea. This could be used as a basis for creation of drugs with combined therapeutic effects.

Farmatsevtichnii Zhurnal (Kiev) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Computed Properties of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vinogradova, L. E. published the artcileProtection of textiles against biodamage, Application In Synthesis of 38146-42-8, the publication is Tekstil’naya Promyshlennost (Moscow, Russian Federation) (1992), 30, database is CAplus.

The protective properties of biocide-impregnated cotton textile packaging were tested during storage of various bleached or dyed cotton textiles under normal conditions and under increased humidity (80-90%) and temperature (20-25°). All the biocides (Ampholan, Katamin AB, Metacid, Decamethoxine, alkyltrimethylammonium chlorides) were effective in normal conditions, but Decamethoxine, alkyltrimethylammonium chlorides failed in textile protection in the humid atm. The best results were obtained with Katamin AB and Metacid.

Tekstil’naya Promyshlennost (Moscow, Russian Federation) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C13H15NO6S, Application In Synthesis of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Volyanskii, Yu. L. published the artcileEffect of prodigiosan in combination with decamethoxine on experimental septicemia in albino mice, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Antibiotiki (Moscow) (1971), 16(5), 441-3, database is CAplus.

Treatment of mice with a combination of prodigiosan (1 mg/kg) and decamethoxine (10 mg/kg) at 7 or 4 days and again 12 hr before or 1 day after infection with a 3-fold lethal dose of Staphylococcus aureus prevented or greatly reduced the development of infection.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C6H10O7, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zaitsev, O. I. published the artcileBuilding a mathematical model of ion exchange of NaA zeolite with decametoxin and its technological optimization, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Farmatsevtichnii Zhurnal (Kiev) (2001), 78-81, database is CAplus.

Full (three-factor) math. model of ion exchange process of NaA zeolite with decametoxin was built, its anal. was carried out, on which base the technol. optimum was received. The most considerable parameter, which exerts an essential influence on technol. process, was determined The following exptl. check of calculated optimum allowed to received a preparation with level of ion exchange which exceeds an exptl. result.

Farmatsevtichnii Zhurnal (Kiev) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C42H63O3P, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kukhar, V. P. published the artcileStudy of the AT-nucleotide specificity in the reaction of decamethoxine with natural DNA, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Doklady Akademii Nauk SSSR (1989), 305(4), 997-9 [Biophys.], database is CAplus.

Decamethoxine, an antibacterial quaternary ammonium compound, react with high-mol.-weight DNA (from calf thymus) with the formation of a complex compound This reaction was very specific and involved the binding of decamethoxine to AT base pairs of DNA. Possible mechanisms of antibacterial action of decamethoxine are discussed.

Doklady Akademii Nauk SSSR published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Skobeeva, V. published the artcileSynthesis of silver nanoparticles and therapeutic films for ophthalmology based on them, Product Details of C38H74Cl2N2O4, the publication is Springer Proceedings in Physics (2020), 179-188, database is CAplus.

This article presents the results of the silver nanoparticles synthesis by a simple and ecol. method of chem. reduction of silver from silver nitrate in an aqueous solution of sodium citrate and their use in the treatment of eye diseases. The technol. conditions that lead to formation of silver nanoparticles with spherical shape and size of 30 nm with an intensive band of surface plasmon resonance are established. The effect of the application of therapeutic films with nanoparticles on the ultrastructure of the epithelium and stroma of the cornea of a rabbit after modeling in animals of moderately severe bacterial keratitis has been studied. It has been established that the application of therapeutic films with silver nanoparticles, as compared with antibiotics, leads to more efficient regeneration of the anterior corneal epithelium, contributes to the rapid restoration of the stroma and active formation of the delicate collagen skeleton typical of healthy corneal tissue.

Springer Proceedings in Physics published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C8H5F3O3, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhebentyaev, A. I. published the artcileElectron and infrared spectra of eosin complexes with nitrogen-containing drugs, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Farmatsiya (Moscow, Russian Federation) (1991), 40(6), 28-31, database is CAplus.

The interaction of eosin with some nitrogen-containing drugs decamethoxin and papaverine was examined by using UV, IR, and spectrophotometric methods in the visible region. The OH-group of eosine was implicated in the complex formation. The mechanism responsible for the complex formation is discussed in the study.

Farmatsiya (Moscow, Russian Federation) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C18H20N2O12, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhebentyaev, A. I. published the artcileSpectrophotometric determination of decamethoxine with eosine, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1984), 27(4), 412-14, database is CAplus.

A reproducible and highly accurate spectrophotometric determination of decamethoxine (I) [38146-42-8] consisted of adding eosin  [17372-87-1] 0.5 (10^-3 mol/L), EtOH 3, and pH 2.8 citrate buffer 5 mL to 75-100 μg I and making the volume to 25 mL with H₂O. The absorbance is measured at 555 nm. NaCl does not interfere with I determination in diluted solutions (0.01-0.05%) containing 0.9% NaCl. The Beer’s law was observed at 0.3-4 μg I/mL. Eosin and I form a 1:2 complex (5-10 min). The addition of 10-20% EtOH increased the stability of the solutions and also the absorbance. At >20% EtOH, the absorbance of the complex decreased. The absorbance is stable for >1 h. At pH 2-3.5 the solution has the highest stability.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C14H28O5S, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics