Tag: M.W=600-700

Hrinovets, I. S. published the artcileJustification of formulation of dental films with decamethoxine as medicinal preparation for treatment of mucous membrane diseases, Computed Properties of 38146-42-8, the publication is Farmatsevtichnii Zhurnal (Kiev, Ukraine) (2008), 99-103, database is CAplus.

Therapeutic drug delivery systems in the form of dental medicinal films with pharmacol. ingredients with prolonged wound-healing, antibacterial, anti-inflammatory, and regenerative activities for use in stomatol. practice were studied. The mucosa-adhesive films containing 0.02% of the antiseptic and disinfecting agent decamethoxine were prepared from methylcellulose, polyvinyl alc., polyvinylpyrrolidone, and gelatin; the auxiliary components were propylene glycol, PEO-400, Tween-80, saccharin, and water. The medicinal films were evaluated for sensory, taste, physicochem., microbiol., and biopharmaceutical properties, including thickness, adhesivity, UV absorption spectra, solubility and drug release in water and in mouth. The decamethoxine levels were determined by spectrophotometry at 540 nm. The antimicrobial activity was examined against test strains of Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and Candida albicans at 37°. The films had pronounced antibacterial effects on G-pos. and less on G-neg. bacteria. The films were also tested in patients with mouth mucosa inflammation and ulcerative damage. The dry films were stable during 24-mo storage.

Farmatsevtichnii Zhurnal (Kiev, Ukraine) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Computed Properties of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zimina, I. F. published the artcileSorption of bioactive inorganic and organic compounds by cellulosic cation exchangers, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg) (1998), 71(6), 920-924, database is CAplus.

The feasibility of modifying monocarboxy cellulose, CM-cellulose, and cellulose phosphate by a series of antiseptic property-imparting organic or inorganic electrolytes was investigated. The sorption of organic cations by H-form cellulosic cation exchangers increased along the series decamethoxin<septonex<chlorohexidine<ethonium due to increased charge d. and lowered screening of hydrophobic hydrocarbon radicals. A complex-forming sorption of Ag⁺, Zn²⁺, Cu²⁺, Co²⁺, Ni²⁺, and Fe³⁺ by cellulosic cation exchangers in chlorohexidine form was discovered.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C15H20O6, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zimina, I. F. published the artcileSorption of some quaternary ammonium salts by ion-exchange materials, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Kolloidnyi Zhurnal (1994), 56(4), 503-8, database is CAplus.

Sorption of various organic electrolytes, having antiseptic properties, was studied on various-structure sorbents. Based on the effects of counter ion, fixed groups, exchange capacity, degree of saturation by H⁺-Na⁺ ions, and matrix permeation, the distribution of organic ions between the phases were determined Sorption mechanism is discussed. Cellulose-based sorbents, carbon fibers, and synthetic sorbents application in a removal of toxic electrolytes from aqueous solutions is proposed for a wide concentration range.

Kolloidnyi Zhurnal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C15H20O6, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Blazheevs’kii, M. E. published the artcileQuantitative determination of decamethoxine in drug formulations by enzyme kinetic method, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Visnik Farmatsii (2007), 13-15, database is CAplus.

An enzyme kinetic method for the decamethoxine (DM; cationic surfactant with antimicrobial and disinfectant effects) determination by enzyme kinetic method based on DM inhibition of acetylcholine hydrolysis by cholinesterase (horse serum acyl hydrolase, EC 3.1.1.8) was developed. The indicator reaction for acetylcholine utilizes p-anisidine oxidation by peracetic acid formed in the auxiliary reaction of acetylcholine perhydrolysis with H₂O₂. The reaction product was measured by spectrophotometry at 358 nm. Comparison of the degree of inhibition of the enzymic reaction in the presence of standard and test samples allows to find the DM level in the formulation. The relative standard deviation at 1-2 μg DM/mL is ≤6%. The lower quantification limit (at 20% reaction inhibition) is 1 ng/mL. The method was used for DM detn in Septefril 0.0002 g tablets.

Visnik Farmatsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Goncharik, V. P. published the artcileAdsorption of decamethoxin by highly disperse silica, Quality Control of 38146-42-8, the publication is Farmatsevtichnii Zhurnal (Kiev) (2000), 55-58, database is CAplus.

Adsorption of decamethoxin by silica from aqueous, physiol. and hypertonical solutions is explored. It is supposed, that the adsorption of decamethoxin from neutral and weakly alk. aqueous solutions is realized by an ionic mechanism and from weakly acidic ones it is by a mechanism based on dispersion interaction of adsorbate mols. with silica surface. In aqueous salt solutions, the adsorption of decamethoxin by silica is reversible and increases with increasing ionic strength of the solution

Farmatsevtichnii Zhurnal (Kiev) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Quality Control of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileStudy of Candida fungus sensitivity to antimicrobial drugs, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Antibiotiki i Meditsinskaya Biotekhnologiya (1986), 31(3), 218-20, database is CAplus.

Fifty strains of Candida (C. albicans 28, C. tropicalis 18, and C. pseudotropicalis 4 strains) were tested in vitro against 5 fungicides: amphotericin B, levorin, decamethoxine, enteroseptol, and intestopan. Decamethoxine was the most active drug, as it inhibited 78% of the strains at 0.08-6.25 μg/mL concentration; at 12.5 μg/mL, the drug showed fungicidal activity against 20% of the strains. Levorin and amphotericin B displayed antifungal activity at 50 μg/mL concentration At 3.9-7.8, μg/mL enteroseptol inhibited 78% of the strains. Intestopan was the least active compound Development of resistance to decamethoxine was slow, and there was no cross-resistance between decamethoxine and levorin.

Antibiotiki i Meditsinskaya Biotekhnologiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagiyev, Kh. D. published the artcileSpectrophotometric study of multi-ligand titanium (IV) complexes, Synthetic Route of 38146-42-8, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2003), 46(7), 94-97, database is CAplus.

The formation of titanium (IV) complexes with 2,3,4-trihydroxy-4′-sulfoazobenzene in the presence and absence of 3rd components, such as tri-Ph guanidine, bathophenanthroline, and decamethoxine, has been studied spectrophotometrically. The optimum conditions for the formation of binary and multi-ligand complexes have been found. The influence of pH, temperature, and time, reagent concentration, and the concentration of the 3rd component on the complexation reaction has been studied. Techniques of the photometric determination of titanium microquantities have been developed. These were approved by analyzing titanium in aluminum alloys M207-4 and M-207-5.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yakovleva, A. M. published the artcileEffect of new synthetic proparations derived from quaternary ammonium salts and phosphoranes on development and survival of Trichocephalus trichiurus eggs, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Paraziti, Parazitozi ta Shlyakhi Ikh Likvidatsii (1973), 165-7, database is CAplus.

When tested in 1% solutions on T. trichiurus eggs, isolated from human feces, quaternary ammonium salts, including ethonium [24771-49-1] and decamethoxin [38146-42-8] showed ovicidal activity. Dimethylformamide solutions of 3 triphenylphosphonium salts were also very effective against T. trichiurus eggs.

Paraziti, Parazitozi ta Shlyakhi Ikh Likvidatsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C28H18O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lopushanskii, A. I. published the artcileSynthesis of quaternary ammonium derivatives of menthol, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1963), 1141-2, database is CAplus.

(R’CH₂CO₂R)⁺Cl^– were prepared, where R = l-menthyl, and R’ = Me₃N (I), Et₃N (II), p-H₂NC₆H₄CO₂(CH₂)₂NEt₂ (III). Also prepared was [RO₂CCH₂N⁺Me₂(CH₂)₁₀N⁺Me₂CH₂CO₂R]2Cl^–, where R was l-menthyl (IV). To prepare II, 3 g. NEt₃ in pure, dry ether was added to a solution of 5 g. chloroacetic acid l-menthyl ester mixed with ether, the mixture refluxed 1 h., cooled, kept 2 days at room temperature, and II filtered off, washed with ether, dissolved in absolute alc., precipitated with ether, and dried in vacuo. III and IV were prepared in the same manner from novocaine and N,N’-tetramethyldecamethylenediamine (V), resp., in pure dry ether. I was prepared by passing dry NMe₃ gas through a solution of menthyl chloroacetate in boiling PhMe. Methods described by Denisenko and L. (CA 58, 6680f) were used for the preparation of menthyl chloroacetate. To prepare V, 10 g. decamethylenediamine was subjected to reductive alkylation (Barber and Gaimster, CA 46, 1970i); 53% yield. V b_2.5 137-9°, d₂₀ 0.8013, n²⁰_D 1.442, MR 75.42. I, 97%, m. 225°; II, 94%, m. 179°. III, 83%, m. 89°; IV, 92%, m. 158°.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Burlyka, A. F. published the artcileFungus-resistant gypsum-paperboard sheets, Category: chlorides-buliding-blocks, the publication is Stroitel’nye Materialy i Konstruktsii (1988), 18, database is CAplus.

Application of 0.2-1.4% aqueous solutions of Katapin to the outer surfaces of gypsum boards gave good antifungal protection. Treatment with a bitumen mastic, Polidim, Decamethoxine, and Fosulen gave unsatisfactory results.

Stroitel’nye Materialy i Konstruktsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics