Tag: M.W=600-700

Kovtun, E. A. published the artcileStability of coated polycaproamide sutures during radiation sterilization, HPLC of Formula: 38146-42-8, the publication is Fibre Chemistry (Translation of Khimicheskie Volokna) (1999), 31(6), 455-459, database is CAplus.

The studies showed that the radiation sterilization, recommended by the State Pharmacopeia, does not cause degradation of polycaproamide-based sutures and has almost no effect on their physicomech. properties and capillarity. The optimum sterilizing dose was 2.5 Mrad for suture based on BF-6 phenol-polyvinylacetal adhesive coatings, SKTN-G dimethylsiloxane rubber, and a composite with addition of an antimicrobial agent Decametoxin.

Fibre Chemistry (Translation of Khimicheskie Volokna) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, HPLC of Formula: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kovtun, E. A. published the artcileCreation of sutures with antimicrobial properties, SDS of cas: 38146-42-8, the publication is Fibre Chemistry (Translation of Khimicheskie Volokna) (2000), 32(4), 287-292, database is CAplus.

It was found that decamethoxin, as a broad-spectrum antiseptic with a pronounced antibacterial and fungicidal action, and BF-6 phenol-polyvinylacetal adhesive, which gives complex sutures the structure of a pseudomonofilament, are best as antimicrobial additives in a modifying composite for giving surgical sutures antimicrobial properties. A decamethoxin content in the modifying composite of 10% of the weight of BF-6 (1.7-2.0% in the suture) is sufficient for manifestation of the antimicrobial effect with respect to Staphylococcus aureus, E. coli, and yeast-like fungi. The antimicrobial activity of a suture with a 1.7-2.0 weight % decamethoxin content in the period from 2 to 24 h increases by 4 times with respect to E. coli and by 8 times with respect to Staphylococcus aureus and yeast-like fungi. Application of a coating of BF-6 adhesive with decamethoxin has almost no effect on the physicomech. properties of the sutures, but the capillarity decreases significantly (by ∼86%), which also decreases the probability of wound infection. The kinetics of release of decamethoxin does not change after radiation sterilization of the sutures, i.e., the composition and content of the antimicrobial additive in the modified sutures and its antimicrobial activity are preserved. The optimum medium for storage of sterile modified sutures is 1% decamethoxin solution After 12 days of storage, the sutures remain sterile and lose a maximum of 6% of the breaking strength.

Fibre Chemistry (Translation of Khimicheskie Volokna) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, SDS of cas: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kosevich, M. V. published the artcileStability of the dication of decamethoxin as revealed by secondary ion mass spectrometry, Synthetic Route of 38146-42-8, the publication is Visnik Kharkivs’kogo Universitetu (1998), 15-22, database is CAplus.

Stability of the dication of the antimicrobial drug decamethoxin under the influence of various phys. factors was studied. Significant differences in the pathways of transformation of decamethoxin under the influence of heating and upon long-term storage were revealed by means of the secondary ion mass spectrometry; it was shown that the changes in the medicine with time upon neglect of storage rules are connected, obviously, with the deleting of chlorine counterions from the crystalline sample with preservation of the structure of the dication, while upon thermal treatment a dequaternization of the quaternary nitrogens of decamethoxin with formation of tertiary amines takes place.

Visnik Kharkivs’kogo Universitetu published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vashchenko, O. V. published the artcileInvestigation of combined effect of quaternary ammonium compounds and organic acid on model phospholipid membranes, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Biofizichnii Visnik (2010), 55-72, database is CAplus.

Effects caused by combined inclusion of two membranotropic agents (MTA) of different nature into model phospholipid membranes have been examined An effect of significant change in activity of individual M1IA based on quaternary and bisquaternary ammonium compounds (QAC, BQAC) – decamethoxinum. aethonium. tetramethylammonium – and organic 2.5-dihydroxybcnzoic acid (DHB) on their combined incorporation into model multibilayer structures of hydrated dipalmitoylphosphatidycholine (DPPC) is revealed. Differential scanning calorimetry (DSC) data have shown that, when both types of MTA are jointly present in the system. significant deviations from additivity values are noted for the measured calorimetry parameters. This shows that it is the MTA complexes. rather than individual MTAs. affect the model membrane properties. Mass-spectrometric and quantum chem. calculations data have demonstrated a possibility of formation of stable noncovalent complexes including (di)cations of quaternary ammonium bases and anions of organic DHB acid. Plotting of “membrane melting temperature (T_m) vs. MTA composition” quasi-binary diagrams permitted us to determine the optimal stoichiometry of the BQAC-DHB membrane-incorporated complexes. It was revealed by means of DSC that incorporation into membranes of individual ionic BQAC and DHB as well as their complexes with stoichiometry providing preservation of the ionic (charged) state of the MTAs causes decrease of T_m and correspondingly, disordering of the membrane structure. At the same time, under MTA concentrations providing neutral complexes of BQAC and DHB. some increase in T_m is observed corresponding to an ordering of membrane structure. which can be interpreted as deactivation of BQAC. i.e. modulation of their activity in the presence of the organic acid. The ascertained possibility of suppression of membranotropic activity of antimicrobial BQAC on their combined use with an organic acid is to be taken into account in design of multi-component antimicrobial drugs.

Biofizichnii Visnik published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C9H17NO, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zaitsev, O. I. published the artcileComposition and technological development of decamethoxin in tablet form as Decaceol, SDS of cas: 38146-42-8, the publication is Visnik Farmatsii (2002), 34-36, database is CAplus.

We have-studied phys.-chem. and technol. peculiarities of Decaceol substance in tablet form. We have investigated influence of ancillary matters on tablet quality. We established the kinetics of decamethoxin release from the tablet form of Decaceol substance.

Visnik Farmatsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C12H9NO, SDS of cas: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kasian, N. A. published the artcileProbing of the combined effect of bisquaternary ammonium antimicrobial agents and acetylsalicylic acid on model phospholipid membranes: differential scanning calorimetry and mass spectrometry studies, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Molecular BioSystems (2014), 10(12), 3155-3162, database is CAplus and MEDLINE.

A model mol. biosystem of hydrated dipalmitoylphosphatidylcholine (DPPC) bilayers that mimics cell biomembranes is used to probe combined membranotropic effects of drugs by instrumental techniques of mol. biophysics. Differential scanning calorimetry reveals that doping of the DPPC model membrane with individual bisquaternary ammonium compounds (BQAC) decamethoxinum, ethonium, thionium and acetylsalicylic acid (ASA) leads to lowering of the membrane melting temperature (T_m) pointing to membrane fluidization. Combined application of the basic BQAC and acidic ASA causes an opposite effect on T_m (increase), corresponding to the membrane densification. Thus, modulation of the membranotropic effects upon combined use of the drugs studied can be revealed at the level of model membranes. Formation of noncovalent supramol. complexes of the individual BQACs and ASA with DPPC mols., which may be involved in the mechanism of the drug-membrane interaction at the mol. level, is demonstrated by electrospray ionization (ESI) mass spectrometry. In the ternary (DPPC + ASA + BQAC) model systems, the stable complexes of the BQAC dication with the ASA anion, which may be responsible for modulation of the membranotropic effects of the drugs, were recorded by ESI mass spectrometry. The proposed approach can be further developed for preliminary evaluation of the combined effects of the drugs at the level of model lipid membranes prior to tests on living organisms.

Molecular BioSystems published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vashchenko, Olga published the artcileLyotropic Mesophase of Hydrated Phospholipids as Model Medium for Studies of Antimicrobial Agents Activity, SDS of cas: 38146-42-8, the publication is Molecular Crystals and Liquid Crystals (2011), 155-163, database is CAplus.

The lyotropic L_α-phase of hydrated dipalmitoylphosphatidylcholine has been proposed as a solvent medium for modeling the effects of membranotropic agents upon cell membranes, including interactions between different agents inside the membrane. For quasibinary systems containing bisquaternary ammonium compounds decamethoxinum or aethonium and 2,5-dihydroxybenzoic acid, calorimetry data allowed us to establish the stoichiometry of the intermol. complexes incorporated in the membrane. The interaction mechanisms have been clarified using addnl. data obtained with tetramethylammonium and 1-menthol, which model the moieties of the decamethoxinum mol. separated by the alkyl chain. Possible implications of the obtained results for pharmacol. are discussed.

Molecular Crystals and Liquid Crystals published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C12H14BNO2, SDS of cas: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Demchuk, B. N. published the artcileEffect of antimicrobial drugs on thermogenesis in yeastlike fungi and Staphylococci, Related Products of chlorides-buliding-blocks, the publication is Antibiotiki (Moscow) (1976), 21(3), 222-6, database is CAplus and MEDLINE.

At concentrations >9.8 × 10-4 μg/ml, levorin [11014-70-3] induced gradual decreases in heat production by Candida albicans. Decamethoxin [38146-42-8] had a similar effect in C. albicans. In Staphylococcus aureus, it decreased heat production at 9.8 × 10-4-3.9 × 10-3 μg/ml, then increased it at higher concentrations Both compounds completely inhibited heat production at ≥1 μg/ml.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Neporada, V. P. published the artcileEffect of decamethoxin on diphtheria bacteria and their sensitivity to antibiotics, Product Details of C38H74Cl2N2O4, the publication is Antibiotiki (Moscow) (1972), 17(5), 445-9, database is CAplus and MEDLINE.

Of 216 strains of diphtheria bacilli tested, 55.3% were sensitive to the bactericidal effect of decamethoxine (I) [38146-42-8] at 0.5-2 μg/ml; 1 strain was sensitive to 0.01 μg/ml and 6 were sensitive to 8 μg/ml. The 2 bacillus types isolated were equally sensitive to I. These organisms were also highly sensitive to erythromycin [114-07-8], neomycin [1404-04-2], monomycin [7542-37-2], levomycetin [56-75-7], and penicillin [1406-05-9]. The dehydrogenase [9035-82-9] activity of diphtheria bacilli was inhibited by bacteriostatic doses of I but was enhanced by subbacteriostatic doses.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nazarchuk, O. A. published the artcileResistance of Staphylococcus aureus strains to antimicrobials, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Anali Mechnikivs’kogo Institutu (2012), 133-139, database is CAplus.

In the research work the results of the study of resistance forming to antibiotics, antiseptics and decametoxin composition with modified polysaccharides in S.aureus strains are presented. The development of resistance to penicillins, cephalosporins, glycopeptides, macrolides is shown. Slow forming of resistance to decasan and decametoxin composition with carboxymethylamylum, oxyethylcellulose was determined

Anali Mechnikivs’kogo Institutu published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics