Tag: M.W=600-700

Pokrovskii, V. A. published the artcileMatrix-assisted laser desorption/ionization mass spectrometric study of bisquaternary ammonium antimicrobial agent decamethoxinum in 2,5-dihydroxybenzoic acid, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Mass-Spektrometriya (2005), 2(3), 183-192, database is CAplus.

The results of investigation of decamethoxinum on matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometer using 2,5-dihydroxybenzoic acid (DHB) matrix were presented. The MALDI mass spectra were obtained in the linear, reflectron and post source decay (PSD) modes. The spectra reveal diagnostic quasimol. ions of the decamethoxinum [Cat·Cl]⁺ and [Cat-H]⁺. The PSD data confirm that the pathways of unimol. decay of the [Cat·Cl]⁺ ions in the gas phase coincide with those of the salt thermal degradation via dequaternization; this agrees with the data obtained earlier with the use of secondary ion mass spectrometry. Abundant clusters containing Cat²⁺ and anions those originate from the DHB matrix were observed, and it was suggested that they were stabilized either by the electrostatic interactions with the carboxylic group (carboxylate anion) of DHB or due to the cation-π interactions with the DHB aromatic ring.

Mass-Spektrometriya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sukhodub, L. F. published the artcileMass spectrometry of decamethoxine, an antimicrobial drug, Quality Control of 38146-42-8, the publication is Antibiotiki i Khimioterapiya (1989), 34(11), 823-7, database is CAplus and MEDLINE.

Desorption mass spectrometry was a suitable method for identification and determination of a novel antimicrobial drug; decamethoxine (I). Thermal decomposition and mass spectrometric fragmentation of I under various ionization conditions are discussed.

Antibiotiki i Khimioterapiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C15H12O6, Quality Control of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pashynska, Vlada A. published the artcileOn the stability of the organic dication of the bisquaternary ammonium salt decamethoxinum under liquid secondary ion mass spectrometry, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Rapid Communications in Mass Spectrometry (2005), 19(6), 785-797, database is CAplus and MEDLINE.

In the course of a liquid secondary ion mass spectrometric (SIMS) investigation on a bisquaternary ammonium antimicrobial agent, decamethoxinum, unusual pathways of fragmentation of the organic dication M²⁺ of this bisquaternary salt, with preservation of the doubly charged state of the fragments, were observed To reveal the structural and electronic parameters of decamethoxinum, which are responsible for the stabilization of its organic dication in the gas phase, a comprehensive SIMS study using metastable decay, collision-induced dissociation and kinetic energy release techniques complemented by ab initio quantum chem. calculations was performed. Pathways of fragmentation of two main precursors originating from decamethoxinum – organic dication M²⁺ and its cluster with a Cl^– counterion [M·Cl]⁺ – and a number of their primary fragments were established and systematized. Differences in the pathways of fragmentation of M²⁺ and [M·Cl]⁺ were revealed: the main directions of [M·Cl]⁺ decay involve dequaternization similar to thermal degradation of this compound, while in M²⁺ fragmentation via loss of one and two terminal radicals with preservation of the doubly charged state of the fragments dominates over charge separation processes. It was shown that pairing of the dication with a Cl^– anion does not preserve the complex from fragmentation via separation of two pos. charged centers or neutralization (dequaternization) of one such center. At the same time the low abundance of M²⁺ in the SIMS spectra is to a larger extent controlled by a probability of M²⁺ association with an anion than by the decay of the dication per se. Quantum chem. calculations of the structural and electronic parameters of the decamethoxinum dication have revealed at least three features which can provide stabilization of the doubly charged state. Firstly, in the most energetically favorable stretch conformation the distance between the quaternary nitrogens (r_N1-N2 = 1.39 nm) is relatively large. Secondly, an intramol. solvation of quaternary groups by carbonyl oxygens of the adjacent groups of the dication occurs, which contribute to structural stabilization. Thirdly, an important feature of the electronic structure of the dication is the presence of a partial neg. charge on the nitrogen atoms and smearing of a pos. charge mainly over the hydrogens of alkyl groups attached to the quaternary nitrogens, which reduces the net repulsion between the quaternary groups. The possible influence of charge smearing on the kinetic energy released on the dication fragmentation is discussed.

Rapid Communications in Mass Spectrometry published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kabashnaya, L. V. published the artcileSensitivity of hyacinth and callalily soft rot agents to certain antimicrobic substances, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Mikrobiologichnii Zhurnal (1934-1977) (1975), 37(4), 492-5, database is CAplus.

Of 8 bactericides tested in vitro, Decamethoxin [38146-42-8] was the most effective, exerting bacteriostatic and bactericidal activity on Erwinia carotovora at 4-20 μg/ml., in dependence on strain, on E. aroideae at 4 μg/ml., and on Pseudomonas at 4-10 μg/ml.

Mikrobiologichnii Zhurnal (1934-1977) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileMicrobiological characteristics and antibiotic sensitivity of Pseudomonas aeruginosa at pedigree cattle stations, Related Products of chlorides-buliding-blocks, the publication is Antibiotiki (Moscow) (1975), 20(11), 998-1001, database is CAplus.

In the 464 strains of P. aeruginosa tested, resistance or low sensitivity to erythromycin [114-07-8] was observed in 95.8%, to chlortetracycline [57-62-5] in 95.8%, to tetracycline [60-54-8] in 84.36%, and to levomycetin [56-75-7] in 70.7%. About half of the strains were sensitive to streptomycin [57-92-1] and monomycin [54597-56-7], and 73.5% were sensitive to neomycin [1404-04-2]. All of the strains were resistant to penicillin [1406-05-9]. The range of bactericidal concentrations of gentamycin [1403-66-3] was 0.31-20 μg/ml, and for neomycin and decamethoxin [38146-42-8], 62.5-125 μg/ml.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Volyanskii, Yu. L. published the artcileEffect of gentamicin, decamethoxin and prodigiozan on the course and outcome of experimental pyocyanic infection in white mice, Category: chlorides-buliding-blocks, the publication is Antibiotiki (Moscow) (1978), 23(3), 254-7, database is CAplus.

Gentamicin [1403-66-3] (0.2 mg/kg) and decamethoxin [38146-42-8] (5 mg/kg) given i.p. to mice 12 h before, at the time of, or for 3 days beginning 2 days after inoculation with Pseudomonas aeruginosa increased survival of the infected animals. Combined treatment with gentamicin and decamethoxin gave the highest survival rates. Prodigiozan [9057-00-5] (1 mg/kg) was ineffective against the infection.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C12H25Br, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pashynska, V. A. published the artcileModel mass spectrometric study of competitive interactions of antimicrobial bisquaternary ammonium drugs and aspirin with membrane phospholipids, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Biopolymers and Cell (2013), 29(2), 157-162, database is CAplus.

Aim: The aim of the study is to reveal mol. mechanisms of possible activity modulation of antimicrobial bisquaternary ammonium compounds (BQAC) and aspirin (ASP) through noncovalent competitive complexation under their combined introduction into the model systems with membrane phospholipids. Methods: Binary and triple systems containing either decamethoxinum or ethonium, or thionium and aspirin, as well as dipalmitoylphosphatidylcholine (DPPC) have been investigated by electrospray ionization mass spectrometry. Results: Basing on the anal. of associates recorded in the mass spectra, the types of nonocovalent complexes formed in the systems studied were determined and the supposed role of the complexation in the BQAC and ASP activity modulation was discussed. The formation of associates of BQA C dications with ASP anion is considered as one of the possible ways of deactivation of ionic forms of the medications. The formation of stable complexes of BQAC with DPPC and ASP with DPPC in binary systems as well as the complexes distribution in triple-components systems BQACASP:DPPC point to the existence of competition between drugs of these two types for the binding to DPPC. Conclusions: The results obtained point to the competitive complexation in the model mol. systems containing the BQAC, aspirin and membrane phospholipids. The observed phenomenon testifies to the possibility of nodularizing the activity of bisquaternary antimicrobial agents and aspirin under their combined usage, due to the competition between the drugs for binding to the target membrane phospholipid mols. and also due to the formation of stable noncovalent complexes between BQAC and ASP.

Biopolymers and Cell published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pashynska, V. A. published the artcileDimethyl sulfoxide as a functional agent for antimicrobial drug’s transport facilitating: mechanistic study by mass spectrometry, Synthetic Route of 38146-42-8, the publication is Functional Materials (2022), 29(1), 100-106, database is CAplus.

Electrospray ionization mass spectrometry (ESI MS) study has been performed to examine biol. significant intermol. interactions between the mols. of DMSO (DMSO, known as a functional agent for transdermal and transmembrane drug’s transfer facilitation) and some antimicrobial drugs. Formation of stable noncovalent complexes of DMSO with the mols. of antibiotics levofloxacin (LEF) and cycloserine (CYS) in the polar solvent methanol has been revealed by ESI MS probing of model binary systems of DMSO with the mentioned drugs. At the same time ESI MS investigation of the similar model systems containing DMSO and antimicrobial chemotherapeutic preparation decamethoxinum (DEC) has shown that any peaks of the noncovalent complexes between DMSO and DEC are not recorded in the mass spectra, that points to the dependence of DMSO-drug complexation peculiarities on the drug’s structure. The data of ESI MS examining of DMSO+d ipalm itoylp hosphatidyl choline model system reveal that the DMSO mols. also do not form stable noncovalent clusters with the membrane phospholipid mols. in the polar surrounding. The obtained results as to formation of stable noncovalent complexes of DMSO with LEF and CYS in the polar solvent are proposed to be considered as one of the possible mol. mechanisms of action of DMSO as transdermal and transmembrane penetration enhancer in drug delivery. The current study confirms the ESI MS method applicability to examining the DMSO complexation with the drugs mole-cules and biomols. with the purpose to predict the DMSO usage efficiency as an agent for the drug’s transdermal and transmembrane transport facilitating.

Functional Materials published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pashynska, V. A. published the artcileThe effect of cone voltage on electrospray mass spectra of the bisquaternary ammonium salt decamethoxinum, Formula: C38H74Cl2N2O4, the publication is Rapid Communications in Mass Spectrometry (2005), 20(5), 755-763, database is CAplus.

The effect of cone voltage (CV) variation on the mass spectral pattern of the bisquaternary ammonium salt decamethoxinum in the electrospray ionization (ESI) mode was studied. The advantage of decamethoxinum as a test compound in ESI mass spectrometry lies in the production of two types of precursor ions, i.e. the doubly charged organic dication Cat²⁺ and its singly charged cluster with a Cl^– counterion, Cat · Cl⁺. This makes it possible to monitor the fragmentation patterns of these ions under identical exptl. conditions. Pronounced qual. and quant. changes in the ESI mass spectra were observed upon a gradual increase of the CV. The model compound decamethoxinum allowed us to reveal the extreme situation, in which the mass spectra at a CV below and over approx. 100 V look quite different, in that they contain different product ions of Cat²⁺ and Cat · Cl⁺. While this effect may be much less pronounced for other classes of organic compounds, it should be properly taken into account for the adequate description of fragmentation pathways of bisquaternary ammonium compounds with ESI. Comparison of ESI, FAB-SIMS and MALDI mass spectra of decamethoxinum shows that taking into account CV effects also permits us to gain information on energy deposition into ions generated with the different ionization techniques.

Rapid Communications in Mass Spectrometry published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karpenko, O. S. published the artcileSynthesis of new polyurethaneureas with decametoxin containing fragments of copolymers of N-vinyl pyrrolidone with vinyl alcohol, Application In Synthesis of 38146-42-8, the publication is Dopovidi Natsional’noi Akademii Nauk Ukraini (2014), 92-96, database is CAplus.

Synthesis of new biol. active polyurethane-polyureas, PUU, was carried out. The PUUs containing was prepared and reacted with hydrolyzed poly(N-vinylpyrrolidone-co-vinyl acetate). Decametoxin was immobilized on the copolymer. The copolymer can be used for the treatment of wounds. The IR-spectroscopy testified that decametoxin was immobilized on the polymer through phys. bonds.

Dopovidi Natsional’noi Akademii Nauk Ukraini published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Application In Synthesis of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics