Tag: M.W=600-700

Bolotov, V. V. published the artcileIonometric identification of methoxine in the medical formulations, HPLC of Formula: 38146-42-8, the publication is Visnik Farmatsii (2003), 30-33, database is CAplus.

We have elaborated the method of express quant. decamethoxine identification in ophthalmic drops, ointments, alc. solution, and tablets by potentiometry methods with the usage of early offered decamethoxine-selective, electrode as indicator. The relative error of identification was 2,0-7,9% in solutions, 4,1-4,2% in ointments, 3,9-4,4% in tablets.

Visnik Farmatsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, HPLC of Formula: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Galatenko, N. A. published the artcileStudy of properties of a composition for osteoplasty with decamethoxine, Category: chlorides-buliding-blocks, the publication is Polimernii Zhurnal (2005), 27(3), 202-206, database is CAplus.

A polymeric composite for osteoplasty, characterized by prolonged antibacterial activity was prepared and its properties investigated. The composition comprised a biocompatible, biodegradable base, a calcium phosphate-based ceramic filler, decamethoxine antibacterial agent, and 2,4,6-tris(dimethylaminomethyl)-phenol polymerization accelerator. The base (oligoether urethane diisocyanate) was obtained from 2,4(2,6)-tolylene diisocyanate (T80) and polypropylene glycol. The effects of hydroxyapatite filler and decamethoxine on the structural properties of the composition were studied by IR-spectroscopic and photometric methods and cohesive strength testing. By changing amounts of the components and physicochem. properties of the filler (particle or granule size, percentage of glassy phase, and mass percentage of calcium), it was possible to obtain the material with necessary strength and antibacterial activity required for application in orthopedic surgery.

Polimernii Zhurnal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Galatenko, N. A. published the artcilePolyurethane composition for osteoplasty with antiseptic activity and its properties, Related Products of chlorides-buliding-blocks, the publication is Plasticheskie Massy (2008), 51-54, database is CAplus.

The goal of the present work was to create an osteoplasty composite with prolonged antiseptic action. The composite comprised biocompatible and biodegradable polyurethane, calcium phosphate bioactive filler osteoapatite, antiseptic agent decamethoxine and polymerization catalyst 2,4,6-tris-dimethylaminomethylphenol. The combination of materials used allowed for regulation of the desired properties of the composite.

Plasticheskie Massy published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Galatenko, N. A. published the artcileStudy of the properties of a plastic composition for bone tissue with antiseptic action, Formula: C38H74Cl2N2O4, the publication is Dopovidi Natsional’noi Akademii Nauk Ukraini (2005), 128-133, database is CAplus.

The polymeric composition containing bioactive components and an antiseptic were developed for bone implants. By changing the structure and content of osteoapatite, it was possible to achieve the regulation of the durability of a composite and the output of a medical substance from the polyurethane matrix.

Dopovidi Natsional’noi Akademii Nauk Ukraini published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileDisinfection of surgical silk with decamethoxin, antibiotics, and their combinations, Formula: C38H74Cl2N2O4, the publication is Antibiotiki (Moscow) (1978), 23(7), 629-33, database is CAplus and MEDLINE.

Exposure of previously infected surgical silk threads to decamethoxin (I) [38146-42-8] solution (0.1%), followed by its treatment with benzylpenicillin [61-33-6], streptomycin [57-92-1] or monomycin [54597-56-7] or their combinations (105 min) provided total sterility. A 0.025% solution of I was not that effective. I or antibiotic combinations alone did not sterilize these threads completely. Exposure of the threads for 24 h with 0.1% I solution did not affect their strength.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Meshchishen, I. F. published the artcileComparative study of the effect of decamethoxin, decamine and levorin on carbohydrate metabolism in the liver of white rats, SDS of cas: 38146-42-8, the publication is Farmakologiya i Toksikologiya (Moscow) (1979), 42(4), 406-9, database is CAplus.

Decamethoxin (I) [38146-42-8] (0.5 or 1.0 mg/kg/day) injected i.m. into rats for 10 days decreased liver glucose [50-99-7], glycogen [9005-79-2] and increased lactate dehydrogenase [9001-60-9] at both doses; the higher dose also decreased phosphorylase [9035-74-9], glucokinase [9001-36-9], phosphoglucoisomerase [9001-41-6], and glucose-6-phosphatase [9001-39-2]. Levorin [1403-17-4] at 0.5 mg/kg/day for 10 days i.m. decreased liver glucose, and glycogen and glucose-6-phosphatase and increased lactate dehydrogenase and phosphoglucoisomerase; at 1.0 mg/kg/day for 10 days i.m. it also decreased phosphorylase and increased glucokinase. Decamine [522-51-0] at neither dose affected carbohydrate metabolism in the liver.

Farmakologiya i Toksikologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, SDS of cas: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sidorchuk, I. I. published the artcileStaphylococcus resistance to decamethoxin and some antibiotics, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Mikrobiologichnii Zhurnal (1934-1977) (1970), 32(5), 610-14, database is CAplus.

Resistance of 2 S. aureus strains (laboratory strain 209 and antibiotic-resistant strain 603 isolated from a patient) to decamethoxin (I) developed more slowly than to streptomycin, penicillin, neomycin, or levomycetin during 10 passages through meat-peptone broth with these preparations There was no cross resistance between decamethoxin and these antibiotics. Variants resistant to I showed a lower pathogenicity and sharply inhibited dehydrogenase activity. The antibiotic-resistant variants of each strain had the same or higher pathogenicity than the initial strain.

Mikrobiologichnii Zhurnal (1934-1977) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C9H21NO3, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileCytogenetic effect of etonium, decamethoxin, and a hexamethylenediamine derivative, Formula: C38H74Cl2N2O4, the publication is Genetika (Moscow) (1974), 10(1), 171-2, database is CAplus.

When added to a human embryonic fibroblast culture, etonium [21954-74-5], decamethoxin (I) [38146-42-8], or a hexamethylenediamine derivative decreased the mitotic activity and induced chromosome aberrations in the cells. Etonium had the strongest mutagenic effect.

Genetika (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gerashchenko, I. I. published the artcileCompositions of highly dispersed silica with trypsin and a cationic surfactant obtained by a mechanosorption method, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) (2001), 35(2), 75-77, database is CAplus.

As part of the effort to develop a technol. for enzyme-containing drug compositions, the effect of cationic surfactants on the stability of trypsin comminuted jointly with a highly dispersed silica in a ball mill was examined The experiment used com. crystalline trypsin with a specific activity of not less than 10 TU/g, a highly dispersed silica in the form of Aerosil A-300 grade, and pharmacopeial preparations of ethonium and decamethoxine. Results indicate that the preliminary incubation of ethonium with trypsin results in a significant stabilization of the enzyme. Based on the results, the high enzymic activity retained in the products of mechanochem. processing of trypsin compositions with highly dispersed silica and cationic surfactant may be explained by the stabilizing action of the latter component. The technol. of obtaining mech. dispersed products with preset properties must include two sequential stages, namely, the initial mechanosorption immobilization of a cationic surfactant on the highly dispersed silica surface, followed by the mechanochem. processing of this modified carrier with the enzyme.

Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nosach, L. V. published the artcileAdsorption modification of finely divided silica with nonvolatile organic compounds in a gaseous dispersion medium, COA of Formula: C38H74Cl2N2O4, the publication is Fizika i Khimiya Tverdogo Tila (2006), 7(3), 540-543, database is CAplus.

An adsorption modification has been examined of high disperse silica with polymers an non-volatile organic compounds in a gaseous dispersion medium. This method has been shown to be more effective one than that of liquid phase impregnation. The solvation of modificator mols. has been found to be the main factor governing the process of modifying high disperse silica with polymers and bioactive compounds

Fizika i Khimiya Tverdogo Tila published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, COA of Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics