Tag: M.W=600-700

Yaremchuk, A. A.’s team published research in Nauchnye Trudy – Vsesoyuznyi Nauchno-Issledovatel’skii Institut Farmatsii in 28 | CAS: 38146-42-8

Nauchnye Trudy – Vsesoyuznyi Nauchno-Issledovatel’skii Institut Farmatsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C5H6BNO2, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Yaremchuk, A. A. published the artcileSurfactant and antibacterial properties of decamethoxine, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Nauchnye Trudy – Vsesoyuznyi Nauchno-Issledovatel’skii Institut Farmatsii (1990), 106-10, database is CAplus.

Decamethoxine showed surfactant properties with critical micellar concentration at 25° of 0.63%. Correlation among surfactant properties, length between N atoms in the quaternary ammonium compound and its antimicrobial activity was observed

Nauchnye Trudy – Vsesoyuznyi Nauchno-Issledovatel’skii Institut Farmatsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C5H6BNO2, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shchetinina, V. N.’s team published research in Mikrobiologicheskii Zhurnal (1978-1993) in 52 | CAS: 38146-42-8

Mikrobiologicheskii Zhurnal (1978-1993) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C8H8O3, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Shchetinina, V. N. published the artcileEffect of decamethoxine on the integrity of cytoplasmic membranes of gram-positive and gram-negative microorganisms, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Mikrobiologicheskii Zhurnal (1978-1993) (1990), 52(3), 24-8, database is CAplus.

Decamethoxine increased the membrane permeability of Pseudomonas aeruginosa, Escherichia coli, and Micrococcus lysodeikticus. Viability decreased and dehydrogenase activity was inhibited. Aspartate and alanine aminotransferases were not inhibited by decamethoxine, and activity even increased. Decamethoxine lysed the protoplasts of these bacteria. At high decamethoxine concentrations (>500 μg/mL for P. aeruginosa and >200 μ/mL for E. coli) the outflow of components from these gram-neg. bacteria ceased; this may be associated with coagulation changes in the cytoplasm. Loss of low-mol. components by M. lysodeikticus cells and protoplast lysis were less than in the gram-neg. microorganisms, explained by less resistance of M. lysodeikticus to decamethoxine and earlier coagulation of the cytoplasm, preventing lysis.

Mikrobiologicheskii Zhurnal (1978-1993) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C8H8O3, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lipkovska, N. A.’s team published research in Journal of Applied Spectroscopy in 81 | CAS: 38146-42-8

Journal of Applied Spectroscopy published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Product Details of C38H74Cl2N2O4.

Lipkovska, N. A. published the artcileSpectral and Acid-Base Properties of Hydroxyflavones in Micellar Solutions of Cationic Surfactants, Product Details of C38H74Cl2N2O4, the publication is Journal of Applied Spectroscopy (2014), 81(4), 644-648, database is CAplus.

It has been shown that the spectral characteristics (intensity, position of the absorption band) and the acid-base properties in a series of structurally similar hydroxyflavones depend on the concentration of the cationic surfactants miramistin and decamethoxin in aqueous solutions and the extent of their changes is more pronounced for hydrophobic quercetin than for hydrophilic rutin. For the first time, we have determined the apparent dissociation constants of quercetin and rutin in solutions of these cationic surfactants (pKa1) over a broad concentration range and we have established that they decrease in the series water-decamethoxin-miramistin.

Journal of Applied Spectroscopy published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kovtun, E. A.’s team published research in Fibre Chemistry (Translation of Khimicheskie Volokna) in 31 | CAS: 38146-42-8

Fibre Chemistry (Translation of Khimicheskie Volokna) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Kovtun, E. A. published the artcileStudy of the kinetics of release of decametoxin from modified surgical sutures in aqueous medium, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Fibre Chemistry (Translation of Khimicheskie Volokna) (1999), 31(5), 374-379, database is CAplus.

The studies showed that Decametoxin is released from thread in amounts not exceeding the standards issued by the Pharmacol. Committee of the USSR Ministry of Health. The rate of release of Decametoxin from the thread decreases in time; according to the data from the extraction-photometric method, the rate of “release” of Decametoxin is constant and maximum for up to 24 h, and according to the calculation based on weight loss, the rate slows according to a logarithmic law and is maximum for up to 6 h. The concentration of Decametoxin in the region of the suture will probably be maximum for two days. Decametoxin does not form chem. bonds with BF-6 adhesive or polycaproamide, but the polymer coating of the thread acts as a microdispenser of the antimicrobial.

Fibre Chemistry (Translation of Khimicheskie Volokna) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Litvinenko, E. I.’s team published research in Plasticheskie Massy in | CAS: 38146-42-8

Plasticheskie Massy published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Product Details of C38H74Cl2N2O4.

Litvinenko, E. I. published the artcileDynamic and physicomechanical properties of acrylic oxide polymer filled with surface-modified aluminosilicate, Product Details of C38H74Cl2N2O4, the publication is Plasticheskie Massy (2004), 19-20, database is CAplus.

Mech. properties of polymethacrylic dental filling composition based on Me methacrylate-Bu methacrylate copolymer and monomeric Me methacrylate and epoxy-methacrylate adduct filled with aluminosilicate surface-modified with decamethoxine (fungicide) and spasmolytin (spasmolytic) was studied.

Plasticheskie Massy published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagiev, Kh. Dzh.’s team published research in Kimya Problemlari in | CAS: 38146-42-8

Kimya Problemlari published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Nagiev, Kh. Dzh. published the artcilePhotometric determination of gallium(III) with 2,3,4-trihydroxyphenylazo-5′-sulfonaphthalene and decamethoxine in various media, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Kimya Problemlari (2008), 41-44, database is CAplus.

With the purpose of establishing of an opportunity of photometric determination of Ga(III), complex formation with 2,3,4-trihydroxyphenylazo-5′-sulfonaphtalene in the presence of decamethoxin in acetate environments-ammoniac buffers, sulfuric and azotic acids was studies. Spectrophotometric characteristics and constants of stability of a complex with relation of components Ga(III): R: Dek = 1:2:1 which has the maximal yield at pH = 4, 0.5M H2SO4 and 0.1M HNO3 were calculated It is positioned that a complex formative in the environment H nitrate characterized by the greatest (Δλ = 117 nm) both the constant of stability (Ig β = 15.29 ± 0.17) and the least sensitivity (ε = 6250). The technique of photometric determination of Ga in all researched environments was developed and established, that reactions in milieu of acetate-ammoniac buffers (pH = 4) and 0.1M HNO3 possess sharp selectivity.

Kimya Problemlari published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Krasil’nikov, A. P.’s team published research in Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii in | CAS: 38146-42-8

Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, HPLC of Formula: 38146-42-8.

Krasil’nikov, A. P. published the artcileResistance of Staphylococcus aureus clinical strains to antiseptics, HPLC of Formula: 38146-42-8, the publication is Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii (1989), 30-6, database is CAplus and MEDLINE.

To evaluate the activity of antiseptics and the sensitivity or resistance of bacteria to antiseptics, a number of characteristics has been used, including the min. inhibiting concentration for different strains, the frequency of statistical and clin. resistance, and the antiseptic activity index. A wide spread of S. aureus strains isolated from patients with hospital infections has been revealed. Differences in the resistance of bacterial strains was observed, depending on the type of the antiseptic and the ecovar of bacteria: among hospital ecovars, resistant strains occur more frequently and can resist a wider range of antibiotics. In staphylococcal hospital ecovars the occurrence and level of resistance to a number of widely used antiseptics increase with time. Due to a wide spread of staphylococcal hospital strains resistant to antiseptics, measures on the control of the circulation of such strains should be introduced into hospitals, and the data thus should be used for the periodic evaluation of antiseptics used in medical practice and for the choice of preparations to be used for individual therapeutic and prophylactic antisepsis.

Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, HPLC of Formula: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tang, Haiming’s team published research in Inorganica Chimica Acta in 2020-06-01 | 67421-02-7

Inorganica Chimica Acta published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Name: (Hexamethylbenzene)ruthenium(II) dichloride dimer.

Tang, Haiming; Saunders, Graham C.; Raymond, Onyekachi; Ma, Xiaochuan; Henderson, William published the artcile< Pyrrole thioamide complexes of organo-rhodium(III), -iridium(III) and -ruthenium(II)>, Name: (Hexamethylbenzene)ruthenium(II) dichloride dimer, the main research area is pyrrole thioamide organo rhodium iridium ruthenium preparation antitumor activity; crystal structure pyrrole thioamide iridium complex.

Reactions of the pentamethylcyclopentadienyl complexes [(η5-Cp*)MCl2]2 (M = Rh, Ir) and the ruthenium arene complex [(η6-C6Me6)RuCl2]2 with pyrrole-2-thioamide ligands (containing various substituents on the pyrrole ring) and triethylamine base were investigated. A set of new dinuclear complexes were obtained in which the pyrrole thioamide ligand bonds as a dianion, through the deprotonated pyrrole, and the sulfur atom bridging the two metal centers, as confirmed by a x-ray structure determination on an iridium derivative When triphenylphosphine was included in the reaction mixture, mononuclear complexes were obtained, with the pyrrole thioamide dianion ligand coordinating through sulfur and the pyrrole nitrogen, forming a five-membered chelate ring. The complexes were characterized by NMR and IR spectroscopies, and ESI mass spectrometry. A preliminary investigation of the activity of a selection of compounds towards A549 (adenocarcinomic human alveolar basal epithelial) cells was also carried out.

Inorganica Chimica Acta published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Name: (Hexamethylbenzene)ruthenium(II) dichloride dimer.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fazlur-Rahman, A K’s team published research in Journal of Organometallic Chemistry in 2022-06-01 | 67421-02-7

Journal of Organometallic Chemistry published new progress about Agostic bond. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Formula: C24H36Cl4Ru2.

Fazlur-Rahman, A. K.; Bennett, Martin A. published the artcile< Activation of carbon-carbon bonds in d9 (Co, Rh, Ir) and d8 (Ru) metal coordinated bicyclo[3.2.1]octa-2,6-diene via agostic M-H-C and M-H interactions>, Formula: C24H36Cl4Ru2, the main research area is bicyclooctadiene Group 9 element ruthenium complex preparation protonation rearrangement; crystal mol structure bicyclooctadiene Group 9 element ruthenium complex.

This contribution reveals the first synthesis, protonation reactions and skeletal rearrangements of a series of Group 9 element complexes [M(η5-C5R5)(bcod)] (bcod = η2:η2-bicyclo[3.2.1]octa-2,6-diene; M = Co, Rh, Ir; R = H, Me) (1-3) and ruthenium complexes [Ru(η6-arene)(bcod)] (4, arene = C6Me6, C6Me4H2, C6H3Me3). Monoprotonation of these coordinated bcod complexes, 1, 3, 4 with super acids such as HPF6 (60% aqueous), HBF4·Et2O or CF3SO3H at low temperature (-80° to -20°) forms agostic M-H-C structures for [Rh(μ-H)(η5-C5R5)(η2:η2-2,6-bcod)]+ (5), [CpCo(μ-H)(η2:η2-bcod)]+ (6) and [Ru(μ-H)(η6-arene)(η2:η2-bcod)]+ (7). Similar reactions of iridium complexes 2a,b gave terminal hydride complexes [Cp*Ir(H)(η2:η2-bcod)][PF6] (8a,b) as isolable salts at room temperature Initial products of all these monoprotonated cationic salts 5-8, undergo isomerization via hydride migration and subsequent cleavage of carbon-carbon bonds to the corresponding η2-vinyl η3-cyclohexenyl cations (9-12), independent of the non-coordinating anions. All metal coordinated η2-vinyl, η3-cyclohexenyl cations were isolated and characterized by 1H and 13C NMR spectroscopic methods. The structure of 9b was solved by x-ray crystallog. anal. Nucleophilic addition of H- to the [Ru(η6-C6Me6)(η2-vinyl-η3-cyclohexenyl)]PF6 cation (12c) resulted in the formation of 5-ethyl-η4-1,3-cyclohexadiene complex (14c) as the isomerized product.

Journal of Organometallic Chemistry published new progress about Agostic bond. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Formula: C24H36Cl4Ru2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Han, Tianyu’s team published research in Inorganic Chemistry in 2021-09-06 | 67421-02-7

Inorganic Chemistry published new progress about Antitumor agents (breast, lung). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Formula: C24H36Cl4Ru2.

Han, Tianyu; Wu, Yuying; Han, Weinan; Yan, Kaiwen; Zhao, Jian; Sun, Yanyan published the artcile< Antitumor Effect of Organometallic Half-Sandwich Ru(II)-Arene Complexes Bearing a Glutathione S-Transferase Inhibitor>, Formula: C24H36Cl4Ru2, the main research area is antitumor human ruthenium half sandwich glutathione transferase inhibitor preparation; mol structure optimized ruthenium half sandwich glutathione transferase inhibitor; hydrolysis kinetics DFT ruthenium half sandwich glutathione transferase inhibitor.

The facile modification of the ligands in organometallic Ru(II)-arene complexes offers more opportunities to optimize their pharmacol. profiles. Herein, three Ru(II)-arene complexes containing a glutathione S-transferase (GST) inhibitor (NBDHEX) in chelate ligand have been designed and synthesized in this study. In vitro results indicated that the ligation with NBDHEX significantly increased the activities and selectivities of the organometallic Ru(II)-arene complexes against tumor cells, especially complex 3, which was the most active compound among the tested compounds DFT calculations and hydrolysis results demonstrated that complex 3 with more alkyl groups in the arene ligand has increased electron d. at the Ru(II) center as compared with complexes 1 and 2, thus resulting in the improved hydrolysis rate, which may be responsible for its higher anticancer activity. Further studies showed that complexes 1-3 can cause the loss of the mitochondrial membrane potential and upregulate the expression of Bcl-2 and Bax in A549 cells, suggesting that complexes 1-3 induced cell death may be mediated via the mitochondrial apoptotic pathway. Thus, these findings suggested that simultaneous modification of the chelate ligands and arene rings in the organometallic Ru(II) arene complexes is an effective way to improve their pharmacol. properties.

Inorganic Chemistry published new progress about Antitumor agents (breast, lung). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Formula: C24H36Cl4Ru2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics